iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021401

Ensembl Protein ID

ENSCPOP00000001654.2

UniProt Accession

H0UX54; H0UX54_CAVPO

Genbank Protein ID

ENSCPOP00000001654

Protein Name

Presenilin

Genbank Nucleotide ID

AAKN02019005

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000001827.3	ENSCPOT00000001848.2	ENSCPOP00000001654.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.20e-08	33.4	293	331

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 293  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 331
           89********************************99986 PP

Organism

Cavia porcellus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

QGPCAFQVRP FPSRVMLTFM ASDSEEEACD ERTSLMLAES PSPRSCQEGR LGEEDGDSAA 60
QWRGQESEED CEDDPDHYIC GGVPGRPAGL EEELTLKYGA KHVIMLFVPV TLCMVVVVAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAGGTCCCT GTGCTTTCCA GGTCCGCCCC TTCCCGAGCA GGGTCATGCT CACCTTCATG 60
GCCTCTGACA GCGAGGAGGA AGCATGCGAC GAGCGGACGT CCCTGATGTT GGCCGAGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	88.00	3.00e-180	624.00
IUUC-Apl-003959	Anas platyrhynchos	76.07	9.00e-162	563.00
IUUC-Aca-005160	Anolis carolinensis	74.34	4.00e-158	550.00
IUUC-Ang-009768	Aspergillus niger	42.86	1.10e+00	28.50
IUUC-Ame-010686	Astyanax mexicanus	79.43	9.00e-147	513.00
IUUC-Bta-013097	Bos taurus	95.32	0.00e+00	715.00
IUUC-Cja-018824	Callithrix jacchus	93.56	0.00e+00	723.00
IUUC-Cfa-020253	Canis familiaris	95.54	0.00e+00	739.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.72	1.00e-29	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.76	0.00e+00	739.00
IUUC-Dre-028526	Danio rerio	68.32	4.00e-143	501.00
IUUC-Dor-031127	Dipodomys ordii	91.74	0.00e+00	689.00
IUUC-Ete-033081	Echinops telfairi	84.40	5.00e-94	337.00
IUUC-Eca-034387	Equus caballus	95.09	0.00e+00	692.00
IUUC-Eeu-034846	Erinaceus europaeus	78.61	3.00e-147	514.00
IUUC-Fca-035396	Felis catus	94.43	0.00e+00	758.00
IUUC-Fal-037457	Ficedula albicollis	75.38	5.00e-160	557.00
IUUC-Gga-040706	Gallus gallus	76.54	7.00e-156	543.00
IUUC-Gac-042511	Gasterosteus aculeatus	65.20	2.00e-129	455.00
IUUC-Ggo-045338	Gorilla gorilla	93.09	0.00e+00	741.00
IUUC-Hsa-046455	Homo sapiens	93.09	0.00e+00	742.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.54	0.00e+00	742.00
IUUC-Lch-049638	Latimeria chalumnae	68.68	3.00e-144	504.00
IUUC-Loc-052427	Lepisosteus oculatus	74.44	2.00e-155	541.00
IUUC-Laf-053758	Loxodonta africana	88.94	0.00e+00	720.00
IUUC-Mcc-054755	Macaca mulatta	95.33	0.00e+00	741.00
IUUC-Mmr-060890	Microcebus murinus	94.64	0.00e+00	726.00
IUUC-Mdo-062197	Monodelphis domestica	80.95	6.00e-178	616.00
IUUC-Mmu-063823	Mus musculus	94.64	0.00e+00	737.00
IUUC-Mac-064858	Musa acuminata	43.86	1.00e-22	100.00
IUUC-Mpu-066181	Mustela putorius furo	94.87	0.00e+00	731.00
IUUC-Nle-069596	Nomascus leucogenys	94.94	0.00e+00	689.00
IUUC-Opr-070344	Ochotona princeps	93.56	0.00e+00	742.00
IUUC-Ont-071867	Oreochromis niloticus	71.46	6.00e-133	467.00
IUUC-Oan-073378	Ornithorhynchus anatinus	73.73	1.00e-152	532.00
IUUC-Ocu-074652	Oryctolagus cuniculus	94.44	0.00e+00	699.00
IUUC-Obr-076302	Oryza brachyantha	36.96	6.00e-17	82.00
IUUC-Ola-086707	Oryzias latipes	69.90	3.00e-105	374.00
IUUC-Oga-088560	Otolemur garnettii	93.57	0.00e+00	690.00
IUUC-Oar-089200	Ovis aries	95.10	0.00e+00	696.00
IUUC-Ptr-090569	Pan troglodytes	95.31	0.00e+00	737.00
IUUC-Pan-091742	Papio anubis	95.54	0.00e+00	739.00
IUUC-Psi-093297	Pelodiscus sinensis	75.79	2.00e-131	462.00
IUUC-Pma-094612	Petromyzon marinus	78.10	9.00e-128	449.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	3.00e-27	116.00
IUUC-Pab-098531	Pongo abelii	95.76	0.00e+00	739.00
IUUC-Pca-101120	Procavia capensis	92.67	0.00e+00	714.00
IUUC-Pva-102934	Pteropus vampyrus	85.33	0.00e+00	686.00
IUUC-Rno-106052	Rattus norvegicus	93.30	0.00e+00	747.00
IUUC-Sha-106876	Sarcophilus harrisii	79.96	6.00e-175	606.00
IUUC-Ssc-115380	Sus scrofa	96.21	0.00e+00	764.00
IUUC-Tgu-117280	Taeniopygia guttata	76.03	1.00e-160	559.00
IUUC-Tbe-127632	Tupaia belangeri	94.12	2.00e-178	618.00
IUUC-Ttr-129008	Tursiops truncatus	94.29	0.00e+00	732.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence