iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ani-009371

Ensembl Protein ID

CADANIAP00008853

UniProt Accession

C8VMA9; C8VMA9_EMENI

Genbank Protein ID

CBF86317.1

Protein Name

E1 ubiquitin activating enzyme (Eurofung)

Genbank Nucleotide ID

BN001307

Gene Name

ANIA_10266

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADANIAG00008853	CADANIAT00008853	CADANIAP00008853

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.30e-195	647.2	422	909

Active Site

Position(s)	Description	Evidence
605	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv 88
           YD+Qi+++G e q+k+ +   +lvGag++GcE+lKn +++G+     g+i+v+Dmd++e+snlnrqFLfr +dvgk K+e+a +a+  +np  
   Q: 422  YDGQIAVFGKEFQDKIANLTQFLVGAGAIGCETLKNWAMMGLgtgpkGKIYVTDMDQIEKSNLNRQFLFRSKDVGKLKSECASAAAVAMNPEL 514
           ********************************************************************************************* PP
   S: 89   nveah..eesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctl 176
           +++++  ++++ +++e+i+   F + +d+V +aldn+ear++v+r+c+  r+pl+esgtlG++G+++v+++ +te+ys+s+dpp+k++P+ctl
   Q: 515  EGKIVtlKDRVGPDTEHIFneeFWEGLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVLPRITESYSSSQDPPEKSFPMCTL 607
           9776522689*******99999*********************************************************************** PP
   S: 177  ketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqll 257
           k++pn +ehti wa            + +n++l++ +  e++l++  + + +++++  ++ l++e++ nf+++i +a+++f+ +++n i+qll
   Q: 608  KSFPNRIEHTIAWArdlfqtyfvgppEAVNMYLSQPNYIEQTLKQ--AGNEKQTLEHLRDFLVTEKPANFDDCIVWARNQFEAQYNNAIQQLL 698
           **************************9999999887777777764..345555555556679999**************************** PP
   S: 258  ksfecdivtkskspfwv............................................................sfcsnaealqvpekve 290
            +f+ d  t+ ++pfw+                                                            s ++ +++ + p+ ++
   Q: 699  YNFPRDSTTSTGQPFWSgpkraptplkfdstnpthlgfiiaganlhaynygiknpgvdkgyyrkivdnmiipeftpkSGVKIQASDNDPDPNA 791
           ************************************************************************999988888888888888888 PP
   S: 291  kdeevvkasap.lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGla 380
           +    + ++++ ++ l+++l + ++ +g   + ++fekddd   ++d++taa+nlrae+++i p +d++++k iag+iipaiatt+a v Gl+
   Q: 792  EASGSSFDDNDeIKRLVEILPSPKSLEGFRLNPVEFEKDDDTnhHIDFITAASNLRAENYEITP-ADRHKTKFIAGKIIPAIATTTALVTGLV 883
           877776666667*****************************999********************.**************************** PP
   S: 381  aqEviKvvsg..kfeplknfflfdae 404
           a+E++K+++g  + e++kn f+++a+
   Q: 884  ALELLKIIDGkdDIEQYKNGFVNLAL 909
           **********777889*****99875 PP

Organism

Aspergillus nidulans

Protein Sequence
(Fasta)

MTDTKMQVDT PTQDTVEKIK QGDIDESLYS RQLYVLGHEA MKRMGSSNVL VVGLKGLGVE 60
IAKNIALAGV KSLTLYDPAP VAISDLSSQF FLQPQDVGKP RAEVTAPRVA ELNSYVPVTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGTAT GTTTGGCCGT GCTTTGTACT TGAGACGCTT ATTCTGATTT GTTTAGGACA 60
CCAAGATGCA GGTCGATACT CCCACACAAG ACACGGTCGA GAAAATCAAA CAAGGCGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0097308--P:cellular response to farnesol

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.49	0.00e+00	813.00
IUUC-Aml-001311	Ailuropoda melanoleuca	53.38	0.00e+00	1095.00
IUUC-Atr-002684	Amborella trichopoda	45.82	0.00e+00	852.00
IUUC-Apl-004158	Anas platyrhynchos	43.23	0.00e+00	710.00
IUUC-Aca-004620	Anolis carolinensis	54.54	0.00e+00	1090.00
IUUC-Aly-005515	Arabidopsis lyrata	45.66	0.00e+00	863.00
IUUC-Ath-006891	Arabidopsis thaliana	45.56	0.00e+00	869.00
IUUC-Ago-007873	Ashbya gossypii	61.15	0.00e+00	1199.00
IUUC-Acl-008181	Aspergillus clavatus	87.69	0.00e+00	1844.00
IUUC-Afl-008455	Aspergillus flavus	88.30	0.00e+00	1794.00
IUUC-Afu-009065	Aspergillus fumigatus	88.80	0.00e+00	1880.00
IUUC-Ang-009737	Aspergillus niger	89.26	0.00e+00	1872.00
IUUC-Aor-010007	Aspergillus oryzae	88.44	0.00e+00	1786.00
IUUC-Ate-010466	Aspergillus terreus	88.00	0.00e+00	1890.00
IUUC-Ame-010933	Astyanax mexicanus	54.54	0.00e+00	1046.00
IUUC-Bgr-012281	Blumeria graminis	68.93	0.00e+00	1479.00
IUUC-Bta-012767	Bos taurus	53.77	0.00e+00	1105.00
IUUC-Bci-013721	Botrytis cinerea	72.14	0.00e+00	1479.00
IUUC-Bdi-014009	Brachypodium distachyon	45.02	0.00e+00	849.00
IUUC-Bol-015665	Brassica oleracea	46.54	0.00e+00	871.00
IUUC-Bra-017252	Brassica rapa	45.76	0.00e+00	871.00
IUUC-Cel-018260	Caenorhabditis elegans	45.02	0.00e+00	810.00
IUUC-Cja-019152	Callithrix jacchus	53.60	0.00e+00	1088.00
IUUC-Cfa-020622	Canis familiaris	52.03	0.00e+00	1037.00
IUUC-Cpo-022526	Cavia porcellus	53.87	0.00e+00	1083.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.76	0.00e+00	795.00
IUUC-Csa-023780	Chlorocebus sabaeus	53.77	0.00e+00	1094.00
IUUC-Cho-024682	Choloepus hoffmanni	42.62	3.00e-99	354.00
IUUC-Cin-025790	Ciona intestinalis	52.96	0.00e+00	1086.00
IUUC-Csv-026084	Ciona savignyi	52.93	0.00e+00	1087.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	71.07	0.00e+00	1539.00
IUUC-Cne-026960	Cryptococcus neoformans	60.74	0.00e+00	1233.00
IUUC-Cme-027290	Cyanidioschyzon merolae	44.65	0.00e+00	843.00
IUUC-Dre-028149	Danio rerio	54.83	0.00e+00	1083.00
IUUC-Dno-028884	Dasypus novemcinctus	53.58	0.00e+00	1097.00
IUUC-Dor-030229	Dipodomys ordii	51.64	0.00e+00	1031.00
IUUC-Dse-031524	Dothistroma septosporum	72.67	0.00e+00	1516.00
IUUC-Dme-032045	Drosophila melanogaster	52.11	0.00e+00	1016.00
IUUC-Ete-033124	Echinops telfairi	41.98	4.00e-149	520.00
IUUC-Eca-033330	Equus caballus	53.58	0.00e+00	1094.00
IUUC-Eeu-035323	Erinaceus europaeus	43.48	1.00e-154	539.00
IUUC-Fca-036255	Felis catus	53.68	0.00e+00	1091.00
IUUC-Fal-036848	Ficedula albicollis	43.39	0.00e+00	719.00
IUUC-Fox-038007	Fusarium oxysporum	70.33	0.00e+00	803.00
IUUC-Fso-038339	Fusarium solani	70.05	0.00e+00	1458.00
IUUC-Gmo-039338	Gadus morhua	52.36	0.00e+00	1030.00
IUUC-Ggr-039823	Gaeumannomyces graminis	69.61	0.00e+00	1528.00
IUUC-Gga-040747	Gallus gallus	43.22	0.00e+00	708.00
IUUC-Gac-041773	Gasterosteus aculeatus	52.22	0.00e+00	1026.00
IUUC-Gma-043198	Glycine max	46.29	0.00e+00	869.00
IUUC-Ggo-045336	Gorilla gorilla	53.77	0.00e+00	1080.00
IUUC-Hsa-045982	Homo sapiens	53.68	0.00e+00	1077.00
IUUC-Hvu-047418	Hordeum vulgare	46.34	0.00e+00	844.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	54.16	0.00e+00	1103.00
IUUC-Kpa-049112	Komagataella pastoris	60.83	0.00e+00	1202.00
IUUC-Lch-050371	Latimeria chalumnae	54.20	0.00e+00	1079.00
IUUC-Lpe-051299	Leersia perrieri	45.36	0.00e+00	870.00
IUUC-Loc-052936	Lepisosteus oculatus	54.64	0.00e+00	1085.00
IUUC-Lma-053315	Leptosphaeria maculans	73.10	0.00e+00	1587.00
IUUC-Laf-053948	Loxodonta africana	52.90	0.00e+00	1053.00
IUUC-Mcc-055843	Macaca mulatta	53.87	0.00e+00	1098.00
IUUC-Meu-056258	Macropus eugenii	53.19	0.00e+00	1077.00
IUUC-Mor-057269	Magnaporthe oryzae	70.07	0.00e+00	1496.00
IUUC-Mpo-057435	Magnaporthe poae	69.13	0.00e+00	1485.00
IUUC-Mtr-058572	Medicago truncatula	45.76	0.00e+00	852.00
IUUC-Mla-059176	Melampsora laricipopulina	61.02	0.00e+00	1183.00
IUUC-Mga-059721	Meleagris gallopavo	43.30	0.00e+00	685.00
IUUC-Mvi-060437	Microbotryum violaceum	58.24	0.00e+00	1162.00
IUUC-Mmr-061405	Microcebus murinus	52.71	0.00e+00	1059.00
IUUC-Mdo-062032	Monodelphis domestica	52.15	0.00e+00	1040.00
IUUC-Mmu-063280	Mus musculus	53.29	0.00e+00	1081.00
IUUC-Mac-065505	Musa acuminata	46.54	0.00e+00	870.00
IUUC-Mpu-066409	Mustela putorius furo	53.58	0.00e+00	1098.00
IUUC-Mlu-067217	Myotis lucifugus	53.38	0.00e+00	1082.00
IUUC-Nfi-068407	Neosartorya fischeri	89.19	0.00e+00	1862.00
IUUC-Ncr-068698	Neurospora crassa	70.34	0.00e+00	1490.00
IUUC-Nle-070072	Nomascus leucogenys	50.87	0.00e+00	997.00
IUUC-Opr-070715	Ochotona princeps	37.07	4.00e-173	600.00
IUUC-Ont-071671	Oreochromis niloticus	54.83	0.00e+00	1071.00
IUUC-Oan-073268	Ornithorhynchus anatinus	43.43	0.00e+00	662.00
IUUC-Ocu-074544	Oryctolagus cuniculus	53.97	0.00e+00	1103.00
IUUC-Oba-075120	Oryza barthii	44.80	0.00e+00	837.00
IUUC-Obr-076557	Oryza brachyantha	45.40	0.00e+00	829.00
IUUC-Ogl-077887	Oryza glaberrima	44.80	0.00e+00	838.00
IUUC-Ogu-078305	Oryza glumaepatula	45.16	0.00e+00	858.00
IUUC-Oin-080154	Oryza indica	45.06	0.00e+00	857.00
IUUC-Olo-081089	Oryza longistaminata	45.36	0.00e+00	862.00
IUUC-Ome-081942	Oryza meridionalis	44.89	0.00e+00	841.00
IUUC-Oni-082365	Oryza nivara	44.89	0.00e+00	841.00
IUUC-Opu-083977	Oryza punctata	45.01	0.00e+00	840.00
IUUC-Oru-084469	Oryza rufipogon	45.16	0.00e+00	859.00
IUUC-Osa-085949	Oryza sativa	44.99	0.00e+00	845.00
IUUC-Ola-087002	Oryzias latipes	53.96	0.00e+00	1071.00
IUUC-Olu-087687	Ostreococcus lucimarinus	44.35	0.00e+00	781.00
IUUC-Oga-088594	Otolemur garnettii	53.77	0.00e+00	1076.00
IUUC-Oar-090068	Ovis aries	53.68	0.00e+00	1103.00
IUUC-Ptr-090609	Pan troglodytes	43.21	0.00e+00	702.00
IUUC-Pan-092114	Papio anubis	53.68	0.00e+00	1096.00
IUUC-Psi-093489	Pelodiscus sinensis	43.22	0.00e+00	726.00
IUUC-Pma-094214	Petromyzon marinus	48.52	4.00e-37	145.00
IUUC-Pno-095154	Phaeosphaeria nodorum	73.11	0.00e+00	1584.00
IUUC-Ppa-095227	Physcomitrella patens	47.75	0.00e+00	883.00
IUUC-Pfo-097184	Poecilia formosa	53.62	0.00e+00	1057.00
IUUC-Pab-097861	Pongo abelii	53.58	0.00e+00	1065.00
IUUC-Pop-099577	Populus trichocarpa	46.24	0.00e+00	883.00
IUUC-Pca-100347	Procavia capensis	51.67	0.00e+00	906.00
IUUC-Ppe-101298	Prunus persica	45.91	0.00e+00	836.00
IUUC-Pva-102584	Pteropus vampyrus	53.77	0.00e+00	1127.00
IUUC-Pgr-103336	Puccinia graminis	57.70	0.00e+00	1102.00
IUUC-Ptt-103939	Puccinia triticina	57.40	0.00e+00	1087.00
IUUC-Pte-104200	Pyrenophora teres	74.11	0.00e+00	1606.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	72.86	0.00e+00	1594.00
IUUC-Rno-105462	Rattus norvegicus	53.24	0.00e+00	1078.00
IUUC-Sce-106245	Saccharomyces cerevisiae	60.10	0.00e+00	1229.00
IUUC-Sha-107142	Sarcophilus harrisii	53.00	0.00e+00	1077.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	59.49	0.00e+00	1260.00
IUUC-Spo-108034	Schizosaccharomyces pombe	60.71	0.00e+00	1249.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	72.02	0.00e+00	1492.00
IUUC-Smo-108912	Selaginella moellendorffii	48.29	0.00e+00	863.00
IUUC-Sit-110281	Setaria italica	45.11	0.00e+00	860.00
IUUC-Sly-111237	Solanum lycopersicum	47.22	0.00e+00	840.00
IUUC-Stu-112001	Solanum tuberosum	47.32	0.00e+00	843.00
IUUC-Sar-113737	Sorex araneus	53.38	0.00e+00	1093.00
IUUC-Sbi-114089	Sorghum bicolor	45.35	0.00e+00	863.00
IUUC-Sre-115148	Sporisorium reilianum	57.10	0.00e+00	1136.00
IUUC-Ssc-115777	Sus scrofa	53.63	0.00e+00	1099.00
IUUC-Tgu-116565	Taeniopygia guttata	43.19	0.00e+00	716.00
IUUC-Tru-118742	Takifugu rubripes	53.91	0.00e+00	1024.00
IUUC-Tsy-119436	Tarsius syrichta	38.35	1.00e-170	592.00
IUUC-Tni-120401	Tetraodon nigroviridis	53.86	0.00e+00	1029.00
IUUC-Tca-121672	Theobroma cacao	46.44	0.00e+00	884.00
IUUC-Tre-122009	Trichoderma reesei	70.07	0.00e+00	1438.00
IUUC-Tvi-122259	Trichoderma virens	70.08	0.00e+00	1436.00
IUUC-Tae-125676	Triticum aestivum	45.46	0.00e+00	867.00
IUUC-Tur-126189	Triticum urartu	46.59	0.00e+00	813.00
IUUC-Tme-127055	Tuber melanosporum	65.99	0.00e+00	1322.00
IUUC-Tbe-127587	Tupaia belangeri	43.04	1.00e-156	545.00
IUUC-Ttr-128331	Tursiops truncatus	53.48	0.00e+00	1085.00
IUUC-Uma-129387	Ustilago maydis	57.70	0.00e+00	1144.00
IUUC-Vda-129977	Verticillium dahliae	70.39	0.00e+00	1449.00
IUUC-Vpa-130716	Vicugna pacos	41.73	0.00e+00	684.00
IUUC-Vvi-130857	Vitis vinifera	46.45	0.00e+00	880.00
IUUC-Xtr-132026	Xenopus tropicalis	45.67	0.00e+00	788.00
IUUC-Xma-133805	Xiphophorus maculatus	53.19	0.00e+00	1040.00
IUUC-Yli-134547	Yarrowia lipolytica	58.91	0.00e+00	1239.00
IUUC-Zma-135052	Zea mays	45.64	0.00e+00	865.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence