iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185798.7	ENST00000332629.6	ENSP00000328079.5
ENSG00000185798.7	ENST00000433160.1	ENSP00000410677.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-25	89.7	239	273

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtg 33
           gHt++v+ ++f ++  ll++G++Dg+i +WD  + 
   Q: 239  GHTSGVSQVCFlPEsYLLLTGGNDGKITLWDANSE 273
           8***********88899**************6655 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAVKWTGGHS SPVLCLNASK EGLLASGAEG GDLTAWGEDG TPLGHTRFQG ADDVTSVLFS 60
PSCPTKLYAS HGETISVLDV RSLKDSLDHF HVNEEEINCL SLNQTENLLA SADDSGAIKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCACGAAGCA AGGGCGCACG CCCAGCTCGT TCGCGGTTCC TCTCGGCCCC GGATGTGACT 60
GTTTGGCTGC GCCGCCTCAC GCCTGACGCT CGACGGGATT GGGCGCCGGC GGGTGAGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm

KEGG

hsa:348793

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000124	Aegilops tauschii	28.22	7.00e-14	72.00
IUUC-Aml-001203	Ailuropoda melanoleuca	91.34	0.00e+00	644.00
IUUC-Atr-002680	Amborella trichopoda	25.45	2.00e-22	100.00
IUUC-Apl-003656	Anas platyrhynchos	57.98	7.00e-105	373.00
IUUC-Aca-004987	Anolis carolinensis	63.51	1.00e-124	439.00
IUUC-Aly-006254	Arabidopsis lyrata	30.69	2.00e-28	120.00
IUUC-Ath-006632	Arabidopsis thaliana	29.84	3.00e-27	115.00
IUUC-Ame-011032	Astyanax mexicanus	46.49	1.00e-91	330.00
IUUC-Bta-012588	Bos taurus	81.84	1.00e-163	568.00
IUUC-Bdi-014532	Brachypodium distachyon	26.16	4.00e-25	108.00
IUUC-Bol-015542	Brassica oleracea	27.96	1.00e-20	95.50
IUUC-Bra-017046	Brassica rapa	30.67	5.00e-28	120.00
IUUC-Cja-019365	Callithrix jacchus	95.53	0.00e+00	708.00
IUUC-Cfa-021090	Canis familiaris	89.94	0.00e+00	642.00
IUUC-Cpo-021517	Cavia porcellus	82.73	7.00e-180	622.00
IUUC-Csa-023041	Chlorocebus sabaeus	98.04	0.00e+00	687.00
IUUC-Cho-024801	Choloepus hoffmanni	89.66	0.00e+00	661.00
IUUC-Dre-028437	Danio rerio	47.99	3.00e-87	315.00
IUUC-Dno-029267	Dasypus novemcinctus	88.83	0.00e+00	660.00
IUUC-Ete-032726	Echinops telfairi	73.74	6.00e-152	530.00
IUUC-Eca-033621	Equus caballus	91.01	1.00e-178	619.00
IUUC-Eeu-034461	Erinaceus europaeus	76.54	9.00e-161	559.00
IUUC-Fca-036410	Felis catus	89.66	0.00e+00	639.00
IUUC-Fal-036676	Ficedula albicollis	64.71	6.00e-129	453.00
IUUC-Gmo-039597	Gadus morhua	34.48	1.00e-17	84.00
IUUC-Gga-040760	Gallus gallus	62.81	2.00e-70	258.00
IUUC-Gac-041905	Gasterosteus aculeatus	49.32	3.00e-90	325.00
IUUC-Gma-043066	Glycine max	22.96	9.00e-17	81.30
IUUC-Ggo-044881	Gorilla gorilla	98.88	0.00e+00	693.00
IUUC-Hvu-047651	Hordeum vulgare	26.09	9.00e-24	104.00
IUUC-Itr-048206	Ictidomys tridecemlineatus	91.60	0.00e+00	650.00
IUUC-Lch-050406	Latimeria chalumnae	52.94	7.00e-95	340.00
IUUC-Loc-052878	Lepisosteus oculatus	53.04	8.00e-99	353.00
IUUC-Laf-053547	Loxodonta africana	87.39	0.00e+00	640.00
IUUC-Mcc-054646	Macaca mulatta	98.04	0.00e+00	687.00
IUUC-Meu-056381	Macropus eugenii	76.26	3.00e-162	564.00
IUUC-Mtr-058656	Medicago truncatula	26.37	1.00e-18	87.40
IUUC-Mmr-061601	Microcebus murinus	89.92	0.00e+00	663.00
IUUC-Mdo-062305	Monodelphis domestica	76.54	3.00e-164	571.00
IUUC-Mmu-063213	Mus musculus	83.52	4.00e-171	593.00
IUUC-Mac-064940	Musa acuminata	24.88	1.00e-28	120.00
IUUC-Mpu-066629	Mustela putorius furo	90.50	0.00e+00	644.00
IUUC-Nle-069860	Nomascus leucogenys	98.88	0.00e+00	690.00
IUUC-Opr-071180	Ochotona princeps	85.35	9.00e-155	539.00
IUUC-Ont-071912	Oreochromis niloticus	47.15	9.00e-98	350.00
IUUC-Ocu-074874	Oryctolagus cuniculus	89.39	0.00e+00	664.00
IUUC-Oba-075815	Oryza barthii	26.14	7.00e-15	74.70
IUUC-Obr-076835	Oryza brachyantha	33.96	2.00e-20	93.20
IUUC-Ogu-077977	Oryza glumaepatula	26.14	7.00e-15	75.10
IUUC-Oin-079206	Oryza indica	26.17	2.00e-24	106.00
IUUC-Olo-080621	Oryza longistaminata	29.23	9.00e-14	71.20
IUUC-Ome-081261	Oryza meridionalis	25.70	2.00e-13	70.10
IUUC-Opu-083256	Oryza punctata	29.44	3.00e-14	73.20
IUUC-Osa-085892	Oryza sativa	26.17	2.00e-24	106.00
IUUC-Ola-086701	Oryzias latipes	47.55	6.00e-91	327.00
IUUC-Olu-087593	Ostreococcus lucimarinus	22.75	4.00e-08	52.80
IUUC-Oga-088152	Otolemur garnettii	89.36	0.00e+00	658.00
IUUC-Oar-089681	Ovis aries	87.99	1.00e-178	619.00
IUUC-Ptr-091142	Pan troglodytes	99.72	0.00e+00	696.00
IUUC-Pan-092435	Papio anubis	98.04	0.00e+00	660.00
IUUC-Psi-093255	Pelodiscus sinensis	68.82	5.00e-145	507.00
IUUC-Ppa-095829	Physcomitrella patens	30.55	9.00e-31	127.00
IUUC-Pfo-097339	Poecilia formosa	45.03	4.00e-86	311.00
IUUC-Pab-098274	Pongo abelii	97.77	0.00e+00	677.00
IUUC-Pop-099705	Populus trichocarpa	25.47	5.00e-28	118.00
IUUC-Pca-100451	Procavia capensis	85.67	0.00e+00	643.00
IUUC-Ppe-101220	Prunus persica	26.20	6.00e-27	115.00
IUUC-Pva-102385	Pteropus vampyrus	90.22	0.00e+00	641.00
IUUC-Rno-105765	Rattus norvegicus	82.12	2.00e-167	581.00
IUUC-Sha-106533	Sarcophilus harrisii	74.58	4.00e-159	554.00
IUUC-Smo-109248	Selaginella moellendorffii	26.84	5.00e-29	121.00
IUUC-Sit-110297	Setaria italica	25.48	1.00e-20	93.60
IUUC-Sly-111617	Solanum lycopersicum	31.86	1.00e-23	103.00
IUUC-Stu-112531	Solanum tuberosum	31.86	3.00e-23	102.00
IUUC-Sar-113647	Sorex araneus	81.01	8.00e-174	602.00
IUUC-Sbi-114621	Sorghum bicolor	26.70	1.00e-25	110.00
IUUC-Tgu-116482	Taeniopygia guttata	64.99	6.00e-125	440.00
IUUC-Tru-118622	Takifugu rubripes	48.51	1.00e-88	320.00
IUUC-Tsy-119474	Tarsius syrichta	89.11	0.00e+00	667.00
IUUC-Tni-120250	Tetraodon nigroviridis	47.97	5.00e-81	294.00
IUUC-Tca-121583	Theobroma cacao	27.54	4.00e-29	122.00
IUUC-Tae-123764	Triticum aestivum	32.54	6.00e-24	105.00
IUUC-Tur-126076	Triticum urartu	23.12	1.00e-13	70.90
IUUC-Tbe-127545	Tupaia belangeri	88.52	1.00e-178	618.00
IUUC-Ttr-128497	Tursiops truncatus	88.27	6.00e-179	620.00
IUUC-Vpa-130772	Vicugna pacos	89.11	0.00e+00	629.00
IUUC-Vvi-131632	Vitis vinifera	26.30	3.00e-32	132.00
IUUC-Xma-133432	Xiphophorus maculatus	45.57	1.00e-89	323.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence