iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067647

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02028910

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000003700.2	ENSMLUT00000003702.2	ENSMLUP00000003371.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.20e-08	34.0	20	59
E3 activity/RING/U-box	3.10e-09	36.8	16	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++  + p++  CgH f+++C+ ++      + +  +CP+Cr
   Q: 20   CPICLDPTVE-PVSIECGHSFCQECISQV-----AKAGGGTCPVCR 59
           ********99.***************888.....6899999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ee  CpI l++  +Pv +++G+++ +++I +  + gg tcPv+r+++  +++ Pnl l +++++
   Q: 16   EEVTCPICLDPTVEPVSIECGHSFCQECISQVAKAGGGTCPVCRKQFLLKNFRPNLQLANMVDN 79
           6889***************************9999999********************999876 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

EHPAMASAKP LAMMWEEVTC PICLDPTVEP VSIECGHSFC QECISQVAKA GGGTCPVCRK 60
QFLLKNFRPN LQLANMVDNL RQISQNAKEG TQKEQCGVHG ERLLLFCERD EKALCLVCSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAACATCCCG CCATGGCCTC AGCAAAGCCC TTGGCAATGA TGTGGGAGGA GGTCACATGC 60
CCCATCTGCC TGGATCCCAC AGTGGAGCCT GTGAGCATTG AATGTGGCCA CAGCTTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	79.44	0.00e+00	783.00
IUUC-Aca-004891	Anolis carolinensis	43.88	4.00e-96	345.00
IUUC-Ang-009772	Aspergillus niger	40.32	5.00e-08	50.80
IUUC-Bta-013083	Bos taurus	72.29	0.00e+00	669.00
IUUC-Cja-019002	Callithrix jacchus	79.35	0.00e+00	755.00
IUUC-Cfa-020415	Canis familiaris	78.37	0.00e+00	772.00
IUUC-Cpo-021948	Cavia porcellus	70.49	0.00e+00	682.00
IUUC-Csa-023135	Chlorocebus sabaeus	80.30	0.00e+00	699.00
IUUC-Cho-024493	Choloepus hoffmanni	68.88	3.00e-99	354.00
IUUC-Cne-026875	Cryptococcus neoformans	36.07	6.00e-08	52.80
IUUC-Dno-030061	Dasypus novemcinctus	73.05	0.00e+00	716.00
IUUC-Ete-033168	Echinops telfairi	69.38	5.00e-167	580.00
IUUC-Eca-033578	Equus caballus	81.84	0.00e+00	771.00
IUUC-Eeu-034749	Erinaceus europaeus	58.26	2.00e-133	469.00
IUUC-Fca-035468	Felis catus	75.36	0.00e+00	724.00
IUUC-Fal-036705	Ficedula albicollis	41.92	3.00e-78	285.00
IUUC-Gac-042446	Gasterosteus aculeatus	37.74	3.00e-70	258.00
IUUC-Ggo-045190	Gorilla gorilla	79.66	0.00e+00	728.00
IUUC-Hsa-046583	Homo sapiens	79.44	0.00e+00	728.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	74.57	0.00e+00	672.00
IUUC-Kpa-049137	Komagataella pastoris	34.43	4.00e-10	59.30
IUUC-Laf-053455	Loxodonta africana	75.34	0.00e+00	676.00
IUUC-Mcc-054609	Macaca mulatta	80.09	0.00e+00	696.00
IUUC-Mtr-058638	Medicago truncatula	48.94	2.00e-09	55.80
IUUC-Mmr-061369	Microcebus murinus	72.79	2.00e-177	615.00
IUUC-Mmu-063166	Mus musculus	69.63	0.00e+00	644.00
IUUC-Mpu-066889	Mustela putorius furo	77.94	0.00e+00	771.00
IUUC-Nle-069567	Nomascus leucogenys	79.44	0.00e+00	726.00
IUUC-Opr-071178	Ochotona princeps	64.24	2.00e-166	578.00
IUUC-Ola-086552	Oryzias latipes	31.73	8.00e-57	214.00
IUUC-Oar-090413	Ovis aries	77.63	0.00e+00	698.00
IUUC-Ptr-091187	Pan troglodytes	79.44	0.00e+00	728.00
IUUC-Pan-092231	Papio anubis	80.09	0.00e+00	696.00
IUUC-Pab-098079	Pongo abelii	74.79	4.00e-142	497.00
IUUC-Pca-100639	Procavia capensis	73.26	5.00e-144	504.00
IUUC-Pva-102476	Pteropus vampyrus	82.66	0.00e+00	775.00
IUUC-Rno-105054	Rattus norvegicus	69.44	2.00e-167	582.00
IUUC-Sar-113204	Sorex araneus	76.01	0.00e+00	675.00
IUUC-Ssc-116291	Sus scrofa	76.61	0.00e+00	714.00
IUUC-Tsy-118803	Tarsius syrichta	73.11	1.00e-130	459.00
IUUC-Tni-119658	Tetraodon nigroviridis	31.55	7.00e-58	218.00
IUUC-Ttr-128914	Tursiops truncatus	76.23	0.00e+00	655.00
IUUC-Vpa-130566	Vicugna pacos	75.37	0.00e+00	669.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence