iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028139

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast)

Genbank Nucleotide ID

CABZ01082152

Gene Name

ube2ka

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000089055.2	ENSDART00000125969.2	ENSDARP00000110951.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	6.90e-46	156.4	11	149
UBD/UBC-like/UBD_UBC	1.60e-72	243.0	11	152
UBD/Alpha-Helix/UBA	1.50e-10	41.8	164	202

Active Site

Position(s)	Description	Evidence
95	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    Rlkkelkel...ekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.GkvClsi 85
           R+k+e+ke+   e++++++i++++vde ++te++ +i Gp+dtpYegg ++lei++pe+YPf+PPkv+f+tki+hPn+++  G++Cl+i
   Q: 11   RIKREFKEVlksEETSKNQIKVDLVDE-NFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVtGAICLDI 98
           7888888873335556699********.9***************************************************99******* PP
   S: 86   lkeeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           lk  ++W +a+++++vlls+q+lla ++p++p+++ +a+++k+n+e++k+++r
   Q: 99   LK--DQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTAR 149
           *9..**********************************************986 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeea...qisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpnins.ngsicldil 85
           rik+e+k++l++ee+   qi++dlvd++++elr++iagppd+pyegg+++l+ik+p++ypf+ppkv+fitki+hpni+s +g+icldil
   Q: 11   RIKREFKEVLKSEETsknQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSvTGAICLDIL 99
           8*************9999*********************************************************************** PP
   S: 86   rsqwsaaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           ++qw+aa+tl++vllsl++lla+aepddp++a++a++yk+++e++k++ar+w+
   Q: 100  KDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWS 152
           ****************************************************5 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLld 40
           e++ k+++l++MGFd+++++ aL + ++++eaA+e+Ll+
   Q: 164  EYTRKIDKLCAMGFDKNAVIVALSSKSWDVEAATELLLS 202
           57889********************************97 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MNSMANIAVQ RIKREFKEVL KSEETSKNQI KVDLVDENFT ELRGEIAGPP DTPYEGGRYQ 60
LEIKIPETYP FNPPKVRFIT KIWHPNISSV TGAICLDILK DQWAAAMTLR TVLLSLQALL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGTGTGTG TGAGAGAGAG AGAGAGAGAG AGAGAGAGAG AGAGGTGTGT GTGTGTGTGC 60
GTGTGTGTGT GTGTGTGCGT GTGTGTATGA ACAGCATGGC CAACATCGCG GTTCAGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50030--UBA
PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00627--UBA
PF00179--UQ_con

SMART

SM00165--UBA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000621	Aegilops tauschii	51.55	4.00e-28	117.00
IUUC-Aml-001286	Ailuropoda melanoleuca	97.00	2.00e-107	381.00
IUUC-Atr-003063	Amborella trichopoda	48.45	5.00e-40	157.00
IUUC-Apl-004122	Anas platyrhynchos	89.50	7.00e-95	339.00
IUUC-Aca-004565	Anolis carolinensis	91.58	1.00e-96	345.00
IUUC-Aly-006390	Arabidopsis lyrata	48.22	2.00e-44	172.00
IUUC-Ath-006637	Arabidopsis thaliana	46.86	2.00e-41	162.00
IUUC-Ago-007714	Ashbya gossypii	44.62	6.00e-38	150.00
IUUC-Acl-008189	Aspergillus clavatus	49.03	2.00e-27	116.00
IUUC-Afl-008489	Aspergillus flavus	41.40	2.00e-28	119.00
IUUC-Afu-008850	Aspergillus fumigatus	40.65	2.00e-29	122.00
IUUC-Ani-009361	Aspergillus nidulans	50.00	3.00e-26	112.00
IUUC-Ang-009548	Aspergillus niger	38.91	2.00e-26	112.00
IUUC-Aor-010105	Aspergillus oryzae	41.40	2.00e-28	119.00
IUUC-Ate-010389	Aspergillus terreus	40.55	2.00e-28	119.00
IUUC-Ame-011454	Astyanax mexicanus	99.00	4.00e-109	386.00
IUUC-Bgr-012255	Blumeria graminis	39.91	1.00e-33	136.00
IUUC-Bta-012992	Bos taurus	97.00	2.00e-107	381.00
IUUC-Bci-013806	Botrytis cinerea	40.09	3.00e-36	145.00
IUUC-Bdi-015024	Brachypodium distachyon	48.73	5.00e-41	160.00
IUUC-Bol-015985	Brassica oleracea	48.22	1.00e-44	173.00
IUUC-Bra-016805	Brassica rapa	48.22	4.00e-45	174.00
IUUC-Cel-018353	Caenorhabditis elegans	53.27	6.00e-58	216.00
IUUC-Cja-019051	Callithrix jacchus	96.50	2.00e-106	378.00
IUUC-Cfa-020016	Canis familiaris	97.00	2.00e-107	381.00
IUUC-Cpo-022026	Cavia porcellus	97.00	2.00e-107	381.00
IUUC-Cre-022987	Chlamydomonas reinhardtii	49.49	2.00e-42	165.00
IUUC-Csa-023059	Chlorocebus sabaeus	97.00	2.00e-107	381.00
IUUC-Cin-025598	Ciona intestinalis	60.20	2.00e-55	208.00
IUUC-Csv-025831	Ciona savignyi	61.73	8.00e-54	202.00
IUUC-Cgl-026449	Colletotrichum gloeosporioides	40.96	5.00e-34	137.00
IUUC-Cne-027068	Cryptococcus neoformans	41.04	7.00e-41	160.00
IUUC-Dno-029169	Dasypus novemcinctus	90.50	1.00e-99	355.00
IUUC-Dor-030382	Dipodomys ordii	83.00	8.00e-86	309.00
IUUC-Dse-031335	Dothistroma septosporum	50.32	2.00e-36	145.00
IUUC-Dme-032003	Drosophila melanogaster	68.34	1.00e-71	262.00
IUUC-Ete-032868	Echinops telfairi	88.00	8.00e-86	309.00
IUUC-Eca-033428	Equus caballus	97.00	2.00e-107	381.00
IUUC-Fca-035366	Felis catus	97.00	2.00e-107	381.00
IUUC-Fal-037016	Ficedula albicollis	97.00	2.00e-107	381.00
IUUC-Fox-037969	Fusarium oxysporum	40.98	8.00e-33	133.00
IUUC-Fso-038296	Fusarium solani	49.33	3.00e-35	141.00
IUUC-Gmo-039135	Gadus morhua	98.00	8.00e-108	382.00
IUUC-Ggr-039768	Gaeumannomyces graminis	39.13	2.00e-25	109.00
IUUC-Gga-041018	Gallus gallus	97.50	7.00e-108	382.00
IUUC-Gac-041503	Gasterosteus aculeatus	98.50	1.00e-108	385.00
IUUC-Gma-042779	Glycine max	50.77	1.00e-43	169.00
IUUC-Ggo-045032	Gorilla gorilla	97.00	2.00e-107	381.00
IUUC-Hsa-046490	Homo sapiens	97.00	2.00e-107	381.00
IUUC-Itr-048373	Ictidomys tridecemlineatus	97.00	2.00e-107	381.00
IUUC-Kpa-049297	Komagataella pastoris	49.02	5.00e-34	137.00
IUUC-Lch-050588	Latimeria chalumnae	69.67	3.00e-77	281.00
IUUC-Lpe-051070	Leersia perrieri	48.73	4.00e-33	134.00
IUUC-Loc-052549	Lepisosteus oculatus	99.00	2.00e-109	387.00
IUUC-Lma-052949	Leptosphaeria maculans	40.85	3.00e-37	148.00
IUUC-Laf-053688	Loxodonta africana	89.22	2.00e-97	348.00
IUUC-Mcc-055606	Macaca mulatta	97.00	2.00e-107	381.00
IUUC-Mor-056946	Magnaporthe oryzae	37.93	1.00e-23	103.00
IUUC-Mpo-057441	Magnaporthe poae	40.65	1.00e-25	110.00
IUUC-Mtr-058002	Medicago truncatula	48.76	3.00e-43	168.00
IUUC-Mla-059007	Melampsora laricipopulina	42.49	6.00e-37	147.00
IUUC-Mga-059254	Meleagris gallopavo	96.67	1.00e-95	341.00
IUUC-Mvi-060346	Microbotryum violaceum	48.37	1.00e-33	135.00
IUUC-Mmr-061211	Microcebus murinus	97.00	2.00e-107	381.00
IUUC-Mdo-062458	Monodelphis domestica	96.00	7.00e-105	372.00
IUUC-Mmu-063648	Mus musculus	97.00	2.00e-107	381.00
IUUC-Mac-065447	Musa acuminata	48.73	1.00e-41	162.00
IUUC-Mpu-066407	Mustela putorius furo	97.00	9.00e-107	379.00
IUUC-Mlu-067682	Myotis lucifugus	89.90	2.00e-97	348.00
IUUC-Nfi-068517	Neosartorya fischeri	41.12	2.00e-29	122.00
IUUC-Ncr-068749	Neurospora crassa	40.49	2.00e-38	152.00
IUUC-Nle-069712	Nomascus leucogenys	96.67	8.00e-96	342.00
IUUC-Opr-070651	Ochotona princeps	97.00	2.00e-107	381.00
IUUC-Ont-071595	Oreochromis niloticus	98.50	1.00e-108	385.00
IUUC-Ocu-074939	Oryctolagus cuniculus	97.00	2.00e-107	381.00
IUUC-Oba-075530	Oryza barthii	49.49	3.00e-32	131.00
IUUC-Obr-076838	Oryza brachyantha	48.99	1.00e-31	129.00
IUUC-Ogl-077606	Oryza glaberrima	49.49	3.00e-32	131.00
IUUC-Ogu-078238	Oryza glumaepatula	49.49	3.00e-32	131.00
IUUC-Oin-079643	Oryza indica	49.49	6.00e-32	130.00
IUUC-Ome-081274	Oryza meridionalis	49.49	3.00e-32	131.00
IUUC-Oni-082651	Oryza nivara	49.49	3.00e-32	131.00
IUUC-Opu-083933	Oryza punctata	49.49	5.00e-32	130.00
IUUC-Oru-085054	Oryza rufipogon	49.49	5.00e-32	130.00
IUUC-Osa-085716	Oryza sativa	49.49	6.00e-32	130.00
IUUC-Ola-087043	Oryzias latipes	98.50	1.00e-108	385.00
IUUC-Olu-087846	Ostreococcus lucimarinus	46.63	3.00e-42	164.00
IUUC-Oga-088897	Otolemur garnettii	90.91	1.00e-97	348.00
IUUC-Oar-089673	Ovis aries	89.90	6.00e-98	349.00
IUUC-Ptr-091295	Pan troglodytes	97.00	2.00e-107	381.00
IUUC-Pan-092034	Papio anubis	96.65	4.00e-95	340.00
IUUC-Psi-093498	Pelodiscus sinensis	97.00	2.00e-107	381.00
IUUC-Pma-094115	Petromyzon marinus	82.91	1.00e-89	322.00
IUUC-Pno-095102	Phaeosphaeria nodorum	41.23	9.00e-39	153.00
IUUC-Ppa-095326	Physcomitrella patens	47.21	6.00e-41	160.00
IUUC-Pfo-096940	Poecilia formosa	98.50	1.00e-108	384.00
IUUC-Pab-098279	Pongo abelii	97.00	2.00e-107	381.00
IUUC-Pop-099543	Populus trichocarpa	49.75	1.00e-44	172.00
IUUC-Pca-100782	Procavia capensis	96.50	2.00e-105	374.00
IUUC-Ppe-101789	Prunus persica	48.45	2.00e-37	149.00
IUUC-Pva-102147	Pteropus vampyrus	68.18	8.00e-56	209.00
IUUC-Pte-104370	Pyrenophora teres	39.81	7.00e-37	147.00
IUUC-Pyt-104592	Pyrenophora triticirepentis	48.72	3.00e-36	145.00
IUUC-Rno-104984	Rattus norvegicus	97.00	2.00e-107	381.00
IUUC-Sce-106394	Saccharomyces cerevisiae	42.63	1.00e-35	142.00
IUUC-Sha-106624	Sarcophilus harrisii	90.50	3.00e-101	360.00
IUUC-Ssl-108609	Sclerotinia sclerotiorum	41.94	3.00e-40	158.00
IUUC-Smo-109656	Selaginella moellendorffii	49.49	3.00e-41	161.00
IUUC-Sit-110639	Setaria italica	48.48	6.00e-40	156.00
IUUC-Sly-110978	Solanum lycopersicum	48.73	2.00e-44	171.00
IUUC-Stu-112088	Solanum tuberosum	48.73	1.00e-44	172.00
IUUC-Sar-113285	Sorex araneus	81.01	1.00e-73	268.00
IUUC-Sbi-113986	Sorghum bicolor	48.48	1.00e-39	155.00
IUUC-Sre-115046	Sporisorium reilianum	46.71	7.00e-37	147.00
IUUC-Ssc-116314	Sus scrofa	97.00	2.00e-107	381.00
IUUC-Tgu-117427	Taeniopygia guttata	96.11	3.00e-95	340.00
IUUC-Tru-118618	Takifugu rubripes	93.50	2.00e-103	368.00
IUUC-Tsy-119208	Tarsius syrichta	94.95	5.00e-104	369.00
IUUC-Tni-119667	Tetraodon nigroviridis	99.00	5.00e-109	386.00
IUUC-Tca-121446	Theobroma cacao	49.75	3.00e-45	174.00
IUUC-Tre-122053	Trichoderma reesei	44.37	8.00e-31	127.00
IUUC-Tae-124726	Triticum aestivum	49.24	9.00e-34	136.00
IUUC-Tme-127024	Tuber melanosporum	50.32	1.00e-38	153.00
IUUC-Tbe-127752	Tupaia belangeri	93.50	3.00e-102	363.00
IUUC-Ttr-128287	Tursiops truncatus	96.65	4.00e-95	340.00
IUUC-Uma-129512	Ustilago maydis	39.71	5.00e-37	147.00
IUUC-Vda-129947	Verticillium dahliae	37.38	9.00e-31	127.00
IUUC-Vpa-130481	Vicugna pacos	96.95	2.00e-105	374.00
IUUC-Vvi-131429	Vitis vinifera	46.70	1.00e-41	162.00
IUUC-Xtr-132710	Xenopus tropicalis	80.20	1.00e-92	332.00
IUUC-Xma-134165	Xiphophorus maculatus	98.00	2.00e-108	384.00
IUUC-Yli-134523	Yarrowia lipolytica	44.00	2.00e-34	138.00
IUUC-Zma-135733	Zea mays	47.62	4.00e-38	150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence