iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMICG00000017923.2	ENSMICT00000029863.1	ENSMICP00000032814.1
ENSMICG00000017923.2	ENSMICT00000017923.2	ENSMICP00000016318.2
ENSMICG00000017923.2	ENSMICT00000032509.1	ENSMICP00000018898.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/CUE	79.01	1.00e-168	590.00	IUUC-Hsa-046822

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Microcebus murinus

Functional Description
(View)

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1. This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (By similarity). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity).

Protein Sequence
(Fasta)

MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNREQQDHGD RRRLGNPEPL SNGRPQGNSG 60
PVVERDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE 120

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Nucleotide Sequence
(Fasta)

ATGACAGAAT TACCTGCACC CTTGTCCTAC TTCCAGAATG CACAGATGTC CGAGGATAAC 60
CACCTGAGCA ATACTGTACG TAGCCAGGTA CCGTGTCAGC CTCTAAAAAG AAATATATAA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01073--PRESENILIN1

SMART

SM00730--PSN

Gene Ontology

GO:0016235--C:aggresome
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0070765--C:gamma-secretase complex
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0005887--C:integral component of plasma membrane
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0042500--F:aspartic endopeptidase activity, intramembrane cleaving
GO:0042982--P:amyloid precursor protein metabolic process
GO:0006915--P:apoptotic process
GO:0034205--P:beta-amyloid formation
GO:0007155--P:cell adhesion
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0060828--P:regulation of canonical Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001648	Ailuropoda melanoleuca	70.41	9.00e-106	376.00
IUUC-Bta-013026	Bos taurus	71.97	1.00e-146	512.00
IUUC-Cja-019994	Callithrix jacchus	77.12	3.00e-141	495.00
IUUC-Cfa-020074	Canis familiaris	76.66	6.00e-157	547.00
IUUC-Cpo-022237	Cavia porcellus	76.31	2.00e-148	518.00
IUUC-Csa-023537	Chlorocebus sabaeus	79.01	4.00e-170	590.00
IUUC-Cho-024735	Choloepus hoffmanni	65.25	2.00e-138	485.00
IUUC-Dno-029758	Dasypus novemcinctus	73.99	2.00e-152	532.00
IUUC-Dor-030609	Dipodomys ordii	64.24	5.00e-144	504.00
IUUC-Ete-032487	Echinops telfairi	82.70	7.00e-50	191.00
IUUC-Fca-036243	Felis catus	76.50	3.00e-154	538.00
IUUC-Ggo-044859	Gorilla gorilla	81.56	4.00e-136	477.00
IUUC-Hsa-046822	Homo sapiens	79.01	6.00e-170	590.00
IUUC-Itr-048420	Ictidomys tridecemlineatus	71.12	4.00e-101	360.00
IUUC-Lch-049946	Latimeria chalumnae	60.73	9.00e-110	390.00
IUUC-Laf-053979	Loxodonta africana	71.62	2.00e-125	442.00
IUUC-Mcc-055682	Macaca mulatta	79.01	6.00e-170	590.00
IUUC-Meu-056004	Macropus eugenii	65.25	4.00e-122	431.00
IUUC-Mdo-062122	Monodelphis domestica	70.70	3.00e-142	498.00
IUUC-Mmu-063176	Mus musculus	75.16	6.00e-153	533.00
IUUC-Mpu-065927	Mustela putorius furo	74.09	6.00e-151	526.00
IUUC-Mlu-067079	Myotis lucifugus	75.64	1.00e-162	565.00
IUUC-Nle-070180	Nomascus leucogenys	79.01	6.00e-170	590.00
IUUC-Opr-070847	Ochotona princeps	70.93	2.00e-138	485.00
IUUC-Ocu-074527	Oryctolagus cuniculus	76.50	3.00e-163	568.00
IUUC-Oar-090348	Ovis aries	73.72	2.00e-159	555.00
IUUC-Ptr-091060	Pan troglodytes	79.01	6.00e-170	590.00
IUUC-Pan-091855	Papio anubis	71.09	4.00e-142	497.00
IUUC-Pab-098591	Pongo abelii	77.94	2.00e-165	575.00
IUUC-Pca-101029	Procavia capensis	70.79	4.00e-138	484.00
IUUC-Pva-102244	Pteropus vampyrus	70.43	7.00e-142	496.00
IUUC-Rno-105861	Rattus norvegicus	74.63	1.00e-148	519.00
IUUC-Sha-107045	Sarcophilus harrisii	70.85	7.00e-142	496.00
IUUC-Ssc-115766	Sus scrofa	75.43	5.00e-153	534.00
IUUC-Tsy-119624	Tarsius syrichta	68.23	2.00e-140	492.00
IUUC-Tbe-128148	Tupaia belangeri	74.73	2.00e-142	498.00
IUUC-Ttr-128793	Tursiops truncatus	74.52	5.00e-149	520.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence