iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046776

UUCD1 version

UUC-HoS-00236

Ensembl Protein ID

ENSP00000295131.2

UniProt Accession

Q8NEG5; B3KXV6; Q53SI3; Q57ZY3; ZSWM2_HUMAN

Genbank Protein ID

BAG54618.1; AAY14907.1; AAX82016.1; EAX10929.1; AAH31094.1

Protein Name

E3 ubiquitin-protein ligase ZSWIM2; MEKK1-related protein X; RING-type E3 ubiquitin transferase ZSWIM2; ZZ-type zinc finger-containing protein 2; Zinc finger SWIM domain-containing protein 2

Genbank Nucleotide ID

AK128006; AC018735; AC103914; CH471058; BC031094

Gene Name

ZSWIM2; ZZZ2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000163012.3	ENST00000295131.2	ENSP00000295131.2
ENSG00000163012.3	ENST00000419862.1	ENSP00000400595.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16522193

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00094	21.3	344	384

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPl 44
           C++Cl  f   + ++++lpC H fh++C+ +w     +  k  +CP+
   Q: 344  CLLCLKAFhlgQ-HTRLLPCTHKFHRKCIDNW-----LFHKCNSCPI 384
           ******887744.4******************.....6788888887 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.

Protein Sequence
(Fasta)

MLRRGYKASE RRRHLSERLS WHQDQALSSS IYLLREMGPT GFLLREEEPE YMDFRVFLGN 60
PHVCNCSTFP KGGELCKHIC WVLLKKFKLP RNHESALQLG LGEREISDLL RGIHRVQTPQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGCACGC CGTCGTCTTG GAGACCGGCT GGCGCCTCAG TGAGCCGAGC AGAGGGGCCG 60
CCTCCGCCCG CACCCAGCAT GCTTCGCCGA GGCTATAAGG CCTCTGAAAG GCGAAGACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR007527--Znf_SWIM
IPR000433--Znf_ZZ

PROSITE

PS50089--ZF_RING_2
PS50966--ZF_SWIM
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF04434--SWIM
PF13639--zf-RING_2
PF00569--ZZ

SMART

SM00184--RING

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:1902043--P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0000209--P:protein polyubiquitination

KEGG

hsa:151112

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001754	Ailuropoda melanoleuca	81.13	0.00e+00	1023.00
IUUC-Apl-003359	Anas platyrhynchos	58.46	1.00e-40	157.00
IUUC-Aca-004923	Anolis carolinensis	56.81	4.00e-117	414.00
IUUC-Afl-008716	Aspergillus flavus	25.00	3.00e-10	59.70
IUUC-Ani-009202	Aspergillus nidulans	31.08	2.00e-12	67.00
IUUC-Bta-012456	Bos taurus	76.38	0.00e+00	986.00
IUUC-Cja-019186	Callithrix jacchus	88.15	0.00e+00	1135.00
IUUC-Cfa-020604	Canis familiaris	77.97	0.00e+00	924.00
IUUC-Cpo-021774	Cavia porcellus	69.72	0.00e+00	885.00
IUUC-Cre-022861	Chlamydomonas reinhardtii	33.33	2.00e-31	130.00
IUUC-Csa-024126	Chlorocebus sabaeus	95.26	0.00e+00	1221.00
IUUC-Cho-024501	Choloepus hoffmanni	83.06	5.00e-180	623.00
IUUC-Cin-025662	Ciona intestinalis	43.38	3.00e-91	328.00
IUUC-Dre-028700	Danio rerio	43.65	8.00e-106	377.00
IUUC-Dno-030007	Dasypus novemcinctus	77.83	0.00e+00	995.00
IUUC-Dor-030562	Dipodomys ordii	61.54	0.00e+00	729.00
IUUC-Ete-032603	Echinops telfairi	76.15	1.00e-152	532.00
IUUC-Eca-033283	Equus caballus	80.38	0.00e+00	1027.00
IUUC-Eeu-034619	Erinaceus europaeus	66.77	0.00e+00	860.00
IUUC-Fca-035573	Felis catus	79.37	0.00e+00	1024.00
IUUC-Fso-038137	Fusarium solani	26.23	4.00e-10	58.90
IUUC-Ggo-045207	Gorilla gorilla	97.79	0.00e+00	1255.00
IUUC-Itr-048416	Ictidomys tridecemlineatus	77.71	0.00e+00	1001.00
IUUC-Lch-050394	Latimeria chalumnae	44.03	1.00e-138	486.00
IUUC-Loc-052123	Lepisosteus oculatus	49.28	5.00e-131	461.00
IUUC-Lma-053033	Leptosphaeria maculans	32.89	1.00e-09	57.40
IUUC-Laf-053456	Loxodonta africana	76.85	0.00e+00	984.00
IUUC-Mcc-055227	Macaca mulatta	95.42	0.00e+00	1222.00
IUUC-Meu-055957	Macropus eugenii	63.95	1.00e-96	347.00
IUUC-Mmr-061710	Microcebus murinus	82.55	0.00e+00	1052.00
IUUC-Mdo-062378	Monodelphis domestica	57.19	0.00e+00	688.00
IUUC-Mmu-064269	Mus musculus	68.03	0.00e+00	884.00
IUUC-Mpu-066736	Mustela putorius furo	74.50	0.00e+00	894.00
IUUC-Mlu-067142	Myotis lucifugus	61.27	0.00e+00	723.00
IUUC-Nfi-068477	Neosartorya fischeri	27.70	1.00e-09	57.80
IUUC-Nle-069268	Nomascus leucogenys	96.68	0.00e+00	1261.00
IUUC-Opr-071154	Ochotona princeps	62.88	6.00e-160	557.00
IUUC-Oan-072878	Ornithorhynchus anatinus	39.53	7.00e-56	210.00
IUUC-Ocu-074017	Oryctolagus cuniculus	76.45	0.00e+00	914.00
IUUC-Oga-088906	Otolemur garnettii	75.28	0.00e+00	962.00
IUUC-Oar-089422	Ovis aries	77.48	0.00e+00	1010.00
IUUC-Ptr-090772	Pan troglodytes	98.26	0.00e+00	1254.00
IUUC-Pan-092838	Papio anubis	94.79	0.00e+00	1197.00
IUUC-Psi-093288	Pelodiscus sinensis	52.72	1.00e-143	503.00
IUUC-Pma-094709	Petromyzon marinus	43.73	2.00e-99	355.00
IUUC-Pfo-096189	Poecilia formosa	40.52	4.00e-92	332.00
IUUC-Pab-098389	Pongo abelii	91.31	0.00e+00	1149.00
IUUC-Pca-100376	Procavia capensis	65.24	0.00e+00	792.00
IUUC-Pva-102163	Pteropus vampyrus	78.77	0.00e+00	987.00
IUUC-Pte-104391	Pyrenophora teres	31.76	5.00e-11	62.00
IUUC-Pyt-104706	Pyrenophora triticirepentis	34.21	3.00e-11	62.80
IUUC-Rno-105988	Rattus norvegicus	70.24	0.00e+00	912.00
IUUC-Sha-107063	Sarcophilus harrisii	58.66	0.00e+00	703.00
IUUC-Sar-113069	Sorex araneus	69.86	0.00e+00	891.00
IUUC-Ssc-116112	Sus scrofa	75.74	0.00e+00	943.00
IUUC-Tsy-118825	Tarsius syrichta	83.50	0.00e+00	850.00
IUUC-Tbe-127891	Tupaia belangeri	76.42	0.00e+00	977.00
IUUC-Ttr-129130	Tursiops truncatus	78.34	0.00e+00	870.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence