iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gac-042342

Ensembl Protein ID

ENSGACP00000007055.1

UniProt Accession

G3NNZ1; G3NNZ1_GASAC

Protein Name

Presenilin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000005327.1	ENSGACT00000007073.1	ENSGACP00000007055.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	5.80e-08	33.0	264	292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+L+++++
   Q: 264  VETAQERNEPIFPALIYSSTMVWLVNMAD 292
           89************************986 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MANHVEDIEN NMSNESVMKE SSCFRHTAAH SCPGNGSGPE QNGQPGAARP PRVVETEEDE 60
DEELTLKYGA KHVIMLFVPV TLCMVVVVAT IKSVSFFTQK DGQRLIYTPF SEDTDTMGQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGAACC ATGTGGAAGA TATAGAAAAC AATATGGTCA GTATGAAAGA ATGGGACCAC 60
TACTTCTGCG TCTGTCTGTG TTGGTTGATG GTTTAACCGC TAACTGGTTC AGCTGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	71.20	6.00e-113	400.00
IUUC-Apl-003727	Anas platyrhynchos	72.79	1.00e-134	473.00
IUUC-Aca-004582	Anolis carolinensis	73.75	1.00e-138	486.00
IUUC-Aly-005455	Arabidopsis lyrata	30.70	8.00e-18	85.10
IUUC-Ath-006730	Arabidopsis thaliana	32.09	2.00e-19	90.50
IUUC-Ame-011500	Astyanax mexicanus	76.35	3.00e-150	525.00
IUUC-Bta-013026	Bos taurus	68.33	3.00e-133	468.00
IUUC-Cja-019994	Callithrix jacchus	73.75	1.00e-133	469.00
IUUC-Cfa-020074	Canis familiaris	71.95	8.00e-135	473.00
IUUC-Cpo-022237	Cavia porcellus	72.18	1.00e-132	466.00
IUUC-Csa-023537	Chlorocebus sabaeus	69.20	8.00e-135	473.00
IUUC-Cho-024735	Choloepus hoffmanni	66.67	2.00e-124	439.00
IUUC-Dre-028689	Danio rerio	74.95	7.00e-150	523.00
IUUC-Dno-029758	Dasypus novemcinctus	72.20	7.00e-136	477.00
IUUC-Ete-032487	Echinops telfairi	59.03	7.00e-50	191.00
IUUC-Eeu-035134	Erinaceus europaeus	70.06	4.00e-99	354.00
IUUC-Fca-036243	Felis catus	71.71	4.00e-135	474.00
IUUC-Fal-036600	Ficedula albicollis	75.25	3.00e-138	484.00
IUUC-Fox-038018	Fusarium oxysporum	41.03	5.10e-01	28.90
IUUC-Gmo-039665	Gadus morhua	78.95	2.00e-130	459.00
IUUC-Gga-040993	Gallus gallus	74.13	4.00e-139	487.00
IUUC-Hsa-046822	Homo sapiens	68.98	2.00e-134	472.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	70.82	1.00e-104	372.00
IUUC-Lch-049946	Latimeria chalumnae	66.02	4.00e-122	431.00
IUUC-Laf-053979	Loxodonta africana	71.39	3.00e-121	428.00
IUUC-Mcc-055682	Macaca mulatta	68.98	2.00e-134	472.00
IUUC-Mga-059466	Meleagris gallopavo	74.59	3.00e-139	488.00
IUUC-Mdo-062122	Monodelphis domestica	71.43	4.00e-134	471.00
IUUC-Mmu-063176	Mus musculus	73.75	2.00e-132	465.00
IUUC-Mpu-065927	Mustela putorius furo	71.36	4.00e-135	474.00
IUUC-Mlu-067079	Myotis lucifugus	70.73	7.00e-141	493.00
IUUC-Nle-070180	Nomascus leucogenys	68.98	2.00e-134	472.00
IUUC-Opr-070847	Ochotona princeps	67.25	4.00e-128	451.00
IUUC-Ont-071846	Oreochromis niloticus	75.51	3.00e-161	561.00
IUUC-Ocu-074527	Oryctolagus cuniculus	68.95	5.00e-137	481.00
IUUC-Oar-090348	Ovis aries	70.73	5.00e-136	477.00
IUUC-Ptr-091060	Pan troglodytes	68.98	2.00e-134	472.00
IUUC-Pan-091855	Papio anubis	65.73	3.00e-126	445.00
IUUC-Psi-093505	Pelodiscus sinensis	74.75	4.00e-137	481.00
IUUC-Pfo-097396	Poecilia formosa	76.92	1.00e-171	595.00
IUUC-Pab-098591	Pongo abelii	69.21	1.00e-134	473.00
IUUC-Pca-101029	Procavia capensis	68.95	2.00e-123	435.00
IUUC-Pva-102244	Pteropus vampyrus	70.50	4.00e-128	451.00
IUUC-Rno-105861	Rattus norvegicus	68.20	4.00e-133	468.00
IUUC-Sha-107045	Sarcophilus harrisii	72.16	4.00e-133	468.00
IUUC-Sar-113169	Sorex araneus	68.23	2.00e-105	375.00
IUUC-Ssc-115766	Sus scrofa	73.63	4.00e-133	468.00
IUUC-Tru-117732	Takifugu rubripes	85.25	5.00e-160	557.00
IUUC-Tsy-119624	Tarsius syrichta	63.99	1.00e-124	439.00
IUUC-Tni-119852	Tetraodon nigroviridis	80.14	4.00e-154	537.00
IUUC-Tbe-128148	Tupaia belangeri	59.72	2.00e-94	338.00
IUUC-Ttr-128793	Tursiops truncatus	70.24	1.00e-128	452.00
IUUC-Vpa-130625	Vicugna pacos	58.78	2.00e-102	366.00
IUUC-Xtr-131790	Xenopus tropicalis	72.70	1.00e-129	456.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence