iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072340

Ensembl Protein ID

ENSONIP00000009489.1

UniProt Accession

I3JKU5; I3JKU5_ORENI

Genbank Protein ID

AKK23720.1

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

AERX01020197

Gene Name

socs2; SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000007523.1	ENSONIT00000009495.1	ENSONIP00000009489.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.50e-12	46.9	156	198

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++ ++ +SLqhLCR+aI++ +++     ++ LPLP++LkdYL  + 
   Q: 156  TKPVYTSTPSLQHLCRIAINQRTRQ-----VQDLPLPNRLKDYLTDYA 198
           66778899*************9999.....7*************9885 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MTCQSSESTE TIEGDRRADN NTGAVESDES RVAAAMKELR NTGWYWGSLT ANEAKEILQD 60
TAEGTFLLRD SSQRDYLFTI SAMTSAGPTN LRIVFNHGKF KLDSVVLVKP KLKQFDSVVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACTTTGACA CCGTGGTGTG AGCAGTCGTG CCCTGCAGAC CTTGTACATG TCTCAGTTGT 60
GGGCCTGAAG GTTGGACTTG TCCAATGACC TGCCAGTCCT CCGAGTCCAC GGAAACCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	60.59	1.00e-57	215.00
IUUC-Apl-003484	Anas platyrhynchos	59.38	2.00e-53	201.00
IUUC-Aca-004253	Anolis carolinensis	57.31	1.00e-57	215.00
IUUC-Ame-011267	Astyanax mexicanus	70.75	8.00e-79	286.00
IUUC-Bta-013183	Bos taurus	60.87	1.00e-55	209.00
IUUC-Cja-018862	Callithrix jacchus	63.12	4.00e-56	210.00
IUUC-Cfa-020226	Canis familiaris	59.75	2.00e-54	204.00
IUUC-Cpo-022414	Cavia porcellus	61.25	7.00e-56	209.00
IUUC-Csa-023758	Chlorocebus sabaeus	60.62	3.00e-55	207.00
IUUC-Cho-024471	Choloepus hoffmanni	54.88	2.00e-44	172.00
IUUC-Dre-028288	Danio rerio	75.62	1.00e-88	318.00
IUUC-Dno-029036	Dasypus novemcinctus	59.41	4.00e-58	217.00
IUUC-Dor-030447	Dipodomys ordii	60.76	4.00e-54	203.00
IUUC-Ete-033023	Echinops telfairi	55.21	2.00e-58	218.00
IUUC-Fca-036469	Felis catus	60.62	2.00e-55	208.00
IUUC-Fal-036642	Ficedula albicollis	58.64	8.00e-54	202.00
IUUC-Gmo-039331	Gadus morhua	77.05	4.00e-53	199.00
IUUC-Gga-040809	Gallus gallus	58.43	5.00e-55	206.00
IUUC-Gac-041398	Gasterosteus aculeatus	74.63	5.00e-89	320.00
IUUC-Ggo-045341	Gorilla gorilla	62.50	6.00e-56	209.00
IUUC-Hsa-046557	Homo sapiens	57.29	4.00e-60	223.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	61.73	2.00e-55	208.00
IUUC-Lch-050160	Latimeria chalumnae	59.02	3.00e-59	220.00
IUUC-Loc-051825	Lepisosteus oculatus	73.13	3.00e-86	310.00
IUUC-Laf-053560	Loxodonta africana	62.50	4.00e-56	210.00
IUUC-Mcc-055890	Macaca mulatta	60.00	1.00e-54	206.00
IUUC-Meu-056218	Macropus eugenii	57.56	3.00e-62	231.00
IUUC-Mga-059755	Meleagris gallopavo	58.49	2.00e-52	198.00
IUUC-Mvi-060489	Microbotryum violaceum	33.33	1.20e+00	27.70
IUUC-Mmr-061387	Microcebus murinus	60.62	2.00e-55	208.00
IUUC-Mdo-062383	Monodelphis domestica	57.56	5.00e-64	237.00
IUUC-Mmu-063443	Mus musculus	61.25	6.00e-55	206.00
IUUC-Mpu-066459	Mustela putorius furo	59.38	7.00e-54	203.00
IUUC-Mlu-068040	Myotis lucifugus	60.59	6.00e-58	216.00
IUUC-Nle-069016	Nomascus leucogenys	53.43	2.00e-56	211.00
IUUC-Opr-071087	Ochotona princeps	52.68	9.00e-57	213.00
IUUC-Oan-073443	Ornithorhynchus anatinus	57.75	2.00e-60	225.00
IUUC-Ocu-074539	Oryctolagus cuniculus	60.76	4.00e-54	204.00
IUUC-Ola-087004	Oryzias latipes	81.76	6.00e-75	272.00
IUUC-Oga-088438	Otolemur garnettii	61.88	6.00e-56	210.00
IUUC-Oar-089932	Ovis aries	59.63	4.00e-55	207.00
IUUC-Ptr-091037	Pan troglodytes	62.50	6.00e-56	209.00
IUUC-Pan-092767	Papio anubis	60.62	3.00e-55	207.00
IUUC-Psi-093099	Pelodiscus sinensis	59.64	4.00e-56	209.00
IUUC-Pma-094671	Petromyzon marinus	45.68	4.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	77.11	1.00e-85	309.00
IUUC-Pab-098319	Pongo abelii	60.82	2.00e-58	218.00
IUUC-Pca-101117	Procavia capensis	63.12	4.00e-57	213.00
IUUC-Pva-102117	Pteropus vampyrus	61.88	2.00e-55	208.00
IUUC-Rno-105913	Rattus norvegicus	60.13	7.00e-55	207.00
IUUC-Sha-106500	Sarcophilus harrisii	58.42	2.00e-62	231.00
IUUC-Ssc-115252	Sus scrofa	60.25	1.00e-55	208.00
IUUC-Tgu-117524	Taeniopygia guttata	59.64	7.00e-56	209.00
IUUC-Tsy-119335	Tarsius syrichta	61.01	2.00e-53	201.00
IUUC-Tni-120263	Tetraodon nigroviridis	76.62	2.00e-83	301.00
IUUC-Tbe-127915	Tupaia belangeri	61.25	4.00e-55	207.00
IUUC-Ttr-128372	Tursiops truncatus	60.25	1.00e-55	208.00
IUUC-Vpa-130422	Vicugna pacos	60.13	7.00e-54	202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence