iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029798.11	ENSMUST00000031817.9	ENSMUSP00000031817.8
ENSMUSG00000029798.11	ENSMUST00000203840.1	ENSMUSP00000145505.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.10e-84	282.8	682	999

Active Site

Position(s)	Description	Evidence
970	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           dl+k+l v f +E   ++gGv++ef++++++e+ +p++++f y e+++++++p + ++    e+ ++F f G+l+g++l + ++++lp+
   Q: 682  DLRKQLSVGFINEIRPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKF----EKSSYFLF-GILCGLSLHNLKVINLPF 765
           799**************************************************99998....68899955.****************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           + ++yk+ll++k sledl+e+   l ++l+e+++ +  dieel++ ++      i+ ++k+++L+p+G ++pV+++Nk++Yv+++v+y+
   Q: 766  PLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEELHMYFS------IYWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYI 848
           ***********************************9999999755555......58999****************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           ++ +ik+ +e+f++Gf++v++ ++++ F++eel + i G+++ d+++++++ kyk+gy +++p+i  Fw+++++++ +e+k+fL F+Tg
   Q: 849  FNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTAIIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTG 937
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           ++rl ++G+++    +f +++  s+++ P+s TC  +L+LP+Yss+  +ke L++Ai++++gF
   Q: 938  CDRLHVKGLQNEG-IVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGF 999
           ***********99.778888899**************************************99 PP

Organism

Mus musculus

Functional Description
(View)

Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon.

Protein Sequence
(Fasta)

MYFSWAAGSR KPRRLKAGTS GIELLQAASG EHHSLLLFSN HRVYSCGDNS WGQLGQRRDQ 60
STERPEPIQA LNDLHVDLVS CGKEHSVAVC HKGKVFAWGA GSEGQLGIGE FKEISFMPTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATACCAG AGCCGCGGGT GGCTGTGCAC CGCAGGGATG TATTTCAGCT GGGCTGCAGG 60
AAGCCGGAAG CCTCGGCGCC TGAAGGCGGG AACCAGCGGC ATTGAACTCT TGCAGGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0030332--F:cyclin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0045087--P:innate immune response
GO:0016567--P:protein ubiquitination

KEGG

mmu:67138

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	62.57	0.00e+00	1170.00
IUUC-Aca-004663	Anolis carolinensis	46.47	0.00e+00	820.00
IUUC-Bta-013080	Bos taurus	62.86	0.00e+00	1194.00
IUUC-Cja-018891	Callithrix jacchus	65.69	0.00e+00	1261.00
IUUC-Cfa-020763	Canis familiaris	63.40	0.00e+00	1164.00
IUUC-Cpo-022346	Cavia porcellus	64.76	0.00e+00	1306.00
IUUC-Csa-023049	Chlorocebus sabaeus	66.31	0.00e+00	1338.00
IUUC-Cho-025101	Choloepus hoffmanni	49.59	3.00e-127	449.00
IUUC-Dno-029093	Dasypus novemcinctus	66.14	0.00e+00	1288.00
IUUC-Dor-030862	Dipodomys ordii	38.44	3.00e-168	586.00
IUUC-Eca-034098	Equus caballus	66.14	0.00e+00	1228.00
IUUC-Eeu-035028	Erinaceus europaeus	51.45	1.00e-142	501.00
IUUC-Fca-036283	Felis catus	63.68	0.00e+00	1192.00
IUUC-Ggo-045553	Gorilla gorilla	65.42	0.00e+00	1290.00
IUUC-Hsa-046396	Homo sapiens	66.63	0.00e+00	1329.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	40.84	0.00e+00	697.00
IUUC-Loc-052700	Lepisosteus oculatus	37.99	0.00e+00	697.00
IUUC-Laf-054433	Loxodonta africana	62.01	0.00e+00	1286.00
IUUC-Mcc-055014	Macaca mulatta	63.11	0.00e+00	1269.00
IUUC-Mmr-060783	Microcebus murinus	40.32	2.00e-180	625.00
IUUC-Mdo-061839	Monodelphis domestica	53.61	0.00e+00	939.00
IUUC-Mpu-066293	Mustela putorius furo	62.78	0.00e+00	1140.00
IUUC-Mlu-067407	Myotis lucifugus	61.25	0.00e+00	1180.00
IUUC-Nle-069978	Nomascus leucogenys	66.05	0.00e+00	1333.00
IUUC-Opr-070190	Ochotona princeps	51.32	3.00e-172	599.00
IUUC-Ocu-074305	Oryctolagus cuniculus	44.97	0.00e+00	795.00
IUUC-Oga-088780	Otolemur garnettii	59.56	0.00e+00	1148.00
IUUC-Oar-090307	Ovis aries	64.42	0.00e+00	1229.00
IUUC-Ptr-091567	Pan troglodytes	67.12	0.00e+00	1331.00
IUUC-Pan-091802	Papio anubis	62.59	0.00e+00	1244.00
IUUC-Pab-098024	Pongo abelii	53.67	0.00e+00	979.00
IUUC-Pca-100315	Procavia capensis	51.31	0.00e+00	693.00
IUUC-Pva-102382	Pteropus vampyrus	61.07	0.00e+00	1145.00
IUUC-Rno-105768	Rattus norvegicus	78.85	0.00e+00	1602.00
IUUC-Sha-106525	Sarcophilus harrisii	49.76	0.00e+00	978.00
IUUC-Sar-113014	Sorex araneus	55.82	5.00e-143	501.00
IUUC-Tsy-119565	Tarsius syrichta	71.18	7.00e-149	521.00
IUUC-Tbe-127787	Tupaia belangeri	40.85	0.00e+00	665.00
IUUC-Ttr-128191	Tursiops truncatus	44.73	0.00e+00	746.00
IUUC-Vpa-130214	Vicugna pacos	61.60	0.00e+00	1090.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence