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Tag Content
UUCD2 ID IUUC-Oan-073658
UUCD1 version UUC-OrA-00873
Ensembl Protein ID ENSOANP00000021146.2
UniProt Accession F7D4T3; F7D4T3_ORNAN
Protein Name Uncharacterized protein
Gene Name CYLD
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000013398.3 ENSOANT00000021149.3 ENSOANP00000021146.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 7.20e-25 88.1 590 946
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + kek + e ++e+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 590  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGyVCATKIMKLRKILEKVEAASGF--TSEE 676
           999***************************99999999999999999999****999887899**************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksq.ik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +       k ++  ++ +++   ++  ek++k +  +i++l+++++ ++ +k    ++c  ++  r+ + ++l 
   Q: 677  KDPEEFLNILFHHILRVE--PLLKIRSAGQKVQDCYFYQIFMEKNEKVGVPTIQQLLEWSFINSsLKfaeAPSCLIIQmPRFGKDFKLF 763
           ****************99..88999999999999**************************9855144444799****99********** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPe....vLilhLkRfsfseeqksrekinkkvefpl 257
            ++  + e    +++d+Le+  ++++++g  + y+c++c+++ + +   k+k++++      +lh kR          ++ ++ v++p+
   Q: 764  KKIFPSLEL---NITDLLEDTPRQCRICGGLAmYECRECYDDPDISAG-KIKQFCKtcntQVHLHPKRQ---------THKFNPVSLPK 839
           ****99998...***************987655********9985444.66666662223466777776.........44578999997 PP
   S: 258  eLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg... 327
            L    + +        ++k eL+av++ +      HYva+vk  +++  Wl fd               +Vt+++e  e l+++    
   Q: 840  DLPDWDWRHG----CIPCQKMELFAVLCIET----SHYVAFVKYGRDDsaWLFFDSmadrdggqngfniPQVTPCPEvGEYLKMSVeel 920
           7533334333....2239**********999....9********666667999999999999999999966666655456666554666 PP
   S: 328  ................staYvlfYkr 337
                           ++aY+++Y++
   Q: 921  hsldsrriqgcarrllCDAYMCMYQS 946
           6788888888999***********85 PP
   
Organism Ornithorhynchus anatinus
Protein Sequence
(Fasta)
MSSSLWSQEK IIPPYWEERI FFLLLQECSF LDKQTQKLLK IPKGSIGQYV QDRSLGHSRI 60
PSSKGKKIQI GLKILEQPHV VLFVDEKDVV EINEKFTELL LAITNCEERY SLFKNQNRLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oan-073658|DUB,USP|Ornithorhynchus anatinus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
NNNNNNNGTG GCGCTCCGGG TCCAGGTATT ATTATTATTT TTTCTTTAGT TTTAAAGGTC 60
CGATAAATGA ACAACGATCC GCCGCCAAGA AACCGGACTC GGTCCTTCCC GGGCTCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oan-073658|DUB,USP|Ornithorhynchus anatinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00845--CAP_GLY_1
PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0097542--C:ciliary tip
GO:0005881--C:cytoplasmic microtubule
GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0030496--C:midbody
GO:0005819--C:spindle
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043369--P:CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
GO:0048872--P:homeostasis of number of cells
GO:0045087--P:innate immune response
GO:0070266--P:necroptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045581--P:negative regulation of T cell differentiation
GO:1903829--P:positive regulation of cellular protein localization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0045582--P:positive regulation of T cell differentiation
GO:0050862--P:positive regulation of T cell receptor signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:0045577--P:regulation of B cell differentiation
GO:1902017--P:regulation of cilium assembly
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0007346--P:regulation of mitotic cell cycle
GO:0043393--P:regulation of protein binding
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:1901026--P:ripoptosome assembly involved in necroptotic process
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG oaa:100090868
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 90.69 0.00e+00 1810.00
IUUC-Apl-003356 Anas platyrhynchos 87.11 0.00e+00 1689.00
IUUC-Aca-004402 Anolis carolinensis 80.86 0.00e+00 1514.00
IUUC-Ago-007723 Ashbya gossypii 52.63 4.10e-01 27.70
IUUC-Ame-011581 Astyanax mexicanus 67.91 0.00e+00 1239.00
IUUC-Bta-012359 Bos taurus 90.24 0.00e+00 1798.00
IUUC-Cel-018528 Caenorhabditis elegans 34.64 4.00e-56 213.00
IUUC-Cja-018797 Callithrix jacchus 90.06 0.00e+00 1799.00
IUUC-Cfa-020264 Canis familiaris 90.98 0.00e+00 1812.00
IUUC-Cpo-022057 Cavia porcellus 89.96 0.00e+00 1802.00
IUUC-Csa-023093 Chlorocebus sabaeus 90.66 0.00e+00 1811.00
IUUC-Cho-024486 Choloepus hoffmanni 74.67 7.00e-163 567.00
IUUC-Cin-025179 Ciona intestinalis 42.86 7.00e-115 406.00
IUUC-Cme-027227 Cyanidioschyzon merolae 36.36 3.20e-02 31.60
IUUC-Dre-028233 Danio rerio 68.11 0.00e+00 1269.00
IUUC-Dno-029496 Dasypus novemcinctus 90.66 0.00e+00 1810.00
IUUC-Dor-030919 Dipodomys ordii 85.04 0.00e+00 1669.00
IUUC-Dme-032159 Drosophila melanogaster 46.14 7.00e-124 437.00
IUUC-Ete-032734 Echinops telfairi 85.67 0.00e+00 1685.00
IUUC-Eca-033350 Equus caballus 91.19 0.00e+00 1821.00
IUUC-Eeu-034566 Erinaceus europaeus 95.70 2.00e-112 399.00
IUUC-Fca-035632 Felis catus 88.33 0.00e+00 1238.00
IUUC-Fal-037313 Ficedula albicollis 82.29 0.00e+00 1572.00
IUUC-Gmo-039239 Gadus morhua 67.91 0.00e+00 1220.00
IUUC-Gga-040668 Gallus gallus 87.21 0.00e+00 1683.00
IUUC-Gac-042630 Gasterosteus aculeatus 68.40 0.00e+00 1213.00
IUUC-Ggo-044462 Gorilla gorilla 90.59 0.00e+00 1807.00
IUUC-Hsa-045846 Homo sapiens 90.59 0.00e+00 1806.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 88.40 0.00e+00 796.00
IUUC-Lch-050303 Latimeria chalumnae 70.85 0.00e+00 1302.00
IUUC-Loc-052190 Lepisosteus oculatus 70.03 0.00e+00 1280.00
IUUC-Laf-054480 Loxodonta africana 90.98 0.00e+00 753.00
IUUC-Mcc-055849 Macaca mulatta 90.38 0.00e+00 1808.00
IUUC-Meu-056755 Macropus eugenii 79.03 0.00e+00 837.00
IUUC-Mga-059561 Meleagris gallopavo 86.73 0.00e+00 1673.00
IUUC-Mmr-060942 Microcebus murinus 90.48 0.00e+00 1797.00
IUUC-Mdo-062618 Monodelphis domestica 90.59 0.00e+00 1794.00
IUUC-Mmu-063843 Mus musculus 88.81 0.00e+00 1732.00
IUUC-Mpu-066919 Mustela putorius furo 90.87 0.00e+00 1812.00
IUUC-Mlu-066983 Myotis lucifugus 86.99 0.00e+00 1717.00
IUUC-Nle-069893 Nomascus leucogenys 90.48 0.00e+00 1805.00
IUUC-Opr-071181 Ochotona princeps 82.91 0.00e+00 1507.00
IUUC-Ont-071697 Oreochromis niloticus 67.35 0.00e+00 1202.00
IUUC-Ocu-074954 Oryctolagus cuniculus 90.69 0.00e+00 1812.00
IUUC-Ola-086523 Oryzias latipes 66.77 0.00e+00 1192.00
IUUC-Oga-089003 Otolemur garnettii 90.48 0.00e+00 1813.00
IUUC-Oar-090376 Ovis aries 89.90 0.00e+00 1802.00
IUUC-Ptr-090520 Pan troglodytes 88.81 0.00e+00 1756.00
IUUC-Pan-092281 Papio anubis 90.66 0.00e+00 1811.00
IUUC-Psi-093047 Pelodiscus sinensis 88.49 0.00e+00 1619.00
IUUC-Pma-094575 Petromyzon marinus 56.81 3.00e-66 243.00
IUUC-Pfo-096358 Poecilia formosa 66.77 0.00e+00 1145.00
IUUC-Pab-097740 Pongo abelii 90.06 0.00e+00 1798.00
IUUC-Pca-100461 Procavia capensis 81.68 0.00e+00 1463.00
IUUC-Pva-102134 Pteropus vampyrus 81.07 0.00e+00 1590.00
IUUC-Rno-105807 Rattus norvegicus 87.62 0.00e+00 1702.00
IUUC-Sha-107236 Sarcophilus harrisii 91.03 0.00e+00 1747.00
IUUC-Sar-113366 Sorex araneus 96.89 0.00e+00 928.00
IUUC-Tgu-117201 Taeniopygia guttata 83.89 0.00e+00 1604.00
IUUC-Tru-117953 Takifugu rubripes 68.26 0.00e+00 1201.00
IUUC-Tsy-119610 Tarsius syrichta 88.70 0.00e+00 1764.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.64 2.00e-162 565.00
IUUC-Tbe-128155 Tupaia belangeri 74.12 0.00e+00 716.00
IUUC-Ttr-128942 Tursiops truncatus 84.94 0.00e+00 1682.00
IUUC-Vpa-130281 Vicugna pacos 80.10 0.00e+00 1553.00
IUUC-Xtr-132627 Xenopus tropicalis 76.86 0.00e+00 1416.00
Created Date 25-Jun-2017

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