iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073150

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01117559

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000014087.1	ENSOANT00000022226.1	ENSOANP00000022222.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.30e-08	33.3	492	530

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f    +++pC+H fha Cl kw       + +++CP C
   Q: 492  CAICYHEFTVSARITPCNHYFHALCLRKW------LYIQDTCPMC 530
           ********88899****************......********** PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

LPGVFGSSVV LTLSRRSLFK FYMSTSAFLL AASSVLVNYY ASLHIDFHGA YNTSAFGIEL 60
LPRRGPSLWM ALVALQLTFG IGYVTLLQIQ SLYSQLIIFD LLVPVIGLVT ELPVQVREVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCAGGCG TATTTGGGTC CAGCGTGGTC CTGACCTTAT CGCGGCGATC GCTTTTCAAG 60
TTCTACATGT CCACCTCGGC CTTTCTCCTA GCTGCATCTT CGGTGTTAGT GAATTACTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	82.13	0.00e+00	995.00
IUUC-Apl-004214	Anas platyrhynchos	84.90	0.00e+00	933.00
IUUC-Aca-005326	Anolis carolinensis	81.18	0.00e+00	927.00
IUUC-Ame-011687	Astyanax mexicanus	75.23	0.00e+00	817.00
IUUC-Bta-013394	Bos taurus	82.27	0.00e+00	1011.00
IUUC-Bci-013624	Botrytis cinerea	30.59	1.00e-07	51.20
IUUC-Cja-019499	Callithrix jacchus	81.77	0.00e+00	1021.00
IUUC-Cfa-020357	Canis familiaris	81.80	0.00e+00	992.00
IUUC-Cpo-021924	Cavia porcellus	81.41	0.00e+00	1023.00
IUUC-Csa-023513	Chlorocebus sabaeus	82.76	0.00e+00	1015.00
IUUC-Cho-024285	Choloepus hoffmanni	76.03	0.00e+00	867.00
IUUC-Cin-025223	Ciona intestinalis	53.93	3.00e-74	270.00
IUUC-Csv-026018	Ciona savignyi	47.63	9.00e-66	243.00
IUUC-Dre-028660	Danio rerio	68.55	0.00e+00	746.00
IUUC-Dno-029463	Dasypus novemcinctus	80.66	6.00e-117	414.00
IUUC-Dor-030728	Dipodomys ordii	85.04	0.00e+00	976.00
IUUC-Dse-031284	Dothistroma septosporum	41.07	1.00e-09	56.20
IUUC-Dme-032186	Drosophila melanogaster	44.32	6.00e-99	354.00
IUUC-Ete-032368	Echinops telfairi	79.21	0.00e+00	967.00
IUUC-Eca-034325	Equus caballus	82.15	0.00e+00	988.00
IUUC-Fca-035537	Felis catus	84.25	0.00e+00	986.00
IUUC-Fal-037459	Ficedula albicollis	84.11	0.00e+00	918.00
IUUC-Gmo-039442	Gadus morhua	78.15	3.00e-96	345.00
IUUC-Gga-041071	Gallus gallus	83.09	0.00e+00	921.00
IUUC-Gac-042483	Gasterosteus aculeatus	69.43	0.00e+00	855.00
IUUC-Ggo-044672	Gorilla gorilla	82.76	0.00e+00	1014.00
IUUC-Hsa-045836	Homo sapiens	82.54	0.00e+00	991.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	82.00	0.00e+00	1021.00
IUUC-Lch-050073	Latimeria chalumnae	74.11	0.00e+00	928.00
IUUC-Loc-052908	Lepisosteus oculatus	72.05	0.00e+00	884.00
IUUC-Laf-053519	Loxodonta africana	80.95	0.00e+00	1017.00
IUUC-Mpo-057601	Magnaporthe poae	33.67	6.00e-10	58.50
IUUC-Mga-059922	Meleagris gallopavo	83.36	0.00e+00	924.00
IUUC-Mmr-061452	Microcebus murinus	80.99	0.00e+00	987.00
IUUC-Mdo-062412	Monodelphis domestica	81.54	0.00e+00	991.00
IUUC-Mmu-063147	Mus musculus	79.71	0.00e+00	1008.00
IUUC-Mpu-065929	Mustela putorius furo	81.64	0.00e+00	989.00
IUUC-Mlu-067899	Myotis lucifugus	80.16	0.00e+00	961.00
IUUC-Nle-070083	Nomascus leucogenys	82.43	0.00e+00	1011.00
IUUC-Opr-070461	Ochotona princeps	79.58	0.00e+00	997.00
IUUC-Ont-072256	Oreochromis niloticus	72.45	0.00e+00	847.00
IUUC-Ocu-073748	Oryctolagus cuniculus	79.67	0.00e+00	957.00
IUUC-Oga-088565	Otolemur garnettii	82.59	0.00e+00	1017.00
IUUC-Oar-089432	Ovis aries	82.51	0.00e+00	1032.00
IUUC-Ptr-091422	Pan troglodytes	82.76	0.00e+00	1015.00
IUUC-Pan-092331	Papio anubis	82.76	0.00e+00	1016.00
IUUC-Psi-092933	Pelodiscus sinensis	83.49	0.00e+00	898.00
IUUC-Pfo-097466	Poecilia formosa	71.65	0.00e+00	855.00
IUUC-Pab-098702	Pongo abelii	82.76	0.00e+00	1013.00
IUUC-Pca-100125	Procavia capensis	81.91	0.00e+00	995.00
IUUC-Pva-102628	Pteropus vampyrus	82.10	0.00e+00	992.00
IUUC-Rno-104886	Rattus norvegicus	80.03	0.00e+00	1013.00
IUUC-Sha-106702	Sarcophilus harrisii	84.64	0.00e+00	996.00
IUUC-Ssc-115482	Sus scrofa	82.35	0.00e+00	992.00
IUUC-Tgu-116829	Taeniopygia guttata	84.23	0.00e+00	932.00
IUUC-Tru-118557	Takifugu rubripes	67.86	0.00e+00	829.00
IUUC-Tsy-119399	Tarsius syrichta	83.82	0.00e+00	634.00
IUUC-Tni-120006	Tetraodon nigroviridis	61.64	0.00e+00	690.00
IUUC-Tbe-127664	Tupaia belangeri	79.64	0.00e+00	967.00
IUUC-Ttr-129144	Tursiops truncatus	80.92	0.00e+00	1010.00
IUUC-Vpa-130226	Vicugna pacos	82.10	0.00e+00	1005.00
IUUC-Xtr-132461	Xenopus tropicalis	76.12	0.00e+00	890.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence