iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gac-041473

Ensembl Protein ID

ENSGACP00000000972.1

UniProt Accession

G3N6P7; G3N6P7_GASAC

Protein Name

Protein HIRA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000000752.1	ENSGACT00000000972.1	ENSGACP00000000972.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-07	31.8	2	31

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 6    vtclaf..sdtllvsGsdDgtikvWDlrtg 33
           v ++a+  +d  l+s+s D+ti +W+ r++
   Q: 2    VMDVAWspHDVWLASCSVDNTIVIWNARKF 31
           6689**9655899*************8766 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.

Protein Sequence
(Fasta)

DVMDVAWSPH DVWLASCSVD NTIVIWNARK FPEMVTCLRG HTGLVKGLTW DPVGKYVASQ 60
ADDHSLRVWR TVDWQMESNI TKPFNECGGT THVLRLSWSP DGQYLVSAHA MNNSGPTAQI 120

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Nucleotide Sequence
(Fasta)

GATGTGATGG ACGTGGCCTG GTCCCCTCAT GACGTGTGGC TGGCCTCCTG CAGCGTGGAC 60
AACACCATCG TCATCTGGAA CGCCCGCAAG TTTCCAGGTA GGAGACGCAG GGAGAGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR031120--HIR1
IPR011494--Hira
IPR019015--HIRA_B_motif
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07569--Hira
PF09453--HIRA_B
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0016569--P:covalent chromatin modification
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gmo-039151	Gadus morhua	72.65	0.00e+00	1193.00
IUUC-Meu-055914	Macropus eugenii	52.06	3.00e-160	559.00
IUUC-Opr-070808	Ochotona princeps	61.72	0.00e+00	945.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence