iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088780

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03071240

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000017223.2	ENSOGAT00000017229.2	ENSOGAP00000015429.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-88	297.8	728	1046

Active Site

Position(s)	Description	Evidence
1017	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dl k l vef +E   + gGv++ef++++++e+ +p++g+f+y e+d+++++p + ++    ++ ++F  +G+l+g++l+++++ +l
   Q: 728  DLWKTLVVEFIKEIRPESGGVSSEFFHCMFEEVTKPQYGMFMYPEKDSYMWFPVNPKI----DKKRYFL-FGILCGLSLFNSNVANL 809
           5667899**********************************************99997....7889995.5**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           p++ ++yk+ll++k sledl+e+ p l k+l+e+++ + +diee  ld++fs++     ++++++L+p+G+++pV+++Nk++Yv+++
   Q: 810  PFPLALYKKLLNQKPSLEDLKELSPVLGKNLQEVLNDEGDDIEEV-LDIQFSIHW----DQTDVDLIPNGNSVPVNQTNKKDYVSKY 891
           ***********************************9999899997.*****9555....778888********************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ ++k+ +e+f++Gf++v+++++++lF++eel   i G++++d+++++++  y +gy++++p+i +Fwe++++++ +e+k+f
   Q: 892  VDYIFNISVKTVYEEFQRGFYRVCDEKIIRLFQPEELMAAIIGDTDYDWKQFEQNSGYGHGYHPSHPTILMFWEAFHRLTLDEKKRF 978
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           L F+Tg++rl ++G++e    +f +++  ++++ P+s TC+n L+LP+Ys++e ++e L++Ai++++gF
   Q: 979  LLFLTGRDRLHVRGLREEG-IMFRCPETFTERDHPRSVTCYNILDLPKYSTMERVEEALQVAINSNRGF 1046
           *****************99.77888888***************************************99 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

AQSGMYLCWG AGSRGLQRRR APGAGGAGLR QAASGERHAL LLLTNRAVHS CGDNSRGQLG 60
RRGVPRRELP VSYTQYLCNS VNFVFTKCND LMNILCFYYV CVYIYNICGN EGVQLGSHEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCAGAGCG GGATGTACCT CTGCTGGGGC GCCGGCTCCC GGGGGCTGCA GCGCCGGAGG 60
GCGCCGGGCG CAGGCGGCGC GGGGCTGCGG CAGGCGGCCA GCGGGGAGCG CCACGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	66.00	0.00e+00	1281.00
IUUC-Aca-004663	Anolis carolinensis	43.95	0.00e+00	816.00
IUUC-Bta-013080	Bos taurus	64.42	0.00e+00	1287.00
IUUC-Cja-018891	Callithrix jacchus	69.32	0.00e+00	1422.00
IUUC-Cfa-020763	Canis familiaris	64.03	0.00e+00	1204.00
IUUC-Cpo-022346	Cavia porcellus	65.05	0.00e+00	1321.00
IUUC-Csa-023049	Chlorocebus sabaeus	71.28	0.00e+00	1507.00
IUUC-Cho-025101	Choloepus hoffmanni	49.71	2.00e-138	486.00
IUUC-Dno-029093	Dasypus novemcinctus	65.75	0.00e+00	1357.00
IUUC-Eca-034098	Equus caballus	69.05	0.00e+00	1300.00
IUUC-Eeu-035028	Erinaceus europaeus	65.59	4.00e-150	525.00
IUUC-Fca-036283	Felis catus	67.34	0.00e+00	1311.00
IUUC-Ggo-045553	Gorilla gorilla	67.37	0.00e+00	1357.00
IUUC-Hsa-046396	Homo sapiens	71.47	0.00e+00	1469.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	44.11	0.00e+00	750.00
IUUC-Loc-052700	Lepisosteus oculatus	38.38	0.00e+00	723.00
IUUC-Laf-054433	Loxodonta africana	66.98	0.00e+00	1413.00
IUUC-Mcc-055014	Macaca mulatta	69.31	0.00e+00	1486.00
IUUC-Mdo-061839	Monodelphis domestica	50.51	0.00e+00	911.00
IUUC-Mmu-064378	Mus musculus	59.56	0.00e+00	1151.00
IUUC-Mpu-066293	Mustela putorius furo	64.35	0.00e+00	1195.00
IUUC-Mlu-067407	Myotis lucifugus	64.53	0.00e+00	1286.00
IUUC-Nle-069978	Nomascus leucogenys	70.81	0.00e+00	1499.00
IUUC-Opr-070190	Ochotona princeps	49.71	1.00e-164	573.00
IUUC-Ocu-074305	Oryctolagus cuniculus	47.86	0.00e+00	862.00
IUUC-Oar-090307	Ovis aries	65.89	0.00e+00	1333.00
IUUC-Ptr-091567	Pan troglodytes	71.35	0.00e+00	1466.00
IUUC-Pan-091802	Papio anubis	66.57	0.00e+00	1398.00
IUUC-Pab-098024	Pongo abelii	58.93	0.00e+00	1040.00
IUUC-Pva-102382	Pteropus vampyrus	62.57	0.00e+00	1239.00
IUUC-Rno-105768	Rattus norvegicus	58.55	0.00e+00	1149.00
IUUC-Sha-106525	Sarcophilus harrisii	49.44	0.00e+00	985.00
IUUC-Sar-113014	Sorex araneus	56.61	7.00e-133	468.00
IUUC-Tsy-119565	Tarsius syrichta	74.24	2.00e-166	580.00
IUUC-Vpa-130214	Vicugna pacos	66.92	0.00e+00	1194.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence