iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096173

Ensembl Protein ID

ENSPFOP00000013330.2

UniProt Accession

A0A087Y5M7; A0A087Y5M7_POEFO

Genbank Protein ID

ENSPFOP00000013330

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AYCK01003988

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000012957.2	ENSPFOT00000013348.2	ENSPFOP00000013330.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-76	258.2	2234	2554

Active Site

Position(s)	Description	Evidence
2524	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 19   ldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
            + +G+tr ++++ +++  + d  ++lf +  +++ ++ +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k llg
   Q: 2234 RKRHGSTRSVVDMELDDPDDGDdnAPLFyQPGKRGFYSPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG 2316
           5566777777777777777666667778233333666666666554....89*********************************** PP
   S: 103  kklsledleevdpelykslkeikena...esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           +k++++d++ +dp +y+sl ++ ++    e+d   +++dl+f ++ ++ + + ++eL++gG n+pVt  N +eYv++++e+r+    
   Q: 2317 RKVNWHDFAFFDPVMYESLRQLIRHSqtgEADAVFAAMDLAFAIDLCKEEGAGQVELLSGGVNMPVTPHNVYEYVRKYAEHRMLVVA 2403
           ******************777766654777799999*************************************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqFvT 269
           ++ ++a+r+G+ +v+p++ l+ +t+e+++ll++G+ e++v++l ++t+++++  e+  ++    +wFw+++e++s++er++++ F+T
   Q: 2404 EQPLHAMRKGLLDVLPKNALEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENADKLlqfkRWFWSIVEKMSMTERQDLVYFWT 2490
           *************************************************9999999888888999********************** PP
   S: 270  gssrlPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +s++lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 2491 SSPSLPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 2554
           *******999******..799999.99**********************************9.99875 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MSLLDADIHS AHPSVIIDAD AMFSEDISYF GYPSFRRSSL SRLGSSRVLL LPLERDSELL 60
RERESVLRLR ERRWLDGATF DTERGSTSRE GEPSLDKKSI PVQSPVSLGE ELQWWPDKDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCCTGT TGGACGCGGA CATCCACTCG GCTCATCCCA GTGTCATCAT CGACGCTGAT 60
GCCATGTTCT CCGAGGACAT CAGCTACTTC GGCTACCCGT CTTTCAGACG CTCCTCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD
IPR009091--RCC1/BLIP-II
IPR003126--Znf_UBR

PROSITE

PS50237--HECT
PS51309--PABC
PS51157--ZF_UBR

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA
SM00396--ZnF_UBR1

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002217	Ailuropoda melanoleuca	88.27	0.00e+00	3782.00
IUUC-Apl-004165	Anas platyrhynchos	88.45	0.00e+00	3785.00
IUUC-Aca-004577	Anolis carolinensis	88.17	0.00e+00	3576.00
IUUC-Ame-010702	Astyanax mexicanus	89.57	0.00e+00	2614.00
IUUC-Bta-012313	Bos taurus	88.73	0.00e+00	3809.00
IUUC-Cel-018165	Caenorhabditis elegans	31.39	7.00e-82	300.00
IUUC-Cja-019858	Callithrix jacchus	88.81	0.00e+00	3834.00
IUUC-Cfa-020973	Canis familiaris	88.85	0.00e+00	3815.00
IUUC-Cpo-022108	Cavia porcellus	89.68	0.00e+00	1755.00
IUUC-Csa-023985	Chlorocebus sabaeus	88.69	0.00e+00	3845.00
IUUC-Cho-025034	Choloepus hoffmanni	79.62	0.00e+00	918.00
IUUC-Cin-025715	Ciona intestinalis	40.55	0.00e+00	809.00
IUUC-Csv-026131	Ciona savignyi	46.96	0.00e+00	676.00
IUUC-Dre-027730	Danio rerio	93.55	0.00e+00	3863.00
IUUC-Dno-029123	Dasypus novemcinctus	86.30	0.00e+00	3678.00
IUUC-Dor-030757	Dipodomys ordii	86.26	0.00e+00	2301.00
IUUC-Dme-032192	Drosophila melanogaster	51.82	1.00e-175	612.00
IUUC-Ete-032292	Echinops telfairi	85.55	0.00e+00	1901.00
IUUC-Eca-034347	Equus caballus	88.58	0.00e+00	3766.00
IUUC-Eeu-034873	Erinaceus europaeus	84.51	0.00e+00	3609.00
IUUC-Fca-036485	Felis catus	87.15	0.00e+00	3706.00
IUUC-Fal-037071	Ficedula albicollis	88.97	0.00e+00	3783.00
IUUC-Gmo-039589	Gadus morhua	94.21	0.00e+00	3947.00
IUUC-Gga-041195	Gallus gallus	87.68	0.00e+00	3699.00
IUUC-Gac-042538	Gasterosteus aculeatus	95.42	0.00e+00	4011.00
IUUC-Ggo-045351	Gorilla gorilla	88.47	0.00e+00	3874.00
IUUC-Hsa-045941	Homo sapiens	88.85	0.00e+00	3859.00
IUUC-Itr-048635	Ictidomys tridecemlineatus	88.85	0.00e+00	3818.00
IUUC-Lch-050480	Latimeria chalumnae	88.78	0.00e+00	3782.00
IUUC-Loc-052664	Lepisosteus oculatus	89.93	0.00e+00	3817.00
IUUC-Laf-053960	Loxodonta africana	86.67	0.00e+00	1404.00
IUUC-Mcc-054703	Macaca mulatta	88.69	0.00e+00	3844.00
IUUC-Meu-056431	Macropus eugenii	80.90	0.00e+00	751.00
IUUC-Mga-059289	Meleagris gallopavo	88.42	0.00e+00	3257.00
IUUC-Mmr-061737	Microcebus murinus	88.50	0.00e+00	3749.00
IUUC-Mdo-062499	Monodelphis domestica	88.50	0.00e+00	3761.00
IUUC-Mmu-063273	Mus musculus	88.30	0.00e+00	3781.00
IUUC-Mpu-066907	Mustela putorius furo	88.54	0.00e+00	3788.00
IUUC-Mlu-067942	Myotis lucifugus	87.98	0.00e+00	3812.00
IUUC-Nle-069527	Nomascus leucogenys	88.77	0.00e+00	3863.00
IUUC-Opr-070626	Ochotona princeps	78.30	0.00e+00	1274.00
IUUC-Ont-071951	Oreochromis niloticus	96.30	0.00e+00	4034.00
IUUC-Oan-072958	Ornithorhynchus anatinus	88.77	0.00e+00	3784.00
IUUC-Ocu-074503	Oryctolagus cuniculus	86.76	0.00e+00	3734.00
IUUC-Ola-086757	Oryzias latipes	95.07	0.00e+00	4046.00
IUUC-Oga-088781	Otolemur garnettii	88.73	0.00e+00	3808.00
IUUC-Oar-089274	Ovis aries	88.38	0.00e+00	3784.00
IUUC-Ptr-090669	Pan troglodytes	88.51	0.00e+00	3623.00
IUUC-Pan-092226	Papio anubis	88.66	0.00e+00	3829.00
IUUC-Psi-093502	Pelodiscus sinensis	88.55	0.00e+00	3777.00
IUUC-Pma-094454	Petromyzon marinus	81.90	0.00e+00	728.00
IUUC-Pab-098355	Pongo abelii	89.73	0.00e+00	2763.00
IUUC-Pca-100570	Procavia capensis	89.77	0.00e+00	1023.00
IUUC-Pva-102572	Pteropus vampyrus	85.25	0.00e+00	1186.00
IUUC-Rno-104916	Rattus norvegicus	86.46	0.00e+00	3556.00
IUUC-Sha-106653	Sarcophilus harrisii	88.35	0.00e+00	3770.00
IUUC-Sar-113517	Sorex araneus	87.78	0.00e+00	1004.00
IUUC-Ssc-115470	Sus scrofa	89.19	0.00e+00	2301.00
IUUC-Tgu-116932	Taeniopygia guttata	88.51	0.00e+00	3763.00
IUUC-Tru-117682	Takifugu rubripes	95.67	0.00e+00	2814.00
IUUC-Tsy-119417	Tarsius syrichta	85.24	0.00e+00	2257.00
IUUC-Tni-120442	Tetraodon nigroviridis	91.57	0.00e+00	3661.00
IUUC-Tbe-127456	Tupaia belangeri	78.23	0.00e+00	1887.00
IUUC-Ttr-128606	Tursiops truncatus	88.87	0.00e+00	1138.00
IUUC-Vpa-130112	Vicugna pacos	85.68	0.00e+00	3346.00
IUUC-Xtr-131929	Xenopus tropicalis	87.29	0.00e+00	3764.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence