iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.10e-80	270.0	2475	2797

Active Site

Position(s)	Description	Evidence
2767	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k l
   Q: 2475 ENRKRHGSSRSVVDMDLEDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVL 2557
           556778***************999878888334444777777777775....89********************************* PP
   S: 101  lgkklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlke 184
           lg+k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+  
   Q: 2558 LGRKVNWHDFAFFDPVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLV 2644
           ********************5556666655556888999************************************************ PP
   S: 185  gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqF 267
             ++ ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F
   Q: 2645 VAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYF 2731
           ***************************************************9999999999989999******************** PP
   S: 268  vTgssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +T+s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2732 WTSSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2797
           *********999******..799999.99**********************************9.99875 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF 60
LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR TSRPGRTSDS PWFLSGSETL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCGAGAC GGAGAAACTG GGGCAGAAGT GAAGATGGCG GCGGCGGCGC TGGCGGCGGC 60
GGTTCGTCGC CAGTGACGCG CGCTGCGGGC TGCTGTCCCT CCCCGCTCCC CGCGTCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024725--E3_UbLigase_EDD_UBA
IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF11547--E3_UbLigase_EDD
PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0035413--P:positive regulation of catenin import into nucleus
GO:0010628--P:positive regulation of gene expression
GO:0033160--P:positive regulation of protein import into nucleus, translocation
GO:0050847--P:progesterone receptor signaling pathway
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	97.57	0.00e+00	4538.00
IUUC-Apl-004165	Anas platyrhynchos	96.08	0.00e+00	4454.00
IUUC-Aca-004577	Anolis carolinensis	94.91	0.00e+00	3891.00
IUUC-Ame-010702	Astyanax mexicanus	84.17	0.00e+00	2472.00
IUUC-Bta-012313	Bos taurus	98.32	0.00e+00	4613.00
IUUC-Cel-018165	Caenorhabditis elegans	35.31	2.00e-69	259.00
IUUC-Cja-019858	Callithrix jacchus	98.16	0.00e+00	4589.00
IUUC-Cfa-020973	Canis familiaris	98.21	0.00e+00	4612.00
IUUC-Cpo-022108	Cavia porcellus	96.96	0.00e+00	1937.00
IUUC-Csa-023985	Chlorocebus sabaeus	98.14	0.00e+00	4640.00
IUUC-Cho-025034	Choloepus hoffmanni	89.54	0.00e+00	989.00
IUUC-Cin-025715	Ciona intestinalis	40.46	0.00e+00	948.00
IUUC-Csv-026088	Ciona savignyi	40.72	1.00e-164	573.00
IUUC-Dre-027730	Danio rerio	87.74	0.00e+00	4033.00
IUUC-Dno-029123	Dasypus novemcinctus	95.33	0.00e+00	4414.00
IUUC-Dor-030757	Dipodomys ordii	93.50	0.00e+00	2877.00
IUUC-Dme-032192	Drosophila melanogaster	51.83	5.00e-174	606.00
IUUC-Ete-032292	Echinops telfairi	95.11	0.00e+00	2175.00
IUUC-Eca-034347	Equus caballus	98.06	0.00e+00	4511.00
IUUC-Eeu-034873	Erinaceus europaeus	93.66	0.00e+00	4341.00
IUUC-Fca-036485	Felis catus	96.80	0.00e+00	4441.00
IUUC-Fal-037071	Ficedula albicollis	96.83	0.00e+00	4477.00
IUUC-Gmo-039589	Gadus morhua	88.39	0.00e+00	3968.00
IUUC-Gga-041195	Gallus gallus	95.46	0.00e+00	4409.00
IUUC-Gac-042538	Gasterosteus aculeatus	88.23	0.00e+00	3990.00
IUUC-Ggo-045351	Gorilla gorilla	97.34	0.00e+00	4620.00
IUUC-Hsa-045941	Homo sapiens	98.21	0.00e+00	4657.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	98.34	0.00e+00	4577.00
IUUC-Lch-050480	Latimeria chalumnae	93.26	0.00e+00	4299.00
IUUC-Loc-052664	Lepisosteus oculatus	89.07	0.00e+00	4122.00
IUUC-Laf-053935	Loxodonta africana	97.09	0.00e+00	1585.00
IUUC-Mcc-054703	Macaca mulatta	98.14	0.00e+00	4645.00
IUUC-Meu-056431	Macropus eugenii	87.14	0.00e+00	800.00
IUUC-Mga-059289	Meleagris gallopavo	96.21	0.00e+00	3579.00
IUUC-Mmr-061737	Microcebus murinus	97.95	0.00e+00	4503.00
IUUC-Mdo-062499	Monodelphis domestica	97.01	0.00e+00	4491.00
IUUC-Mpu-066907	Mustela putorius furo	97.96	0.00e+00	4194.00
IUUC-Mlu-067942	Myotis lucifugus	97.70	0.00e+00	4556.00
IUUC-Nle-069527	Nomascus leucogenys	98.27	0.00e+00	4624.00
IUUC-Opr-070626	Ochotona princeps	85.89	0.00e+00	1451.00
IUUC-Ont-071951	Oreochromis niloticus	87.04	0.00e+00	3966.00
IUUC-Oan-072958	Ornithorhynchus anatinus	97.18	0.00e+00	4146.00
IUUC-Ocu-074503	Oryctolagus cuniculus	95.93	0.00e+00	4508.00
IUUC-Ola-086757	Oryzias latipes	88.54	0.00e+00	4071.00
IUUC-Oga-088781	Otolemur garnettii	98.11	0.00e+00	4601.00
IUUC-Oar-089274	Ovis aries	98.09	0.00e+00	4538.00
IUUC-Ptr-090669	Pan troglodytes	97.98	0.00e+00	4016.00
IUUC-Pan-092226	Papio anubis	98.07	0.00e+00	4616.00
IUUC-Psi-093502	Pelodiscus sinensis	97.02	0.00e+00	4471.00
IUUC-Pma-094454	Petromyzon marinus	77.11	0.00e+00	735.00
IUUC-Pfo-096173	Poecilia formosa	87.87	0.00e+00	3731.00
IUUC-Pab-098355	Pongo abelii	98.30	0.00e+00	3187.00
IUUC-Pca-100570	Procavia capensis	98.06	0.00e+00	1173.00
IUUC-Pva-102572	Pteropus vampyrus	94.25	0.00e+00	1359.00
IUUC-Rno-104916	Rattus norvegicus	97.00	0.00e+00	4014.00
IUUC-Sha-106653	Sarcophilus harrisii	97.18	0.00e+00	4536.00
IUUC-Sar-113517	Sorex araneus	89.66	0.00e+00	1265.00
IUUC-Ssc-115470	Sus scrofa	98.67	0.00e+00	2525.00
IUUC-Tgu-116932	Taeniopygia guttata	96.58	0.00e+00	4461.00
IUUC-Tru-117682	Takifugu rubripes	87.47	0.00e+00	2574.00
IUUC-Tsy-119417	Tarsius syrichta	94.45	0.00e+00	2476.00
IUUC-Tni-120442	Tetraodon nigroviridis	83.89	0.00e+00	3631.00
IUUC-Tbe-127456	Tupaia belangeri	85.52	0.00e+00	2116.00
IUUC-Ttr-128606	Tursiops truncatus	93.90	0.00e+00	1578.00
IUUC-Vpa-130112	Vicugna pacos	95.44	0.00e+00	3721.00
IUUC-Xtr-131929	Xenopus tropicalis	93.54	0.00e+00	4424.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence