iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cgl-026512

Ensembl Protein ID

ELA25965

UniProt Accession

L2FIH5; L2FIH5_COLGN

Genbank Protein ID

ELA25965.1

Protein Name

Ubiquitin-activating enzyme e1 1

Genbank Nucleotide ID

KB021087

Gene Name

CGGC5_12947

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CGGC5_12947	ELA25965	ELA25965

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.20e-191	634.6	425	914

Active Site

Position(s)	Description	Evidence
608	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnvea..he 94
           YD+Qi ++G e+qek+ + + +lvGag++GcE+lKn +++G+     g+itv+Dmd +e+snlnrqFLfra+dvg  K+++aa+a++ +npd n+ +   +
   Q: 425  YDGQIVVFGREYQEKIANLRQFLVGAGAIGCEMLKNWAMIGLgtgpkGKITVTDMDSIEKSNLNRQFLFRAKDVGNMKSDCAAAAVQAMNPDLNGHIvcLK 525
           *********************************************************************************************86551169 PP
   S: 95   esiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.. 190
           +++++++ee +   F +++d+V +aldn+ear++v+r+c+  r+pl+esgtlG++G+++v++++lte+ys+s+dpp+k++P+ct+k++pn++ehti wa  
   Q: 526  DRVSPETEETFneqFWNDLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVLPHLTESYSSSQDPPEKEFPMCTVKSFPNKIEHTIAWAkd 626
           99999999988889*************************************************************************************** PP
   S: 191  ...........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv...... 274
                      + +n +l + +  e +l+  +  + + +++  ++ l++ ++++fe++i++a+  f+k ++n+i+qll++f++d  t+s++pfw+      
   Q: 627  hmfenlfitspSTVNLYLTQPNYIEATLK--QGGSAKLTLETLRDYLTTDRPRTFEDCIAWARILFEKEFNNKIQQLLHNFPKDSTTSSGTPFWSgpkrap 725
           55555555555444444333333333333..1222333333334556669*************************************************** PP
   S: 275  .........................................sfcsnaealqvpekvekdeevvkasap...............lylllralerfekkkgrk 319
                                                    +++++     +p  ++k ++++++++p               l+  +++l + +   g +
   Q: 726  dplkfdaknpthfafvvaaanlhafnynikspgtdkdiylrELENVIVPDFSPAEGVKIQANDSDPDPnaeggegssfddnneLQKIIASLPSPNDLAGFQ 826
           **********999999888877777777777777777666633333333335577777777777777777777777777778899**************** PP
   S: 320  pgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
            + ++fekddds  ++d++ta++nlra +++ie+ +d++++k iag+iipaiatt+a v Gl+ +E++Kv+ g  + e++kn f+++a+
   Q: 827  LQPVDFEKDDDSnhHIDFITACSNLRAANYKIEQ-ADRHKTKFIAGKIIPAIATTTALVTGLVILELYKVIGGkqDLEQYKNGFINLAL 914
           **********************************.*************************************9878899******9875 PP

Organism

Colletotrichum gloeosporioides

Protein Sequence
(Fasta)

MADKKLTEVD LVTRMQVDDS VVGLTEIDES LYSRQLYVLG HEAMKRMGAS NVLIAGLKGL 60
GVEIAKNIAL AGVKSLTLYD PGLVSLADLS SQFFLHPEDV GKPRDEVTAP RVAELNAYTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGTAC GTTTTACCCC CTCGACTACG GTTGTGGCCG AAGCGAATGC TTCGCCAGAA 60
CGATCTTCTA ACCCCGCAGC GCCGCTGCAG CTCGCGGCGT GGCCGGCCTC TTCACGTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR010987--Glutathione-S-Trfase_C-like
IPR004045--Glutathione_S-Trfase_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR012336--Thioredoxin-like_fold
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS50405--GST_CTER
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF13409--GST_N_2
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000456	Aegilops tauschii	47.32	0.00e+00	873.00
IUUC-Aml-001311	Ailuropoda melanoleuca	54.26	0.00e+00	1080.00
IUUC-Atr-002684	Amborella trichopoda	45.20	0.00e+00	858.00
IUUC-Apl-004158	Anas platyrhynchos	43.98	0.00e+00	712.00
IUUC-Aca-004620	Anolis carolinensis	54.79	0.00e+00	1076.00
IUUC-Aly-005515	Arabidopsis lyrata	46.73	0.00e+00	872.00
IUUC-Ath-006891	Arabidopsis thaliana	46.27	0.00e+00	867.00
IUUC-Ago-007873	Ashbya gossypii	59.24	0.00e+00	1167.00
IUUC-Acl-008181	Aspergillus clavatus	69.70	0.00e+00	1456.00
IUUC-Afl-008455	Aspergillus flavus	71.07	0.00e+00	1429.00
IUUC-Afu-009065	Aspergillus fumigatus	71.24	0.00e+00	1497.00
IUUC-Ani-009371	Aspergillus nidulans	71.07	0.00e+00	1461.00
IUUC-Ang-009737	Aspergillus niger	72.14	0.00e+00	1500.00
IUUC-Aor-010007	Aspergillus oryzae	71.07	0.00e+00	1427.00
IUUC-Ate-010466	Aspergillus terreus	70.16	0.00e+00	1502.00
IUUC-Ame-010933	Astyanax mexicanus	53.96	0.00e+00	1008.00
IUUC-Bgr-012281	Blumeria graminis	71.23	0.00e+00	1499.00
IUUC-Bta-012767	Bos taurus	54.06	0.00e+00	1076.00
IUUC-Bci-013721	Botrytis cinerea	75.57	0.00e+00	1526.00
IUUC-Bdi-014843	Brachypodium distachyon	47.17	0.00e+00	858.00
IUUC-Bol-015665	Brassica oleracea	46.58	0.00e+00	852.00
IUUC-Bra-017252	Brassica rapa	45.53	0.00e+00	868.00
IUUC-Cel-018260	Caenorhabditis elegans	44.75	0.00e+00	789.00
IUUC-Cja-019152	Callithrix jacchus	54.04	0.00e+00	1077.00
IUUC-Cfa-020622	Canis familiaris	53.33	0.00e+00	1023.00
IUUC-Cpo-022526	Cavia porcellus	54.36	0.00e+00	1057.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	45.24	0.00e+00	779.00
IUUC-Csa-023780	Chlorocebus sabaeus	54.26	0.00e+00	1071.00
IUUC-Cho-024682	Choloepus hoffmanni	41.70	8.00e-97	347.00
IUUC-Cin-025790	Ciona intestinalis	52.23	0.00e+00	1068.00
IUUC-Csv-026084	Ciona savignyi	52.66	0.00e+00	1072.00
IUUC-Cne-026960	Cryptococcus neoformans	59.77	0.00e+00	1189.00
IUUC-Cme-027290	Cyanidioschyzon merolae	42.34	0.00e+00	780.00
IUUC-Dre-028149	Danio rerio	54.15	0.00e+00	1044.00
IUUC-Dno-028884	Dasypus novemcinctus	54.46	0.00e+00	1079.00
IUUC-Dor-030229	Dipodomys ordii	51.12	0.00e+00	994.00
IUUC-Dse-031524	Dothistroma septosporum	66.60	0.00e+00	1382.00
IUUC-Dme-032045	Drosophila melanogaster	51.53	0.00e+00	1001.00
IUUC-Ete-033124	Echinops telfairi	42.98	1.00e-149	522.00
IUUC-Eca-033330	Equus caballus	54.16	0.00e+00	1071.00
IUUC-Eeu-035323	Erinaceus europaeus	41.05	3.00e-154	537.00
IUUC-Fca-036255	Felis catus	54.03	0.00e+00	1078.00
IUUC-Fal-036848	Ficedula albicollis	43.61	0.00e+00	723.00
IUUC-Fox-038007	Fusarium oxysporum	79.79	0.00e+00	904.00
IUUC-Fso-038339	Fusarium solani	82.68	0.00e+00	1693.00
IUUC-Gmo-039338	Gadus morhua	51.71	0.00e+00	990.00
IUUC-Ggr-039823	Gaeumannomyces graminis	76.26	0.00e+00	1667.00
IUUC-Gga-040747	Gallus gallus	43.68	0.00e+00	711.00
IUUC-Gac-041773	Gasterosteus aculeatus	52.79	0.00e+00	1008.00
IUUC-Gma-043198	Glycine max	46.47	0.00e+00	866.00
IUUC-Ggo-045336	Gorilla gorilla	53.95	0.00e+00	1056.00
IUUC-Hsa-045982	Homo sapiens	54.06	0.00e+00	1054.00
IUUC-Hvu-047418	Hordeum vulgare	47.61	0.00e+00	876.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	54.36	0.00e+00	1074.00
IUUC-Kpa-049112	Komagataella pastoris	58.62	0.00e+00	1140.00
IUUC-Lch-050371	Latimeria chalumnae	54.26	0.00e+00	1058.00
IUUC-Lpe-051299	Leersia perrieri	44.51	0.00e+00	865.00
IUUC-Loc-052936	Lepisosteus oculatus	54.15	0.00e+00	1050.00
IUUC-Lma-053315	Leptosphaeria maculans	70.41	0.00e+00	1474.00
IUUC-Laf-053948	Loxodonta africana	53.57	0.00e+00	1048.00
IUUC-Mcc-055843	Macaca mulatta	54.15	0.00e+00	1077.00
IUUC-Meu-056258	Macropus eugenii	53.55	0.00e+00	1066.00
IUUC-Mor-057269	Magnaporthe oryzae	76.28	0.00e+00	1640.00
IUUC-Mpo-057435	Magnaporthe poae	76.55	0.00e+00	1634.00
IUUC-Mtr-058572	Medicago truncatula	45.51	0.00e+00	855.00
IUUC-Mla-059176	Melampsora laricipopulina	57.54	0.00e+00	1134.00
IUUC-Mga-059721	Meleagris gallopavo	43.62	0.00e+00	693.00
IUUC-Mvi-060437	Microbotryum violaceum	57.35	0.00e+00	1152.00
IUUC-Mmr-061405	Microcebus murinus	52.39	0.00e+00	1025.00
IUUC-Mdo-062032	Monodelphis domestica	52.27	0.00e+00	1025.00
IUUC-Mmu-063280	Mus musculus	54.12	0.00e+00	1066.00
IUUC-Mac-065505	Musa acuminata	47.73	0.00e+00	884.00
IUUC-Mpu-066409	Mustela putorius furo	54.00	0.00e+00	1079.00
IUUC-Mlu-067217	Myotis lucifugus	54.41	0.00e+00	1066.00
IUUC-Nfi-068407	Neosartorya fischeri	70.91	0.00e+00	1486.00
IUUC-Ncr-068698	Neurospora crassa	77.57	0.00e+00	1667.00
IUUC-Nle-070072	Nomascus leucogenys	51.27	0.00e+00	966.00
IUUC-Opr-070715	Ochotona princeps	38.83	6.00e-175	606.00
IUUC-Ont-071671	Oreochromis niloticus	55.03	0.00e+00	1043.00
IUUC-Oan-073268	Ornithorhynchus anatinus	43.13	0.00e+00	672.00
IUUC-Ocu-074544	Oryctolagus cuniculus	54.02	0.00e+00	1075.00
IUUC-Oba-075120	Oryza barthii	46.91	0.00e+00	856.00
IUUC-Obr-076557	Oryza brachyantha	47.04	0.00e+00	843.00
IUUC-Ogl-077887	Oryza glaberrima	46.91	0.00e+00	858.00
IUUC-Ogu-078793	Oryza glumaepatula	45.82	0.00e+00	848.00
IUUC-Oin-079370	Oryza indica	45.68	0.00e+00	838.00
IUUC-Olo-080255	Oryza longistaminata	45.91	0.00e+00	848.00
IUUC-Ome-081942	Oryza meridionalis	46.81	0.00e+00	860.00
IUUC-Oni-082365	Oryza nivara	47.01	0.00e+00	861.00
IUUC-Opu-083977	Oryza punctata	47.01	0.00e+00	862.00
IUUC-Oru-085015	Oryza rufipogon	45.82	0.00e+00	848.00
IUUC-Osa-085949	Oryza sativa	46.81	0.00e+00	862.00
IUUC-Ola-087002	Oryzias latipes	54.46	0.00e+00	1046.00
IUUC-Olu-087687	Ostreococcus lucimarinus	43.73	0.00e+00	758.00
IUUC-Oga-088594	Otolemur garnettii	53.91	0.00e+00	1050.00
IUUC-Oar-090068	Ovis aries	54.02	0.00e+00	1075.00
IUUC-Ptr-090609	Pan troglodytes	42.87	0.00e+00	706.00
IUUC-Pan-092114	Papio anubis	54.05	0.00e+00	1075.00
IUUC-Psi-093489	Pelodiscus sinensis	43.33	0.00e+00	716.00
IUUC-Pma-094214	Petromyzon marinus	44.13	3.00e-37	145.00
IUUC-Pno-095154	Phaeosphaeria nodorum	70.55	0.00e+00	1480.00
IUUC-Ppa-095227	Physcomitrella patens	47.81	0.00e+00	874.00
IUUC-Pfo-097184	Poecilia formosa	54.21	0.00e+00	1045.00
IUUC-Pab-097861	Pongo abelii	54.16	0.00e+00	1045.00
IUUC-Pop-098934	Populus trichocarpa	46.06	0.00e+00	875.00
IUUC-Pca-100347	Procavia capensis	52.04	0.00e+00	897.00
IUUC-Ppe-102012	Prunus persica	45.68	0.00e+00	877.00
IUUC-Pva-102584	Pteropus vampyrus	54.46	0.00e+00	1107.00
IUUC-Pgr-103336	Puccinia graminis	55.80	0.00e+00	1083.00
IUUC-Ptt-103939	Puccinia triticina	55.97	0.00e+00	1082.00
IUUC-Pte-104200	Pyrenophora teres	70.25	0.00e+00	1484.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	68.62	0.00e+00	1476.00
IUUC-Rno-105462	Rattus norvegicus	54.00	0.00e+00	1065.00
IUUC-Sce-106245	Saccharomyces cerevisiae	59.92	0.00e+00	1207.00
IUUC-Sha-107142	Sarcophilus harrisii	53.92	0.00e+00	1063.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	59.37	0.00e+00	1214.00
IUUC-Spo-108034	Schizosaccharomyces pombe	58.36	0.00e+00	1166.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	74.61	0.00e+00	1529.00
IUUC-Smo-108912	Selaginella moellendorffii	47.51	0.00e+00	846.00
IUUC-Sit-110281	Setaria italica	47.86	0.00e+00	887.00
IUUC-Sly-110914	Solanum lycopersicum	45.87	0.00e+00	884.00
IUUC-Stu-112109	Solanum tuberosum	45.77	0.00e+00	889.00
IUUC-Sar-113737	Sorex araneus	54.41	0.00e+00	1077.00
IUUC-Sbi-114089	Sorghum bicolor	47.96	0.00e+00	883.00
IUUC-Sre-115148	Sporisorium reilianum	56.68	0.00e+00	1122.00
IUUC-Ssc-115777	Sus scrofa	54.27	0.00e+00	1080.00
IUUC-Tgu-116565	Taeniopygia guttata	43.62	0.00e+00	723.00
IUUC-Tru-118742	Takifugu rubripes	54.12	0.00e+00	1001.00
IUUC-Tsy-119436	Tarsius syrichta	38.22	5.00e-169	586.00
IUUC-Tni-120401	Tetraodon nigroviridis	54.36	0.00e+00	1007.00
IUUC-Tca-121436	Theobroma cacao	46.34	0.00e+00	876.00
IUUC-Tre-122009	Trichoderma reesei	79.57	0.00e+00	1630.00
IUUC-Tvi-122259	Trichoderma virens	79.71	0.00e+00	2216.00
IUUC-Tae-125113	Triticum aestivum	47.66	0.00e+00	839.00
IUUC-Tur-126330	Triticum urartu	47.32	0.00e+00	873.00
IUUC-Tme-127055	Tuber melanosporum	63.35	0.00e+00	1268.00
IUUC-Tbe-127587	Tupaia belangeri	43.27	3.00e-156	543.00
IUUC-Ttr-128331	Tursiops truncatus	54.41	0.00e+00	1067.00
IUUC-Uma-129387	Ustilago maydis	56.75	0.00e+00	1132.00
IUUC-Vda-129977	Verticillium dahliae	87.50	0.00e+00	1771.00
IUUC-Vpa-130716	Vicugna pacos	41.72	0.00e+00	683.00
IUUC-Vvi-130857	Vitis vinifera	45.68	0.00e+00	871.00
IUUC-Xtr-132947	Xenopus tropicalis	38.95	0.00e+00	643.00
IUUC-Xma-133805	Xiphophorus maculatus	54.15	0.00e+00	1026.00
IUUC-Yli-134547	Yarrowia lipolytica	59.49	0.00e+00	1222.00
IUUC-Zma-135052	Zea mays	47.48	0.00e+00	886.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence