iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072470

Ensembl Protein ID

ENSONIP00000013423.1

UniProt Accession

I3JX28; I3JX28_ORENI

Genbank Protein ID

ENSONIP00000013423

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01013630

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000010676.1	ENSONIT00000013433.1	ENSONIP00000013423.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-76	258.3	3661	4021

Active Site

Position(s)	Description	Evidence
3995	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq++ l+l+        + +++k+ l+p p s+     +++l +f+G+llg+a++
   Q: 3661 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSALSLLlpcpsaaANRNKGKYVLTPCPISY----AEEQLLHFFGQLLGIAIR 3743
           5667788**********************************888887666677999999999999....689*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeikena.esdieelgldltfsvseei...............lgetke 153
            + +l+l+l  sf+k l+g++l+  +dl+e d  +y+++k+ ++   e+++e+l+++++++ ++ +                 + +e
   Q: 3744 ADVPLPLDLLGSFWKGLVGEPLDSeQDLQEADVLTYNYVKKFENVTdETELEALCAEISSQHHSGEspdspsrpcctftyvTMTGEE 3830
           ************************9*************88888765367888888888888666668999*******9966555566 PP
   S: 154  eeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggy 239
           +eL++gG++  V ++Nk+ Y ++v ++rl+e +  e+++a+r+G+ ++ipl+ll+++++ e+el +cG ++i++e lk++t+y+ g+
   Q: 3831 VELCQGGRSLIVSWQNKDVYARAVRSLRLRElQNVECMTAVRAGLGSIIPLQLLTMLSPIEIELRTCGLPYINLEFLKAHTMYQVGL 3917
           67*****************************9******************************************************* PP
   S: 240  tedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLPeY 313
           +e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC+++ kLP+Y
   Q: 3918 METDQHIEFFWTALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgaaGQPDSRYIRVETCMFMVKLPQY 4004
           *******************************************9999999998888888888*955666****************** PP
   S: 314  sskeilkekLlyAieet 330
           +s +++ ekL+yAi+++
   Q: 4005 TSLDVMLEKLRYAIHYR 4021
           **************986 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MPAHHFPVGS SMTTLHLCSD GTYLYWVWSP ASLNEKTQKG HSVFMDVFHL STQTGLCVAD 60
ILQERVILTR KEGESSKCLN ELLLSRMSRF RASHSATLAA LTGSAITNTV KEEQSAVNTS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCACTGA CAGACACCGG GCCATTAGCA GAGCTGCTTG CAGTCGGGTT TTAGCCGTGA 60
AATGAGAGTA CTACAGGTTC ACTTTGCGTC TTGAAAATAC TGTCGTTTAG ACGGTGCGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	84.06	0.00e+00	4638.00
IUUC-Apl-004161	Anas platyrhynchos	85.11	0.00e+00	3071.00
IUUC-Aca-005341	Anolis carolinensis	79.37	0.00e+00	5957.00
IUUC-Ame-011574	Astyanax mexicanus	88.16	0.00e+00	4860.00
IUUC-Bta-012514	Bos taurus	76.35	0.00e+00	1613.00
IUUC-Cja-019148	Callithrix jacchus	82.44	0.00e+00	3109.00
IUUC-Cfa-020499	Canis familiaris	82.82	0.00e+00	4616.00
IUUC-Cpo-021894	Cavia porcellus	84.99	0.00e+00	2434.00
IUUC-Csa-023079	Chlorocebus sabaeus	81.17	0.00e+00	6202.00
IUUC-Cho-024415	Choloepus hoffmanni	80.85	0.00e+00	4374.00
IUUC-Dre-027452	Danio rerio	85.83	0.00e+00	4831.00
IUUC-Dno-029595	Dasypus novemcinctus	82.60	0.00e+00	4594.00
IUUC-Dor-030849	Dipodomys ordii	85.49	0.00e+00	1576.00
IUUC-Ete-032563	Echinops telfairi	73.54	0.00e+00	969.00
IUUC-Eca-034202	Equus caballus	84.07	0.00e+00	4622.00
IUUC-Eeu-035175	Erinaceus europaeus	86.08	0.00e+00	977.00
IUUC-Fca-036295	Felis catus	83.33	0.00e+00	4445.00
IUUC-Fal-037003	Ficedula albicollis	80.56	0.00e+00	5519.00
IUUC-Gmo-038579	Gadus morhua	93.71	0.00e+00	3127.00
IUUC-Gga-040961	Gallus gallus	83.56	0.00e+00	4687.00
IUUC-Gac-041899	Gasterosteus aculeatus	95.24	0.00e+00	3209.00
IUUC-Ggo-045099	Gorilla gorilla	83.18	0.00e+00	5509.00
IUUC-Hsa-046331	Homo sapiens	81.54	0.00e+00	6223.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	75.23	0.00e+00	1796.00
IUUC-Lch-049923	Latimeria chalumnae	79.44	0.00e+00	2447.00
IUUC-Loc-052630	Lepisosteus oculatus	88.73	0.00e+00	4235.00
IUUC-Laf-053394	Loxodonta africana	82.65	0.00e+00	4617.00
IUUC-Mcc-055763	Macaca mulatta	81.10	0.00e+00	6187.00
IUUC-Meu-056039	Macropus eugenii	80.38	0.00e+00	3030.00
IUUC-Mga-059500	Meleagris gallopavo	83.86	0.00e+00	4666.00
IUUC-Mmr-060868	Microcebus murinus	77.81	0.00e+00	5936.00
IUUC-Mdo-062772	Monodelphis domestica	82.07	0.00e+00	4598.00
IUUC-Mmu-063606	Mus musculus	82.69	0.00e+00	4637.00
IUUC-Mpu-065860	Mustela putorius furo	81.89	0.00e+00	4506.00
IUUC-Mlu-067376	Myotis lucifugus	84.07	0.00e+00	4636.00
IUUC-Nle-069693	Nomascus leucogenys	81.04	0.00e+00	6115.00
IUUC-Opr-071065	Ochotona princeps	83.71	0.00e+00	1043.00
IUUC-Oan-073693	Ornithorhynchus anatinus	84.71	0.00e+00	3043.00
IUUC-Ocu-074032	Oryctolagus cuniculus	80.53	0.00e+00	6183.00
IUUC-Ola-087433	Oryzias latipes	94.38	0.00e+00	1781.00
IUUC-Oga-088546	Otolemur garnettii	84.69	0.00e+00	4397.00
IUUC-Oar-089643	Ovis aries	82.76	0.00e+00	696.00
IUUC-Ptr-090504	Pan troglodytes	82.41	0.00e+00	6245.00
IUUC-Pan-092543	Papio anubis	80.99	0.00e+00	6174.00
IUUC-Psi-093952	Pelodiscus sinensis	81.96	0.00e+00	4490.00
IUUC-Pfo-096356	Poecilia formosa	93.96	0.00e+00	7071.00
IUUC-Pab-098240	Pongo abelii	81.10	0.00e+00	6192.00
IUUC-Pca-100994	Procavia capensis	85.00	0.00e+00	2598.00
IUUC-Pva-102263	Pteropus vampyrus	83.19	0.00e+00	4557.00
IUUC-Rno-104888	Rattus norvegicus	82.72	0.00e+00	4627.00
IUUC-Sha-106944	Sarcophilus harrisii	83.50	0.00e+00	4642.00
IUUC-Sar-113556	Sorex araneus	80.65	0.00e+00	909.00
IUUC-Ssc-116187	Sus scrofa	86.01	0.00e+00	2925.00
IUUC-Tgu-116655	Taeniopygia guttata	85.32	0.00e+00	3066.00
IUUC-Tru-118093	Takifugu rubripes	94.64	0.00e+00	3342.00
IUUC-Tni-119739	Tetraodon nigroviridis	94.16	0.00e+00	1800.00
IUUC-Tbe-127962	Tupaia belangeri	66.59	0.00e+00	934.00
IUUC-Ttr-128819	Tursiops truncatus	84.91	0.00e+00	2166.00
IUUC-Vpa-130482	Vicugna pacos	83.09	0.00e+00	3895.00
IUUC-Xtr-132222	Xenopus tropicalis	80.10	0.00e+00	6119.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence