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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Sce-106402
UUCD1 version UUC-SaC-00041
Ensembl Protein ID YNL116W
UniProt Accession P53924; B0KZS8; B0KZU6; B0KZW4; B0L009; D6W166; Q66GT0; DMA2_YEAST
Genbank Protein ID ABN58541.1; ABN58550.1; ABN58559.1; ABN58568.1; ABN58576.1; ABN58586.1; ABN58595.1; ABN58604.1; ABN58613.1; ABN58622.1; ABN58631.1; ABN58649.1; CAA93391.1; CAA95996.1; DAA05594.1; DAA10432.1
Protein Name E3 ubiquitin-protein ligase DMA2; Checkpoint forkhead associated with RING domains-containing protein 1; Defective in mitotic arrest protein 2; RING-type E3 ubiquitin transferase DMA2
Genbank Nucleotide ID EF125216; EF125217; EF125218; EF125219; EF125220; EF125221; EF125222; EF125223; EF125224; EF125225; EF125226; EF125228; Z69382; Z71392; BK005579; BK006947
Gene Name DMA2; CHF2; YNL116W; N1925
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YNL116W YNL116W YNL116W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18597043
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.0014 17.6 433 477
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
    C+iCl+ + ++ ++ pC H +h+ C+ ++ +s+++f CP Cr
   Q: 433 CSICLCKIkpCQAIFISPCAHSWHFRCVRRL---VMLSYPQFVCPNCR 477
    ******9955333899***********9777...5669*********8 PP
   

Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.
E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes. Involved in nutritional control of the cell cycle. Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck.
Protein Sequence
(Fasta)
MYTPIPANTP APTAPTSSMT SNSSSASNAN TTSSSGINPR NRASGTPSNE RARPASGISS 60
FLNTFGIRQN SQTASSSAAP DQRLFGTTPS NSHMSVAMES IDTAPQQQEP RLHHPIQMPL 120
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Protein Fasta Sequence



>IUUC-Sce-106402|E3,RING|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTACACGC CTATCCCTGC TAATACCCCT GCTCCCACTG CACCAACTTC ATCGATGACG 60
TCCAACTCTT CATCCGCATC AAATGCCAAC ACCACTAGCA GTAGTGGCAT AAACCCAAGG 120
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Nucleotide Fasta Sequence



>IUUC-Sce-106402|E3,RING|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50006--FHA_DOMAIN
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF17123--zf-RING_11

SMART

SM00240--FHA

Gene Ontology

GO:0032177--C:cellular bud neck split septin rings
GO:0005934--C:cellular bud tip
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032186--P:cellular bud neck septin ring organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0031578--P:mitotic spindle orientation checkpoint
GO:0051865--P:protein autoubiquitination
GO:0097271--P:protein localization to bud neck
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090337--P:regulation of formin-nucleated actin cable assembly
GO:0000921--P:septin ring assembly

KEGG sce:YNL116W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Atr-002947 Amborella trichopoda 34.38 1.00e-06 43.90
IUUC-Aca-005036 Anolis carolinensis 36.67 2.00e-07 48.50
IUUC-Ath-006857 Arabidopsis thaliana 33.71 1.00e-07 48.90
IUUC-Ago-007705 Ashbya gossypii 71.54 3.00e-121 426.00
IUUC-Acl-008234 Aspergillus clavatus 46.32 1.00e-53 202.00
IUUC-Afl-008606 Aspergillus flavus 44.44 2.00e-45 175.00
IUUC-Afu-008908 Aspergillus fumigatus 39.21 6.00e-36 143.00
IUUC-Aor-009904 Aspergillus oryzae 46.98 2.00e-50 191.00
IUUC-Ate-010354 Aspergillus terreus 47.81 3.00e-52 197.00
IUUC-Bol-015277 Brassica oleracea 35.16 6.00e-07 46.60
IUUC-Cja-018953 Callithrix jacchus 31.37 8.00e-07 45.80
IUUC-Cpo-022372 Cavia porcellus 32.63 5.00e-07 46.20
IUUC-Cgl-026486 Colletotrichum gloeosporioides 50.65 1.00e-62 231.00
IUUC-Cne-026927 Cryptococcus neoformans 43.33 4.00e-47 181.00
IUUC-Dno-029774 Dasypus novemcinctus 34.83 6.00e-08 50.10
IUUC-Dse-031157 Dothistroma septosporum 47.48 4.00e-59 220.00
IUUC-Eca-033607 Equus caballus 40.35 2.00e-07 48.10
IUUC-Fal-037569 Ficedula albicollis 43.86 6.00e-09 53.50
IUUC-Fox-037681 Fusarium oxysporum 53.39 3.00e-64 237.00
IUUC-Fso-038129 Fusarium solani 43.40 2.00e-50 191.00
IUUC-Gmo-038588 Gadus morhua 35.38 2.00e-05 41.60
IUUC-Ggr-039871 Gaeumannomyces graminis 50.22 7.00e-61 226.00
IUUC-Gga-040777 Gallus gallus 43.86 3.00e-09 54.70
IUUC-Kpa-049298 Komagataella pastoris 59.21 2.00e-73 266.00
IUUC-Lch-049805 Latimeria chalumnae 33.63 2.00e-10 58.50
IUUC-Lpe-050916 Leersia perrieri 42.55 1.00e-06 47.00
IUUC-Loc-051914 Lepisosteus oculatus 31.03 8.00e-07 46.20
IUUC-Lma-053220 Leptosphaeria maculans 47.68 3.00e-55 207.00
IUUC-Mor-057012 Magnaporthe oryzae 51.30 7.00e-65 239.00
IUUC-Mpo-057371 Magnaporthe poae 53.49 8.00e-14 69.70
IUUC-Mla-058879 Melampsora laricipopulina 46.31 1.00e-53 201.00
IUUC-Mga-060049 Meleagris gallopavo 45.61 1.00e-09 55.50
IUUC-Mdo-062016 Monodelphis domestica 34.48 4.00e-08 52.40
IUUC-Mac-065139 Musa acuminata 44.00 9.00e-08 50.10
IUUC-Mlu-068174 Myotis lucifugus 40.98 7.00e-07 47.40
IUUC-Nfi-068378 Neosartorya fischeri 47.62 8.00e-55 206.00
IUUC-Ncr-068692 Neurospora crassa 51.71 3.00e-65 241.00
IUUC-Opr-070300 Ochotona princeps 40.35 7.00e-06 43.10
IUUC-Oan-073250 Ornithorhynchus anatinus 33.33 5.00e-07 43.90
IUUC-Oba-075378 Oryza barthii 38.98 5.00e-07 48.90
IUUC-Ogl-076930 Oryza glaberrima 41.67 7.00e-07 47.00
IUUC-Ogu-078193 Oryza glumaepatula 39.34 3.00e-06 46.60
IUUC-Oin-080046 Oryza indica 43.75 2.00e-07 48.50
IUUC-Oni-082348 Oryza nivara 42.00 3.00e-06 46.60
IUUC-Opu-083145 Oryza punctata 43.75 2.00e-06 46.60
IUUC-Oru-085151 Oryza rufipogon 42.00 3.00e-06 46.60
IUUC-Osa-086063 Oryza sativa 38.98 9.00e-09 53.90
IUUC-Psi-093038 Pelodiscus sinensis 35.96 5.00e-09 53.10
IUUC-Pno-094949 Phaeosphaeria nodorum 43.12 1.00e-31 128.00
IUUC-Pfo-097514 Poecilia formosa 29.73 3.00e-06 44.30
IUUC-Pop-099775 Populus trichocarpa 33.33 3.00e-06 45.10
IUUC-Pca-100201 Procavia capensis 40.98 9.00e-07 47.00
IUUC-Ppe-101276 Prunus persica 38.81 2.00e-07 46.20
IUUC-Ptt-103791 Puccinia triticina 47.45 5.00e-37 146.00
IUUC-Pte-104124 Pyrenophora teres 46.41 1.00e-53 202.00
IUUC-Pyt-104430 Pyrenophora triticirepentis 46.64 9.00e-54 202.00
IUUC-Sha-107202 Sarcophilus harrisii 40.98 8.00e-07 47.40
IUUC-Sja-107979 Schizosaccharomyces japonicus 43.23 8.00e-48 181.00
IUUC-Spo-108168 Schizosaccharomyces pombe 44.98 5.00e-50 189.00
IUUC-Stu-112794 Solanum tuberosum 43.75 8.00e-07 47.00
IUUC-Sre-115012 Sporisorium reilianum 46.70 9.00e-48 183.00
IUUC-Tre-121954 Trichoderma reesei 51.08 2.00e-62 231.00
IUUC-Tvi-122295 Trichoderma virens 51.75 3.00e-64 237.00
IUUC-Tme-126881 Tuber melanosporum 48.50 2.00e-61 228.00
IUUC-Uma-129400 Ustilago maydis 36.24 3.00e-47 181.00
IUUC-Vda-130024 Verticillium dahliae 50.66 1.00e-62 232.00
IUUC-Vpa-130154 Vicugna pacos 33.71 2.00e-07 48.10
IUUC-Vvi-131426 Vitis vinifera 33.33 1.00e-07 47.40
IUUC-Xma-133568 Xiphophorus maculatus 29.73 3.00e-06 44.30
IUUC-Yli-134472 Yarrowia lipolytica 50.00 2.00e-63 234.00
Created Date 25-Jun-2017

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