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Tag Content
UUCD2 ID IUUC-Ssc-115846
UUCD1 version UUC-SuS-00727
Ensembl Protein ID ENSSSCP00000019934.1
UniProt Accession I3L7C9; I3L7C9_PIG
Genbank Protein ID ENSSSCP00000019934
Protein Name Breast cancer type 1 susceptibility protein homolog
Genbank Nucleotide ID FP340289
Gene Name BRCA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSSCG00000022101.1 ENSSSCT00000025436.1 ENSSSCP00000019934.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 7.20e-08 33.1 22 63
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle +k+ p+++ C H+f++ C  k+    n++++  +CPlC+
   Q: 22   CPICLELIKE-PVSTKCDHIFCKFCMLKL---LNQKKGPSQCPLCK 63
           ********99.**************9666...68899********7 PP
   
Organism Sus scrofa
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
 E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator.
Protein Sequence
(Fasta)
LSVDHIEEVQ NVLNAMQKIL ECPICLELIK EPVSTKCDHI FCKFCMLKLL NQKKGPSQCP 60
LCKNDITKRS LQESTRFSQL VEELLKIIHA FELDTGLQFA NNYNFSKKTE NNSPEHLKEE 120
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Protein Fasta Sequence


>IUUC-Ssc-115846|E3,RING|Sus scrofa
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Nucleotide Sequence
(Fasta)
TTATCTGTGG ATCACATTGA AGAAGTACAA AATGTCCTTA ATGCTATGCA GAAAATCTTA 60
GAGTGTCCAA TCTGGTAAGT TGAGAGGTTT TTTTTTATTT TTTGTTATCA TATATTTTTT 120
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Nucleotide Fasta Sequence


>IUUC-Ssc-115846|E3,RING|Sus scrofa
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011364--BRCA1
IPR031099--BRCA1-associated
IPR025994--BRCA1_serine_dom
IPR001357--BRCT_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50172--BRCT
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00533--BRCT
PF12820--BRCT_assoc
PF00097--zf-C3HC4
PRINTS

PR00493--BRSTCANCERI
SMART

SM00292--BRCT
SM00184--RING
Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005737--C:cytoplasm
GO:0030529--C:intracellular ribonucleoprotein complex
GO:0000800--C:lateral element
GO:0005886--C:plasma membrane
GO:0003684--F:damaged DNA binding
GO:0003723--F:RNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071681--P:cellular response to indole-3-methanol
GO:0071356--P:cellular response to tumor necrosis factor
GO:0007098--P:centrosome cycle
GO:0043009--P:chordate embryonic development
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0009048--P:dosage compensation by inactivation of X chromosome
GO:0000724--P:double-strand break repair via homologous recombination
GO:0031572--P:G2 DNA damage checkpoint
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0051572--P:negative regulation of histone H3-K4 methylation
GO:0051573--P:negative regulation of histone H3-K9 methylation
GO:0033147--P:negative regulation of intracellular estrogen receptor signaling pathway
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045766--P:positive regulation of angiogenesis
GO:0071158--P:positive regulation of cell cycle arrest
GO:0045739--P:positive regulation of DNA repair
GO:0035066--P:positive regulation of histone acetylation
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:2000617--P:positive regulation of histone H3-K9 acetylation
GO:0051574--P:positive regulation of histone H3-K9 methylation
GO:2000620--P:positive regulation of histone H4-K16 acetylation
GO:0070512--P:positive regulation of histone H4-K20 methylation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010575--P:positive regulation of vascular endothelial growth factor production
GO:0006301--P:postreplication repair
GO:0051865--P:protein autoubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0044030--P:regulation of DNA methylation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0043627--P:response to estrogen
GO:0010212--P:response to ionizing radiation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002388 Ailuropoda melanoleuca 75.91 0.00e+00 2750.00
IUUC-Apl-003252 Anas platyrhynchos 35.45 1.00e-122 435.00
IUUC-Aca-004526 Anolis carolinensis 57.96 3.00e-75 276.00
IUUC-Ame-011720 Astyanax mexicanus 50.25 8.00e-55 209.00
IUUC-Bgr-011969 Blumeria graminis 38.89 1.00e-08 53.90
IUUC-Bta-013433 Bos taurus 76.40 0.00e+00 2736.00
IUUC-Cel-018208 Caenorhabditis elegans 35.44 2.00e-10 60.80
IUUC-Cja-019149 Callithrix jacchus 72.93 0.00e+00 2522.00
IUUC-Cfa-020322 Canis familiaris 74.30 0.00e+00 2645.00
IUUC-Cpo-021583 Cavia porcellus 45.94 0.00e+00 1316.00
IUUC-Cre-022597 Chlamydomonas reinhardtii 29.76 2.00e-08 53.10
IUUC-Csa-024227 Chlorocebus sabaeus 77.08 2.00e-156 546.00
IUUC-Cho-024530 Choloepus hoffmanni 67.56 0.00e+00 948.00
IUUC-Cin-025364 Ciona intestinalis 44.16 3.00e-15 75.50
IUUC-Csv-026245 Ciona savignyi 39.74 2.00e-13 69.30
IUUC-Dno-029247 Dasypus novemcinctus 69.84 0.00e+00 2039.00
IUUC-Dme-032032 Drosophila melanogaster 54.35 6.00e-11 58.50
IUUC-Ete-032472 Echinops telfairi 54.20 0.00e+00 1624.00
IUUC-Eca-033446 Equus caballus 78.51 0.00e+00 2867.00
IUUC-Eeu-034858 Erinaceus europaeus 61.09 0.00e+00 978.00
IUUC-Fca-035991 Felis catus 76.09 0.00e+00 2771.00
IUUC-Fal-036803 Ficedula albicollis 29.34 4.00e-101 363.00
IUUC-Gmo-038782 Gadus morhua 47.92 2.00e-48 188.00
IUUC-Ggr-039833 Gaeumannomyces graminis 36.73 8.00e-08 51.60
IUUC-Gga-040969 Gallus gallus 55.31 3.00e-83 304.00
IUUC-Gac-042296 Gasterosteus aculeatus 46.41 3.00e-52 200.00
IUUC-Ggo-044740 Gorilla gorilla 71.34 0.00e+00 2446.00
IUUC-Hsa-046086 Homo sapiens 74.21 0.00e+00 2526.00
IUUC-Itr-048512 Ictidomys tridecemlineatus 70.57 0.00e+00 2543.00
IUUC-Lch-049789 Latimeria chalumnae 36.63 4.00e-89 323.00
IUUC-Loc-051952 Lepisosteus oculatus 54.09 7.00e-69 256.00
IUUC-Laf-053648 Loxodonta africana 71.87 0.00e+00 2417.00
IUUC-Mcc-055210 Macaca mulatta 72.72 0.00e+00 2579.00
IUUC-Meu-056342 Macropus eugenii 38.63 2.00e-125 444.00
IUUC-Mor-057034 Magnaporthe oryzae 38.78 2.00e-08 53.10
IUUC-Mga-060163 Meleagris gallopavo 38.81 6.00e-113 402.00
IUUC-Mmr-061402 Microcebus murinus 68.50 0.00e+00 795.00
IUUC-Mdo-062209 Monodelphis domestica 45.79 0.00e+00 1315.00
IUUC-Mmu-064003 Mus musculus 54.55 0.00e+00 1723.00
IUUC-Mpu-065825 Mustela putorius furo 78.70 0.00e+00 821.00
IUUC-Mlu-068176 Myotis lucifugus 72.29 0.00e+00 2452.00
IUUC-Nle-069178 Nomascus leucogenys 74.05 0.00e+00 2565.00
IUUC-Opr-070574 Ochotona princeps 59.56 0.00e+00 1924.00
IUUC-Ont-072380 Oreochromis niloticus 51.94 3.00e-61 230.00
IUUC-Oan-073243 Ornithorhynchus anatinus 74.39 2.00e-33 134.00
IUUC-Ocu-074424 Oryctolagus cuniculus 67.90 0.00e+00 2333.00
IUUC-Ola-086863 Oryzias latipes 50.24 2.00e-55 211.00
IUUC-Oar-089938 Ovis aries 76.11 0.00e+00 2784.00
IUUC-Ptr-090960 Pan troglodytes 74.32 0.00e+00 2557.00
IUUC-Pan-092609 Papio anubis 71.78 0.00e+00 2239.00
IUUC-Psi-093889 Pelodiscus sinensis 29.27 5.00e-45 176.00
IUUC-Pfo-096328 Poecilia formosa 53.37 2.00e-60 227.00
IUUC-Pab-097982 Pongo abelii 74.21 0.00e+00 2565.00
IUUC-Pca-100698 Procavia capensis 65.69 0.00e+00 676.00
IUUC-Pva-102631 Pteropus vampyrus 79.27 0.00e+00 1229.00
IUUC-Rno-105879 Rattus norvegicus 53.62 0.00e+00 1671.00
IUUC-Sha-106701 Sarcophilus harrisii 38.25 0.00e+00 688.00
IUUC-Spo-108335 Schizosaccharomyces pombe 34.83 5.00e-10 58.90
IUUC-Sar-113047 Sorex araneus 64.29 0.00e+00 1542.00
IUUC-Tgu-116785 Taeniopygia guttata 50.66 6.00e-82 299.00
IUUC-Tru-117895 Takifugu rubripes 46.38 2.00e-51 197.00
IUUC-Tsy-118885 Tarsius syrichta 57.12 0.00e+00 698.00
IUUC-Tni-119654 Tetraodon nigroviridis 44.17 2.00e-48 187.00
IUUC-Tbe-127421 Tupaia belangeri 59.53 4.00e-153 536.00
IUUC-Ttr-128685 Tursiops truncatus 81.59 0.00e+00 2819.00
IUUC-Vpa-130216 Vicugna pacos 75.87 0.00e+00 962.00
IUUC-Xtr-132398 Xenopus tropicalis 38.53 9.00e-69 255.00
IUUC-Xma-133651 Xiphophorus maculatus 53.33 6.00e-46 179.00
Created Date 25-Jun-2017

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