iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116490

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01003025

Gene Name

AREL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000012150.1	ENSTGUT00000012658.1	ENSTGUP00000012519.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.60e-101	337.3	485	822

Active Site

Position(s)	Description	Evidence
790	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdg..... 85
           sd++k++ev f++Ee+ld+gG+ re+++l++k+l++++ +lf ++s+n+++ ++pnp + +    +lk++ef+Grl+gk+l+++     
   Q: 485  SDWSKNFEVIFQDEEALDWGGPRREWFELICKALFDTTSQLFtRFSDNNQALVHPNPGRPT--YLRLKVYEFAGRLVGKCLYESslgga 571
           7999**************************************788999**********985..59******************999999 PP
   S: 86   ..rlldlplsksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNke 171
             +l+++++++sf+ +++g +++++ +e+ dpe+yks + +i++n   d++e++l ++ ++ ++  +  k++eL+ gG+++pVtneNk 
   Q: 572  ykQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSkVCFILNN---DVSEMDLVFAEEKYSKTGQLEKVVELVAGGAQVPVTNENKI 657
           99***********************************99****99...9*********9999999999********************* PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkket.kykggytedspaiqwFwevleefsse 259
            Y +l+++yrl ++++e+v++f +G+ne++p++ll++F+e+elell+cG+ +i+v d+k+++    g ++ ++++++wFw v+++f++e
   Q: 658  LYLNLLAQYRLANQVREEVDHFLKGLNELVPENLLAIFDENELELLMCGTGDISVCDFKAHAvVVGGSWHFREKVMRWFWTVVSSFTQE 746
           **************************************************************555788999****************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           e +++LqF+Tgss+lP+gGfa+l p++ +i    +++ lP+++TCfn+L+LP+Y+s+e+++++L++Ai+e+ +gF++
   Q: 747  ELARLLQFTTGSSQLPPGGFAALCPSFQIIAA-PTHSTLPTAHTCFNQLCLPTYDSYEEVHKMLQLAISEGcEGFGM 822
           ************************99555555.**************************************9***97 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

MFYIIGGITV SVVAFFFTIK FLFELAARIV SFLQHEDRER RGERTIYDYV RGNYLDPRSC 60
KISWDWKDPY EVGHSMAFRV HLFYKNGQPF PAHRPVGLQV HICHVELAID IPATQEALQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTACA TTATTGGTAA GTGAAGGAAA GGCTGCCACT GTATTTGATG ACCTCTCCAT 60
AGGCTTTAGA AGGGTTTCTT GAAAACCTTT GATTTGATTT TAGCTCAGCG TTTACATGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR017868--Filamin/ABP280_repeat-like
IPR000569--HECT_dom
IPR013783--Ig-like_fold
IPR014756--Ig_E-set

PROSITE

PS50194--FILAMIN_REPEAT
PS50237--HECT

Pfam

PF00630--Filamin
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043066--P:negative regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001308	Ailuropoda melanoleuca	91.61	0.00e+00	1554.00
IUUC-Apl-004071	Anas platyrhynchos	96.35	0.00e+00	1540.00
IUUC-Aca-005218	Anolis carolinensis	94.17	0.00e+00	1536.00
IUUC-Ame-011871	Astyanax mexicanus	79.34	0.00e+00	1388.00
IUUC-Bta-012978	Bos taurus	91.01	0.00e+00	1547.00
IUUC-Cja-019081	Callithrix jacchus	91.13	0.00e+00	1550.00
IUUC-Cfa-020736	Canis familiaris	89.51	0.00e+00	1466.00
IUUC-Cpo-021581	Cavia porcellus	90.89	0.00e+00	1545.00
IUUC-Csa-024189	Chlorocebus sabaeus	88.94	0.00e+00	861.00
IUUC-Cho-024751	Choloepus hoffmanni	91.01	0.00e+00	1488.00
IUUC-Cin-025773	Ciona intestinalis	42.71	1.00e-148	519.00
IUUC-Csv-026090	Ciona savignyi	40.20	2.00e-172	598.00
IUUC-Dre-027788	Danio rerio	79.59	0.00e+00	1388.00
IUUC-Dno-030022	Dasypus novemcinctus	90.89	0.00e+00	1547.00
IUUC-Dme-031577	Drosophila melanogaster	47.66	0.00e+00	728.00
IUUC-Ete-032402	Echinops telfairi	89.26	0.00e+00	1468.00
IUUC-Eca-033908	Equus caballus	91.62	0.00e+00	1558.00
IUUC-Eeu-034869	Erinaceus europaeus	93.30	0.00e+00	889.00
IUUC-Fca-036023	Felis catus	91.98	0.00e+00	1560.00
IUUC-Fal-037477	Ficedula albicollis	98.91	0.00e+00	1628.00
IUUC-Gmo-039197	Gadus morhua	80.07	0.00e+00	1373.00
IUUC-Gga-040704	Gallus gallus	96.96	0.00e+00	1589.00
IUUC-Gac-041511	Gasterosteus aculeatus	78.61	0.00e+00	1371.00
IUUC-Ggo-044527	Gorilla gorilla	87.86	0.00e+00	1478.00
IUUC-Hsa-046082	Homo sapiens	91.13	0.00e+00	1551.00
IUUC-Itr-048168	Ictidomys tridecemlineatus	91.86	0.00e+00	1558.00
IUUC-Lch-049772	Latimeria chalumnae	76.55	0.00e+00	1245.00
IUUC-Loc-052541	Lepisosteus oculatus	81.70	0.00e+00	1408.00
IUUC-Laf-053852	Loxodonta africana	91.01	0.00e+00	1543.00
IUUC-Mcc-054759	Macaca mulatta	88.91	0.00e+00	776.00
IUUC-Meu-056247	Macropus eugenii	75.67	0.00e+00	815.00
IUUC-Mga-060161	Meleagris gallopavo	95.63	0.00e+00	1568.00
IUUC-Mmr-061447	Microcebus murinus	91.49	0.00e+00	1553.00
IUUC-Mdo-062110	Monodelphis domestica	91.13	0.00e+00	1493.00
IUUC-Mmu-064349	Mus musculus	90.89	0.00e+00	1549.00
IUUC-Mpu-065824	Mustela putorius furo	91.74	0.00e+00	1547.00
IUUC-Mlu-067729	Myotis lucifugus	91.37	0.00e+00	1521.00
IUUC-Nle-069721	Nomascus leucogenys	91.01	0.00e+00	1541.00
IUUC-Opr-070189	Ochotona princeps	91.55	0.00e+00	1545.00
IUUC-Ont-072122	Oreochromis niloticus	80.07	0.00e+00	1367.00
IUUC-Oan-072700	Ornithorhynchus anatinus	82.82	0.00e+00	1205.00
IUUC-Ocu-074057	Oryctolagus cuniculus	91.37	0.00e+00	1554.00
IUUC-Ola-087492	Oryzias latipes	78.76	0.00e+00	1375.00
IUUC-Oga-088084	Otolemur garnettii	91.49	0.00e+00	1549.00
IUUC-Oar-090354	Ovis aries	90.66	0.00e+00	1523.00
IUUC-Ptr-091456	Pan troglodytes	91.13	0.00e+00	1549.00
IUUC-Pan-092596	Papio anubis	89.93	0.00e+00	1523.00
IUUC-Psi-092942	Pelodiscus sinensis	94.41	0.00e+00	1560.00
IUUC-Pma-094662	Petromyzon marinus	63.04	0.00e+00	769.00
IUUC-Pfo-096838	Poecilia formosa	80.32	0.00e+00	1349.00
IUUC-Pab-097849	Pongo abelii	90.64	0.00e+00	1544.00
IUUC-Pca-100498	Procavia capensis	89.38	0.00e+00	885.00
IUUC-Pva-102599	Pteropus vampyrus	91.74	0.00e+00	1537.00
IUUC-Rno-105776	Rattus norvegicus	91.37	0.00e+00	1547.00
IUUC-Sha-106699	Sarcophilus harrisii	91.01	0.00e+00	1493.00
IUUC-Sar-113621	Sorex araneus	89.79	0.00e+00	1496.00
IUUC-Ssc-115742	Sus scrofa	91.13	0.00e+00	1550.00
IUUC-Tru-117679	Takifugu rubripes	79.47	0.00e+00	1358.00
IUUC-Tsy-119607	Tarsius syrichta	88.28	0.00e+00	1074.00
IUUC-Tni-120376	Tetraodon nigroviridis	75.73	0.00e+00	1277.00
IUUC-Tbe-127348	Tupaia belangeri	63.30	2.00e-173	602.00
IUUC-Ttr-128786	Tursiops truncatus	87.85	0.00e+00	1481.00
IUUC-Vpa-130180	Vicugna pacos	89.92	0.00e+00	1220.00
IUUC-Xtr-132631	Xenopus tropicalis	68.00	0.00e+00	1143.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence