iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-097418

Ensembl Protein ID

ENSPFOP00000018784.2

UniProt Accession

A0A087YL81; A0A087YL81_POEFO

Genbank Protein ID

ENSPFOP00000018784

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AYCK01000451

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000018667.2	ENSPFOT00000018806.2	ENSPFOP00000018784.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	2.70e-159	530.7	3	727

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           +k+wleLesdPglftllvedfgvk++ qvee+y+L++++      pv+g+++lFk++e+r+s+rk+++++++++v+de+i++ +ffa+q
   Q: 3    NKGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----HSPVYGFIFLFKWIEERRSRRKVNTLVDETSVIDEEIVNDMFFAHQ 86
           69************************.************....9********************************************* PP
   S: 94   vigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           +i+NsCat+Allsvllnc+ +  +lGttlsr+k +tk++spe+k++a+gn+++l+ +hns+ar+e+r++pe+q++ ++++t+eafhfvs
   Q: 87   LIPNSCATHALLSVLLNCSGV--ELGTTLSRIKAFTKGFSPESKGYAIGNAPELARAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVS 173
           *******************99..9***************************************************************** PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid........ 259
           yv+i++rl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l++lk +        
   Q: 174  YVPIKDRLFELDGLKAYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYESKLDILKRNrqtilegl 260
           **************************************..************************************************* PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qkmirltqpevvqdkkqqnssspdentvkkeadadsvdesggqskdgagpsgsskvmgkpaaptgggaqqvnpivqrlpafldnhnyak 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  spmqeeedlaagvgrsrtagppqppfsddedefdedeeeaagsasassrfrrkaslrsrtgrvgtgmesqialnvlaeklkkeaqrkdg 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vntplsvrtegrtggicitsasqpsptpsnestdtaseigsafnsplrsparsqaatrpsspvashlsrvlfgedemlrldsrhnravr 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  elgpsvsasllhlqddgviyalppsgdsaegtklctpekvklkvkedekdaikegdegpsvavkkedenedgaelkpgkeklnvtesga 616
           ***************************************************************************************** PP
   S: 260  ...........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvneg 337
                      keLl+Llk++e+ ++++e  l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l+ lve++is++r++gv++g
   Q: 617  dskppgdkyspKELLALLKCVEADIANYEVFLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIG 705
           ***************************************************************************************** PP
   S: 338  rlakqrkqgrekkirplkrkrk 359
           rl+kqrk++r+k++rp+k+kr+
   Q: 706  RLHKQRKPDRRKRSRPYKAKRQ 727
           ********************97 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MNNKGWLELE SDPGLFTLLV EDFGVKGVQV EEIYDLQSKC HSPVYGFIFL FKWIEERRSR 60
RKVNTLVDET SVIDEEIVND MFFAHQLIPN SCATHALLSV LLNCSGVELG TTLSRIKAFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGCTAAAG CACAACATAT ACTGTAAACG TTTCCTTACT TGTTCTTTAA GAGTCGTTTG 60
GGATTCGAAA AATCCTTCTC TTTTTGATGA GGCGATCCGA ATCCCAGTTA GGTCGGACTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	64.88	0.00e+00	874.00
IUUC-Apl-003405	Anas platyrhynchos	53.41	7.00e-126	444.00
IUUC-Aca-004836	Anolis carolinensis	66.05	0.00e+00	916.00
IUUC-Ame-011946	Astyanax mexicanus	70.39	0.00e+00	994.00
IUUC-Bta-013131	Bos taurus	60.56	0.00e+00	736.00
IUUC-Cja-019599	Callithrix jacchus	66.32	0.00e+00	906.00
IUUC-Cfa-021003	Canis familiaris	65.21	0.00e+00	877.00
IUUC-Cpo-022143	Cavia porcellus	65.34	0.00e+00	890.00
IUUC-Csa-023477	Chlorocebus sabaeus	65.71	0.00e+00	895.00
IUUC-Cho-024734	Choloepus hoffmanni	48.99	1.00e-122	433.00
IUUC-Csv-025842	Ciona savignyi	65.06	2.00e-93	336.00
IUUC-Dre-027793	Danio rerio	75.36	0.00e+00	1060.00
IUUC-Dno-029253	Dasypus novemcinctus	64.82	0.00e+00	884.00
IUUC-Dor-030891	Dipodomys ordii	61.32	0.00e+00	822.00
IUUC-Dme-031796	Drosophila melanogaster	62.26	1.00e-92	333.00
IUUC-Ete-032646	Echinops telfairi	84.71	1.00e-119	424.00
IUUC-Eca-033805	Equus caballus	64.49	0.00e+00	889.00
IUUC-Eeu-035216	Erinaceus europaeus	63.23	3.00e-94	339.00
IUUC-Fca-035611	Felis catus	63.91	0.00e+00	846.00
IUUC-Fal-037186	Ficedula albicollis	66.07	0.00e+00	791.00
IUUC-Gmo-038824	Gadus morhua	81.96	0.00e+00	753.00
IUUC-Gga-040875	Gallus gallus	65.95	0.00e+00	902.00
IUUC-Gac-042226	Gasterosteus aculeatus	84.82	0.00e+00	1170.00
IUUC-Ggo-045122	Gorilla gorilla	65.76	0.00e+00	906.00
IUUC-Hsa-045882	Homo sapiens	66.05	0.00e+00	904.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	65.97	0.00e+00	898.00
IUUC-Lch-049960	Latimeria chalumnae	64.11	0.00e+00	850.00
IUUC-Loc-052408	Lepisosteus oculatus	72.73	2.00e-178	619.00
IUUC-Laf-054187	Loxodonta africana	65.56	0.00e+00	909.00
IUUC-Mcc-055273	Macaca mulatta	64.84	0.00e+00	875.00
IUUC-Meu-056267	Macropus eugenii	63.46	0.00e+00	876.00
IUUC-Mga-059958	Meleagris gallopavo	90.66	4.00e-144	503.00
IUUC-Mmr-061280	Microcebus murinus	66.05	0.00e+00	888.00
IUUC-Mdo-062625	Monodelphis domestica	66.93	0.00e+00	934.00
IUUC-Mmu-063853	Mus musculus	64.73	0.00e+00	889.00
IUUC-Mlu-067771	Myotis lucifugus	65.60	0.00e+00	888.00
IUUC-Opr-070741	Ochotona princeps	65.48	0.00e+00	896.00
IUUC-Ont-072172	Oreochromis niloticus	88.39	0.00e+00	1279.00
IUUC-Oan-073167	Ornithorhynchus anatinus	66.91	7.00e-90	325.00
IUUC-Ocu-074176	Oryctolagus cuniculus	65.56	0.00e+00	880.00
IUUC-Ola-087203	Oryzias latipes	91.63	4.00e-144	503.00
IUUC-Oga-089153	Otolemur garnettii	63.91	0.00e+00	882.00
IUUC-Oar-090008	Ovis aries	64.43	0.00e+00	885.00
IUUC-Ptr-091234	Pan troglodytes	65.76	0.00e+00	905.00
IUUC-Pan-092005	Papio anubis	65.58	0.00e+00	903.00
IUUC-Psi-093995	Pelodiscus sinensis	76.90	4.00e-167	582.00
IUUC-Pma-094110	Petromyzon marinus	45.64	1.00e-117	417.00
IUUC-Pab-098267	Pongo abelii	65.62	0.00e+00	879.00
IUUC-Pca-101084	Procavia capensis	63.38	0.00e+00	841.00
IUUC-Pva-102292	Pteropus vampyrus	65.90	2.00e-179	622.00
IUUC-Rno-105251	Rattus norvegicus	63.93	0.00e+00	879.00
IUUC-Sha-107100	Sarcophilus harrisii	66.00	0.00e+00	920.00
IUUC-Sar-113559	Sorex araneus	57.62	9.00e-114	404.00
IUUC-Ssc-115688	Sus scrofa	65.57	0.00e+00	899.00
IUUC-Tgu-117424	Taeniopygia guttata	67.39	0.00e+00	919.00
IUUC-Tru-118585	Takifugu rubripes	82.24	0.00e+00	1166.00
IUUC-Tsy-119299	Tarsius syrichta	55.00	2.00e-175	609.00
IUUC-Tni-120808	Tetraodon nigroviridis	81.83	0.00e+00	1149.00
IUUC-Tbe-127705	Tupaia belangeri	73.58	6.00e-146	510.00
IUUC-Ttr-128225	Tursiops truncatus	64.37	0.00e+00	874.00
IUUC-Vpa-130193	Vicugna pacos	69.55	2.00e-91	330.00
IUUC-Xtr-132449	Xenopus tropicalis	65.84	0.00e+00	855.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence