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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063104
UUCD1 version UUC-MuM-00149
Ensembl Protein ID ENSMUSP00000093622.3
UniProt Accession D3Z3K2; CIP1_MOUSE
Genbank Protein ID EDL20823.1
Protein Name E3 ubiquitin-protein ligase CCNB1IP1; Cyclin-B1-interacting protein 1; RING-type E3 ubiquitin transferase CCNB1IP1
Genbank Nucleotide ID AC027184
Gene Name Ccnb1ip1; Gm288; Hei10; Mei4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000071470.3 ENSMUST00000095932.3 ENSMUSP00000093622.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBaseTRANSFACRAID2
Protein-protein Interaction
IIDHINTMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 24390283
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 88.45 5.00e-144 508.00 IUUC-Hsa-046298
Organism Mus musculus
Functional Description
(View)

Functional Description



     Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Protein Sequence
(Fasta)
MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA CNSTLSGKLD 60
IVRTELSPSE EYKAMVLAGL RPEVVLDISS RALAFWTYQV HQERLYQEYN FSKAENHLKQ 120
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Protein Fasta Sequence



>IUUC-Mmu-063104|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
AGGCCTTGCG CACCACGCAT GCGCCCTGGC GGCTTGGCCA CGCGAAATCT GTCTTGAGTG 60
GAGGATCGAC ACCTTTACTT TACCTTGTTG CAGGTATTTT TTTCTGTTTT TGCTTTTCTG 120
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Nucleotide Fasta Sequence



>IUUC-Mmu-063104|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0469--Meiosis
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF14634--zf-RING_5

Gene Ontology

GO:0000794--C:condensed nuclear chromosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001825--P:blastocyst formation
GO:0051026--P:chiasma assembly
GO:0016567--P:protein ubiquitination
GO:0007131--P:reciprocal meiotic recombination
GO:0007286--P:spermatid development

KEGG mmu:239083
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001494 Ailuropoda melanoleuca 88.45 1.00e-136 478.00
IUUC-Atr-002590 Amborella trichopoda 27.12 2.00e-15 76.60
IUUC-Aca-004727 Anolis carolinensis 74.82 1.00e-116 412.00
IUUC-Aly-005623 Arabidopsis lyrata 26.82 2.00e-15 76.30
IUUC-Ath-007676 Arabidopsis thaliana 26.82 2.00e-15 76.30
IUUC-Ago-007882 Ashbya gossypii 20.39 3.10e-01 28.90
IUUC-Acl-008069 Aspergillus clavatus 29.63 3.00e-26 112.00
IUUC-Afl-008624 Aspergillus flavus 30.94 1.00e-14 72.80
IUUC-Afu-008843 Aspergillus fumigatus 22.47 5.00e-03 34.30
IUUC-Ang-009632 Aspergillus niger 27.27 1.00e-20 94.00
IUUC-Aor-010103 Aspergillus oryzae 25.13 7.00e-15 74.70
IUUC-Ame-011272 Astyanax mexicanus 66.85 1.00e-72 265.00
IUUC-Bgr-012009 Blumeria graminis 34.54 3.00e-26 112.00
IUUC-Bta-013554 Bos taurus 88.81 2.00e-146 511.00
IUUC-Bci-013777 Botrytis cinerea 34.04 3.00e-30 125.00
IUUC-Bdi-014526 Brachypodium distachyon 24.02 2.00e-13 70.10
IUUC-Bol-015609 Brassica oleracea 22.58 4.00e-10 58.90
IUUC-Bra-017490 Brassica rapa 22.34 2.00e-10 60.10
IUUC-Cja-019479 Callithrix jacchus 88.81 5.00e-136 476.00
IUUC-Cfa-020587 Canis familiaris 88.45 2.00e-137 481.00
IUUC-Cpo-022322 Cavia porcellus 89.53 1.00e-148 518.00
IUUC-Csa-023413 Chlorocebus sabaeus 88.81 5.00e-136 476.00
IUUC-Cho-024774 Choloepus hoffmanni 88.45 4.00e-137 480.00
IUUC-Cin-025768 Ciona intestinalis 37.89 3.00e-32 132.00
IUUC-Csv-025979 Ciona savignyi 50.46 2.00e-29 121.00
IUUC-Dre-027844 Danio rerio 51.72 2.00e-74 271.00
IUUC-Dno-029464 Dasypus novemcinctus 89.17 1.00e-139 488.00
IUUC-Ete-032388 Echinops telfairi 59.27 6.00e-82 297.00
IUUC-Eca-034091 Equus caballus 89.17 5.00e-137 480.00
IUUC-Eeu-034849 Erinaceus europaeus 97.98 3.00e-56 211.00
IUUC-Fca-036196 Felis catus 88.81 1.00e-146 512.00
IUUC-Fox-038053 Fusarium oxysporum 33.33 2.00e-26 112.00
IUUC-Fso-038281 Fusarium solani 30.21 2.00e-22 100.00
IUUC-Gmo-038640 Gadus morhua 68.20 3.00e-88 317.00
IUUC-Gac-042089 Gasterosteus aculeatus 63.02 1.00e-93 335.00
IUUC-Gma-043411 Glycine max 25.70 2.00e-13 69.30
IUUC-Ggo-044908 Gorilla gorilla 88.81 3.00e-137 481.00
IUUC-Hsa-046298 Homo sapiens 88.45 1.00e-136 479.00
IUUC-Hvu-047386 Hordeum vulgare 25.70 7.00e-15 73.90
IUUC-Itr-048597 Ictidomys tridecemlineatus 63.90 1.00e-94 338.00
IUUC-Lch-049554 Latimeria chalumnae 71.84 1.00e-104 372.00
IUUC-Lpe-051573 Leersia perrieri 24.58 1.00e-13 70.10
IUUC-Lma-052964 Leptosphaeria maculans 33.09 8.00e-16 79.30
IUUC-Laf-053637 Loxodonta africana 89.17 5.00e-140 489.00
IUUC-Mcc-055204 Macaca mulatta 88.45 2.00e-136 478.00
IUUC-Meu-055940 Macropus eugenii 92.96 4.00e-80 289.00
IUUC-Mpo-057618 Magnaporthe poae 27.91 3.00e-11 62.80
IUUC-Mtr-058578 Medicago truncatula 24.02 2.00e-13 69.70
IUUC-Mla-058981 Melampsora laricipopulina 31.55 3.00e-25 108.00
IUUC-Mvi-060402 Microbotryum violaceum 40.00 2.00e-25 110.00
IUUC-Mmr-061554 Microcebus murinus 89.89 1.00e-139 488.00
IUUC-Mdo-062669 Monodelphis domestica 84.84 5.00e-131 460.00
IUUC-Mac-064883 Musa acuminata 27.93 1.00e-16 80.10
IUUC-Mpu-066581 Mustela putorius furo 89.17 1.00e-137 481.00
IUUC-Mlu-067434 Myotis lucifugus 88.45 5.00e-131 460.00
IUUC-Nfi-068592 Neosartorya fischeri 26.90 1.00e-16 80.10
IUUC-Ncr-068708 Neurospora crassa 32.22 6.00e-24 104.00
IUUC-Nle-070183 Nomascus leucogenys 87.73 5.00e-136 476.00
IUUC-Opr-070894 Ochotona princeps 87.36 1.00e-136 478.00
IUUC-Oan-072769 Ornithorhynchus anatinus 77.26 8.00e-127 446.00
IUUC-Ocu-073947 Oryctolagus cuniculus 88.09 1.00e-146 511.00
IUUC-Oba-075070 Oryza barthii 24.46 2.00e-14 73.60
IUUC-Obr-076808 Oryza brachyantha 24.91 1.00e-15 77.00
IUUC-Ogl-077330 Oryza glaberrima 24.58 3.00e-14 72.40
IUUC-Ogu-078072 Oryza glumaepatula 23.63 3.00e-09 55.80
IUUC-Oin-079403 Oryza indica 24.46 4.00e-14 72.40
IUUC-Ome-081922 Oryza meridionalis 20.67 1.00e-04 40.40
IUUC-Oni-082103 Oryza nivara 21.88 2.10e-02 32.30
IUUC-Opu-083915 Oryza punctata 23.76 9.00e-09 54.30
IUUC-Oru-085264 Oryza rufipogon 21.88 2.00e-02 32.70
IUUC-Osa-086002 Oryza sativa 24.58 3.00e-14 72.40
IUUC-Ola-087405 Oryzias latipes 77.66 2.00e-90 324.00
IUUC-Oga-088542 Otolemur garnettii 88.09 2.00e-136 478.00
IUUC-Oar-089270 Ovis aries 88.09 2.00e-145 508.00
IUUC-Ptr-090658 Pan troglodytes 88.81 3.00e-137 480.00
IUUC-Pan-092852 Papio anubis 87.81 6.00e-135 473.00
IUUC-Psi-093949 Pelodiscus sinensis 76.17 8.00e-125 439.00
IUUC-Pma-094220 Petromyzon marinus 48.37 1.00e-51 195.00
IUUC-Ppa-095443 Physcomitrella patens 25.00 3.00e-10 59.30
IUUC-Pfo-096277 Poecilia formosa 76.56 3.00e-90 324.00
IUUC-Pab-098550 Pongo abelii 88.81 1.00e-136 478.00
IUUC-Pop-099903 Populus trichocarpa 26.14 3.00e-15 75.90
IUUC-Pca-100150 Procavia capensis 89.17 3.00e-139 487.00
IUUC-Ppe-101240 Prunus persica 24.58 6.00e-15 74.70
IUUC-Pva-102742 Pteropus vampyrus 90.25 9.00e-141 492.00
IUUC-Pte-104396 Pyrenophora teres 29.27 2.00e-11 64.30
IUUC-Rno-105452 Rattus norvegicus 95.29 3.00e-160 557.00
IUUC-Sha-107359 Sarcophilus harrisii 84.12 6.00e-129 453.00
IUUC-Spo-108203 Schizosaccharomyces pombe 31.67 1.40e-01 30.80
IUUC-Ssl-108502 Sclerotinia sclerotiorum 33.33 4.00e-19 89.00
IUUC-Sit-110136 Setaria italica 25.86 1.00e-14 73.60
IUUC-Sly-111297 Solanum lycopersicum 24.84 1.00e-12 66.60
IUUC-Stu-112496 Solanum tuberosum 21.35 6.50e-02 30.80
IUUC-Sar-113186 Sorex araneus 87.36 4.00e-144 503.00
IUUC-Sbi-114871 Sorghum bicolor 24.81 2.00e-14 72.80
IUUC-Ssc-116149 Sus scrofa 88.81 9.00e-141 492.00
IUUC-Tsy-119353 Tarsius syrichta 98.99 2.00e-56 212.00
IUUC-Tni-120854 Tetraodon nigroviridis 73.10 3.00e-90 323.00
IUUC-Tca-121749 Theobroma cacao 24.80 6.00e-16 78.20
IUUC-Tre-122199 Trichoderma reesei 24.74 1.00e-02 32.00
IUUC-Tvi-122257 Trichoderma virens 29.52 6.00e-19 87.00
IUUC-Tae-125852 Triticum aestivum 25.70 3.00e-15 75.50
IUUC-Tme-126923 Tuber melanosporum 33.52 3.00e-26 112.00
IUUC-Tbe-127608 Tupaia belangeri 86.28 3.00e-134 471.00
IUUC-Ttr-128671 Tursiops truncatus 82.97 4.00e-134 470.00
IUUC-Vda-129697 Verticillium dahliae 33.15 3.00e-26 111.00
IUUC-Vpa-130711 Vicugna pacos 85.96 2.00e-76 278.00
IUUC-Vvi-131396 Vitis vinifera 23.21 6.00e-06 44.30
IUUC-Xtr-132491 Xenopus tropicalis 68.12 1.00e-109 388.00
IUUC-Xma-133340 Xiphophorus maculatus 76.04 1.00e-90 325.00
IUUC-Zma-134799 Zea mays 22.67 2.00e-12 66.20
Created Date 25-Jun-2017

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