iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088546

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03071003

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000026797.1	ENSOGAT00000027804.1	ENSOGAP00000017886.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-80	270.0	3451	3811

Active Site

Position(s)	Description	Evidence
3785	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3451 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3533
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3534 ADVPLPLDLLPSFWKMLVGEPLDPdQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 3618
           **************************************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 3619 EEVELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNIECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 3705
           6667*****************************9999************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+fs+ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3706 GLMETDQHIEFFWGALEMFSQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 3792
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3793 QYSSLEIMLEKLRCAIHYR 3811
           ****************986 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

VGACYDTVNN MLWTCSNDYI DQWCNPGNQA FHYVCQRLGV SHIITEPKEE AITTNEVINQ 60
LLHHVGAMCI HQLNLLATNP NLPITSVLGK QHPIEAHHLS SICDIMEKAM VNGDTCIIRC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGGTGCCT GTTATGATAC AGTGAATAAT ATGCTGTGGA CATGCTCAAA TGACTATATC 60
GATCAGTGGT GTAATCCTGG GAATCAAGCC TTCCATTATG TCTGCCAGAG ACTTGGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.57	0.00e+00	6937.00
IUUC-Apl-004161	Anas platyrhynchos	92.66	0.00e+00	5202.00
IUUC-Aca-005341	Anolis carolinensis	89.35	0.00e+00	6373.00
IUUC-Ame-011574	Astyanax mexicanus	82.82	0.00e+00	4303.00
IUUC-Bta-012514	Bos taurus	96.90	0.00e+00	1934.00
IUUC-Cja-019148	Callithrix jacchus	97.45	0.00e+00	5320.00
IUUC-Cfa-020499	Canis familiaris	97.96	0.00e+00	6959.00
IUUC-Cpo-021894	Cavia porcellus	97.38	0.00e+00	2771.00
IUUC-Csa-023079	Chlorocebus sabaeus	98.51	0.00e+00	7004.00
IUUC-Cho-024415	Choloepus hoffmanni	94.78	0.00e+00	4837.00
IUUC-Dre-027452	Danio rerio	81.50	0.00e+00	4304.00
IUUC-Dno-029595	Dasypus novemcinctus	97.36	0.00e+00	6952.00
IUUC-Dor-030849	Dipodomys ordii	97.59	0.00e+00	1800.00
IUUC-Ete-032563	Echinops telfairi	90.42	0.00e+00	1632.00
IUUC-Eca-034202	Equus caballus	97.91	0.00e+00	6891.00
IUUC-Eeu-035175	Erinaceus europaeus	97.29	0.00e+00	1081.00
IUUC-Fca-036295	Felis catus	97.59	0.00e+00	6981.00
IUUC-Fal-037003	Ficedula albicollis	92.87	0.00e+00	5942.00
IUUC-Gmo-038579	Gadus morhua	84.63	0.00e+00	2866.00
IUUC-Gga-040961	Gallus gallus	93.01	0.00e+00	6729.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.64	0.00e+00	2903.00
IUUC-Ggo-045099	Gorilla gorilla	98.26	0.00e+00	6448.00
IUUC-Hsa-046331	Homo sapiens	98.30	0.00e+00	7049.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	97.15	0.00e+00	2180.00
IUUC-Lch-049923	Latimeria chalumnae	85.64	0.00e+00	2459.00
IUUC-Loc-052630	Lepisosteus oculatus	84.02	0.00e+00	4039.00
IUUC-Laf-053394	Loxodonta africana	97.46	0.00e+00	7040.00
IUUC-Mcc-055763	Macaca mulatta	98.59	0.00e+00	7008.00
IUUC-Meu-056039	Macropus eugenii	89.17	0.00e+00	5088.00
IUUC-Mga-059500	Meleagris gallopavo	92.25	0.00e+00	6667.00
IUUC-Mmr-060868	Microcebus murinus	94.71	0.00e+00	6738.00
IUUC-Mdo-062772	Monodelphis domestica	94.35	0.00e+00	6802.00
IUUC-Mmu-063606	Mus musculus	96.83	0.00e+00	6940.00
IUUC-Mpu-065860	Mustela putorius furo	96.32	0.00e+00	6853.00
IUUC-Mlu-067376	Myotis lucifugus	97.24	0.00e+00	5058.00
IUUC-Nle-069693	Nomascus leucogenys	96.82	0.00e+00	6917.00
IUUC-Opr-071065	Ochotona princeps	95.71	0.00e+00	1217.00
IUUC-Ont-072470	Oreochromis niloticus	83.94	0.00e+00	4414.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.55	0.00e+00	5238.00
IUUC-Ocu-074032	Oryctolagus cuniculus	96.58	0.00e+00	6961.00
IUUC-Ola-087433	Oryzias latipes	83.28	0.00e+00	1581.00
IUUC-Oar-089643	Ovis aries	91.15	0.00e+00	762.00
IUUC-Ptr-090504	Pan troglodytes	98.33	0.00e+00	7046.00
IUUC-Pan-092543	Papio anubis	98.48	0.00e+00	6997.00
IUUC-Psi-093952	Pelodiscus sinensis	90.06	0.00e+00	6581.00
IUUC-Pfo-096356	Poecilia formosa	81.53	0.00e+00	6033.00
IUUC-Pab-098240	Pongo abelii	98.43	0.00e+00	6990.00
IUUC-Pca-100994	Procavia capensis	97.49	0.00e+00	3001.00
IUUC-Pva-102263	Pteropus vampyrus	96.57	0.00e+00	6846.00
IUUC-Rno-104888	Rattus norvegicus	96.91	0.00e+00	6921.00
IUUC-Sha-106944	Sarcophilus harrisii	93.45	0.00e+00	6808.00
IUUC-Sar-113556	Sorex araneus	83.25	0.00e+00	990.00
IUUC-Ssc-116187	Sus scrofa	97.87	0.00e+00	5184.00
IUUC-Tgu-116655	Taeniopygia guttata	92.32	0.00e+00	5150.00
IUUC-Tru-118093	Takifugu rubripes	83.49	0.00e+00	3003.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.30	0.00e+00	1608.00
IUUC-Tbe-127962	Tupaia belangeri	93.37	0.00e+00	1222.00
IUUC-Ttr-128819	Tursiops truncatus	92.81	0.00e+00	2875.00
IUUC-Vpa-130482	Vicugna pacos	95.87	0.00e+00	4171.00
IUUC-Xtr-132222	Xenopus tropicalis	86.93	0.00e+00	6445.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence