iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045099

UUCD1 version

UUC-GoG-00053

Ensembl Protein ID

ENSGGOP00000001156.2

UniProt Accession

G3QFS6; G3QFS6_GORGO

Protein Name

Uncharacterized protein

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000001169.2	ENSGGOT00000001180.2	ENSGGOP00000001156.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-80	270.1	3146	3506

Active Site

Position(s)	Description	Evidence
3480	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3146 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3228
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3229 ADVPLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 3313
           ************************9*************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 3314 EEVELCSRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 3400
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3401 GLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 3487
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3488 QYSSLEIMLEKLRCAIHYR 3506
           ****************986 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

ELKVSILALA TQILTGCDEV LEMLQQVTTA LINSDIADRE QRLKGLEQVT KATMLGHLLP 60
VLLTSLMHPN LQTLIMADAL MPQLVQLVLY TSQTALLLKT QCPVFAEVGC SPCGAPDQKC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGCTAAA AGTCAGTATT TTGGCTCTTG CCACCCAAAT CCTGACTGGA TGTGATGAAG 60
TGTTGGAAAT GCTACAGCAG GTCACAACTG CCCTCATAAA TAGTGACATA GCAGACCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.72	0.00e+00	6346.00
IUUC-Apl-004161	Anas platyrhynchos	92.53	0.00e+00	5182.00
IUUC-Aca-005341	Anolis carolinensis	89.17	0.00e+00	5808.00
IUUC-Ame-011574	Astyanax mexicanus	83.55	0.00e+00	3845.00
IUUC-Bta-012514	Bos taurus	97.24	0.00e+00	1947.00
IUUC-Cja-019148	Callithrix jacchus	98.48	0.00e+00	5361.00
IUUC-Cfa-020499	Canis familiaris	97.69	0.00e+00	6319.00
IUUC-Cpo-021894	Cavia porcellus	97.32	0.00e+00	2770.00
IUUC-Csa-023079	Chlorocebus sabaeus	99.20	0.00e+00	6434.00
IUUC-Cho-024415	Choloepus hoffmanni	93.85	0.00e+00	4214.00
IUUC-Dre-027452	Danio rerio	81.86	0.00e+00	3826.00
IUUC-Dno-029595	Dasypus novemcinctus	96.76	0.00e+00	6333.00
IUUC-Dor-030849	Dipodomys ordii	96.69	0.00e+00	1793.00
IUUC-Ete-032563	Echinops telfairi	90.14	0.00e+00	1613.00
IUUC-Eca-034202	Equus caballus	97.84	0.00e+00	6265.00
IUUC-Eeu-035175	Erinaceus europaeus	97.11	0.00e+00	1073.00
IUUC-Fca-036295	Felis catus	97.32	0.00e+00	6336.00
IUUC-Fal-037003	Ficedula albicollis	92.75	0.00e+00	5338.00
IUUC-Gmo-038579	Gadus morhua	84.57	0.00e+00	2865.00
IUUC-Gga-040961	Gallus gallus	92.75	0.00e+00	6111.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.30	0.00e+00	2898.00
IUUC-Hsa-046331	Homo sapiens	99.83	0.00e+00	6522.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.77	0.00e+00	2155.00
IUUC-Lch-049923	Latimeria chalumnae	85.53	0.00e+00	1923.00
IUUC-Loc-052630	Lepisosteus oculatus	83.98	0.00e+00	4035.00
IUUC-Laf-053394	Loxodonta africana	96.92	0.00e+00	6386.00
IUUC-Mcc-055763	Macaca mulatta	99.23	0.00e+00	6431.00
IUUC-Meu-056039	Macropus eugenii	89.10	0.00e+00	5087.00
IUUC-Mga-059500	Meleagris gallopavo	92.30	0.00e+00	6075.00
IUUC-Mmr-060868	Microcebus murinus	93.89	0.00e+00	6098.00
IUUC-Mdo-062772	Monodelphis domestica	94.02	0.00e+00	6193.00
IUUC-Mmu-063606	Mus musculus	96.75	0.00e+00	6333.00
IUUC-Mpu-065860	Mustela putorius furo	96.36	0.00e+00	6257.00
IUUC-Mlu-067376	Myotis lucifugus	97.59	0.00e+00	4460.00
IUUC-Nle-069693	Nomascus leucogenys	98.01	0.00e+00	6379.00
IUUC-Opr-071065	Ochotona princeps	94.92	0.00e+00	777.00
IUUC-Ont-072470	Oreochromis niloticus	84.09	0.00e+00	3920.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.69	0.00e+00	5219.00
IUUC-Ocu-074032	Oryctolagus cuniculus	96.56	0.00e+00	6344.00
IUUC-Ola-087433	Oryzias latipes	83.18	0.00e+00	1585.00
IUUC-Oga-088546	Otolemur garnettii	98.26	0.00e+00	6391.00
IUUC-Oar-089643	Ovis aries	91.89	0.00e+00	763.00
IUUC-Ptr-090504	Pan troglodytes	99.72	0.00e+00	6506.00
IUUC-Pan-092543	Papio anubis	99.06	0.00e+00	6421.00
IUUC-Psi-093952	Pelodiscus sinensis	90.19	0.00e+00	5995.00
IUUC-Pfo-096356	Poecilia formosa	81.52	0.00e+00	5534.00
IUUC-Pab-098240	Pongo abelii	99.35	0.00e+00	6432.00
IUUC-Pca-100994	Procavia capensis	97.11	0.00e+00	2638.00
IUUC-Pva-102263	Pteropus vampyrus	96.19	0.00e+00	6217.00
IUUC-Rno-104888	Rattus norvegicus	96.78	0.00e+00	6309.00
IUUC-Sha-106944	Sarcophilus harrisii	93.35	0.00e+00	6217.00
IUUC-Sar-113556	Sorex araneus	82.98	0.00e+00	976.00
IUUC-Ssc-116187	Sus scrofa	98.01	0.00e+00	5190.00
IUUC-Tgu-116655	Taeniopygia guttata	92.32	0.00e+00	5134.00
IUUC-Tru-118093	Takifugu rubripes	83.39	0.00e+00	3000.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.30	0.00e+00	1610.00
IUUC-Tbe-127962	Tupaia belangeri	93.02	0.00e+00	1227.00
IUUC-Ttr-128819	Tursiops truncatus	93.09	0.00e+00	2885.00
IUUC-Vpa-130482	Vicugna pacos	94.97	0.00e+00	3540.00
IUUC-Xtr-132222	Xenopus tropicalis	87.16	0.00e+00	5912.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence