iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aly-005515

UUCD1 version

UUC-ArL-01191

Ensembl Protein ID

fgenesh2_kg.6__589__AT5G06460.1

UniProt Accession

D7LZQ7; D7LZQ7_ARALL

Genbank Protein ID

EFH47478.1

Protein Name

ATUBA2

Genbank Nucleotide ID

GL348718

Gene Name

ATUBA2; ARALYDRAFT_487455

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
fgenesh2_kg.6__589__AT5G06460.1	fgenesh2_kg.6__589__AT5G06460.1	fgenesh2_kg.6__589__AT5G06460.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.40e-170	567.4	474	961

Active Site

Position(s)	Description	Evidence
655	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksK 73
           YD Qi ++G++ q+kl+ a+v++vGag+lGcE+lKnL+l+Gv     g++tv+D+d +e+snl+rqFLfr++++g+ K
   Q: 474  YDAQISVFGSTLQKKLEDARVFVVGAGALGCEFLKNLALMGVscgtqGKLTVTDDDVIEKSNLSRQFLFRDWNIGQAK 551
           ****************************************************************************** PP
   S: 74   Aevaaealkelnpdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGq 148
           + vaa a++ +n+  n++a ++++ +++e+++   F ++++vVv+aldn+ ar++v+++c++ ++pl+esgtlG + +
   Q: 552  STVAATAAAGINSCLNIDALQNRVGPETENVFddsFWENLTVVVNALDNVTARLYVDSRCVYFQKPLLESGTLGAKCN 629
           ******************************99********************************************** PP
   S: 149  vrviikgltecyscsddppqktiPfctlketpnaaehtiewa............vlfnklleeeageeevlekldsee 214
           ++ +i++lte y +s+dpp+k++P+ct+ ++p +++h+++wa            + +n +l++  +  +  +    ++
   Q: 630  TQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWArsefegllektpAEVNAYLSDPVEYMKAMSTAGDAQ 707
           ************************************************999999777888877777777777778889 PP
   S: 215  keegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv.................. 274
            ++++ +v + l++e+ ++f+++i++a+  f+ ++ n +kql   f+ d  t+ ++pfw+                  
   Q: 708  ARDTLGRVVECLEKEKCNSFQDCITWARLRFEDYFANRVKQLCYTFPEDAATSTGAPFWSapkrfprplqfsstdlgh 785
           99999999999999**************************************************************** PP
   S: 275  .......................................sfcsnaealqvpekvekdeevvkasap..lylllrale. 310
                                                   f++ ++a  v +  +    + +++++  +  l ++le 
   Q: 786  infvmaasilraetfgiptpewakdptglaeavervivpDFEPRKDANIVTDEKATTLSTASVDDAaiIDELNTKLEw 863
           ***************************999999999999777776666655555555555555555576666666663 PP
   S: 311  .rfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEvi 385
            r + +++  ++ ++fekddd   ++d+++ +an+ra ++++++ +d+ + k iag+iipaiat +a+  Gl+++E++
   Q: 864  cRRSLQPEFRMKPIQFEKDDDTnyHMDMIAGLANMRARNYSVPE-VDKLKAKFIAGRIIPAIATSTAMATGLVCLELY 940
           3556788999999*******************************.********************************* PP
   S: 386  Kvvsg..kfeplknfflfdae 404
           Kv++g  k e ++n+f ++a+
   Q: 941  KVLDGshKVEDYRNTFANLAL 961
           ****99999*******99875 PP

Organism

Arabidopsis lyrata

Protein Sequence
(Fasta)

MEPFVAKENI IASASSPMKK RRIDHTESTK ADGSAINASN SGSIGLNNSI GGNDTVMNMA 60
EFGNDNSNNQ EIDEDLHSRQ LAVYGRETMR KLFASNVLIS GMQGLGVEIA KNIILAGVKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTTTAACA ACAAATTCGC CGCTTATCGC CTCCGATCTT CTCTCAAAGG TACGGTTTCG 60
TTTTCTTCTT CTCCGATTCT CGTTTCTTCT TCAGATTCCT TCATCGATTA GCTCTAGGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0016881--F:acid-amino acid ligase activity
GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

aly:ARALYDRAFT_487455

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	45.32	0.00e+00	886.00
IUUC-Apl-004158	Anas platyrhynchos	39.16	0.00e+00	683.00
IUUC-Aca-004620	Anolis carolinensis	45.85	0.00e+00	893.00
IUUC-Ath-006891	Arabidopsis thaliana	96.11	0.00e+00	2089.00
IUUC-Ago-007873	Ashbya gossypii	45.67	0.00e+00	838.00
IUUC-Ani-009371	Aspergillus nidulans	45.55	0.00e+00	808.00
IUUC-Ang-009737	Aspergillus niger	45.21	0.00e+00	808.00
IUUC-Ame-010933	Astyanax mexicanus	45.12	0.00e+00	868.00
IUUC-Bgr-012281	Blumeria graminis	44.60	0.00e+00	834.00
IUUC-Bta-012767	Bos taurus	46.13	0.00e+00	902.00
IUUC-Bci-013721	Botrytis cinerea	45.97	0.00e+00	799.00
IUUC-Bol-015665	Brassica oleracea	90.19	0.00e+00	1975.00
IUUC-Bra-017522	Brassica rapa	92.84	0.00e+00	1891.00
IUUC-Cel-018260	Caenorhabditis elegans	37.11	0.00e+00	655.00
IUUC-Cja-019152	Callithrix jacchus	45.51	0.00e+00	892.00
IUUC-Cfa-020622	Canis familiaris	44.86	0.00e+00	850.00
IUUC-Cpo-022526	Cavia porcellus	45.64	0.00e+00	881.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	59.96	0.00e+00	1173.00
IUUC-Csa-023780	Chlorocebus sabaeus	45.84	0.00e+00	894.00
IUUC-Cho-024682	Choloepus hoffmanni	36.71	1.00e-104	374.00
IUUC-Cin-025790	Ciona intestinalis	44.47	0.00e+00	877.00
IUUC-Csv-026084	Ciona savignyi	43.09	0.00e+00	869.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	46.73	0.00e+00	877.00
IUUC-Dre-028149	Danio rerio	45.30	0.00e+00	892.00
IUUC-Dno-028884	Dasypus novemcinctus	45.94	0.00e+00	895.00
IUUC-Dor-030229	Dipodomys ordii	43.98	0.00e+00	843.00
IUUC-Dse-031524	Dothistroma septosporum	42.65	0.00e+00	827.00
IUUC-Eca-033330	Equus caballus	45.56	0.00e+00	889.00
IUUC-Eeu-035323	Erinaceus europaeus	40.26	2.00e-150	525.00
IUUC-Fca-036255	Felis catus	45.84	0.00e+00	884.00
IUUC-Fal-036848	Ficedula albicollis	38.74	0.00e+00	691.00
IUUC-Fox-038007	Fusarium oxysporum	45.83	6.00e-132	463.00
IUUC-Fso-038339	Fusarium solani	46.76	0.00e+00	826.00
IUUC-Gmo-039338	Gadus morhua	43.74	0.00e+00	840.00
IUUC-Ggr-039823	Gaeumannomyces graminis	44.82	0.00e+00	865.00
IUUC-Gga-040747	Gallus gallus	39.51	0.00e+00	694.00
IUUC-Gac-041773	Gasterosteus aculeatus	43.32	0.00e+00	851.00
IUUC-Ggo-045336	Gorilla gorilla	45.74	0.00e+00	877.00
IUUC-Hsa-045982	Homo sapiens	45.74	0.00e+00	876.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	45.94	0.00e+00	895.00
IUUC-Kpa-049112	Komagataella pastoris	46.58	0.00e+00	875.00
IUUC-Lch-050371	Latimeria chalumnae	44.74	0.00e+00	894.00
IUUC-Lpe-051299	Leersia perrieri	75.40	0.00e+00	1609.00
IUUC-Loc-052936	Lepisosteus oculatus	45.12	0.00e+00	890.00
IUUC-Lma-053315	Leptosphaeria maculans	46.45	0.00e+00	879.00
IUUC-Laf-053948	Loxodonta africana	45.03	0.00e+00	871.00
IUUC-Mcc-055843	Macaca mulatta	45.84	0.00e+00	895.00
IUUC-Meu-056258	Macropus eugenii	45.33	0.00e+00	877.00
IUUC-Mla-059176	Melampsora laricipopulina	47.01	0.00e+00	866.00
IUUC-Mga-059721	Meleagris gallopavo	40.06	0.00e+00	675.00
IUUC-Mvi-060437	Microbotryum violaceum	43.60	0.00e+00	821.00
IUUC-Mmr-061405	Microcebus murinus	44.97	0.00e+00	854.00
IUUC-Mdo-062032	Monodelphis domestica	45.03	0.00e+00	860.00
IUUC-Mmu-063721	Mus musculus	46.15	0.00e+00	905.00
IUUC-Mac-065505	Musa acuminata	76.81	0.00e+00	1651.00
IUUC-Mpu-066409	Mustela putorius furo	45.84	0.00e+00	896.00
IUUC-Mlu-067217	Myotis lucifugus	45.45	0.00e+00	884.00
IUUC-Ncr-068698	Neurospora crassa	46.18	0.00e+00	860.00
IUUC-Nle-070072	Nomascus leucogenys	42.91	0.00e+00	799.00
IUUC-Opr-070715	Ochotona princeps	35.59	1.00e-151	530.00
IUUC-Ont-071671	Oreochromis niloticus	44.76	0.00e+00	880.00
IUUC-Oan-073268	Ornithorhynchus anatinus	40.57	0.00e+00	632.00
IUUC-Ocu-074544	Oryctolagus cuniculus	46.13	0.00e+00	899.00
IUUC-Oin-079370	Oryza indica	75.95	0.00e+00	1599.00
IUUC-Ola-087002	Oryzias latipes	45.59	0.00e+00	897.00
IUUC-Oga-088594	Otolemur garnettii	44.60	0.00e+00	877.00
IUUC-Oar-090068	Ovis aries	45.94	0.00e+00	897.00
IUUC-Ptr-090609	Pan troglodytes	38.34	0.00e+00	678.00
IUUC-Pan-092114	Papio anubis	45.84	0.00e+00	895.00
IUUC-Psi-093489	Pelodiscus sinensis	38.45	0.00e+00	681.00
IUUC-Pno-095154	Phaeosphaeria nodorum	45.14	0.00e+00	852.00
IUUC-Ppa-095227	Physcomitrella patens	70.67	0.00e+00	1504.00
IUUC-Pfo-097184	Poecilia formosa	45.07	0.00e+00	880.00
IUUC-Pab-097861	Pongo abelii	45.54	0.00e+00	861.00
IUUC-Pca-100347	Procavia capensis	42.83	0.00e+00	710.00
IUUC-Pva-102584	Pteropus vampyrus	46.03	0.00e+00	922.00
IUUC-Pgr-103336	Puccinia graminis	45.99	0.00e+00	823.00
IUUC-Ptt-103939	Puccinia triticina	46.98	0.00e+00	828.00
IUUC-Pte-104200	Pyrenophora teres	46.74	0.00e+00	888.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	46.21	0.00e+00	883.00
IUUC-Rno-105462	Rattus norvegicus	45.64	0.00e+00	877.00
IUUC-Sce-106245	Saccharomyces cerevisiae	45.02	0.00e+00	875.00
IUUC-Sha-107142	Sarcophilus harrisii	45.61	0.00e+00	887.00
IUUC-Spo-108034	Schizosaccharomyces pombe	44.05	0.00e+00	832.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	45.48	0.00e+00	821.00
IUUC-Sar-113737	Sorex araneus	45.89	0.00e+00	888.00
IUUC-Sbi-114520	Sorghum bicolor	79.17	0.00e+00	1656.00
IUUC-Sre-115148	Sporisorium reilianum	44.73	0.00e+00	818.00
IUUC-Ssc-115777	Sus scrofa	45.51	0.00e+00	891.00
IUUC-Tgu-116565	Taeniopygia guttata	38.45	0.00e+00	680.00
IUUC-Tru-118742	Takifugu rubripes	45.50	0.00e+00	850.00
IUUC-Tsy-119436	Tarsius syrichta	33.53	6.00e-159	554.00
IUUC-Tni-120401	Tetraodon nigroviridis	44.83	0.00e+00	845.00
IUUC-Tvi-122259	Trichoderma virens	45.72	0.00e+00	837.00
IUUC-Tbe-127714	Tupaia belangeri	36.39	7.00e-139	487.00
IUUC-Ttr-128331	Tursiops truncatus	45.74	0.00e+00	882.00
IUUC-Uma-129387	Ustilago maydis	45.12	0.00e+00	827.00
IUUC-Vda-129977	Verticillium dahliae	47.42	0.00e+00	805.00
IUUC-Vpa-130716	Vicugna pacos	37.66	0.00e+00	664.00
IUUC-Xtr-132026	Xenopus tropicalis	40.44	0.00e+00	670.00
IUUC-Xma-133805	Xiphophorus maculatus	44.55	0.00e+00	863.00
IUUC-Zma-135758	Zea mays	78.15	0.00e+00	1632.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence