iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012446

UUCD1 version

UUC-BoT-00770

Ensembl Protein ID

ENSBTAP00000034071.4

UniProt Accession

Q3SX24; FBX6_BOVIN

Genbank Protein ID

ABQ12947.1; AAI04547.1

Protein Name

F-box only protein 6; F-box protein that recognizes sugar chains 2

Genbank Nucleotide ID

BT030507; BC104546

Gene Name

FBXO6; FBS2; FBX6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014777.5	ENSBTAT00000034170.4	ENSBTAP00000034071.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	23.05	4.00e-12	68.60	IUUC-Cel-018409
E3 adaptor/Cullin RING/SCF/F-box	80.68	4.00e-130	461.00	IUUC-Hsa-046047

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity).

Protein Sequence
(Fasta)

MALVSINQLP ENILLEVFMH VPARQLLRNC RPVCCLWRDL IDLVSLWKRK CLREGYVTED 60
WDQPVSDWKV FYFLCSLRRN LLRNPCAEED MKSWKIDSNG GDQWKVESLP GAHGTGFPDS 120

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Nucleotide Sequence
(Fasta)

GGCTCCAGGC CGATACCGAG CTCCGGTCCC GCGGAGCGCT CCTTCCCGTG CCCAGGTCTC 60
AGCCCAGCCG GGGGACGGGT AGGGGGGCGA CAGGCGCGGG ATGGGGCTTG GATGTCAGGC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF12937--F-box-like
PF04300--FBA

SMART

SM01198--FBA
SM00256--FBOX

Gene Ontology

GO:0005737--C:cytoplasm
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030246--F:carbohydrate binding
GO:0001948--F:glycoprotein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0006281--P:DNA repair
GO:0006516--P:glycoprotein catabolic process
GO:0006986--P:response to unfolded protein
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

bta:513023

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002387	Ailuropoda melanoleuca	81.13	1.00e-126	445.00
IUUC-Apl-003256	Anas platyrhynchos	58.96	1.00e-90	325.00
IUUC-Aca-005249	Anolis carolinensis	60.10	2.00e-77	281.00
IUUC-Ame-011181	Astyanax mexicanus	49.59	1.00e-64	239.00
IUUC-Bdi-014683	Brachypodium distachyon	47.50	5.00e-03	37.00
IUUC-Cel-018409	Caenorhabditis elegans	23.05	6.00e-13	68.60
IUUC-Cja-019690	Callithrix jacchus	77.64	8.00e-118	416.00
IUUC-Cfa-020399	Canis familiaris	84.15	1.00e-136	478.00
IUUC-Cpo-022113	Cavia porcellus	81.01	6.00e-132	462.00
IUUC-Csa-023732	Chlorocebus sabaeus	80.65	9.00e-124	436.00
IUUC-Dre-027973	Danio rerio	47.79	9.00e-67	246.00
IUUC-Dno-029725	Dasypus novemcinctus	83.27	3.00e-123	434.00
IUUC-Dor-030820	Dipodomys ordii	82.20	1.00e-120	425.00
IUUC-Ete-032617	Echinops telfairi	85.80	2.00e-90	324.00
IUUC-Eca-033658	Equus caballus	81.45	1.00e-124	438.00
IUUC-Eeu-035144	Erinaceus europaeus	73.71	6.00e-114	403.00
IUUC-Fca-036511	Felis catus	83.40	4.00e-132	463.00
IUUC-Fal-037154	Ficedula albicollis	60.99	3.00e-87	314.00
IUUC-Gga-041011	Gallus gallus	61.45	2.00e-91	328.00
IUUC-Gac-041813	Gasterosteus aculeatus	49.60	8.00e-66	243.00
IUUC-Ggo-044771	Gorilla gorilla	80.65	3.00e-123	434.00
IUUC-Hsa-046047	Homo sapiens	80.65	7.00e-124	436.00
IUUC-Itr-048961	Ictidomys tridecemlineatus	87.30	2.00e-131	461.00
IUUC-Lpe-051265	Leersia perrieri	36.84	1.00e-03	38.90
IUUC-Loc-051984	Lepisosteus oculatus	54.55	2.00e-61	228.00
IUUC-Laf-054388	Loxodonta africana	80.61	1.00e-124	439.00
IUUC-Mcc-055219	Macaca mulatta	81.05	2.00e-124	437.00
IUUC-Meu-056508	Macropus eugenii	74.10	4.00e-113	400.00
IUUC-Mga-060039	Meleagris gallopavo	62.61	2.00e-86	311.00
IUUC-Mmr-060599	Microcebus murinus	83.02	4.00e-129	453.00
IUUC-Mmu-064158	Mus musculus	79.03	6.00e-121	426.00
IUUC-Mpu-065798	Mustela putorius furo	81.89	3.00e-131	460.00
IUUC-Mlu-067931	Myotis lucifugus	78.71	9.00e-130	456.00
IUUC-Opr-070619	Ochotona princeps	79.55	4.00e-121	427.00
IUUC-Ont-072665	Oreochromis niloticus	52.89	5.00e-73	267.00
IUUC-Ocu-074270	Oryctolagus cuniculus	79.77	1.00e-127	448.00
IUUC-Oni-082367	Oryza nivara	48.48	3.00e-03	37.40
IUUC-Oru-084280	Oryza rufipogon	48.39	9.00e-03	35.00
IUUC-Ola-086867	Oryzias latipes	49.38	1.00e-67	249.00
IUUC-Oga-088988	Otolemur garnettii	83.92	2.00e-131	461.00
IUUC-Oar-089871	Ovis aries	96.23	8.00e-154	535.00
IUUC-Ptr-091362	Pan troglodytes	80.65	6.00e-124	436.00
IUUC-Pan-091935	Papio anubis	80.65	1.00e-123	436.00
IUUC-Psi-092980	Pelodiscus sinensis	64.35	6.00e-93	333.00
IUUC-Pma-094635	Petromyzon marinus	42.26	3.00e-32	130.00
IUUC-Pno-094803	Phaeosphaeria nodorum	50.00	8.00e-03	34.70
IUUC-Pfo-097249	Poecilia formosa	49.10	1.00e-60	226.00
IUUC-Pab-098167	Pongo abelii	80.65	8.00e-124	436.00
IUUC-Pca-100483	Procavia capensis	82.74	1.00e-84	305.00
IUUC-Pva-103073	Pteropus vampyrus	79.25	1.00e-128	452.00
IUUC-Pte-104184	Pyrenophora teres	29.07	1.20e-02	33.90
IUUC-Rno-106045	Rattus norvegicus	79.03	2.00e-122	431.00
IUUC-Sha-107560	Sarcophilus harrisii	74.51	3.00e-116	410.00
IUUC-Sar-113378	Sorex araneus	78.46	2.00e-122	431.00
IUUC-Ssc-115889	Sus scrofa	86.79	7.00e-141	492.00
IUUC-Tgu-116573	Taeniopygia guttata	60.36	3.00e-84	304.00
IUUC-Tru-117734	Takifugu rubripes	50.83	2.00e-63	235.00
IUUC-Tni-120432	Tetraodon nigroviridis	48.98	2.00e-67	248.00
IUUC-Tbe-127475	Tupaia belangeri	85.21	9.00e-136	476.00
IUUC-Ttr-129048	Tursiops truncatus	88.59	2.00e-137	481.00
IUUC-Xtr-132515	Xenopus tropicalis	51.43	1.00e-60	225.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence