iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000010004.1	ENSSHAT00000011739.1	ENSSHAP00000011643.1
ENSSHAG00000010004.1	ENSSHAT00000011740.1	ENSSHAP00000011644.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	2.00e-07	31.1	284	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e++++iFP+l+ys+ +v+ + +++ ++++ +
   Q: 284  VETAQERNEPIFPALIYSSAMVWTVGMAKVDTPTKG 319
           89**************************99998855 PP

Organism

Sarcophilus harrisii

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNSDSE EEVCNERTSL MSTESPPARS YHEGICTEER DKEIQEPWKR QGSLCNHGNA 60
DQCTPDSRGS SRSSSLEEDE EEEELTLKYG AKHVIMLFVP VTLCMVVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAGCATCTT TACCATTTTA TTGATTCAAT AGGTCTCATC TATGTTATAC CCAAACTGCT 60
TCATTCCTTT TTGCCTACTA CTTTTAATGG CCATCTGGGG GCAGTGAGGT GCGGGTCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	72.36	6.00e-139	487.00
IUUC-Apl-003959	Anas platyrhynchos	77.23	2.00e-161	562.00
IUUC-Aca-005160	Anolis carolinensis	76.29	9.00e-161	559.00
IUUC-Ame-010686	Astyanax mexicanus	77.66	2.00e-136	478.00
IUUC-Bta-013097	Bos taurus	79.74	5.00e-164	570.00
IUUC-Bra-017580	Brassica rapa	57.47	1.00e-17	84.00
IUUC-Cja-018824	Callithrix jacchus	78.02	4.00e-161	560.00
IUUC-Cfa-020253	Canis familiaris	79.10	2.00e-166	578.00
IUUC-Cpo-021401	Cavia porcellus	79.74	2.00e-165	574.00
IUUC-Csa-023369	Chlorocebus sabaeus	79.74	6.00e-166	576.00
IUUC-Dre-028526	Danio rerio	65.07	4.00e-142	497.00
IUUC-Dor-031127	Dipodomys ordii	75.91	8.00e-159	553.00
IUUC-Ete-033081	Echinops telfairi	72.95	2.00e-76	279.00
IUUC-Eca-034387	Equus caballus	79.09	1.00e-160	559.00
IUUC-Eeu-034846	Erinaceus europaeus	63.71	5.00e-112	397.00
IUUC-Fca-035396	Felis catus	78.59	2.00e-173	601.00
IUUC-Fal-037457	Ficedula albicollis	77.59	2.00e-164	572.00
IUUC-Gga-040706	Gallus gallus	78.62	1.00e-164	572.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.52	5.00e-127	447.00
IUUC-Ggo-045338	Gorilla gorilla	79.74	7.00e-166	576.00
IUUC-Hsa-046455	Homo sapiens	79.74	7.00e-166	576.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	80.39	2.00e-166	578.00
IUUC-Lch-049638	Latimeria chalumnae	68.80	5.00e-143	500.00
IUUC-Lpe-051132	Leersia perrieri	50.00	4.00e-16	79.00
IUUC-Loc-052427	Lepisosteus oculatus	71.67	2.00e-154	538.00
IUUC-Laf-053758	Loxodonta africana	76.50	9.00e-171	592.00
IUUC-Mcc-054755	Macaca mulatta	79.53	9.00e-166	576.00
IUUC-Mmr-060890	Microcebus murinus	79.53	7.00e-164	569.00
IUUC-Mdo-062197	Monodelphis domestica	96.32	0.00e+00	760.00
IUUC-Mmu-063823	Mus musculus	79.53	9.00e-167	579.00
IUUC-Mac-064858	Musa acuminata	42.13	1.00e-22	99.80
IUUC-Mpu-066181	Mustela putorius furo	78.98	2.00e-167	582.00
IUUC-Nle-069596	Nomascus leucogenys	77.13	3.00e-151	527.00
IUUC-Opr-070344	Ochotona princeps	78.71	1.00e-169	588.00
IUUC-Ont-071867	Oreochromis niloticus	70.24	2.00e-133	468.00
IUUC-Oan-073378	Ornithorhynchus anatinus	77.97	5.00e-157	546.00
IUUC-Ocu-074652	Oryctolagus cuniculus	78.37	6.00e-163	566.00
IUUC-Oin-079244	Oryza indica	60.49	2.00e-16	80.10
IUUC-Oni-082057	Oryza nivara	60.49	2.00e-16	80.10
IUUC-Opu-084176	Oryza punctata	60.49	2.00e-16	80.10
IUUC-Ola-086707	Oryzias latipes	71.34	3.00e-101	360.00
IUUC-Oga-088560	Otolemur garnettii	79.09	2.00e-160	558.00
IUUC-Oar-089200	Ovis aries	78.23	9.00e-162	563.00
IUUC-Ptr-090569	Pan troglodytes	79.53	5.00e-165	573.00
IUUC-Pan-091742	Papio anubis	79.53	5.00e-166	577.00
IUUC-Pma-094612	Petromyzon marinus	75.26	1.00e-126	446.00
IUUC-Ppa-095431	Physcomitrella patens	32.57	8.00e-24	104.00
IUUC-Pab-098531	Pongo abelii	79.74	6.00e-166	576.00
IUUC-Pop-099661	Populus trichocarpa	32.07	6.00e-32	131.00
IUUC-Pca-101120	Procavia capensis	77.20	2.00e-155	542.00
IUUC-Pva-102934	Pteropus vampyrus	73.61	3.00e-159	554.00
IUUC-Rno-106052	Rattus norvegicus	78.46	8.00e-170	589.00
IUUC-Sit-110624	Setaria italica	58.02	6.00e-16	78.60
IUUC-Ssc-115380	Sus scrofa	80.39	1.00e-167	582.00
IUUC-Tgu-117280	Taeniopygia guttata	77.75	3.00e-166	578.00
IUUC-Tbe-127632	Tupaia belangeri	76.86	2.00e-137	481.00
IUUC-Ttr-129008	Tursiops truncatus	79.31	2.00e-162	565.00
IUUC-Xtr-132756	Xenopus tropicalis	74.03	2.00e-162	565.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence