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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046038
UUCD1 version UUC-HoS-00868
Ensembl Protein ID ENSP00000382779.1
UniProt Accession Q96EE3; A8K5B1; Q8NFU6; Q96MH3; Q9C069; SEH1_HUMAN
Genbank Protein ID AAM21169.1; AAM44214.1; AAM76707.1; AAG49437.1; BAB71317.1; BAF83915.1; AAH12430.1
Protein Name Nucleoporin SEH1; Nup107-160 subcomplex subunit SEH1; SEC13-like protein
Genbank Nucleotide ID AF255625; AF431970; AF514996; AF136976; AK056940; AK291226; BC012430
Gene Name SEH1L; SEC13L; SEH1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000085415.15 ENST00000262124.15 ENSP00000262124.10
ENSG00000085415.15 ENST00000585730.5 ENSP00000466959.1
ENSG00000085415.15 ENST00000399892.6 ENSP00000382779.1
ENSG00000085415.15 ENST00000589446.5 ENSP00000467276.1
ENSG00000085415.15 ENST00000587761.1 ENSP00000466234.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.70e-21 75.0 11 40
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H+d +++++f  ++++++++s D ++kvWD
   Q: 11   HKDLIHDVSFdfHGRRMATCSSDQSVKVWD 40
           9*********976599************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
 As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).
Protein Sequence
(Fasta)
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046038|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
TTTTCCCCGG AGGACTCTGG CTCCCGGGTA GCAAGCAGCC CACTTCCCCG GCCGCTTCCT 60
TCCCCCGGGA TGACACGTTT CTACAGGCGG ACTCTTCTAA TTCATACTAT TTCCCTACCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046038|E3,WD_repeat|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0061700--C:GATOR2 complex
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0051315--P:attachment of mitotic spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0034629--P:cellular protein complex localization
GO:0034198--P:cellular response to amino acid starvation
GO:0002534--P:cytokine production involved in inflammatory response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007080--P:mitotic metaphase plate congression
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0006999--P:nuclear pore organization
GO:0032008--P:positive regulation of TOR signaling
GO:1904263--P:positive regulation of TORC1 signaling
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0007062--P:sister chromatid cohesion
GO:0006409--P:tRNA export from nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription
KEGG hsa:81929
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001926 Ailuropoda melanoleuca 95.77 0.00e+00 686.00
IUUC-Apl-003654 Anas platyrhynchos 92.45 0.00e+00 694.00
IUUC-Aca-004378 Anolis carolinensis 90.43 7.00e-169 586.00
IUUC-Ago-007816 Ashbya gossypii 34.34 7.00e-50 191.00
IUUC-Ame-011945 Astyanax mexicanus 85.47 4.00e-172 597.00
IUUC-Bta-013306 Bos taurus 98.32 0.00e+00 656.00
IUUC-Cel-018235 Caenorhabditis elegans 42.31 5.00e-75 274.00
IUUC-Cja-018849 Callithrix jacchus 96.21 0.00e+00 756.00
IUUC-Cfa-020841 Canis familiaris 90.78 2.00e-180 627.00
IUUC-Cpo-021379 Cavia porcellus 96.64 0.00e+00 647.00
IUUC-Csa-023900 Chlorocebus sabaeus 98.81 0.00e+00 772.00
IUUC-Cho-024660 Choloepus hoffmanni 94.72 0.00e+00 657.00
IUUC-Cin-025471 Ciona intestinalis 56.48 6.00e-104 370.00
IUUC-Csv-026242 Ciona savignyi 59.76 4.00e-89 320.00
IUUC-Dre-028068 Danio rerio 83.24 1.00e-180 625.00
IUUC-Dno-029981 Dasypus novemcinctus 90.00 0.00e+00 694.00
IUUC-Dme-031763 Drosophila melanogaster 58.15 4.00e-112 397.00
IUUC-Ete-032243 Echinops telfairi 62.36 2.00e-117 415.00
IUUC-Eca-033425 Equus caballus 98.12 2.00e-166 578.00
IUUC-Eeu-035119 Erinaceus europaeus 78.74 2.00e-137 481.00
IUUC-Fca-036520 Felis catus 98.01 0.00e+00 746.00
IUUC-Fal-037234 Ficedula albicollis 94.69 6.00e-176 612.00
IUUC-Gmo-039013 Gadus morhua 86.59 7.00e-178 616.00
IUUC-Gga-041059 Gallus gallus 93.11 0.00e+00 772.00
IUUC-Gac-041337 Gasterosteus aculeatus 86.03 8.00e-173 599.00
IUUC-Ggo-044944 Gorilla gorilla 99.29 0.00e+00 821.00
IUUC-Hvu-047455 Hordeum vulgare 30.70 3.00e-35 142.00
IUUC-Itr-048858 Ictidomys tridecemlineatus 98.75 5.00e-167 580.00
IUUC-Kpa-049201 Komagataella pastoris 36.45 2.00e-50 192.00
IUUC-Lch-050466 Latimeria chalumnae 80.81 0.00e+00 722.00
IUUC-Loc-052773 Lepisosteus oculatus 75.66 2.00e-170 591.00
IUUC-Laf-053409 Loxodonta africana 97.20 0.00e+00 650.00
IUUC-Meu-055958 Macropus eugenii 73.08 4.00e-156 543.00
IUUC-Mga-059348 Meleagris gallopavo 94.97 2.00e-173 601.00
IUUC-Mmr-060977 Microcebus murinus 99.18 3.00e-135 473.00
IUUC-Mdo-061806 Monodelphis domestica 95.81 0.00e+00 682.00
IUUC-Mmu-064328 Mus musculus 97.85 0.00e+00 671.00
IUUC-Mpu-066873 Mustela putorius furo 98.01 0.00e+00 700.00
IUUC-Mlu-067563 Myotis lucifugus 91.60 0.00e+00 644.00
IUUC-Nle-068977 Nomascus leucogenys 99.70 0.00e+00 654.00
IUUC-Opr-070773 Ochotona princeps 67.71 7.00e-118 417.00
IUUC-Ont-072644 Oreochromis niloticus 86.87 9.00e-178 615.00
IUUC-Oan-073098 Ornithorhynchus anatinus 95.03 3.00e-166 577.00
IUUC-Ocu-073911 Oryctolagus cuniculus 96.45 0.00e+00 789.00
IUUC-Ola-087096 Oryzias latipes 85.48 1.00e-180 625.00
IUUC-Oga-088798 Otolemur garnettii 98.32 0.00e+00 701.00
IUUC-Oar-090298 Ovis aries 97.52 1.00e-167 585.00
IUUC-Ptr-091074 Pan troglodytes 99.44 0.00e+00 708.00
IUUC-Pan-092013 Papio anubis 100.00 1.00e-142 498.00
IUUC-Psi-093508 Pelodiscus sinensis 93.75 5.00e-173 600.00
IUUC-Pma-094288 Petromyzon marinus 83.81 2.00e-103 367.00
IUUC-Ppa-095228 Physcomitrella patens 32.39 3.00e-37 149.00
IUUC-Pfo-096384 Poecilia formosa 85.75 1.00e-175 609.00
IUUC-Pab-098629 Pongo abelii 99.72 0.00e+00 708.00
IUUC-Pca-100322 Procavia capensis 72.35 9.00e-135 473.00
IUUC-Pva-102861 Pteropus vampyrus 97.76 0.00e+00 722.00
IUUC-Rno-104895 Rattus norvegicus 85.41 0.00e+00 657.00
IUUC-Sce-106420 Saccharomyces cerevisiae 34.76 3.00e-54 205.00
IUUC-Sha-106829 Sarcophilus harrisii 90.28 0.00e+00 633.00
IUUC-Sja-107923 Schizosaccharomyces japonicus 40.00 1.00e-66 246.00
IUUC-Spo-108184 Schizosaccharomyces pombe 38.44 2.00e-64 239.00
IUUC-Smo-109282 Selaginella moellendorffii 33.76 1.00e-37 150.00
IUUC-Sar-113279 Sorex araneus 97.01 0.00e+00 644.00
IUUC-Sbi-114110 Sorghum bicolor 30.34 2.00e-36 146.00
IUUC-Ssc-115589 Sus scrofa 95.64 2.00e-175 607.00
IUUC-Tgu-117523 Taeniopygia guttata 92.64 0.00e+00 768.00
IUUC-Tru-117985 Takifugu rubripes 81.69 5.00e-158 553.00
IUUC-Tsy-118913 Tarsius syrichta 96.74 0.00e+00 686.00
IUUC-Tni-120670 Tetraodon nigroviridis 86.11 3.00e-177 613.00
IUUC-Tae-122796 Triticum aestivum 30.38 9.00e-35 140.00
IUUC-Tme-126885 Tuber melanosporum 36.69 9.00e-56 210.00
IUUC-Tbe-127344 Tupaia belangeri 81.00 1.00e-169 588.00
IUUC-Ttr-128347 Tursiops truncatus 97.00 0.00e+00 644.00
IUUC-Vpa-130656 Vicugna pacos 92.60 6.00e-178 616.00
IUUC-Xtr-132736 Xenopus tropicalis 91.34 0.00e+00 650.00
IUUC-Xma-133678 Xiphophorus maculatus 86.03 1.00e-176 612.00
IUUC-Yli-134659 Yarrowia lipolytica 40.62 6.00e-63 234.00
Created Date 25-Jun-2017

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