iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000007762.3	ENSMMUT00000078163.1	ENSMMUP00000049141.1
ENSMMUG00000007762.3	ENSMMUT00000010870.3	ENSMMUP00000010197.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.20e-49	168.0	42	231

Active Site

Position(s)	Description	Evidence
49	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
52	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
225		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s+sd
   Q: 42   AIRKTKGDGNCFYRALGYSylesllgksreifkfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSASD 130
           79*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a+ +++i+i+aL+q+Ls++++v++vd++++    +l++++fpe++ +
   Q: 131  HIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATeCDHIQITALSQALSIALQVEYVDEMDT----ALNHHVFPEAA-T 214
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 215  PSVYLLYKTSHYNILYA 231
           ***************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MRSETSFNLI SEKCDILSIL RDHPENRIYR RKIEELSKRF TAIRKTKGDG NCFYRALGYS 60
YLESLLGKSR EIFKFKERVL QTPNDLLAAG FEEHKFRNFF NAFYSVVELV EKDGSVSSLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAATTGCGGG GCGTGTGTCT TCCTGGGACA CAGTGGAGGT CTAACCTTTG GTTTGCGGAG 60
TGGTCGGGTG TATTCTCCGC CGCCCCCACG CCCTCGAGGT CCCCGCCACC GAACCAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	94.85	1.00e-131	461.00
IUUC-Bta-012766	Bos taurus	95.71	2.00e-131	461.00
IUUC-Cja-019480	Callithrix jacchus	96.57	2.00e-133	467.00
IUUC-Cfa-021106	Canis familiaris	95.28	2.00e-132	464.00
IUUC-Cpo-022187	Cavia porcellus	94.02	1.00e-130	458.00
IUUC-Csa-023493	Chlorocebus sabaeus	99.57	2.00e-137	481.00
IUUC-Cho-024411	Choloepus hoffmanni	75.12	1.00e-83	301.00
IUUC-Dno-029346	Dasypus novemcinctus	95.26	4.00e-131	459.00
IUUC-Dor-031012	Dipodomys ordii	95.28	3.00e-132	463.00
IUUC-Ete-032266	Echinops telfairi	85.78	1.00e-117	415.00
IUUC-Eca-033356	Equus caballus	96.14	8.00e-132	462.00
IUUC-Eeu-034775	Erinaceus europaeus	95.69	2.00e-131	461.00
IUUC-Fca-035363	Felis catus	93.56	2.00e-129	454.00
IUUC-Ggo-045023	Gorilla gorilla	99.57	1.00e-136	478.00
IUUC-Hsa-046984	Homo sapiens	100.00	2.00e-137	481.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	95.28	2.00e-132	464.00
IUUC-Lch-050514	Latimeria chalumnae	60.89	4.00e-83	301.00
IUUC-Loc-052003	Lepisosteus oculatus	49.78	1.00e-63	236.00
IUUC-Laf-054382	Loxodonta africana	94.42	2.00e-131	460.00
IUUC-Meu-056038	Macropus eugenii	87.83	6.00e-99	352.00
IUUC-Mmr-060918	Microcebus murinus	96.14	1.00e-132	465.00
IUUC-Mdo-062638	Monodelphis domestica	89.22	1.00e-123	434.00
IUUC-Mmu-063973	Mus musculus	94.04	2.00e-131	461.00
IUUC-Mpu-066013	Mustela putorius furo	96.12	1.00e-132	464.00
IUUC-Mlu-067509	Myotis lucifugus	93.56	5.00e-128	449.00
IUUC-Nle-069673	Nomascus leucogenys	100.00	2.00e-137	481.00
IUUC-Opr-070761	Ochotona princeps	87.27	2.00e-80	291.00
IUUC-Oan-072922	Ornithorhynchus anatinus	81.22	1.00e-111	395.00
IUUC-Ocu-074643	Oryctolagus cuniculus	94.42	1.00e-130	458.00
IUUC-Oni-082026	Oryza nivara	28.32	3.00e-16	80.10
IUUC-Oru-084761	Oryza rufipogon	28.32	3.00e-16	80.10
IUUC-Ola-086603	Oryzias latipes	44.91	2.00e-51	195.00
IUUC-Oga-088936	Otolemur garnettii	95.30	2.00e-132	464.00
IUUC-Oar-089460	Ovis aries	95.73	8.00e-132	462.00
IUUC-Ptr-090805	Pan troglodytes	99.57	5.00e-137	479.00
IUUC-Pan-091969	Papio anubis	100.00	2.00e-137	481.00
IUUC-Pab-098476	Pongo abelii	99.15	1.00e-136	478.00
IUUC-Pca-100252	Procavia capensis	89.00	9.00e-52	196.00
IUUC-Pva-102204	Pteropus vampyrus	94.42	1.00e-131	461.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.60e-02	31.60
IUUC-Rno-105062	Rattus norvegicus	94.85	1.00e-131	461.00
IUUC-Sha-106968	Sarcophilus harrisii	88.70	5.00e-122	430.00
IUUC-Sar-113295	Sorex araneus	95.26	3.00e-129	454.00
IUUC-Ssc-115288	Sus scrofa	95.26	7.00e-131	459.00
IUUC-Tni-120440	Tetraodon nigroviridis	38.96	2.00e-42	165.00
IUUC-Tbe-127717	Tupaia belangeri	94.59	5.00e-78	282.00
IUUC-Ttr-128221	Tursiops truncatus	76.72	8.00e-100	355.00
IUUC-Uma-129443	Ustilago maydis	33.17	2.00e-24	106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence