iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134399

Ensembl Protein ID

CAG79756

UniProt Accession

Q6C5A1; Q6C5A1_YARLI

Genbank Protein ID

CAG79756.1

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

CR382131

Gene Name

YALI0_E19767g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E19767g	CAG79756	CAG79756

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-32	108.6	58	94
UBD/Beta-Prp	8.20e-77	256.7	10	359

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           H ++v++++f  + +l+vs++dD +ikvW+l t ++l
   Q: 58   HDGPVRGVDFhKTqPLFVSCGDDYKIKVWSLQTRKCL 94
           99*********4459****************999987 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            t +++++s+ + ++f+  +++++++  ++ti++wd+++g+l+ ++++h+++v+ v+f+++++++v++++D+ ikvw+l+t+kc+ tl gh d+v+++ f+
   Q: 10   LTQFESKSSRAKGLAFHSTRPWVLVSLHSSTIQLWDYRMGTLVDRFEDHDGPVRGVDFHKTQPLFVSCGDDYKIKVWSLQTRKCLFTLVGHLDYVRTVFFH 110
           677889999******************************************************************************************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...................................... 166
            +  +++s s+d+tir+w+++++q++  +l+gh++ ++++++hp+++l+vs++lD+tvr+Wd+                                      
   Q: 111  HELPWIISCSDDQTIRIWNWQNRQEIA-CLTGHSHYIMSAQFHPSEDLVVSACLDQTVRVWDIsglrkkhsagggvsaggagssmsfeeqmmmaarnsggp 210
           ***************************.************************************************************************* PP
   S: 167  ................ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
                           +++++++   +gh++ v++ +f+++ + +vsg++d+ +k+w ++ ++   v+t++ght+n++s  f+p ++ +vs+s+D++ir W
   Q: 211  ggpgghpqqggqdmfgNQDCIVKYVLEGHDGGVNWATFHPTLPLIVSGGDDRVLKIWRMSDTKAweVDTCRGHTNNILSCCFHPYQDVIVSVSEDKTIRTW 311
           ***************5555555555667********************************777668*********************************** PP
   S: 250  dlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           dl +++l+k+++++n+++++ ++ +++ n +++g  +s ++++k+++++p
   Q: 312  DLHKRTLIKQFKRENDKFWALTA-HPNINLFAAGH-ESGIMVFKMERERP 359
           ***********************.66666666665.599*****988765 PP

Organism

Yarrowia lipolytica

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MPYPDSTRIL TQFESKSSRA KGLAFHSTRP WVLVSLHSST IQLWDYRMGT LVDRFEDHDG 60
PVRGVDFHKT QPLFVSCGDD YKIKVWSLQT RKCLFTLVGH LDYVRTVFFH HELPWIISCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCATATC CTGATTCCAC TCGTATACTA ACCCAGTTTG AATCAAAATC TTCCCGAGCC 60
AAAGGCCTAG CCTTTCACTC GACCCGCCCC TGGGTCCTGG TCTCGCTCCA CTCGTCCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

KEGG

yli:YALI0E19767g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	49.25	0.00e+00	848.00
IUUC-Aml-001758	Ailuropoda melanoleuca	50.81	0.00e+00	877.00
IUUC-Atr-002493	Amborella trichopoda	50.06	0.00e+00	846.00
IUUC-Apl-003385	Anas platyrhynchos	48.44	5.00e-174	603.00
IUUC-Aca-005154	Anolis carolinensis	59.39	1.00e-80	290.00
IUUC-Aly-006020	Arabidopsis lyrata	49.01	0.00e+00	841.00
IUUC-Ath-007360	Arabidopsis thaliana	49.48	0.00e+00	849.00
IUUC-Ago-007992	Ashbya gossypii	58.52	0.00e+00	1043.00
IUUC-Acl-008027	Aspergillus clavatus	61.03	0.00e+00	1090.00
IUUC-Afl-008644	Aspergillus flavus	60.85	0.00e+00	1084.00
IUUC-Afu-008964	Aspergillus fumigatus	61.37	0.00e+00	1101.00
IUUC-Ani-009379	Aspergillus nidulans	61.07	0.00e+00	1088.00
IUUC-Ang-009756	Aspergillus niger	60.54	0.00e+00	1082.00
IUUC-Aor-010174	Aspergillus oryzae	60.85	0.00e+00	1084.00
IUUC-Ate-010302	Aspergillus terreus	61.48	0.00e+00	1097.00
IUUC-Ame-011229	Astyanax mexicanus	50.76	0.00e+00	873.00
IUUC-Bgr-012300	Blumeria graminis	60.43	0.00e+00	1011.00
IUUC-Bta-012524	Bos taurus	51.40	0.00e+00	883.00
IUUC-Bci-013781	Botrytis cinerea	61.37	0.00e+00	1094.00
IUUC-Bol-015925	Brassica oleracea	49.71	0.00e+00	839.00
IUUC-Bra-016978	Brassica rapa	49.25	0.00e+00	836.00
IUUC-Cel-018115	Caenorhabditis elegans	50.50	0.00e+00	813.00
IUUC-Cja-019107	Callithrix jacchus	50.06	0.00e+00	860.00
IUUC-Cfa-020675	Canis familiaris	50.59	0.00e+00	850.00
IUUC-Cpo-021813	Cavia porcellus	51.28	0.00e+00	880.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	50.58	0.00e+00	863.00
IUUC-Csa-023523	Chlorocebus sabaeus	51.28	0.00e+00	880.00
IUUC-Cho-024704	Choloepus hoffmanni	54.76	9.00e-110	389.00
IUUC-Cin-025572	Ciona intestinalis	49.65	0.00e+00	845.00
IUUC-Csv-025864	Ciona savignyi	49.83	0.00e+00	820.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	62.41	0.00e+00	1118.00
IUUC-Cne-027053	Cryptococcus neoformans	56.48	0.00e+00	949.00
IUUC-Cme-027222	Cyanidioschyzon merolae	37.44	2.00e-116	412.00
IUUC-Dre-027421	Danio rerio	50.64	0.00e+00	868.00
IUUC-Dno-029303	Dasypus novemcinctus	51.22	0.00e+00	885.00
IUUC-Dor-030290	Dipodomys ordii	42.35	2.00e-128	452.00
IUUC-Dse-031543	Dothistroma septosporum	61.23	0.00e+00	1046.00
IUUC-Dme-031945	Drosophila melanogaster	48.90	0.00e+00	830.00
IUUC-Ete-032873	Echinops telfairi	48.68	0.00e+00	816.00
IUUC-Eca-033773	Equus caballus	51.28	0.00e+00	882.00
IUUC-Eeu-034874	Erinaceus europaeus	37.95	2.00e-82	298.00
IUUC-Fca-035739	Felis catus	51.05	0.00e+00	875.00
IUUC-Fal-037263	Ficedula albicollis	46.96	0.00e+00	755.00
IUUC-Fox-037738	Fusarium oxysporum	62.18	0.00e+00	1112.00
IUUC-Gmo-039602	Gadus morhua	50.12	0.00e+00	858.00
IUUC-Ggr-039931	Gaeumannomyces graminis	61.25	0.00e+00	1097.00
IUUC-Gga-040590	Gallus gallus	51.40	0.00e+00	885.00
IUUC-Gac-041318	Gasterosteus aculeatus	50.86	0.00e+00	872.00
IUUC-Gma-043585	Glycine max	49.48	0.00e+00	850.00
IUUC-Ggo-045029	Gorilla gorilla	50.69	0.00e+00	874.00
IUUC-Hsa-046078	Homo sapiens	50.69	0.00e+00	874.00
IUUC-Hvu-047556	Hordeum vulgare	49.13	0.00e+00	842.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	43.22	3.00e-104	370.00
IUUC-Kpa-049256	Komagataella pastoris	60.70	0.00e+00	1099.00
IUUC-Lch-049706	Latimeria chalumnae	51.75	0.00e+00	882.00
IUUC-Lpe-051316	Leersia perrieri	49.48	0.00e+00	846.00
IUUC-Loc-051867	Lepisosteus oculatus	38.27	1.00e-119	422.00
IUUC-Lma-053138	Leptosphaeria maculans	61.96	0.00e+00	1112.00
IUUC-Laf-053510	Loxodonta africana	51.28	0.00e+00	883.00
IUUC-Mcc-055836	Macaca mulatta	50.81	0.00e+00	875.00
IUUC-Meu-056238	Macropus eugenii	47.15	0.00e+00	630.00
IUUC-Mor-057172	Magnaporthe oryzae	61.02	0.00e+00	1092.00
IUUC-Mpo-057300	Magnaporthe poae	61.25	0.00e+00	1096.00
IUUC-Mtr-058248	Medicago truncatula	49.88	0.00e+00	851.00
IUUC-Mla-059019	Melampsora laricipopulina	54.94	0.00e+00	965.00
IUUC-Mga-059499	Meleagris gallopavo	51.16	0.00e+00	878.00
IUUC-Mvi-060336	Microbotryum violaceum	56.15	0.00e+00	981.00
IUUC-Mmr-061102	Microcebus murinus	50.98	0.00e+00	876.00
IUUC-Mdo-062594	Monodelphis domestica	51.28	0.00e+00	882.00
IUUC-Mmu-063736	Mus musculus	50.92	0.00e+00	877.00
IUUC-Mac-065398	Musa acuminata	45.92	0.00e+00	766.00
IUUC-Mpu-066701	Mustela putorius furo	50.93	0.00e+00	885.00
IUUC-Mlu-067392	Myotis lucifugus	51.16	0.00e+00	878.00
IUUC-Nfi-068270	Neosartorya fischeri	61.26	0.00e+00	1092.00
IUUC-Ncr-068892	Neurospora crassa	61.60	0.00e+00	1110.00
IUUC-Nle-069634	Nomascus leucogenys	54.18	0.00e+00	777.00
IUUC-Opr-070952	Ochotona princeps	42.52	9.00e-98	349.00
IUUC-Ont-072488	Oreochromis niloticus	51.11	0.00e+00	874.00
IUUC-Oan-073184	Ornithorhynchus anatinus	60.76	1.00e-57	214.00
IUUC-Ocu-074211	Oryctolagus cuniculus	51.28	0.00e+00	880.00
IUUC-Oba-075761	Oryza barthii	49.25	0.00e+00	845.00
IUUC-Obr-076429	Oryza brachyantha	49.71	0.00e+00	848.00
IUUC-Ogl-077364	Oryza glaberrima	49.25	0.00e+00	845.00
IUUC-Ogu-078257	Oryza glumaepatula	49.25	0.00e+00	843.00
IUUC-Oin-080029	Oryza indica	49.71	0.00e+00	851.00
IUUC-Olo-080895	Oryza longistaminata	49.82	0.00e+00	845.00
IUUC-Ome-081993	Oryza meridionalis	51.61	0.00e+00	813.00
IUUC-Oni-082608	Oryza nivara	49.31	0.00e+00	844.00
IUUC-Opu-083697	Oryza punctata	49.48	0.00e+00	848.00
IUUC-Oru-084274	Oryza rufipogon	49.48	0.00e+00	845.00
IUUC-Osa-085841	Oryza sativa	49.36	0.00e+00	845.00
IUUC-Ola-086921	Oryzias latipes	50.63	0.00e+00	875.00
IUUC-Olu-087639	Ostreococcus lucimarinus	52.61	0.00e+00	892.00
IUUC-Oga-087991	Otolemur garnettii	49.07	0.00e+00	824.00
IUUC-Oar-089590	Ovis aries	51.40	0.00e+00	882.00
IUUC-Ptr-090808	Pan troglodytes	50.69	0.00e+00	874.00
IUUC-Pan-092475	Papio anubis	51.22	0.00e+00	870.00
IUUC-Psi-093044	Pelodiscus sinensis	46.89	0.00e+00	732.00
IUUC-Pno-094839	Phaeosphaeria nodorum	61.10	0.00e+00	1043.00
IUUC-Ppa-095254	Physcomitrella patens	51.92	0.00e+00	889.00
IUUC-Pfo-097493	Poecilia formosa	51.22	0.00e+00	877.00
IUUC-Pab-098497	Pongo abelii	51.28	0.00e+00	880.00
IUUC-Pop-099992	Populus trichocarpa	50.29	0.00e+00	857.00
IUUC-Pca-100413	Procavia capensis	47.77	2.00e-158	551.00
IUUC-Ppe-101392	Prunus persica	42.88	0.00e+00	995.00
IUUC-Pva-102126	Pteropus vampyrus	49.02	0.00e+00	835.00
IUUC-Pgr-103376	Puccinia graminis	54.82	0.00e+00	952.00
IUUC-Ptt-103978	Puccinia triticina	47.56	0.00e+00	758.00
IUUC-Pte-104126	Pyrenophora teres	60.62	0.00e+00	1062.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	51.32	0.00e+00	697.00
IUUC-Rno-105428	Rattus norvegicus	51.40	0.00e+00	882.00
IUUC-Sce-106464	Saccharomyces cerevisiae	47.23	0.00e+00	777.00
IUUC-Sha-107301	Sarcophilus harrisii	51.12	0.00e+00	863.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	52.74	0.00e+00	939.00
IUUC-Spo-108217	Schizosaccharomyces pombe	54.91	0.00e+00	970.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	61.48	0.00e+00	1092.00
IUUC-Smo-109582	Selaginella moellendorffii	52.39	0.00e+00	895.00
IUUC-Sit-109697	Setaria italica	49.59	0.00e+00	848.00
IUUC-Sly-111447	Solanum lycopersicum	49.83	0.00e+00	853.00
IUUC-Stu-112564	Solanum tuberosum	49.88	0.00e+00	853.00
IUUC-Sar-113313	Sorex araneus	38.39	2.00e-80	291.00
IUUC-Sbi-114388	Sorghum bicolor	49.36	0.00e+00	847.00
IUUC-Sre-115209	Sporisorium reilianum	54.89	0.00e+00	962.00
IUUC-Ssc-115933	Sus scrofa	51.28	0.00e+00	882.00
IUUC-Tgu-117109	Taeniopygia guttata	38.73	3.00e-70	256.00
IUUC-Tru-117772	Takifugu rubripes	50.17	0.00e+00	851.00
IUUC-Tsy-119105	Tarsius syrichta	44.15	0.00e+00	729.00
IUUC-Tni-120556	Tetraodon nigroviridis	37.73	2.00e-113	402.00
IUUC-Tca-121046	Theobroma cacao	43.07	0.00e+00	996.00
IUUC-Tre-121951	Trichoderma reesei	61.02	0.00e+00	1092.00
IUUC-Tvi-122359	Trichoderma virens	61.37	0.00e+00	1103.00
IUUC-Tae-125527	Triticum aestivum	49.25	0.00e+00	849.00
IUUC-Tur-126754	Triticum urartu	49.13	0.00e+00	846.00
IUUC-Tme-127170	Tuber melanosporum	61.70	0.00e+00	1081.00
IUUC-Tbe-127882	Tupaia belangeri	40.27	4.00e-122	430.00
IUUC-Ttr-128217	Tursiops truncatus	49.02	0.00e+00	823.00
IUUC-Uma-129337	Ustilago maydis	54.89	0.00e+00	963.00
IUUC-Vda-129828	Verticillium dahliae	61.68	0.00e+00	1081.00
IUUC-Vpa-130537	Vicugna pacos	50.58	0.00e+00	862.00
IUUC-Vvi-130958	Vitis vinifera	44.05	0.00e+00	1011.00
IUUC-Xtr-132857	Xenopus tropicalis	49.94	0.00e+00	810.00
IUUC-Xma-133138	Xiphophorus maculatus	51.22	0.00e+00	877.00
IUUC-Zma-135612	Zea mays	49.59	0.00e+00	845.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence