iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000028133.3	ENSGALT00000053441.1	ENSGALP00000046131.1
ENSGALG00000028133.3	ENSGALT00000086103.1	ENSGALP00000064386.1
ENSGALG00000028133.3	ENSGALT00000073421.1	ENSGALP00000052174.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	5.40e-67	224.5	4	142
E2/UBC	1.80e-19	70.2	29	135

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 7    lkvvvprnfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtvrfsskinmaevnd 95
           + v+vprnfrlleeleeg+kg+gdgtvs+gl+D++d++l+++tg+Iigp+rt+ye+rIy+lk+++g+kYPe+PPtvrf++kinm+++n+
   Q: 4    STVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPTVRFVTKINMNGINN 92
           789************************************************************************************** PP
   S: 96   snGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPpeGnlf 145
           snG+vd+r++pvLa+W+++ysi+vvl++l++ ++sken+kl+qPpeG+++
   Q: 93   SNGMVDARSIPVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQTY 142
           ***********************************************986 PP

E2/UBC

   S: 16   gisakpvdesd..ltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyen.Gkv...ClsilkeeekWspalsv 98
           ++s +++d++d  lt+w  +i+Gp++t+Ye+++++l++e+ ++YP  PP+v+f+tki    ++++ G v    + +l    kW+  +s+
   Q: 29   TVSWGLEDDEDmtLTRWTGMIIGPPRTNYENRIYSLKVECGPKYPEAPPTVRFVTKINMNGINNSnGMVdarSIPVL---AKWQNSYSI 114
           456667777776689*****************************************9999998877*9943335555...7******** PP
   S: 99   esvllsiqsll.aepnpespl 118
           + vl ++ +l+ ++ n++ p+
   Q: 115  KVVLQELRRLMmSKENMKLPQ 135
           *********996667777775 PP

Organism

Gallus gallus

Functional Description
(View)

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity).

Protein Sequence
(Fasta)

MAGSTVKVPR NFRLLEELEE GQKGVGDGTV SWGLEDDEDM TLTRWTGMII GPPRTNYENR 60
IYSLKVECGP KYPEAPPTVR FVTKINMNGI NNSNGMVDAR SIPVLAKWQN SYSIKVVLQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGCCCGG CCCGGCGCGG GGGGGTTTGG ACAAGATGGC TGGCTCTACA GGTCTGTGAG 60
GGGGCTCGGC GGGCCTGGGG CTGCGGTGGG GAGTTGGGTG TTGTGCCCGG GGGTGGGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

gga:421109

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001275	Ailuropoda melanoleuca	98.56	2.00e-78	283.00
IUUC-Apl-003790	Anas platyrhynchos	99.29	4.00e-71	259.00
IUUC-Aca-004448	Anolis carolinensis	97.18	4.00e-70	256.00
IUUC-Aly-006035	Arabidopsis lyrata	52.48	1.00e-38	151.00
IUUC-Ath-007596	Arabidopsis thaliana	52.82	1.00e-38	151.00
IUUC-Acl-008375	Aspergillus clavatus	47.52	4.00e-33	133.00
IUUC-Afu-008838	Aspergillus fumigatus	47.83	2.00e-34	137.00
IUUC-Ang-009631	Aspergillus niger	50.00	3.00e-35	139.00
IUUC-Ate-010471	Aspergillus terreus	45.65	2.00e-29	120.00
IUUC-Bgr-012010	Blumeria graminis	51.08	5.00e-34	136.00
IUUC-Bta-012471	Bos taurus	97.24	5.00e-79	285.00
IUUC-Bol-015323	Brassica oleracea	51.77	1.00e-38	151.00
IUUC-Bra-018041	Brassica rapa	51.77	1.00e-38	151.00
IUUC-Cja-019506	Callithrix jacchus	96.55	6.00e-79	285.00
IUUC-Cfa-020370	Canis familiaris	97.24	5.00e-79	285.00
IUUC-Cpo-021317	Cavia porcellus	98.56	2.00e-78	283.00
IUUC-Csa-023412	Chlorocebus sabaeus	97.24	5.00e-79	285.00
IUUC-Cho-025024	Choloepus hoffmanni	97.78	1.00e-48	183.00
IUUC-Dre-028062	Danio rerio	95.10	4.00e-78	282.00
IUUC-Dno-029546	Dasypus novemcinctus	98.56	1.00e-78	285.00
IUUC-Fca-035746	Felis catus	98.56	2.00e-78	283.00
IUUC-Fal-037369	Ficedula albicollis	100.00	7.00e-74	268.00
IUUC-Ggr-039839	Gaeumannomyces graminis	46.41	3.00e-31	127.00
IUUC-Gac-041936	Gasterosteus aculeatus	83.80	1.00e-60	224.00
IUUC-Gma-042869	Glycine max	56.20	2.00e-39	154.00
IUUC-Ggo-044696	Gorilla gorilla	97.24	5.00e-79	285.00
IUUC-Hsa-046699	Homo sapiens	97.24	5.00e-79	285.00
IUUC-Itr-048151	Ictidomys tridecemlineatus	97.24	5.00e-79	285.00
IUUC-Loc-052012	Lepisosteus oculatus	94.48	2.00e-77	280.00
IUUC-Laf-053991	Loxodonta africana	97.84	6.00e-78	282.00
IUUC-Mcc-055850	Macaca mulatta	98.56	1.00e-78	284.00
IUUC-Mpo-057437	Magnaporthe poae	45.75	9.00e-31	125.00
IUUC-Mtr-058655	Medicago truncatula	54.23	6.00e-39	152.00
IUUC-Mla-058919	Melampsora laricipopulina	53.96	9.00e-34	135.00
IUUC-Mga-059210	Meleagris gallopavo	99.29	2.00e-71	260.00
IUUC-Mmr-061751	Microcebus murinus	94.48	4.00e-76	276.00
IUUC-Mdo-062503	Monodelphis domestica	97.93	5.00e-71	259.00
IUUC-Mmu-063294	Mus musculus	95.86	3.00e-78	283.00
IUUC-Mpu-065942	Mustela putorius furo	97.24	5.00e-79	285.00
IUUC-Mlu-067702	Myotis lucifugus	98.56	2.00e-78	283.00
IUUC-Nfi-068400	Neosartorya fischeri	43.16	2.00e-26	110.00
IUUC-Nle-069327	Nomascus leucogenys	97.24	5.00e-79	285.00
IUUC-Opr-070697	Ochotona princeps	82.73	7.00e-62	228.00
IUUC-Ont-072098	Oreochromis niloticus	90.14	4.00e-66	243.00
IUUC-Oan-073215	Ornithorhynchus anatinus	93.75	1.00e-66	244.00
IUUC-Ocu-073859	Oryctolagus cuniculus	97.24	5.00e-79	285.00
IUUC-Olo-080528	Oryza longistaminata	49.30	5.00e-35	139.00
IUUC-Ola-087529	Oryzias latipes	90.58	5.00e-65	239.00
IUUC-Oar-090010	Ovis aries	98.56	2.00e-78	283.00
IUUC-Ptr-091024	Pan troglodytes	98.56	2.00e-78	283.00
IUUC-Pan-091955	Papio anubis	97.24	5.00e-79	285.00
IUUC-Psi-093138	Pelodiscus sinensis	100.00	7.00e-74	268.00
IUUC-Pma-094142	Petromyzon marinus	78.95	4.00e-22	95.50
IUUC-Ppa-095557	Physcomitrella patens	52.82	1.00e-40	158.00
IUUC-Pfo-096483	Poecilia formosa	90.85	2.00e-66	244.00
IUUC-Pab-098753	Pongo abelii	97.24	5.00e-79	285.00
IUUC-Ppe-101725	Prunus persica	56.20	1.00e-39	155.00
IUUC-Pva-102989	Pteropus vampyrus	97.24	5.00e-79	285.00
IUUC-Pgr-103617	Puccinia graminis	52.82	4.00e-32	129.00
IUUC-Ptt-104008	Puccinia triticina	46.38	2.00e-16	77.80
IUUC-Rno-105839	Rattus norvegicus	96.55	2.00e-78	283.00
IUUC-Sce-106349	Saccharomyces cerevisiae	50.00	6.00e-33	132.00
IUUC-Sha-106779	Sarcophilus harrisii	96.55	1.00e-69	254.00
IUUC-Sar-113406	Sorex araneus	69.78	4.00e-48	182.00
IUUC-Ssc-115259	Sus scrofa	97.84	3.00e-78	283.00
IUUC-Tgu-116732	Taeniopygia guttata	100.00	3.00e-70	256.00
IUUC-Tru-118526	Takifugu rubripes	89.13	4.00e-55	206.00
IUUC-Tni-120169	Tetraodon nigroviridis	86.81	4.00e-57	213.00
IUUC-Tca-121025	Theobroma cacao	56.20	1.00e-39	156.00
IUUC-Tre-121971	Trichoderma reesei	53.96	5.00e-38	149.00
IUUC-Ttr-128959	Tursiops truncatus	96.55	6.00e-79	285.00
IUUC-Xtr-131975	Xenopus tropicalis	95.68	5.00e-77	278.00
IUUC-Xma-133222	Xiphophorus maculatus	90.85	2.00e-66	244.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence