iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000038697.15	ENSMUST00000093039.5	ENSMUSP00000090726.5
ENSMUSG00000038697.15	ENSMUST00000212010.1	ENSMUSP00000148808.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-40	136.9	508	543
UBD/Beta-Prp	1.50e-66	225.7	271	570

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHtds+t+laf +d +l++s+s D++++vWD+r+  
   Q: 508  GHTDSITSLAFsPDsGLIASASMDNSVRVWDIRSTC 543
           8***********999****************98765 PP

UBD/Beta-Prp

   S: 13   itcvkfspdksllatgsrdgtikvwdvttgkl................................lrslsgheaevtavkfspdgkilvt 69
           ++   +s d++lla+g+++++ik+w+++++kl                                ++ l gh ++v++++f  d++ l++
   Q: 271  LNTAEISSDSKLLAAGFDNSCIKLWSLRSKKLksephhvdtsrirlacdtleeeeneedntgteMKILRGHCGPVYSTRFLADSSGLLS 359
           55567899*******************************************************99999********************* PP
   S: 70   gseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslD 158
           +seD+ i+ wdl +++ ++ ++gh + v+++++sp + +++sGshdrt+r+w  +  + l+ + +gh + v cv++hp++n+l++Gs+D
   Q: 360  CSEDMSIRYWDLGSFTNTVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTD 447
           ***********************************99************************.*************************** PP
   S: 159  rtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsir 247
           +tvrlW+ ++g+ +r +tg h ++v slsf++ngk+l+s+++d+++klwdl +g+  ++l+ghtd ++s++fsp++ +++s+s+D+s+r
   Q: 448  KTVRLWSAQQGNSVRLFTG-HRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKELRGHTDSITSLAFSPDSGLIASASMDNSVR 535
           ******************9.********************************************************************* PP
   S: 248  iWdlrsgdllktlqlhn...........ssvisva 271
           +Wd+rs  +++   ++            s+v sv+
   Q: 536  VWDIRSTCCNTPADGSSgelvgvytgqmSNVLSVQ 570
           **999988888777777333333333334444444 PP

Organism

Mus musculus

Functional Description
(View)

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity).

Protein Sequence
(Fasta)

MKRVRTEQVQ VAVSCYLKRR QYVDSEGPLK QGLRLSQTPE EMAANLTVQS ESGCANAVSA 60
APCQAEPQQY EVQFGRLRSF LTDSDSQYSR EVMPLLYPLF VYLHLNLVQS GPKSTVESFY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGCGTCG CGCGTCCGCG GCCTAGCCCG GCGTGCCCGC TCCGTCAGGC GGTCATGGGG 60
CGGCCACCGA GAACCGCGAG CGCGGGAGGA CGTAGGGCGC GGGGACCCGG CTAGCCGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR007582--TFIID_NTD2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04494--TFIID_NTD2
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000932--C:P-body
GO:0030914--C:STAGA complex
GO:0033276--C:transcription factor TFTC complex
GO:0004402--F:histone acetyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0043966--P:histone H3 acetylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:102162

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002016	Ailuropoda melanoleuca	93.04	0.00e+00	1064.00
IUUC-Apl-003636	Anas platyrhynchos	89.17	0.00e+00	1091.00
IUUC-Aca-004229	Anolis carolinensis	88.29	0.00e+00	1063.00
IUUC-Ame-010599	Astyanax mexicanus	66.56	0.00e+00	815.00
IUUC-Bta-013404	Bos taurus	89.47	0.00e+00	1016.00
IUUC-Cja-019643	Callithrix jacchus	93.21	0.00e+00	1085.00
IUUC-Cfa-020913	Canis familiaris	93.04	0.00e+00	1078.00
IUUC-Cpo-021777	Cavia porcellus	93.72	0.00e+00	1070.00
IUUC-Csa-024184	Chlorocebus sabaeus	93.21	0.00e+00	1089.00
IUUC-Cho-024638	Choloepus hoffmanni	93.21	0.00e+00	1061.00
IUUC-Cin-025618	Ciona intestinalis	34.96	2.00e-92	333.00
IUUC-Csv-025874	Ciona savignyi	33.28	4.00e-90	325.00
IUUC-Dre-028817	Danio rerio	66.11	0.00e+00	801.00
IUUC-Dno-029969	Dasypus novemcinctus	86.08	0.00e+00	1026.00
IUUC-Dor-031117	Dipodomys ordii	94.74	0.00e+00	1110.00
IUUC-Ete-032712	Echinops telfairi	84.89	0.00e+00	951.00
IUUC-Eca-033742	Equus caballus	92.70	0.00e+00	1075.00
IUUC-Eeu-035096	Erinaceus europaeus	90.17	0.00e+00	1074.00
IUUC-Fca-035769	Felis catus	92.05	0.00e+00	1096.00
IUUC-Fal-036645	Ficedula albicollis	88.67	0.00e+00	1028.00
IUUC-Fso-038302	Fusarium solani	32.75	5.00e-41	162.00
IUUC-Gmo-038636	Gadus morhua	67.11	0.00e+00	780.00
IUUC-Gga-040144	Gallus gallus	89.13	0.00e+00	1063.00
IUUC-Gac-041716	Gasterosteus aculeatus	67.39	0.00e+00	805.00
IUUC-Ggo-044568	Gorilla gorilla	93.38	0.00e+00	1085.00
IUUC-Hsa-046178	Homo sapiens	93.38	0.00e+00	1085.00
IUUC-Itr-048967	Ictidomys tridecemlineatus	89.47	0.00e+00	1088.00
IUUC-Lch-050501	Latimeria chalumnae	75.35	0.00e+00	854.00
IUUC-Loc-052895	Lepisosteus oculatus	78.59	0.00e+00	629.00
IUUC-Laf-053950	Loxodonta africana	89.13	0.00e+00	1028.00
IUUC-Mcc-055450	Macaca mulatta	93.21	0.00e+00	1081.00
IUUC-Meu-056182	Macropus eugenii	85.74	0.00e+00	994.00
IUUC-Mga-059619	Meleagris gallopavo	89.30	0.00e+00	1066.00
IUUC-Mmr-061074	Microcebus murinus	92.05	0.00e+00	1092.00
IUUC-Mdo-062307	Monodelphis domestica	90.83	0.00e+00	876.00
IUUC-Mpu-066016	Mustela putorius furo	92.70	0.00e+00	1058.00
IUUC-Mlu-067257	Myotis lucifugus	85.81	0.00e+00	1056.00
IUUC-Nle-070139	Nomascus leucogenys	93.55	0.00e+00	1088.00
IUUC-Opr-070243	Ochotona princeps	88.12	0.00e+00	1042.00
IUUC-Ont-072686	Oreochromis niloticus	69.00	0.00e+00	840.00
IUUC-Oan-073670	Ornithorhynchus anatinus	82.09	0.00e+00	832.00
IUUC-Ocu-074525	Oryctolagus cuniculus	92.70	0.00e+00	1090.00
IUUC-Ola-086524	Oryzias latipes	69.17	0.00e+00	858.00
IUUC-Oga-088540	Otolemur garnettii	92.19	0.00e+00	1068.00
IUUC-Oar-089793	Ovis aries	86.76	0.00e+00	954.00
IUUC-Ptr-091154	Pan troglodytes	93.38	0.00e+00	1085.00
IUUC-Pan-092759	Papio anubis	93.21	0.00e+00	1081.00
IUUC-Psi-094008	Pelodiscus sinensis	86.25	0.00e+00	1053.00
IUUC-Pma-094593	Petromyzon marinus	46.18	2.00e-135	476.00
IUUC-Pfo-097409	Poecilia formosa	66.39	0.00e+00	802.00
IUUC-Pab-097946	Pongo abelii	81.83	0.00e+00	933.00
IUUC-Pca-100727	Procavia capensis	85.40	0.00e+00	959.00
IUUC-Pva-103211	Pteropus vampyrus	83.02	0.00e+00	1003.00
IUUC-Pgr-103603	Puccinia graminis	42.86	1.00e-73	271.00
IUUC-Ptt-103995	Puccinia triticina	43.36	8.00e-72	265.00
IUUC-Rno-105236	Rattus norvegicus	97.62	0.00e+00	1098.00
IUUC-Sha-106833	Sarcophilus harrisii	90.88	0.00e+00	1063.00
IUUC-Sar-113381	Sorex araneus	92.19	0.00e+00	1099.00
IUUC-Ssc-116421	Sus scrofa	91.00	0.00e+00	1093.00
IUUC-Tgu-117143	Taeniopygia guttata	88.96	0.00e+00	1092.00
IUUC-Tru-118680	Takifugu rubripes	67.67	0.00e+00	830.00
IUUC-Tsy-119622	Tarsius syrichta	77.59	0.00e+00	815.00
IUUC-Tni-120131	Tetraodon nigroviridis	67.33	0.00e+00	830.00
IUUC-Ttr-129171	Tursiops truncatus	90.49	0.00e+00	1035.00
IUUC-Xtr-132241	Xenopus tropicalis	78.81	0.00e+00	941.00
IUUC-Xma-133554	Xiphophorus maculatus	66.85	0.00e+00	741.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence