iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-068227

Ensembl Protein ID

ENSMLUP00000012958.2

UniProt Accession

G1PPL4; G1PPL4_MYOLU

Genbank Protein ID

ENSMLUP00000012958

Protein Name

Non-specific serine/threonine protein kinase

Genbank Nucleotide ID

AAPE02020500

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000014242.2	ENSMLUT00000014246.2	ENSMLUP00000012958.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	39.67	2.00e-97	350.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM 60
VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGCAAAC ACGAATTGAC TGGGCATAAA GTTGCTGTGA AGATACTCAA TCGACAGAAG 60
ATTCGAAGCC TTGATGTGGT AGGAAAAATC CGCAGAGAAA TTCAGAACCT CAAGCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001907	Ailuropoda melanoleuca	98.25	0.00e+00	983.00
IUUC-Atr-002770	Amborella trichopoda	47.47	2.00e-116	412.00
IUUC-Ago-007957	Ashbya gossypii	41.25	1.00e-107	384.00
IUUC-Acl-008103	Aspergillus clavatus	61.57	2.00e-95	343.00
IUUC-Afl-008555	Aspergillus flavus	60.78	2.00e-95	343.00
IUUC-Afu-008949	Aspergillus fumigatus	61.18	5.00e-95	342.00
IUUC-Ani-009408	Aspergillus nidulans	61.90	2.00e-95	343.00
IUUC-Ang-009551	Aspergillus niger	61.57	3.00e-96	346.00
IUUC-Aor-010176	Aspergillus oryzae	60.78	2.00e-95	343.00
IUUC-Ate-010287	Aspergillus terreus	61.18	4.00e-95	342.00
IUUC-Bta-012786	Bos taurus	98.05	0.00e+00	991.00
IUUC-Cfa-020177	Canis familiaris	98.45	0.00e+00	991.00
IUUC-Cho-024859	Choloepus hoffmanni	95.48	0.00e+00	977.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.30	4.00e-101	362.00
IUUC-Dre-027749	Danio rerio	83.36	0.00e+00	890.00
IUUC-Dno-030006	Dasypus novemcinctus	98.05	0.00e+00	981.00
IUUC-Dse-031507	Dothistroma septosporum	63.56	3.00e-98	353.00
IUUC-Ete-033055	Echinops telfairi	94.33	0.00e+00	1006.00
IUUC-Eca-034239	Equus caballus	98.65	0.00e+00	991.00
IUUC-Fca-035754	Felis catus	95.27	0.00e+00	967.00
IUUC-Fal-037363	Ficedula albicollis	94.56	0.00e+00	962.00
IUUC-Gmo-039633	Gadus morhua	82.29	0.00e+00	916.00
IUUC-Ggr-039987	Gaeumannomyces graminis	50.59	4.00e-96	345.00
IUUC-Gma-042712	Glycine max	46.58	1.00e-115	410.00
IUUC-Ggo-044797	Gorilla gorilla	98.25	0.00e+00	983.00
IUUC-Hsa-045867	Homo sapiens	98.44	0.00e+00	984.00
IUUC-Lch-049623	Latimeria chalumnae	89.36	0.00e+00	912.00
IUUC-Lpe-051392	Leersia perrieri	51.72	6.00e-117	414.00
IUUC-Loc-052362	Lepisosteus oculatus	90.34	0.00e+00	877.00
IUUC-Lma-053054	Leptosphaeria maculans	61.63	2.00e-99	357.00
IUUC-Laf-053799	Loxodonta africana	98.05	0.00e+00	1016.00
IUUC-Mor-057170	Magnaporthe oryzae	50.89	3.00e-96	346.00
IUUC-Mpo-057302	Magnaporthe poae	50.59	2.00e-96	346.00
IUUC-Mtr-058309	Medicago truncatula	47.62	1.00e-116	413.00
IUUC-Mla-059058	Melampsora laricipopulina	40.31	2.00e-97	349.00
IUUC-Mmr-061761	Microcebus murinus	98.25	0.00e+00	984.00
IUUC-Nfi-068493	Neosartorya fischeri	61.18	3.00e-95	343.00
IUUC-Opr-070272	Ochotona princeps	93.95	0.00e+00	959.00
IUUC-Ont-072027	Oreochromis niloticus	82.66	0.00e+00	885.00
IUUC-Oan-073322	Ornithorhynchus anatinus	93.25	0.00e+00	966.00
IUUC-Ocu-074188	Oryctolagus cuniculus	94.89	0.00e+00	966.00
IUUC-Oba-075436	Oryza barthii	47.41	1.00e-117	416.00
IUUC-Obr-076507	Oryza brachyantha	47.53	2.00e-117	415.00
IUUC-Ogu-078349	Oryza glumaepatula	47.41	2.00e-117	416.00
IUUC-Olo-080521	Oryza longistaminata	47.41	2.00e-117	416.00
IUUC-Ome-081630	Oryza meridionalis	47.20	4.00e-117	415.00
IUUC-Oni-082211	Oryza nivara	47.41	7.00e-118	417.00
IUUC-Opu-083617	Oryza punctata	47.10	1.00e-116	413.00
IUUC-Oru-084252	Oryza rufipogon	47.41	1.00e-117	416.00
IUUC-Osa-085548	Oryza sativa	47.41	1.00e-117	416.00
IUUC-Ola-086366	Oryzias latipes	83.24	0.00e+00	899.00
IUUC-Olu-087861	Ostreococcus lucimarinus	49.39	9.00e-110	390.00
IUUC-Oga-088003	Otolemur garnettii	98.25	0.00e+00	983.00
IUUC-Oar-089933	Ovis aries	98.05	0.00e+00	991.00
IUUC-Ptr-090718	Pan troglodytes	98.44	0.00e+00	984.00
IUUC-Pan-092526	Papio anubis	98.64	0.00e+00	985.00
IUUC-Psi-094034	Pelodiscus sinensis	94.17	0.00e+00	954.00
IUUC-Pno-095030	Phaeosphaeria nodorum	61.24	5.00e-98	351.00
IUUC-Pfo-097050	Poecilia formosa	82.80	0.00e+00	888.00
IUUC-Pab-098519	Pongo abelii	98.44	0.00e+00	984.00
IUUC-Pop-099781	Populus trichocarpa	52.17	1.00e-117	416.00
IUUC-Pca-101104	Procavia capensis	95.15	0.00e+00	699.00
IUUC-Pgr-103406	Puccinia graminis	60.82	7.00e-84	305.00
IUUC-Pte-104259	Pyrenophora teres	56.94	7.00e-98	352.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	57.39	1.00e-98	354.00
IUUC-Sha-107603	Sarcophilus harrisii	97.08	0.00e+00	980.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	40.96	3.00e-103	369.00
IUUC-Spo-108202	Schizosaccharomyces pombe	39.67	2.00e-100	359.00
IUUC-Smo-109309	Selaginella moellendorffii	45.40	4.00e-114	404.00
IUUC-Sit-109745	Setaria italica	52.31	7.00e-119	421.00
IUUC-Sar-113521	Sorex araneus	88.18	0.00e+00	855.00
IUUC-Sbi-114764	Sorghum bicolor	47.46	6.00e-120	424.00
IUUC-Ssc-115732	Sus scrofa	98.26	0.00e+00	989.00
IUUC-Tgu-117190	Taeniopygia guttata	93.98	0.00e+00	956.00
IUUC-Tni-119833	Tetraodon nigroviridis	83.15	0.00e+00	883.00
IUUC-Tre-122070	Trichoderma reesei	60.69	1.00e-97	350.00
IUUC-Tvi-122305	Trichoderma virens	60.39	2.00e-95	343.00
IUUC-Tme-127174	Tuber melanosporum	41.14	2.00e-69	256.00
IUUC-Ttr-129224	Tursiops truncatus	94.33	0.00e+00	978.00
IUUC-Vda-129819	Verticillium dahliae	53.82	1.00e-79	291.00
IUUC-Vvi-131649	Vitis vinifera	47.56	3.00e-116	412.00
IUUC-Xma-134082	Xiphophorus maculatus	83.20	0.00e+00	812.00
IUUC-Zma-135621	Zea mays	54.03	3.00e-111	396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence