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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046588
UUCD1 version UUC-HoS-00455
Ensembl Protein ID ENSP00000444711.1
UniProt Accession Q9Y225; D3DVZ2; D3DVZ3; Q9UMH1; RNF24_HUMAN
Genbank Protein ID CAB46627.1; AAP36074.1; CAB43182.1; EAX10467.1; EAX10468.1; EAX10469.1; EAX10471.1; AAH00213.1; AAH39584.1; CAB45279.1
Protein Name RING finger protein 24
Genbank Nucleotide ID AL096778; BT007406; AL031670; CH471133; CH471133; CH471133; CH471133; BC000213; BC039584; AL079313
Gene Name RNF24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101236.16 ENST00000545616.2 ENSP00000444711.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDMentha
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 11513855
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.20e-07 32.9 99 140
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+Cledf  +d++ + pC+H+fh++Cl kw         +  CPlC+
   Q: 99   CAVCLEDFkpRDELGICPCKHAFHRKCLIKW------LEVRKVCPLCN 140
           ********885558899**************......999*******7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in TRPCs intracellular trafficking.
 May play a role in TRPCs intracellular trafficking.
Protein Sequence
(Fasta)
MLNKSGESRY PALFPVLGGS SMSSDFPHYN FRMPNIGFQN LPLNIYIVVF GTAIFVFILS 60
LLFCCYLIRL RHQAHKEFYA YKQVILKEKV KELNLHELCA VCLEDFKPRD ELGICPCKHA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046588|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCCCTCGCG AGGGGCCGCC GGGCGCAGTC AGCCGCCGCC ACCTCCGCCG CGCTCTGTCC 60
GGACGGACGC TCGCCGCCCG CAGCCTGCCG CCCGCCGCAG GGCGCTGACG GTCCCGCACG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046588|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
SM00744--RINGv
Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:11237
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000179 Aegilops tauschii 52.73 2.00e-13 67.00
IUUC-Aml-001325 Ailuropoda melanoleuca 96.23 2.00e-86 310.00
IUUC-Apl-003423 Anas platyrhynchos 95.35 6.00e-70 256.00
IUUC-Aly-005601 Arabidopsis lyrata 43.10 5.00e-12 64.70
IUUC-Ath-007601 Arabidopsis thaliana 43.33 2.00e-12 66.60
IUUC-Ame-010971 Astyanax mexicanus 90.29 5.00e-52 195.00
IUUC-Bta-012688 Bos taurus 99.32 5.00e-84 302.00
IUUC-Cja-019693 Callithrix jacchus 100.00 4.00e-86 309.00
IUUC-Cfa-020659 Canis familiaris 100.00 5.00e-85 305.00
IUUC-Cpo-021977 Cavia porcellus 99.32 3.00e-84 303.00
IUUC-Csa-023052 Chlorocebus sabaeus 100.00 5.00e-85 305.00
IUUC-Cho-024589 Choloepus hoffmanni 98.51 5.00e-75 272.00
IUUC-Cin-025407 Ciona intestinalis 45.37 1.00e-23 102.00
IUUC-Csv-026249 Ciona savignyi 46.30 2.00e-24 104.00
IUUC-Dre-027784 Danio rerio 82.80 2.00e-71 261.00
IUUC-Dno-029622 Dasypus novemcinctus 88.62 9.00e-87 311.00
IUUC-Dor-030780 Dipodomys ordii 99.32 2.00e-84 303.00
IUUC-Ete-032257 Echinops telfairi 97.30 1.00e-79 287.00
IUUC-Eca-033551 Equus caballus 100.00 5.00e-85 305.00
IUUC-Eeu-034897 Erinaceus europaeus 98.65 9.00e-83 298.00
IUUC-Fca-035708 Felis catus 100.00 4.00e-86 309.00
IUUC-Fal-036814 Ficedula albicollis 88.39 2.00e-70 258.00
IUUC-Gmo-038553 Gadus morhua 84.46 3.00e-66 243.00
IUUC-Gga-040496 Gallus gallus 95.27 2.00e-74 271.00
IUUC-Gac-042434 Gasterosteus aculeatus 87.25 5.00e-72 263.00
IUUC-Ggo-044530 Gorilla gorilla 100.00 1.00e-97 348.00
IUUC-Itr-048721 Ictidomys tridecemlineatus 98.65 1.00e-83 301.00
IUUC-Lch-049966 Latimeria chalumnae 88.82 2.00e-76 277.00
IUUC-Loc-052245 Lepisosteus oculatus 86.00 4.00e-73 266.00
IUUC-Laf-053477 Loxodonta africana 100.00 5.00e-85 305.00
IUUC-Mcc-055700 Macaca mulatta 94.67 2.00e-88 317.00
IUUC-Meu-056179 Macropus eugenii 86.49 6.00e-71 259.00
IUUC-Mga-059784 Meleagris gallopavo 78.00 3.00e-62 230.00
IUUC-Mmr-060797 Microcebus murinus 97.04 1.00e-93 335.00
IUUC-Mdo-062152 Monodelphis domestica 96.62 2.00e-82 297.00
IUUC-Mmu-063431 Mus musculus 97.97 7.00e-84 301.00
IUUC-Mpu-066435 Mustela putorius furo 93.25 2.00e-86 310.00
IUUC-Mlu-067711 Myotis lucifugus 100.00 5.00e-85 305.00
IUUC-Nle-069294 Nomascus leucogenys 100.00 5.00e-85 305.00
IUUC-Opr-070557 Ochotona princeps 100.00 5.00e-85 305.00
IUUC-Ont-071797 Oreochromis niloticus 86.09 1.00e-71 261.00
IUUC-Ocu-074412 Oryctolagus cuniculus 98.68 5.00e-86 309.00
IUUC-Ola-087239 Oryzias latipes 86.58 4.00e-69 253.00
IUUC-Oga-088923 Otolemur garnettii 97.63 3.00e-95 340.00
IUUC-Oar-090126 Ovis aries 98.05 6.00e-87 312.00
IUUC-Ptr-091225 Pan troglodytes 100.00 1.00e-97 348.00
IUUC-Pan-092018 Papio anubis 99.34 3.00e-86 310.00
IUUC-Pma-094208 Petromyzon marinus 47.71 1.00e-24 104.00
IUUC-Pfo-097399 Poecilia formosa 86.18 2.00e-72 264.00
IUUC-Pab-098071 Pongo abelii 100.00 5.00e-85 305.00
IUUC-Pca-100136 Procavia capensis 89.86 8.00e-75 271.00
IUUC-Pva-102139 Pteropus vampyrus 100.00 1.00e-69 254.00
IUUC-Sha-107160 Sarcophilus harrisii 96.08 7.00e-85 305.00
IUUC-Sar-113430 Sorex araneus 95.95 6.00e-81 292.00
IUUC-Tgu-117344 Taeniopygia guttata 94.17 1.00e-54 204.00
IUUC-Tru-117961 Takifugu rubripes 94.49 2.00e-68 251.00
IUUC-Tsy-118956 Tarsius syrichta 72.30 4.00e-55 206.00
IUUC-Tni-120481 Tetraodon nigroviridis 93.70 6.00e-68 249.00
IUUC-Tbe-127610 Tupaia belangeri 85.29 9.00e-46 174.00
IUUC-Ttr-128794 Tursiops truncatus 100.00 5.00e-85 305.00
IUUC-Vpa-130388 Vicugna pacos 99.02 3.00e-56 209.00
IUUC-Xtr-132561 Xenopus tropicalis 90.54 1.00e-76 278.00
Created Date 25-Jun-2017

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