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Tag Content
iUUCD ID IUUC-Ola-086707
Ensembl Protein ID ENSORLP00000025023.1
UniProt Accession H2N0U7; H2N0U7_ORYLA
Protein Name Presenilin
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSORLG00000020169.1 ENSORLT00000025024.1 ENSORLP00000025023.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 59.72 7.00e-70 260.00 IUUC-Cel-018553
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Oryzias latipes
Functional Description
(View)

Functional Description


     Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Protein Sequence
(Fasta)
MDLSDSEDDL YNERTALVAA EKPAVPSYKP GSDCSPPDGS PTKPTRASGR AREGASDQEA 60
EAEEEELTLK YGAKHVIMLF IPVTLCMLVV VATIKSVSFY TEKTNQQLIY TPFTEDTPSV 120
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Protein Fasta Sequence


>IUUC-Ola-086707|UBD,CUE|Oryzias latipes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCACGTGA CAGCGCCTGC CGGTCACGTG ACTGCTGCCG GGTTCCGGGT GCCTGTTTTC 60
TTCGGTTTCT CGGACCCTAA ATTCAGGTAC AACTTCATCT TCTTTGTTCC TGCCGAACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ola-086707|UBD,CUE|Oryzias latipes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
SMART

SM00730--PSN
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0034205--P:beta-amyloid formation
GO:0007420--P:brain development
GO:0035556--P:intracellular signal transduction
GO:0030318--P:melanocyte differentiation
GO:0022008--P:neurogenesis
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
GO:0061053--P:somite development
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 36.03 8.00e-12 65.90
IUUC-Aml-002356 Ailuropoda melanoleuca 61.64 2.00e-82 299.00
IUUC-Atr-003039 Amborella trichopoda 31.84 8.00e-21 94.70
IUUC-Apl-003959 Anas platyrhynchos 72.58 1.00e-105 376.00
IUUC-Aca-005160 Anolis carolinensis 70.71 5.00e-106 377.00
IUUC-Aly-005455 Arabidopsis lyrata 32.27 4.00e-18 85.90
IUUC-Ath-006730 Arabidopsis thaliana 31.94 9.00e-19 87.80
IUUC-Ame-010686 Astyanax mexicanus 80.62 6.00e-110 390.00
IUUC-Bta-013097 Bos taurus 69.93 4.00e-107 381.00
IUUC-Bdi-014196 Brachypodium distachyon 36.03 4.00e-15 76.30
IUUC-Bol-015841 Brassica oleracea 31.02 4.00e-14 72.40
IUUC-Bra-017580 Brassica rapa 31.58 7.00e-12 65.10
IUUC-Cel-018553 Caenorhabditis elegans 59.72 4.00e-67 248.00
IUUC-Cja-018824 Callithrix jacchus 69.51 5.00e-107 380.00
IUUC-Cfa-020253 Canis familiaris 70.16 4.00e-108 384.00
IUUC-Cpo-021401 Cavia porcellus 70.82 1.00e-108 386.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 33.94 5.00e-30 125.00
IUUC-Csa-023369 Chlorocebus sabaeus 71.80 3.00e-112 398.00
IUUC-Cho-024735 Choloepus hoffmanni 63.71 2.00e-80 293.00
IUUC-Cin-025780 Ciona intestinalis 67.10 7.00e-81 294.00
IUUC-Csv-025967 Ciona savignyi 70.22 2.00e-82 299.00
IUUC-Dre-028526 Danio rerio 71.90 2.00e-107 382.00
IUUC-Dno-029758 Dasypus novemcinctus 82.19 1.00e-87 316.00
IUUC-Dor-031127 Dipodomys ordii 66.77 1.00e-99 356.00
IUUC-Dme-031929 Drosophila melanogaster 65.28 2.00e-77 283.00
IUUC-Ete-033081 Echinops telfairi 83.33 2.00e-37 149.00
IUUC-Eca-034387 Equus caballus 71.48 5.00e-107 380.00
IUUC-Eeu-034846 Erinaceus europaeus 60.42 7.00e-86 310.00
IUUC-Fca-035396 Felis catus 69.84 4.00e-106 377.00
IUUC-Fal-037457 Ficedula albicollis 71.61 3.00e-104 371.00
IUUC-Gmo-038550 Gadus morhua 82.64 4.00e-106 377.00
IUUC-Gga-040706 Gallus gallus 71.61 1.00e-105 376.00
IUUC-Gac-042511 Gasterosteus aculeatus 79.54 3.00e-108 385.00
IUUC-Gma-043822 Glycine max 36.50 2.00e-08 53.10
IUUC-Ggo-045338 Gorilla gorilla 71.48 3.00e-112 398.00
IUUC-Hsa-046455 Homo sapiens 71.48 3.00e-112 398.00
IUUC-Hvu-047141 Hordeum vulgare 31.05 1.00e-12 67.80
IUUC-Itr-048731 Ictidomys tridecemlineatus 70.49 3.00e-110 391.00
IUUC-Lch-049638 Latimeria chalumnae 71.88 8.00e-112 397.00
IUUC-Lpe-051132 Leersia perrieri 35.29 3.00e-16 79.30
IUUC-Loc-052427 Lepisosteus oculatus 76.97 1.00e-115 409.00
IUUC-Laf-053758 Loxodonta africana 70.82 1.00e-111 396.00
IUUC-Mcc-054755 Macaca mulatta 71.15 2.00e-111 395.00
IUUC-Meu-056004 Macropus eugenii 75.23 1.00e-82 300.00
IUUC-Mtr-058392 Medicago truncatula 34.08 4.00e-13 68.90
IUUC-Mga-059466 Meleagris gallopavo 82.57 1.00e-89 323.00
IUUC-Mmr-060890 Microcebus murinus 71.15 1.00e-111 396.00
IUUC-Mdo-062197 Monodelphis domestica 71.90 2.00e-110 392.00
IUUC-Mmu-063823 Mus musculus 71.48 8.00e-111 393.00
IUUC-Mac-064858 Musa acuminata 60.00 1.30e-02 33.50
IUUC-Mpu-066181 Mustela putorius furo 69.35 2.00e-108 385.00
IUUC-Mlu-067079 Myotis lucifugus 81.57 4.00e-95 341.00
IUUC-Nle-069596 Nomascus leucogenys 71.48 3.00e-112 398.00
IUUC-Opr-070344 Ochotona princeps 70.82 1.00e-106 379.00
IUUC-Ont-071867 Oreochromis niloticus 81.25 5.00e-114 404.00
IUUC-Oan-073378 Ornithorhynchus anatinus 72.55 7.00e-110 390.00
IUUC-Ocu-074652 Oryctolagus cuniculus 67.92 1.00e-108 387.00
IUUC-Oba-075256 Oryza barthii 33.59 2.00e-11 63.50
IUUC-Obr-076302 Oryza brachyantha 34.53 2.00e-15 77.40
IUUC-Ogl-077097 Oryza glaberrima 35.29 3.00e-15 76.60
IUUC-Ogu-078570 Oryza glumaepatula 35.04 3.00e-15 76.30
IUUC-Oin-079244 Oryza indica 36.03 2.00e-15 77.00
IUUC-Olo-080484 Oryza longistaminata 50.85 1.00e-06 47.00
IUUC-Ome-081814 Oryza meridionalis 35.29 2.00e-15 77.00
IUUC-Oni-082057 Oryza nivara 36.03 2.00e-15 77.00
IUUC-Opu-084176 Oryza punctata 35.77 3.00e-15 75.90
IUUC-Oru-084618 Oryza rufipogon 35.77 2.00e-15 77.00
IUUC-Osa-085602 Oryza sativa 35.77 2.00e-15 77.00
IUUC-Olu-087811 Ostreococcus lucimarinus 35.41 1.00e-31 130.00
IUUC-Oga-088560 Otolemur garnettii 71.80 1.00e-110 392.00
IUUC-Oar-089200 Ovis aries 68.37 2.00e-107 382.00
IUUC-Ptr-090569 Pan troglodytes 71.48 2.00e-111 395.00
IUUC-Pan-091742 Papio anubis 71.48 2.00e-111 395.00
IUUC-Psi-093297 Pelodiscus sinensis 70.19 2.00e-106 379.00
IUUC-Pma-094612 Petromyzon marinus 82.51 3.00e-85 308.00
IUUC-Ppa-095431 Physcomitrella patens 33.33 9.00e-28 117.00
IUUC-Pfo-097396 Poecilia formosa 77.98 6.00e-87 314.00
IUUC-Pab-098531 Pongo abelii 71.80 3.00e-112 398.00
IUUC-Pop-099661 Populus trichocarpa 31.11 6.00e-18 85.10
IUUC-Pca-101120 Procavia capensis 68.20 1.00e-105 376.00
IUUC-Ppe-101495 Prunus persica 32.29 3.00e-21 96.30
IUUC-Pva-102934 Pteropus vampyrus 64.59 8.00e-102 363.00
IUUC-Rno-106052 Rattus norvegicus 72.13 5.00e-111 394.00
IUUC-Sha-106876 Sarcophilus harrisii 71.34 3.00e-109 388.00
IUUC-Smo-109325 Selaginella moellendorffii 38.85 3.00e-19 89.00
IUUC-Sit-110624 Setaria italica 34.56 2.00e-12 66.60
IUUC-Stu-112433 Solanum tuberosum 33.64 2.00e-19 90.10
IUUC-Sar-113169 Sorex araneus 75.71 3.00e-63 235.00
IUUC-Sbi-114305 Sorghum bicolor 36.03 2.00e-12 67.00
IUUC-Ssc-115380 Sus scrofa 70.82 6.00e-115 407.00
IUUC-Tgu-117280 Taeniopygia guttata 71.61 1.00e-105 376.00
IUUC-Tru-117732 Takifugu rubripes 79.07 2.00e-86 312.00
IUUC-Tsy-119624 Tarsius syrichta 75.23 1.00e-81 296.00
IUUC-Tni-119852 Tetraodon nigroviridis 73.95 3.00e-82 298.00
IUUC-Tca-121865 Theobroma cacao 32.97 1.00e-19 90.90
IUUC-Tae-125925 Triticum aestivum 36.03 8.00e-12 64.70
IUUC-Tur-126237 Triticum urartu 35.29 2.00e-11 63.20
IUUC-Tbe-127632 Tupaia belangeri 71.48 1.00e-109 389.00
IUUC-Ttr-129008 Tursiops truncatus 68.93 5.00e-105 374.00
IUUC-Vpa-130625 Vicugna pacos 65.14 4.00e-68 251.00
IUUC-Vvi-131312 Vitis vinifera 34.50 4.00e-18 85.50
IUUC-Xtr-132756 Xenopus tropicalis 73.51 1.00e-114 406.00
IUUC-Xma-133377 Xiphophorus maculatus 77.98 1.00e-86 313.00
Created Date 25-Jun-2017

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