iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121696

Ensembl Protein ID

EOY19369

UniProt Accession

A0A061FX36; A0A061FX36_THECC

Genbank Protein ID

EOY19369.1

Protein Name

Ubiquitin-specific protease 12 isoform 2

Genbank Nucleotide ID

CM001888

Gene Name

TCM_044465

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_044465	EOY19369	EOY19369
TCM_044465	EOY19370	EOY19370
TCM_044465	EOY19368	EOY19368

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-71	241.3	194	517
ULD/UDP/UBQ/UBQ_Other	3.80e-07	30.8	587	629

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflld 101
           +GlkN+g+tCYmNS+LQ+L++ip +r+++ +     ++ ++++ p+g++  +lq+lf +l ++++++v+++el+k++++    +++++q+D+qE+ ++l +
   Q: 194  VGLKNQGATCYMNSLLQTLYHIPYFRKAVYH-----MPTTENDMPSGSIPLALQSLFYKL-QYSDTSVATKELTKSFGWDT--YDSFMQHDVQELNRVLCE 286
           6******************************.....555556789***************.888889***********877..67**************** PP
   S: 102  qleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeeleg 202
           +le+++                          k +  + +i++lF+g+  + i c + d +s+r+e+f+dl+l+v+g +     ++  +++++++ e+leg
   Q: 287  KLEDKM--------------------------KGTVVEGTIQQLFEGHHMNYIECINVDYKSTRKESFYDLQLDVKGCK-----DVYASFDKYVEVERLEG 356
           ******..........................7899*******************************************.....9**************** PP
   S: 203  enkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls....pfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           +n+y+ e+  ++q+a+k + +  +P+vL l+LkRf+++  ++   kin+++efpl+Ldl+    ++++ pe + ++++ Y L++v+vHsG++++GHY+ay+
   Q: 357  DNRYHAEQY-GLQDARKGVLFIDFPPVLQLQLKRFEYDFMRDTMVKINDRYEFPLQLDLDrengKYLS-PEADRSVRNLYTLHSVLVHSGGVHGGHYYAYI 455
           *******97.69***********************************************965544554.5666778************************* PP
   S: 300  kn.ekgkWllfdDskVtevkeeevleetg.......................staYvlfYkr 337
           +   +++W++fdD++Vt+ ++++ lee+                        s+aY+l+Y r
   Q: 456  RPtLSDQWFKFDDERVTKEDMKRALEEQYggeeelpqtnpgfnntpfkftkySNAYMLVYIR 517
           *945677*****************997779******************************87 PP

ULD/UDP/UBQ/UBQ_Other

   S: 10   gs.eltlkvnpsdtVaeLKekiekklgippeqqrLiyk....G 47
           +  + ++++ + +++ ++Ke++ k++g+p++ qr +++    +
   Q: 587  HEkVRSFRIQKLTPFNVFKEEVAKEFGVPVQNQRFWLWakrqN 629
           55588899999*************************9844442 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MTLMAPPPLD QEDDEMLVPH NDFVDGPQPM EAAEAASTVD AQAVDDPPSG RFTWTIENFS 60
RLNTKKLYSD IFFVGGYKWR ILIFPKGNNV DHLSMYLDVA DSATLPYGWS RYAQFSLAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCATGAC TCTGATGGCT CCTCCACCGT TAGATGTAAC CATCCAATCC CTCACTCTTG 60
TTTTTCTTTT TCTCCTTTTC TTTTCTCTAT GTCGCTTCAA TTCAATTTCG ATCCCCAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome

Interpro

IPR002083--MATH/TRAF_dom
IPR023173--NADPH_Cyt_P450_Rdtase_dom3
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00917--MATH
PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002408	Ailuropoda melanoleuca	36.60	2.00e-164	572.00
IUUC-Apl-003558	Anas platyrhynchos	36.54	2.00e-168	586.00
IUUC-Ani-009257	Aspergillus nidulans	31.56	4.00e-33	137.00
IUUC-Bta-013192	Bos taurus	36.84	3.00e-165	575.00
IUUC-Bci-013924	Botrytis cinerea	35.71	4.00e-164	572.00
IUUC-Cja-019006	Callithrix jacchus	36.31	6.00e-165	574.00
IUUC-Cfa-020361	Canis familiaris	36.66	6.00e-164	570.00
IUUC-Dno-029696	Dasypus novemcinctus	36.69	2.00e-163	569.00
IUUC-Ete-033191	Echinops telfairi	36.27	2.00e-159	555.00
IUUC-Eca-034122	Equus caballus	36.50	1.00e-164	573.00
IUUC-Eeu-035292	Erinaceus europaeus	39.66	8.00e-66	244.00
IUUC-Fca-036377	Felis catus	36.66	5.00e-164	571.00
IUUC-Fso-038084	Fusarium solani	36.63	7.00e-175	607.00
IUUC-Ggo-044947	Gorilla gorilla	37.30	1.00e-163	570.00
IUUC-Mga-060148	Meleagris gallopavo	36.60	1.00e-169	589.00
IUUC-Mmr-060946	Microcebus murinus	37.39	1.00e-164	573.00
IUUC-Mlu-067949	Myotis lucifugus	36.69	1.00e-163	569.00
IUUC-Ncr-068818	Neurospora crassa	36.97	0.00e+00	627.00
IUUC-Opr-071001	Ochotona princeps	36.91	2.00e-138	486.00
IUUC-Oan-073483	Ornithorhynchus anatinus	36.82	6.00e-163	567.00
IUUC-Ocu-073967	Oryctolagus cuniculus	36.57	2.00e-160	559.00
IUUC-Olu-087874	Ostreococcus lucimarinus	45.10	0.00e+00	893.00
IUUC-Oar-089710	Ovis aries	36.73	2.00e-165	576.00
IUUC-Ptr-091334	Pan troglodytes	37.30	1.00e-163	570.00
IUUC-Psi-093933	Pelodiscus sinensis	36.35	3.00e-167	582.00
IUUC-Ppa-095922	Physcomitrella patens	80.36	0.00e+00	1796.00
IUUC-Pab-098231	Pongo abelii	35.88	1.00e-149	523.00
IUUC-Pop-099680	Populus trichocarpa	89.23	0.00e+00	2015.00
IUUC-Pca-100543	Procavia capensis	37.63	3.00e-93	335.00
IUUC-Ppe-101847	Prunus persica	87.78	0.00e+00	1928.00
IUUC-Rno-105816	Rattus norvegicus	36.75	3.00e-164	572.00
IUUC-Ssc-116297	Sus scrofa	36.66	1.00e-163	570.00
IUUC-Tsy-119277	Tarsius syrichta	42.96	2.00e-74	273.00
IUUC-Ttr-129161	Tursiops truncatus	36.55	2.00e-162	566.00
IUUC-Vpa-130141	Vicugna pacos	36.65	4.00e-55	209.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence