iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062638

UUCD1 version

UUC-MoD-01084

Ensembl Protein ID

ENSMODP00000002824.3

UniProt Accession

F6YDA8; F6YDA8_MONDO

Protein Name

Uncharacterized protein

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000002317.3	ENSMODT00000002880.3	ENSMODP00000002824.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.20e-46	158.7	42	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsda 33
            +ktkgDGnC++rA+++s                                                          ll+vf+d+s sd 
   Q: 42   LRKTKGDGNCFYRALGYSyleslignsreilrfkervlqtpkdllaagfeehkfrnffnafyslvemvekdgsvsnLLKVFNDQSFSDR 130
           689************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           +v++Lr+lts+++++++dff++fi+e++d+k+fc ++vep+a+ +++++i+aL+q+L++p++v++vd++++    +l++++f e++ ++
   Q: 131  IVQFLRLLTSAFIKNRADFFRHFIDEEMDVKDFCAQEVEPMATeCDHVQITALSQALNIPLQVEYVDEMDT----ALNHHVFSEAA-CP 214
           *********************************************************************95....9**********.** PP
   S: 122  pivLlYrsgHYdaLva 137
           +++LlY+++HY++L+a
   Q: 215  SVYLLYKTSHYNILYA 230
           **************97 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSESSFNLIS EKCDILSILC DHPENRIYQR KIQELSKRFS ALRKTKGDGN CFYRALGYSY 60
LESLIGNSRE ILRFKERVLQ TPKDLLAAGF EEHKFRNFFN AFYSLVEMVE KDGSVSNLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCCCTCT ATCTGTGACG TATATGCTTC CCGGCTTCTG ATTGCATCCT TTAGGCGTCA 60
ACCCCAGGGT GTGTATCTTA CTGGGACACT GTGGAGATCT CACCTCTTGT TTGCTGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	89.66	3.00e-124	437.00
IUUC-Bta-012766	Bos taurus	90.99	1.00e-126	445.00
IUUC-Cja-019480	Callithrix jacchus	88.79	3.00e-123	433.00
IUUC-Cfa-021106	Canis familiaris	90.09	6.00e-125	439.00
IUUC-Cpo-022187	Cavia porcellus	89.22	2.00e-124	437.00
IUUC-Csa-023493	Chlorocebus sabaeus	89.22	1.00e-123	435.00
IUUC-Cho-024411	Choloepus hoffmanni	73.17	5.00e-81	293.00
IUUC-Dno-029346	Dasypus novemcinctus	92.27	2.00e-127	447.00
IUUC-Dor-031012	Dipodomys ordii	90.52	1.00e-125	441.00
IUUC-Ete-032266	Echinops telfairi	83.62	6.00e-114	402.00
IUUC-Eca-033356	Equus caballus	90.95	6.00e-125	439.00
IUUC-Eeu-034775	Erinaceus europaeus	89.22	7.00e-124	436.00
IUUC-Fca-035363	Felis catus	89.66	8.00e-124	435.00
IUUC-Ggo-045023	Gorilla gorilla	88.84	1.00e-123	435.00
IUUC-Hsa-046984	Homo sapiens	89.27	3.00e-124	437.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	90.13	2.00e-125	441.00
IUUC-Lch-050514	Latimeria chalumnae	58.67	2.00e-79	288.00
IUUC-Loc-052003	Lepisosteus oculatus	49.55	5.00e-62	230.00
IUUC-Laf-054382	Loxodonta africana	91.38	1.00e-125	442.00
IUUC-Mcc-055516	Macaca mulatta	89.22	1.00e-123	434.00
IUUC-Meu-056038	Macropus eugenii	98.94	7.00e-110	389.00
IUUC-Mmr-060918	Microcebus murinus	91.42	1.00e-126	445.00
IUUC-Mmu-063973	Mus musculus	90.09	1.00e-123	435.00
IUUC-Mpu-066013	Mustela putorius furo	90.09	7.00e-125	439.00
IUUC-Mlu-067509	Myotis lucifugus	87.50	3.00e-120	424.00
IUUC-Nle-069673	Nomascus leucogenys	89.27	3.00e-124	437.00
IUUC-Opr-070761	Ochotona princeps	81.33	7.00e-76	275.00
IUUC-Oan-072922	Ornithorhynchus anatinus	84.05	8.00e-115	405.00
IUUC-Ocu-074643	Oryctolagus cuniculus	89.70	8.00e-125	439.00
IUUC-Oni-082026	Oryza nivara	31.53	7.00e-18	85.10
IUUC-Oru-084761	Oryza rufipogon	31.53	7.00e-18	85.10
IUUC-Ola-086603	Oryzias latipes	45.83	4.00e-51	194.00
IUUC-Oga-088936	Otolemur garnettii	88.79	3.00e-123	434.00
IUUC-Oar-089460	Ovis aries	91.38	3.00e-126	444.00
IUUC-Ptr-090805	Pan troglodytes	88.84	6.00e-124	436.00
IUUC-Pan-091969	Papio anubis	89.27	3.00e-124	437.00
IUUC-Pab-098476	Pongo abelii	89.22	5.00e-123	432.00
IUUC-Pca-100252	Procavia capensis	87.13	2.00e-50	192.00
IUUC-Pva-102204	Pteropus vampyrus	87.98	2.00e-123	434.00
IUUC-Pgr-103552	Puccinia graminis	75.00	3.10e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	89.70	2.00e-124	437.00
IUUC-Sha-106968	Sarcophilus harrisii	100.00	3.00e-135	474.00
IUUC-Sar-113295	Sorex araneus	90.52	3.00e-123	433.00
IUUC-Ssc-115288	Sus scrofa	89.70	1.00e-124	438.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.83	1.00e-41	162.00
IUUC-Tbe-127717	Tupaia belangeri	89.19	5.00e-74	269.00
IUUC-Ttr-128221	Tursiops truncatus	72.96	5.00e-95	340.00
IUUC-Uma-129443	Ustilago maydis	34.27	2.00e-23	102.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence