iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000109046.14	ENST00000581440.5	ENSP00000462737.1
ENSG00000109046.14	ENST00000262394.6	ENSP00000262394.2
ENSG00000109046.14	ENST00000583742.1	ENSP00000462365.1
ENSG00000109046.14	ENST00000579733.5	ENSP00000461991.1
ENSG00000109046.14	ENST00000583193.5	ENSP00000462595.1
ENSG00000109046.14	ENST00000581185.5	ENSP00000464109.1
ENSG00000109046.14	ENST00000427287.6	ENSP00000416112.2
ENSG00000109046.14	ENST00000348811.6	ENSP00000327055.2
ENSG00000109046.14	ENST00000582208.1	ENSP00000463621.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	15965468; 19651899; 18093972; 17588513
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	15965468; 19651899; 18093972; 17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.20e-16	62.0	375	420
E3 adaptor/Cullin RING/DCX/DWD	4.70e-32	110.3	169	203
UBD/Beta-Prp	4.70e-48	165.6	135	378

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +++w ++++++SLqhLCR++Irr +++q++   ++LP+P++L ++L+y+
   Q: 375  VYFWATPRQVPSLQHLCRMSIRRVMPTQEV---QELPIPSKLLEFLSYR 420
           689************************999...**************97 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd..tllvsGsdDgtikvWDlrtg 33
           Ht+ v++l f +d   +lvs+s+D+t++vWDl+++
   Q: 169  HTEVVRDLTFaPDgsLILVSASRDKTLRVWDLKDD 203
           9**********8865668*************9987 PP

UBD/Beta-Prp

   S: 17   kfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsg 106
            f +d+ llatg  +g+ik+wdv tgkll  l +h++ v++++f pdg+ ilv++s+D+t++vwdl+ +g ++ +l+gh++ v+s++fsp++
   Q: 135  RFGQDQLLLATGLNNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSlILVSASRDKTLRVWDLKdDGNMMKVLRGHQNWVYSCAFSPDS 226
           5678999***********************************************************9799********************** PP
   S: 107  dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl............tgghtdsvysl 186
           + l s ++ + + +w++++++ ++  l+gh++ v    ++pdg ll+++s+D+ v +Wd  +g++l ++             g++++ v+s+
   Q: 227  SMLCSVGASKAVFLWNMDKYTMIR-KLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEFghlfppptpifaGGANDRWVRSV 317
           ************************.9******************************************************9888******** PP
   S: 187  sfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           sf+++g +++s ++d+ v++w + +      + +  +n ++ +fs ++  l+ g++Dgs+++W
   Q: 318  SFSHDGLHVASLADDKMVRFWRIDED--YPVQVAPLSNGLCCAFSTDGSVLAAGTHDGSVYFW 378
           ***********************888..68899****************************** PP

Organism

Homo sapiens

Functional Description
(View)

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation.

Protein Sequence
(Fasta)

MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL 60
VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCAGATAT CTCCGGCGCC GCCCGCCATT TTGACTCCAG TGTCTCGTTT GCAGTCGGCG 60
CTTTAGGGGA ACTGTCTTCC TCCGCAGGCG CGAGGCTGGG TACAGGGTCT ATTGTCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
GO:0000209--P:protein polyubiquitination

KEGG

hsa:26118

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001635	Ailuropoda melanoleuca	97.86	0.00e+00	837.00
IUUC-Apl-003903	Anas platyrhynchos	90.42	0.00e+00	778.00
IUUC-Aca-005214	Anolis carolinensis	78.17	0.00e+00	697.00
IUUC-Ame-011740	Astyanax mexicanus	75.06	0.00e+00	678.00
IUUC-Bta-013475	Bos taurus	97.86	0.00e+00	838.00
IUUC-Cja-019053	Callithrix jacchus	99.28	0.00e+00	866.00
IUUC-Cfa-020103	Canis familiaris	98.81	0.00e+00	843.00
IUUC-Cpo-022438	Cavia porcellus	95.72	0.00e+00	843.00
IUUC-Csa-024062	Chlorocebus sabaeus	99.29	0.00e+00	872.00
IUUC-Cho-024334	Choloepus hoffmanni	84.80	0.00e+00	705.00
IUUC-Cin-025590	Ciona intestinalis	39.65	3.00e-78	285.00
IUUC-Csv-026023	Ciona savignyi	39.67	2.00e-79	289.00
IUUC-Dre-028089	Danio rerio	75.06	0.00e+00	680.00
IUUC-Dno-029436	Dasypus novemcinctus	92.01	0.00e+00	675.00
IUUC-Dor-031107	Dipodomys ordii	90.74	0.00e+00	759.00
IUUC-Ete-032326	Echinops telfairi	93.61	0.00e+00	785.00
IUUC-Eca-033401	Equus caballus	97.39	0.00e+00	830.00
IUUC-Eeu-034520	Erinaceus europaeus	94.30	0.00e+00	837.00
IUUC-Fca-036386	Felis catus	97.86	0.00e+00	838.00
IUUC-Fal-036616	Ficedula albicollis	86.73	0.00e+00	749.00
IUUC-Gmo-039335	Gadus morhua	72.73	1.00e-179	622.00
IUUC-Gga-040856	Gallus gallus	88.36	0.00e+00	787.00
IUUC-Gac-042140	Gasterosteus aculeatus	74.18	0.00e+00	667.00
IUUC-Ggo-044619	Gorilla gorilla	99.05	0.00e+00	868.00
IUUC-Itr-048830	Ictidomys tridecemlineatus	97.39	0.00e+00	857.00
IUUC-Lch-049550	Latimeria chalumnae	80.06	3.00e-170	590.00
IUUC-Loc-051769	Lepisosteus oculatus	77.67	0.00e+00	690.00
IUUC-Laf-054576	Loxodonta africana	96.20	0.00e+00	830.00
IUUC-Mcc-054666	Macaca mulatta	99.24	3.00e-156	543.00
IUUC-Meu-055989	Macropus eugenii	88.57	0.00e+00	644.00
IUUC-Mga-059722	Meleagris gallopavo	87.95	0.00e+00	779.00
IUUC-Mmr-060970	Microcebus murinus	97.39	0.00e+00	833.00
IUUC-Mdo-062249	Monodelphis domestica	79.10	0.00e+00	652.00
IUUC-Mmu-063742	Mus musculus	92.86	0.00e+00	821.00
IUUC-Mpu-066518	Mustela putorius furo	97.15	0.00e+00	857.00
IUUC-Mlu-068063	Myotis lucifugus	95.49	0.00e+00	820.00
IUUC-Nle-069561	Nomascus leucogenys	99.29	0.00e+00	871.00
IUUC-Opr-071158	Ochotona princeps	91.90	0.00e+00	808.00
IUUC-Ont-072542	Oreochromis niloticus	73.24	0.00e+00	660.00
IUUC-Oan-073217	Ornithorhynchus anatinus	91.45	0.00e+00	805.00
IUUC-Ocu-074251	Oryctolagus cuniculus	96.58	0.00e+00	810.00
IUUC-Ola-086549	Oryzias latipes	72.30	0.00e+00	661.00
IUUC-Oga-088382	Otolemur garnettii	97.86	0.00e+00	839.00
IUUC-Oar-090263	Ovis aries	95.96	0.00e+00	837.00
IUUC-Ptr-090922	Pan troglodytes	99.29	0.00e+00	871.00
IUUC-Pan-092518	Papio anubis	99.29	0.00e+00	872.00
IUUC-Psi-093512	Pelodiscus sinensis	89.31	0.00e+00	793.00
IUUC-Pma-094324	Petromyzon marinus	58.33	3.00e-136	478.00
IUUC-Pfo-096264	Poecilia formosa	73.00	0.00e+00	664.00
IUUC-Pab-098018	Pongo abelii	97.62	0.00e+00	853.00
IUUC-Pca-101034	Procavia capensis	94.10	0.00e+00	768.00
IUUC-Pva-102862	Pteropus vampyrus	93.35	0.00e+00	769.00
IUUC-Rno-106116	Rattus norvegicus	93.35	0.00e+00	825.00
IUUC-Sha-106952	Sarcophilus harrisii	90.24	0.00e+00	756.00
IUUC-Sar-113211	Sorex araneus	84.28	2.00e-149	521.00
IUUC-Ssc-116440	Sus scrofa	98.34	0.00e+00	839.00
IUUC-Tgu-116675	Taeniopygia guttata	87.01	0.00e+00	751.00
IUUC-Tru-118295	Takifugu rubripes	72.54	0.00e+00	643.00
IUUC-Tsy-118916	Tarsius syrichta	85.04	0.00e+00	707.00
IUUC-Tni-120302	Tetraodon nigroviridis	71.60	0.00e+00	635.00
IUUC-Tbe-127416	Tupaia belangeri	83.54	0.00e+00	677.00
IUUC-Ttr-128185	Tursiops truncatus	98.10	0.00e+00	839.00
IUUC-Xtr-132465	Xenopus tropicalis	82.86	0.00e+00	741.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence