iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21388379

Classification

Family	E-value	Score	Start	End
DUB/USP	5.10e-71	240.5	198	521
ULD/UDP/UBQ/UBQ_Other	1.50e-06	28.8	591	643

Active Site

Position(s)	Description	Evidence
207	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
454	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaf 98
           +GlkN+g+tCYmNS+LQ+L++ip +r+++ +     ++ ++++ p++++  +lq+lf +l ++++++v+++el+k++++    +++++q+D+qE+ ++
   Q: 198  VGLKNQGATCYMNSLLQTLYHIPYFRKAVYH-----MPTTENDAPTASIPLALQSLFYKL-QYNDTSVATKELTKSFGWDT--YDSFMQHDVQELNRV 287
           6******************************.....555555789***************.88999************877..67************* PP
   S: 99   lldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           l ++le+++                          k +  + +i++lF+g+  + i c + d +s+r+e+f+dl+l+v+g +     ++  +++++++
   Q: 288  LCEKLEDKM--------------------------KGTVVEGTIQKLFEGHHMNYIECINVDYKSTRKESFYDLQLDVKGCK-----DVYASFDKYVE 354
           *********..........................7899*******************************************.....9********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....pfctspeekqkekkkYeLiavvvHsGsl 290
            e+leg+nky+ e   ++q+a+k + +  +P+vL l+LkRf+++  ++   kin+++efpl+Ldl+    ++++  + ++++++ Y L++v+vHsG++
   Q: 355  VERLEGDNKYHAEGH-DLQDAKKGVLFIDFPPVLQLQLKRFEYDFMRDTMVKINDRYEFPLQLDLDredgRYLSP-DADKSVRNLYTLHSVLVHSGGV 450
           ***********9996.59***********************************************9776556665.666678**************** PP
   S: 291  ssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg.......................staYvlfYkr 337
           ++GHY+a+++   +++W++fdD++Vt+ + ++ lee+                        s+aY+l+Y r
   Q: 451  HGGHYYAFIRPtLSDQWYKFDDERVTKEDVKRALEEQYggeeelpqnnpgfnnppfkftkySNAYMLVYIR 521
           **********945677*************9999997779******************************87 PP

ULD/UDP/UBQ/UBQ_Other

   S: 10   gs.eltlkvnpsdtVaeLKekiekklgippeqqrLiyk..........GkiLeddktLa 57
           +  + ++++ ++++++++Ke++ k++g+p++ qr +++          +      ++L+
   Q: 591  HEkVRSFRIQKQTPFQQFKEEVAKEFGVPVQLQRFWIWakrqnhtyrpN------RPLS 643
           555889999***************************9855664444444......4444 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MTMMTPPPLD QQEDEEMLVP NPDLVEGPQP MEVAQTDPAA TAVENPPPED PPSLKFTWTI 60
PMFTRLNTRK HYSDVFVVGG YKWRILIFPK GNNVDHLSMY LDVADAANLP YGWSRYSQFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGTTTCTCA GACGAACACT CAGGGAAACA TATAAATCTG AATCCAAATA GTAATTGGAA 60
TTACAATAGA AACCCTTAAT TTAGTGAAAA TATCGTAATT ATCCTATCGA AAAGTGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0009506--C:plasmodesma
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT3G11910

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003067	Amborella trichopoda	84.55	0.00e+00	1479.00
IUUC-Apl-003558	Anas platyrhynchos	36.75	3.00e-168	585.00
IUUC-Aly-006453	Arabidopsis lyrata	98.48	0.00e+00	2179.00
IUUC-Ang-009776	Aspergillus niger	37.82	6.00e-178	617.00
IUUC-Bol-016286	Brassica oleracea	91.32	0.00e+00	1946.00
IUUC-Bra-016714	Brassica rapa	91.03	0.00e+00	1931.00
IUUC-Csv-025963	Ciona savignyi	34.20	1.00e-147	517.00
IUUC-Dno-029696	Dasypus novemcinctus	36.64	4.00e-163	568.00
IUUC-Eeu-035292	Erinaceus europaeus	38.29	4.00e-63	235.00
IUUC-Fox-037695	Fusarium oxysporum	35.50	3.00e-178	618.00
IUUC-Gac-041740	Gasterosteus aculeatus	36.17	2.00e-167	582.00
IUUC-Loc-052234	Lepisosteus oculatus	38.55	4.00e-132	465.00
IUUC-Mpo-057536	Magnaporthe poae	35.58	6.00e-172	597.00
IUUC-Mga-060148	Meleagris gallopavo	36.82	2.00e-169	589.00
IUUC-Mac-064796	Musa acuminata	82.36	0.00e+00	1846.00
IUUC-Opr-071001	Ochotona princeps	36.43	3.00e-133	468.00
IUUC-Osa-085418	Oryza sativa	69.56	0.00e+00	1309.00
IUUC-Oar-089710	Ovis aries	35.81	4.00e-165	575.00
IUUC-Pab-098231	Pongo abelii	35.15	8.00e-150	524.00
IUUC-Pca-100543	Procavia capensis	35.60	9.00e-93	334.00
IUUC-Sre-115156	Sporisorium reilianum	39.44	0.00e+00	700.00
IUUC-Tru-118208	Takifugu rubripes	36.18	2.00e-163	569.00
IUUC-Tsy-119277	Tarsius syrichta	44.63	7.00e-73	268.00
IUUC-Tbe-127696	Tupaia belangeri	42.57	7.00e-68	251.00
IUUC-Uma-129535	Ustilago maydis	39.73	0.00e+00	702.00
IUUC-Vda-129708	Verticillium dahliae	35.31	5.00e-171	594.00
IUUC-Xtr-132073	Xenopus tropicalis	36.34	9.00e-164	570.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence