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Tag Content
iUUCD ID IUUC-Psi-093734
Ensembl Protein ID ENSPSIP00000020522.1
UniProt Accession K7GJR1; K7GJR1_PELSI
Genbank Protein ID ENSPSIP00000020522
Protein Name Histone deacetylase
Genbank Nucleotide ID AGCU01115720
Gene Name HDAC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPSIG00000018148.1 ENSPSIT00000020619.1 ENSPSIP00000020522.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 89.31 0.00e+00 1587.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
803 N/A {ECO:0000256|PIRSR:PIRSR037911-1}
Organism Pelodiscus sinensis
Functional Description
(View)

Functional Description



     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Protein Sequence
(Fasta)
LGNGGGRGGV SKKRGHVLLL NEAALTNQDF AVDVNTALPL QVAPASVPMD LRLDHQFSMP 60
VTEPTLREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120
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Protein Fasta Sequence



>IUUC-Psi-093734|E3,E3 activity/Other|Pelodiscus sinensis
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Nucleotide Sequence
(Fasta)
TTGGGAAACG GTGGTGGGAG GGGAGGTGTT TCCAAAAAGA GGGGGCACGT TTTGCTTTTA 60
AATGAAGCTG CATTGACAAA CCAAGATTGA GGCCTTTTAC AATATGAAAT CTGAGACATG 120
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Nucleotide Fasta Sequence



>IUUC-Psi-093734|E3,E3 activity/Other|Pelodiscus sinensis
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Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 48.56 8.00e-61 228.00
IUUC-Aml-002279 Ailuropoda melanoleuca 89.76 0.00e+00 1644.00
IUUC-Atr-002745 Amborella trichopoda 36.69 1.00e-71 263.00
IUUC-Apl-003250 Anas platyrhynchos 92.33 0.00e+00 1689.00
IUUC-Aca-004668 Anolis carolinensis 84.57 0.00e+00 1638.00
IUUC-Aly-006432 Arabidopsis lyrata 40.66 1.00e-68 253.00
IUUC-Ath-007355 Arabidopsis thaliana 41.97 2.00e-74 273.00
IUUC-Ago-007972 Ashbya gossypii 37.84 3.00e-69 256.00
IUUC-Acl-008187 Aspergillus clavatus 39.69 1.00e-71 264.00
IUUC-Afl-008399 Aspergillus flavus 43.88 1.00e-40 160.00
IUUC-Afu-008954 Aspergillus fumigatus 35.81 6.00e-59 221.00
IUUC-Ani-009142 Aspergillus nidulans 38.50 2.00e-67 250.00
IUUC-Ang-009522 Aspergillus niger 29.34 4.00e-34 139.00
IUUC-Aor-010069 Aspergillus oryzae 38.22 2.00e-65 243.00
IUUC-Ate-010291 Aspergillus terreus 40.36 2.00e-73 270.00
IUUC-Ame-010780 Astyanax mexicanus 39.12 5.00e-73 269.00
IUUC-Bta-013215 Bos taurus 88.78 0.00e+00 1627.00
IUUC-Bci-013789 Botrytis cinerea 36.23 4.00e-66 245.00
IUUC-Bdi-014007 Brachypodium distachyon 41.24 9.00e-72 264.00
IUUC-Bol-015468 Brassica oleracea 41.33 8.00e-75 274.00
IUUC-Bra-016680 Brassica rapa 41.58 2.00e-74 273.00
IUUC-Cel-018220 Caenorhabditis elegans 38.22 2.00e-66 247.00
IUUC-Cja-019816 Callithrix jacchus 89.00 0.00e+00 1660.00
IUUC-Cfa-020861 Canis familiaris 88.82 0.00e+00 1617.00
IUUC-Cpo-021562 Cavia porcellus 87.55 0.00e+00 1637.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 51.13 2.00e-53 201.00
IUUC-Csa-023612 Chlorocebus sabaeus 88.95 0.00e+00 1628.00
IUUC-Csv-026359 Ciona savignyi 53.72 1.00e-89 322.00
IUUC-Cgl-026709 Colletotrichum gloeosporioides 35.49 2.00e-65 243.00
IUUC-Cne-026978 Cryptococcus neoformans 38.50 2.00e-72 266.00
IUUC-Dre-028284 Danio rerio 85.35 0.00e+00 847.00
IUUC-Dno-029951 Dasypus novemcinctus 87.02 0.00e+00 1535.00
IUUC-Dor-030362 Dipodomys ordii 78.23 0.00e+00 1368.00
IUUC-Dse-031186 Dothistroma septosporum 34.00 7.00e-61 228.00
IUUC-Dme-031766 Drosophila melanogaster 56.63 7.00e-158 551.00
IUUC-Ete-032279 Echinops telfairi 36.48 2.00e-55 210.00
IUUC-Eca-033842 Equus caballus 43.14 5.00e-75 276.00
IUUC-Eeu-034487 Erinaceus europaeus 51.44 9.00e-61 228.00
IUUC-Fca-036187 Felis catus 90.51 0.00e+00 1642.00
IUUC-Fox-038067 Fusarium oxysporum 37.19 1.00e-65 243.00
IUUC-Fso-038263 Fusarium solani 36.21 1.00e-65 244.00
IUUC-Gmo-038473 Gadus morhua 77.55 0.00e+00 763.00
IUUC-Ggr-040062 Gaeumannomyces graminis 38.83 2.00e-64 239.00
IUUC-Gga-040501 Gallus gallus 94.23 0.00e+00 1725.00
IUUC-Gac-042335 Gasterosteus aculeatus 84.32 0.00e+00 839.00
IUUC-Gma-043738 Glycine max 42.15 5.00e-66 245.00
IUUC-Ggo-045380 Gorilla gorilla 88.99 0.00e+00 1632.00
IUUC-Hsa-046925 Homo sapiens 89.37 0.00e+00 1654.00
IUUC-Hvu-047285 Hordeum vulgare 42.65 5.00e-72 264.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 88.54 0.00e+00 1592.00
IUUC-Kpa-049281 Komagataella pastoris 38.13 9.00e-71 261.00
IUUC-Lch-050325 Latimeria chalumnae 84.45 0.00e+00 1511.00
IUUC-Lpe-051214 Leersia perrieri 42.94 6.00e-75 275.00
IUUC-Loc-052231 Lepisosteus oculatus 81.95 0.00e+00 1470.00
IUUC-Lma-053263 Leptosphaeria maculans 39.05 1.00e-73 271.00
IUUC-Laf-054490 Loxodonta africana 83.57 0.00e+00 1575.00
IUUC-Mcc-055265 Macaca mulatta 88.92 0.00e+00 1663.00
IUUC-Meu-056676 Macropus eugenii 87.42 0.00e+00 751.00
IUUC-Mor-057095 Magnaporthe oryzae 36.10 7.00e-67 248.00
IUUC-Mpo-057389 Magnaporthe poae 37.98 1.00e-63 237.00
IUUC-Mtr-058463 Medicago truncatula 39.12 1.00e-68 253.00
IUUC-Mla-059143 Melampsora laricipopulina 40.16 1.00e-68 253.00
IUUC-Mmr-061633 Microcebus murinus 80.40 0.00e+00 1444.00
IUUC-Mdo-062198 Monodelphis domestica 42.57 1.00e-75 278.00
IUUC-Mmu-063089 Mus musculus 88.47 0.00e+00 1587.00
IUUC-Mac-064630 Musa acuminata 41.19 2.00e-71 263.00
IUUC-Mpu-065887 Mustela putorius furo 88.99 0.00e+00 1648.00
IUUC-Mlu-067470 Myotis lucifugus 89.79 0.00e+00 1661.00
IUUC-Nfi-068404 Neosartorya fischeri 38.93 1.00e-70 260.00
IUUC-Ncr-068672 Neurospora crassa 36.95 4.00e-67 249.00
IUUC-Nle-069099 Nomascus leucogenys 84.91 0.00e+00 1055.00
IUUC-Opr-071074 Ochotona princeps 43.86 2.00e-85 310.00
IUUC-Ont-071613 Oreochromis niloticus 72.57 0.00e+00 1271.00
IUUC-Oan-073275 Ornithorhynchus anatinus 92.60 0.00e+00 1690.00
IUUC-Ocu-074627 Oryctolagus cuniculus 44.70 2.00e-83 304.00
IUUC-Oba-075489 Oryza barthii 42.53 1.00e-73 270.00
IUUC-Obr-076150 Oryza brachyantha 42.53 1.00e-74 273.00
IUUC-Ogl-077437 Oryza glaberrima 42.53 4.00e-74 272.00
IUUC-Ogu-078370 Oryza glumaepatula 43.10 2.00e-74 273.00
IUUC-Oin-079210 Oryza indica 43.10 2.00e-74 273.00
IUUC-Olo-080971 Oryza longistaminata 44.33 5.00e-65 241.00
IUUC-Oni-082031 Oryza nivara 43.10 2.00e-74 273.00
IUUC-Opu-083471 Oryza punctata 43.10 2.00e-74 273.00
IUUC-Oru-084755 Oryza rufipogon 43.10 2.00e-74 273.00
IUUC-Osa-085447 Oryza sativa 43.10 2.00e-74 273.00
IUUC-Ola-087031 Oryzias latipes 67.50 0.00e+00 1189.00
IUUC-Oga-088201 Otolemur garnettii 82.60 0.00e+00 1461.00
IUUC-Oar-089997 Ovis aries 80.95 0.00e+00 1363.00
IUUC-Ptr-091116 Pan troglodytes 89.28 0.00e+00 1670.00
IUUC-Pan-092132 Papio anubis 90.21 0.00e+00 1099.00
IUUC-Pma-094347 Petromyzon marinus 71.37 0.00e+00 710.00
IUUC-Pno-095131 Phaeosphaeria nodorum 45.65 2.00e-64 239.00
IUUC-Ppa-095550 Physcomitrella patens 42.90 7.00e-72 265.00
IUUC-Pfo-096293 Poecilia formosa 70.00 0.00e+00 1191.00
IUUC-Pab-098491 Pongo abelii 86.34 0.00e+00 1572.00
IUUC-Pop-099174 Populus trichocarpa 38.34 3.00e-69 256.00
IUUC-Pca-101004 Procavia capensis 76.74 0.00e+00 877.00
IUUC-Ppe-101644 Prunus persica 40.46 5.00e-72 265.00
IUUC-Pva-102961 Pteropus vampyrus 67.00 0.00e+00 825.00
IUUC-Ptt-103841 Puccinia triticina 38.40 1.00e-67 251.00
IUUC-Pte-104383 Pyrenophora teres 39.07 1.00e-71 264.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 40.24 7.00e-71 261.00
IUUC-Rno-105005 Rattus norvegicus 88.75 0.00e+00 1561.00
IUUC-Sce-106274 Saccharomyces cerevisiae 35.92 1.00e-65 244.00
IUUC-Sha-107646 Sarcophilus harrisii 66.38 0.00e+00 1028.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 37.25 3.00e-71 262.00
IUUC-Spo-108300 Schizosaccharomyces pombe 38.46 3.00e-73 269.00
IUUC-Smo-109615 Selaginella moellendorffii 42.86 3.00e-77 282.00
IUUC-Sit-110160 Setaria italica 41.79 3.00e-69 256.00
IUUC-Sly-111164 Solanum lycopersicum 43.23 9.00e-77 281.00
IUUC-Stu-112685 Solanum tuberosum 38.16 2.00e-57 216.00
IUUC-Sar-113692 Sorex araneus 34.45 2.00e-45 177.00
IUUC-Sbi-114301 Sorghum bicolor 41.38 1.00e-67 250.00
IUUC-Sre-115013 Sporisorium reilianum 39.90 2.00e-68 253.00
IUUC-Ssc-115428 Sus scrofa 88.43 0.00e+00 1598.00
IUUC-Tgu-116776 Taeniopygia guttata 93.10 0.00e+00 1711.00
IUUC-Tru-118180 Takifugu rubripes 83.47 0.00e+00 828.00
IUUC-Tsy-119468 Tarsius syrichta 83.77 0.00e+00 736.00
IUUC-Tni-120196 Tetraodon nigroviridis 69.71 0.00e+00 1252.00
IUUC-Tca-121312 Theobroma cacao 43.31 4.00e-75 275.00
IUUC-Tre-121930 Trichoderma reesei 38.73 2.00e-71 263.00
IUUC-Tvi-122373 Trichoderma virens 37.68 6.00e-68 251.00
IUUC-Tae-123064 Triticum aestivum 40.80 5.00e-67 247.00
IUUC-Tme-127027 Tuber melanosporum 38.17 7.00e-61 227.00
IUUC-Tbe-127675 Tupaia belangeri 38.64 1.00e-19 92.00
IUUC-Ttr-128360 Tursiops truncatus 81.56 0.00e+00 944.00
IUUC-Uma-129408 Ustilago maydis 43.07 1.00e-68 254.00
IUUC-Vda-129994 Verticillium dahliae 41.54 3.00e-62 233.00
IUUC-Vpa-130525 Vicugna pacos 57.89 2.00e-16 80.50
IUUC-Vvi-131038 Vitis vinifera 40.56 6.00e-75 275.00
IUUC-Xtr-132956 Xenopus tropicalis 80.06 0.00e+00 1444.00
IUUC-Xma-134265 Xiphophorus maculatus 69.32 0.00e+00 1203.00
IUUC-Yli-134680 Yarrowia lipolytica 40.10 2.00e-67 250.00
IUUC-Zma-135110 Zea mays 41.95 4.00e-70 258.00
Created Date 25-Jun-2017

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