iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109906.13	ENST00000335953.8	ENSP00000338157.4
ENSG00000109906.13	ENST00000539918.5	ENSP00000445047.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	4.40e-09	38.2	34	94

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv++ v+ +ef+ah+ vLa  S++F+ lf        ++  ++++ ++p+ f+++l++ Yt +l+ 
   Q: 34   CDVVIMVDSQEFHAHRTVLACTSKMFEILFHR------NSQHYTLDFLSPKTFQQILEYAYTATLQA 94
           8*****************************33......3668889989***************9985 PP

Organism

Homo sapiens

Functional Description
(View)

Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. Probable substrate-recognition component of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT VLACTSKMFE 60
ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD DLLYAAEILE IEYLEEQCLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCTCGGCC GCCAGCACTA AAGATGGAGA GGCGCCGGGG CCTTGCAGGG GAGGGGGCTC 60
GGCGTTGACG TGGGACGCGG CGGAGGCGCA GCAGCCGGTG GTGATTTGCT AACCTCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0017053--C:transcriptional repressor complex
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0042803--F:protein homodimerization activity
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001206--F:transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0009952--P:anterior/posterior pattern specification
GO:0006915--P:apoptotic process
GO:0051216--P:cartilage development
GO:0007417--P:central nervous system development
GO:0042733--P:embryonic digit morphogenesis
GO:0035116--P:embryonic hindlimb morphogenesis
GO:0009880--P:embryonic pattern specification
GO:0035136--P:forelimb morphogenesis
GO:0030097--P:hemopoiesis
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0001823--P:mesonephros development
GO:0030099--P:myeloid cell differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0045638--P:negative regulation of myeloid cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process
GO:0061036--P:positive regulation of cartilage development
GO:0032332--P:positive regulation of chondrocyte differentiation
GO:0045600--P:positive regulation of fat cell differentiation
GO:0051138--P:positive regulation of NK T cell differentiation
GO:0045778--P:positive regulation of ossification
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0034504--P:protein localization to nucleus
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:7704

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001304	Ailuropoda melanoleuca	97.47	0.00e+00	1280.00
IUUC-Apl-003955	Anas platyrhynchos	86.78	0.00e+00	1165.00
IUUC-Aca-005156	Anolis carolinensis	72.54	4.00e-149	520.00
IUUC-Ame-011629	Astyanax mexicanus	77.57	0.00e+00	946.00
IUUC-Bta-012807	Bos taurus	96.14	0.00e+00	1281.00
IUUC-Cja-019347	Callithrix jacchus	99.11	0.00e+00	1350.00
IUUC-Cfa-020219	Canis familiaris	95.99	0.00e+00	1253.00
IUUC-Cpo-021404	Cavia porcellus	94.35	0.00e+00	1234.00
IUUC-Csa-023837	Chlorocebus sabaeus	99.41	0.00e+00	1354.00
IUUC-Cho-024691	Choloepus hoffmanni	84.47	0.00e+00	850.00
IUUC-Dre-027842	Danio rerio	78.94	0.00e+00	990.00
IUUC-Dno-029711	Dasypus novemcinctus	97.33	0.00e+00	1293.00
IUUC-Ete-032980	Echinops telfairi	95.84	0.00e+00	1281.00
IUUC-Eca-033437	Equus caballus	98.07	0.00e+00	1308.00
IUUC-Fca-035631	Felis catus	95.26	0.00e+00	725.00
IUUC-Fal-037329	Ficedula albicollis	81.74	0.00e+00	1015.00
IUUC-Gmo-039421	Gadus morhua	71.98	0.00e+00	849.00
IUUC-Gga-041063	Gallus gallus	86.18	0.00e+00	1132.00
IUUC-Gac-041889	Gasterosteus aculeatus	71.60	0.00e+00	863.00
IUUC-Ggo-045452	Gorilla gorilla	99.55	0.00e+00	1355.00
IUUC-Itr-048417	Ictidomys tridecemlineatus	94.95	0.00e+00	1273.00
IUUC-Lch-049446	Latimeria chalumnae	72.54	3.00e-162	564.00
IUUC-Loc-051811	Lepisosteus oculatus	80.53	0.00e+00	1027.00
IUUC-Laf-053594	Loxodonta africana	97.03	0.00e+00	1327.00
IUUC-Mcc-054941	Macaca mulatta	99.55	0.00e+00	1357.00
IUUC-Mga-059231	Meleagris gallopavo	86.48	0.00e+00	1132.00
IUUC-Mmr-061486	Microcebus murinus	93.38	0.00e+00	1231.00
IUUC-Mdo-063075	Monodelphis domestica	91.99	0.00e+00	1255.00
IUUC-Mmu-063142	Mus musculus	96.73	0.00e+00	1314.00
IUUC-Mpu-066057	Mustela putorius furo	96.73	0.00e+00	1294.00
IUUC-Mlu-067412	Myotis lucifugus	95.11	0.00e+00	1298.00
IUUC-Nle-069210	Nomascus leucogenys	99.55	0.00e+00	1355.00
IUUC-Opr-070631	Ochotona princeps	91.84	0.00e+00	1203.00
IUUC-Ont-071326	Oreochromis niloticus	75.99	0.00e+00	918.00
IUUC-Oan-073311	Ornithorhynchus anatinus	71.73	9.00e-80	289.00
IUUC-Ocu-074156	Oryctolagus cuniculus	97.03	0.00e+00	1271.00
IUUC-Ola-086952	Oryzias latipes	58.58	0.00e+00	674.00
IUUC-Oga-088714	Otolemur garnettii	98.66	0.00e+00	1298.00
IUUC-Ptr-090490	Pan troglodytes	98.67	0.00e+00	1185.00
IUUC-Pan-092563	Papio anubis	99.55	0.00e+00	1357.00
IUUC-Psi-093644	Pelodiscus sinensis	85.44	0.00e+00	1123.00
IUUC-Pma-094677	Petromyzon marinus	50.07	4.00e-158	551.00
IUUC-Pfo-096399	Poecilia formosa	75.66	0.00e+00	919.00
IUUC-Pab-097934	Pongo abelii	99.67	0.00e+00	1196.00
IUUC-Pca-101003	Procavia capensis	89.90	0.00e+00	1207.00
IUUC-Pva-102802	Pteropus vampyrus	97.15	0.00e+00	1147.00
IUUC-Rno-105871	Rattus norvegicus	96.14	0.00e+00	1308.00
IUUC-Sha-107295	Sarcophilus harrisii	91.54	0.00e+00	1191.00
IUUC-Spo-108233	Schizosaccharomyces pombe	25.00	2.50e-01	30.00
IUUC-Sar-113057	Sorex araneus	91.23	0.00e+00	668.00
IUUC-Ssc-116179	Sus scrofa	96.45	0.00e+00	762.00
IUUC-Tgu-116805	Taeniopygia guttata	73.72	0.00e+00	830.00
IUUC-Tru-118282	Takifugu rubripes	59.17	0.00e+00	689.00
IUUC-Tni-120296	Tetraodon nigroviridis	59.88	0.00e+00	709.00
IUUC-Tbe-127742	Tupaia belangeri	88.97	0.00e+00	1167.00
IUUC-Ttr-128285	Tursiops truncatus	96.58	0.00e+00	1288.00
IUUC-Xtr-132970	Xenopus tropicalis	77.00	0.00e+00	1002.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence