iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046766

UUCD1 version

UUC-HoS-01141

Ensembl Protein ID

ENSP00000402551.2

UniProt Accession

Q96FW1; Q32Q78; Q96II3; Q9NXQ4; Q9P0B8; OTUB1_HUMAN

Genbank Protein ID

AAO27702.1; AAF28941.1; BAA90956.1; AAH07519.1; AAH10368.1; AAI07702.1

Protein Name

Ubiquitin thioesterase OTUB1; Deubiquitinating enzyme OTUB1; OTU domain-containing ubiquitin aldehyde-binding protein 1; Otubain-1; Ubiquitin-specific-processing protease OTUB1

Genbank Nucleotide ID

AY177200; AF161381; AK000120; AP000721; BC010368; BC107701

Gene Name

OTUB1; OTB1; OTU1; HSPC263

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000167770.11	ENST00000541478.5	ENSP00000439142.1
ENSG00000167770.11	ENST00000535715.5	ENSP00000440211.1
ENSG00000167770.11	ENST00000428192.6	ENSP00000402551.2
ENSG00000167770.11	ENST00000543004.5	ENSP00000437453.1
ENSG00000167770.11	ENST00000535140.1	ENSP00000444968.1
ENSG00000167770.11	ENST00000422031.6	ENSP00000416973.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	CircNet	miRTarBase	microRNA
TRANSFAC	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/OTU	OTU	19996094; 12704427

Classification

Family	E-value	Score	Start	End
DUB/OTU	6.00e-51	174.1	81	271

Active Site

Position(s)	Description	Evidence
88	N/A	{ECO:0000244\|PDB:4DHZ, ECO:0000269\|PubMed:22367539}
91	Nucleophile	{ECO:0000269\|PubMed:22325355, ECO:0000305\|PubMed:18954305}
265		{ECO:0000269\|PubMed:22325355, ECO:0000305\|PubMed:18954305}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsdalv 35
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd+lv
   Q: 81   YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSDYLV 172
           89****************************************************************************************** PP
   S: 36   eaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkkpivLl 126
           ++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +++++Ll
   Q: 173  VYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-EPKVYLL 260
           *******************************************************************9...9************.******* PP
   S: 127  YrsgHYdaLva 137
           Yr+gHYd+L++
   Q: 261  YRPGHYDILYK 271
           *********96 PP

Organism

Homo sapiens

Functional Description
(View)

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Protein Sequence
(Fasta)

MAAEEPQQQK QEPLGSDSEG VNCLAYDEAI MAQQDRIQQE IAVQNPLVSE RLELSVLYKE 60
YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN CFYRAFGFSH LEALLDDSKE LQRFKAVSAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTAGGTCA TGAGGCTTTG GCCTTGACAC CAAGGGATGC TGTCTCCTTG CCGGAAGCAG 60
CTCACCAAAG CCGGCAGAGA ACCCAGGTTC CGTGGGGCCA CGATGTGGGG CTCCGCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0391--Immunity
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0002250--P:adaptive immune response
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0006281--P:DNA repair
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination

KEGG

hsa:55611

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	98.17	7.00e-156	542.00
IUUC-Apl-003233	Anas platyrhynchos	58.46	6.00e-19	85.10
IUUC-Aca-004648	Anolis carolinensis	85.40	3.00e-137	481.00
IUUC-Aly-005710	Arabidopsis lyrata	42.12	6.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	41.97	6.00e-51	194.00
IUUC-Afl-008439	Aspergillus flavus	34.18	2.00e-08	52.80
IUUC-Ame-010662	Astyanax mexicanus	82.89	4.00e-130	457.00
IUUC-Bta-013533	Bos taurus	98.89	8.00e-153	532.00
IUUC-Bol-016100	Brassica oleracea	42.05	2.00e-50	192.00
IUUC-Bra-017705	Brassica rapa	39.15	3.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	34.42	9.00e-42	163.00
IUUC-Cja-019190	Callithrix jacchus	100.00	3.00e-154	537.00
IUUC-Cfa-020430	Canis familiaris	100.00	1.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	99.63	5.00e-154	536.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	38.80	1.00e-46	179.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.79	9.00e-152	529.00
IUUC-Cin-025507	Ciona intestinalis	43.33	2.00e-44	172.00
IUUC-Csv-026273	Ciona savignyi	49.80	5.00e-69	254.00
IUUC-Dre-027843	Danio rerio	79.32	8.00e-127	446.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	8.00e-118	415.00
IUUC-Dor-030943	Dipodomys ordii	99.63	5.00e-154	536.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	2.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	96.23	1.00e-89	323.00
IUUC-Eca-033695	Equus caballus	98.81	3.00e-148	516.00
IUUC-Fca-036441	Felis catus	100.00	1.00e-149	522.00
IUUC-Gmo-038908	Gadus morhua	80.30	1.00e-126	445.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	1.00e-32	134.00
IUUC-Gga-040460	Gallus gallus	81.55	8.00e-134	469.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	1.00e-122	432.00
IUUC-Gma-043712	Glycine max	41.13	1.00e-51	196.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	1.00e-92	332.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.63	5.00e-154	536.00
IUUC-Lch-050602	Latimeria chalumnae	81.35	3.00e-119	421.00
IUUC-Laf-053705	Loxodonta africana	99.63	5.00e-154	536.00
IUUC-Mcc-055745	Macaca mulatta	93.77	1.00e-150	525.00
IUUC-Meu-056569	Macropus eugenii	85.61	2.00e-135	474.00
IUUC-Mtr-057712	Medicago truncatula	43.49	1.00e-46	180.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	3.00e-15	75.90
IUUC-Mmr-061123	Microcebus murinus	99.57	7.00e-128	449.00
IUUC-Mdo-062613	Monodelphis domestica	87.08	1.00e-123	435.00
IUUC-Mmu-063658	Mus musculus	99.63	5.00e-154	536.00
IUUC-Mac-065274	Musa acuminata	37.60	2.00e-39	155.00
IUUC-Mpu-066172	Mustela putorius furo	100.00	3.00e-154	536.00
IUUC-Mlu-066966	Myotis lucifugus	99.26	2.00e-153	534.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	2.00e-93	335.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	4.00e-125	440.00
IUUC-Ola-087331	Oryzias latipes	80.90	5.00e-86	310.00
IUUC-Oga-088064	Otolemur garnettii	100.00	3.00e-154	536.00
IUUC-Oar-089251	Ovis aries	98.03	1.00e-147	515.00
IUUC-Ptr-091430	Pan troglodytes	100.00	5.00e-154	536.00
IUUC-Psi-093823	Pelodiscus sinensis	87.74	4.00e-134	470.00
IUUC-Pma-094366	Petromyzon marinus	72.01	3.00e-103	368.00
IUUC-Pfo-096734	Poecilia formosa	80.88	4.00e-114	404.00
IUUC-Pab-097919	Pongo abelii	100.00	3.00e-127	447.00
IUUC-Pop-099401	Populus trichocarpa	41.24	2.00e-48	186.00
IUUC-Ppe-101977	Prunus persica	42.38	2.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	3.00e-149	520.00
IUUC-Rno-105233	Rattus norvegicus	99.63	5.00e-154	536.00
IUUC-Sha-107081	Sarcophilus harrisii	96.51	2.00e-148	518.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	100.00	3.00e-154	536.00
IUUC-Tru-117664	Takifugu rubripes	77.32	8.00e-123	432.00
IUUC-Tca-121467	Theobroma cacao	41.54	2.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	2.00e-93	335.00
IUUC-Ttr-128622	Tursiops truncatus	99.26	1.00e-151	528.00
IUUC-Vvi-131389	Vitis vinifera	43.75	6.00e-53	201.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	5.00e-115	407.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence