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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Dme-031702
UUCD1 version UUC-DrM-00042
Ensembl Protein ID FBpp0073102
UniProt Accession Q9VZF4; A4V1G6; FBXW7_DROME
Genbank Protein ID AAF47869.1; AAG22246.1; AAG22247.1; AAL28848.1; AAL68231.1
Protein Name F-box/WD repeat-containing protein 7; F-box and WD-40 domain-containing protein 7; Protein archipelago
Genbank Nucleotide ID AE014296; AE014296; AE014296; AY061300; AY075401
Gene Name ago; CG15010
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0041171 FBtr0073246 FBpp0073102
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19723762; 21148181; 19364825; 19346490; 19285057; 11565033; 20176921
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 15182669; 21148181; 19364825; 19346490; 11565033
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.80e-57 187.4 1237 1271
E3 adaptor/Cullin RING/SCF/F-box 4.60e-05 23.5 889 935
UBD/Beta-Prp 3.70e-94 315.3 988 1268
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvll 36
    H + vtcl+f+++++v++sdDgt+k+WD++tg+ +
   Q: 1237 HHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFI 1271
    8889******559******************9865 PP
   


   E3 adaptor/Cullin RING/SCF/F-box

   S: 100  aglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
    ++ ++ lp e+ + +l++l++++llraa++cr+w+ l++++ lwk+
   Q: 889 RDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEK 935
    667889*****************************88888****975 PP
   


   UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
    k+lkgh+++vitc++f +++ +++gs+d+t+kvw++ +gk+lr+l gh+++v++ ++s + i+++gs+Drt+kvwd+++g cvhtl+gh+++v+
   Q: 988 KVLKGHDDHVITCLQF--SGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGN--IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVR 1079
    6799************..*****************************************99..********************************* PP
   S: 99 slsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngke 194
    +++++ +k+vsGs+d t+rvwd+e+g+cl+ +l gh ++v+cv++++ +l+vsG++D +v++W +++++l+tl+g ht++vysl+fd +
   Q: 1080 CMHLHG--SKVVSGSRDATLRVWDIEQGSCLH-VLVGHLAAVRCVQYDG--KLIVSGAYDYMVKIWHPERQECLHTLQG-HTNRVYSLQFDG--LH 1167
    *****9..************************.****************..***************************9.***********9..89 PP
   S: 195 lvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvn 290
    +vsgsld+++++wd++tg+c +tl gh++ ++ +++ +++lvsg++D ++++Wd+++g++l+tl+++n++ ++v++l+f+ + +v+ s+d++v+
   Q: 1168 VVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELR--QNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVK 1261
    *************************************..********************************************************* PP
   S: 291 iwklkkn 297
    +w++k+
   Q: 1262 LWDVKTG 1268
    ***9876 PP
   

Organism Drosophila melanogaster
Functional Description
(View)

Functional Description



     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Involved in the degradation of cyclin E and dm/Myc. Required for endocycles, but not mitosis in follicle cell epithelium.
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Involved in the degradation of cyclin E and dm/Myc. Required for endocycles, but not mitosis in follicle cell epithelium.
Protein Sequence
(Fasta)
MERGCPAASS ESVTSAGERT QSAVTSSTST WVKSQASTSR KTEASEESGL GAVDAEVGAG 60
REAFVSMSTL REDVEDVCVS SNSQHGFAVV LDDESSTFEI SSSNSLPTSA GAASTVGVVA 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dme-031702|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCGAGCGGT GGTCACACTG GATCCGCATT AGTTTTTTTT CGGGTCCAAA ATCTGTCCAA 60
ATCCGCAAAT TGCACGCATA TTCTAGTATC TGAAAACCAG AAATTTAGAT AGACTGGGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dme-031702|E3,F-box;E3,WD_repeat;UBD,Beta-Prp|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030332--F:cyclin binding
GO:0007411--P:axon guidance
GO:0035147--P:branch fusion, open tracheal system
GO:0071456--P:cellular response to hypoxia
GO:0042023--P:DNA endoreduplication
GO:1900038--P:negative regulation of cellular response to hypoxia
GO:0060253--P:negative regulation of glial cell proliferation
GO:0045926--P:negative regulation of growth
GO:0016567--P:protein ubiquitination
GO:0007096--P:regulation of exit from mitosis
GO:1903146--P:regulation of mitophagy
GO:0007088--P:regulation of mitotic nuclear division
GO:0030162--P:regulation of proteolysis
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0060438--P:trachea development
GO:0007419--P:ventral cord development

KEGG dme:Dmel_CG15010
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 78.08 0.00e+00 803.00
IUUC-Apl-003176 Anas platyrhynchos 74.90 0.00e+00 795.00
IUUC-Aca-005318 Anolis carolinensis 78.12 0.00e+00 802.00
IUUC-Ago-007888 Ashbya gossypii 29.27 1.00e-61 230.00
IUUC-Acl-008123 Aspergillus clavatus 34.02 6.00e-75 274.00
IUUC-Afl-008730 Aspergillus flavus 33.26 7.00e-78 284.00
IUUC-Afu-009014 Aspergillus fumigatus 32.58 5.00e-76 278.00
IUUC-Ani-009332 Aspergillus nidulans 33.20 3.00e-75 275.00
IUUC-Ang-009529 Aspergillus niger 36.31 5.00e-80 291.00
IUUC-Aor-010215 Aspergillus oryzae 37.39 7.00e-68 251.00
IUUC-Ate-010535 Aspergillus terreus 31.60 6.00e-74 271.00
IUUC-Ame-010898 Astyanax mexicanus 77.43 0.00e+00 795.00
IUUC-Bgr-012075 Blumeria graminis 34.26 1.00e-81 296.00
IUUC-Bta-012391 Bos taurus 78.12 0.00e+00 801.00
IUUC-Bci-013725 Botrytis cinerea 38.22 2.00e-73 269.00
IUUC-Cel-018495 Caenorhabditis elegans 49.90 2.00e-135 475.00
IUUC-Cja-018902 Callithrix jacchus 78.29 0.00e+00 805.00
IUUC-Cfa-020237 Canis familiaris 78.29 0.00e+00 804.00
IUUC-Cpo-022234 Cavia porcellus 78.12 0.00e+00 803.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.18 4.00e-45 174.00
IUUC-Csa-023532 Chlorocebus sabaeus 78.29 0.00e+00 804.00
IUUC-Cho-025026 Choloepus hoffmanni 72.62 4.00e-143 501.00
IUUC-Cin-025516 Ciona intestinalis 63.88 8.00e-130 455.00
IUUC-Csv-026312 Ciona savignyi 69.72 0.00e+00 724.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 36.20 2.00e-86 312.00
IUUC-Cne-027018 Cryptococcus neoformans 31.87 7.00e-74 271.00
IUUC-Cme-027168 Cyanidioschyzon merolae 32.58 1.00e-33 137.00
IUUC-Dre-028303 Danio rerio 77.92 0.00e+00 793.00
IUUC-Dno-029576 Dasypus novemcinctus 75.99 0.00e+00 783.00
IUUC-Dor-030196 Dipodomys ordii 77.66 0.00e+00 790.00
IUUC-Dse-031558 Dothistroma septosporum 39.66 7.00e-74 271.00
IUUC-Ete-032791 Echinops telfairi 78.92 0.00e+00 785.00
IUUC-Eca-033424 Equus caballus 78.12 0.00e+00 802.00
IUUC-Eeu-034996 Erinaceus europaeus 71.46 0.00e+00 791.00
IUUC-Fca-036422 Felis catus 78.29 0.00e+00 804.00
IUUC-Fal-037478 Ficedula albicollis 74.56 0.00e+00 795.00
IUUC-Fox-037800 Fusarium oxysporum 34.74 3.00e-84 305.00
IUUC-Fso-038258 Fusarium solani 34.55 3.00e-85 308.00
IUUC-Gmo-039478 Gadus morhua 67.96 0.00e+00 657.00
IUUC-Ggr-039781 Gaeumannomyces graminis 35.59 2.00e-87 316.00
IUUC-Gga-040170 Gallus gallus 74.51 0.00e+00 799.00
IUUC-Gac-042423 Gasterosteus aculeatus 71.67 0.00e+00 694.00
IUUC-Ggo-044422 Gorilla gorilla 78.29 0.00e+00 804.00
IUUC-Hsa-045898 Homo sapiens 78.29 0.00e+00 805.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 79.06 0.00e+00 786.00
IUUC-Kpa-049097 Komagataella pastoris 32.11 7.00e-81 294.00
IUUC-Lch-050414 Latimeria chalumnae 77.87 0.00e+00 800.00
IUUC-Loc-052348 Lepisosteus oculatus 77.92 0.00e+00 796.00
IUUC-Lma-053185 Leptosphaeria maculans 33.47 1.00e-77 283.00
IUUC-Laf-054054 Loxodonta africana 78.50 0.00e+00 805.00
IUUC-Mcc-055056 Macaca mulatta 78.29 0.00e+00 804.00
IUUC-Meu-056778 Macropus eugenii 72.13 2.00e-106 379.00
IUUC-Mor-057076 Magnaporthe oryzae 30.57 3.00e-64 239.00
IUUC-Mpo-057423 Magnaporthe poae 35.59 4.00e-85 308.00
IUUC-Mla-059081 Melampsora laricipopulina 36.46 2.00e-78 285.00
IUUC-Mga-060171 Meleagris gallopavo 74.75 0.00e+00 791.00
IUUC-Mvi-060490 Microbotryum violaceum 37.88 2.00e-68 254.00
IUUC-Mmr-061292 Microcebus murinus 78.29 0.00e+00 803.00
IUUC-Mdo-062304 Monodelphis domestica 77.92 0.00e+00 807.00
IUUC-Mmu-063610 Mus musculus 78.08 0.00e+00 803.00
IUUC-Mpu-065931 Mustela putorius furo 78.29 0.00e+00 804.00
IUUC-Mlu-066976 Myotis lucifugus 78.29 0.00e+00 806.00
IUUC-Nfi-068428 Neosartorya fischeri 32.47 5.00e-76 278.00
IUUC-Ncr-068688 Neurospora crassa 36.55 4.00e-88 318.00
IUUC-Nle-070174 Nomascus leucogenys 78.29 0.00e+00 805.00
IUUC-Opr-070851 Ochotona princeps 74.62 2.00e-119 421.00
IUUC-Ont-071997 Oreochromis niloticus 72.36 0.00e+00 791.00
IUUC-Oan-072936 Ornithorhynchus anatinus 78.12 0.00e+00 805.00
IUUC-Ocu-074742 Oryctolagus cuniculus 78.12 0.00e+00 805.00
IUUC-Ola-087098 Oryzias latipes 72.74 0.00e+00 792.00
IUUC-Olu-087837 Ostreococcus lucimarinus 33.58 4.00e-36 143.00
IUUC-Oga-088884 Otolemur garnettii 83.29 0.00e+00 641.00
IUUC-Oar-090220 Ovis aries 77.48 0.00e+00 799.00
IUUC-Ptr-090492 Pan troglodytes 78.29 0.00e+00 805.00
IUUC-Pan-091770 Papio anubis 78.29 0.00e+00 804.00
IUUC-Psi-093207 Pelodiscus sinensis 78.12 0.00e+00 803.00
IUUC-Pma-094749 Petromyzon marinus 78.71 0.00e+00 779.00
IUUC-Pno-095026 Phaeosphaeria nodorum 37.50 2.00e-73 270.00
IUUC-Pfo-096493 Poecilia formosa 78.17 0.00e+00 796.00
IUUC-Pab-098141 Pongo abelii 78.12 0.00e+00 802.00
IUUC-Pca-100571 Procavia capensis 74.30 8.00e-148 516.00
IUUC-Pva-102988 Pteropus vampyrus 78.29 0.00e+00 805.00
IUUC-Pgr-103612 Puccinia graminis 34.41 4.00e-61 228.00
IUUC-Pte-104275 Pyrenophora teres 32.76 1.00e-79 290.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 32.38 7.00e-79 287.00
IUUC-Rno-105706 Rattus norvegicus 78.29 0.00e+00 804.00
IUUC-Sce-106314 Saccharomyces cerevisiae 30.12 6.00e-66 244.00
IUUC-Sha-107653 Sarcophilus harrisii 78.08 0.00e+00 804.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 32.17 2.00e-77 283.00
IUUC-Spo-108063 Schizosaccharomyces pombe 28.97 2.00e-59 223.00
IUUC-Sar-113600 Sorex araneus 72.65 0.00e+00 734.00
IUUC-Sre-114901 Sporisorium reilianum 42.70 2.00e-64 240.00
IUUC-Ssc-115787 Sus scrofa 76.41 0.00e+00 778.00
IUUC-Tgu-117510 Taeniopygia guttata 78.08 0.00e+00 803.00
IUUC-Tru-117819 Takifugu rubripes 72.99 0.00e+00 798.00
IUUC-Tsy-118828 Tarsius syrichta 78.29 0.00e+00 804.00
IUUC-Tni-120468 Tetraodon nigroviridis 72.80 0.00e+00 795.00
IUUC-Tre-122193 Trichoderma reesei 37.31 3.00e-89 322.00
IUUC-Tvi-122615 Trichoderma virens 35.90 1.00e-85 310.00
IUUC-Tur-126271 Triticum urartu 32.59 2.00e-29 122.00
IUUC-Tme-127021 Tuber melanosporum 35.63 3.00e-89 321.00
IUUC-Tbe-127925 Tupaia belangeri 78.12 0.00e+00 803.00
IUUC-Ttr-128899 Tursiops truncatus 77.92 0.00e+00 802.00
IUUC-Uma-129449 Ustilago maydis 42.81 9.00e-65 241.00
IUUC-Vda-129936 Verticillium dahliae 37.60 6.00e-76 278.00
IUUC-Vpa-130082 Vicugna pacos 76.79 0.00e+00 644.00
IUUC-Xtr-132213 Xenopus tropicalis 77.66 0.00e+00 799.00
IUUC-Xma-133646 Xiphophorus maculatus 78.01 0.00e+00 792.00
IUUC-Yli-134429 Yarrowia lipolytica 34.17 2.00e-86 312.00
Created Date 25-Jun-2017

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