iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fox-038007

Ensembl Protein ID

FOXG_08381P0

UniProt Accession

A0A0D2XWL5; A0A0D2XWL5_FUSO4

Genbank Protein ID

KNB07084.1

Protein Name

Ubiquitin-activating enzyme E1

Genbank Nucleotide ID

DS231705

Gene Name

FOXG_08381

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FOXG_08381	FOXG_08381T0	FOXG_08381P0

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	8.50e-97	324.7	20	464

Active Site

Position(s)	Description	Evidence
162	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 42   v.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveah..eesiteleeeiv...FfkkfdvVvlaldnrearrkvnr 128
           +     g+i v+Dmd +e snlnrqFLfra+dvg+ K++ aa a++++npd ++ ++  +e++++++e+++   F +++d+V +aldn+ear++v+r
   Q: 20   LgtgpeGKIWVTDMDSIERSNLNRQFLFRADDVGQMKSDRAALAVQRMNPDLEGHMVtlKERVSPETENVFnedFWRNLDGVTNALDNVEARTYVDR 116
           44466699********************************************9876522799*******999************************* PP
   S: 129  lclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa.............vlfnklleeeageeevleklds 212
           +c+  ++pl+esgtlG++G+++v++++lte+ys+s+dpp+k++P+ct++++pn+++hti wa               +n +l + ++ e+  +  + 
   Q: 117  RCVFFQKPLLESGTLGTKGNTQVVLPHLTESYSSSQDPPEKEFPMCTIRSFPNKIDHTIAWAkeymfeklfvkapQTVNLYLTQPQFIENSMK--QG 211
           ****************************************************************55555555554444444444444444443..67 PP
   S: 213  eekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtkskspfwv................................... 274
            +++e+++ +++ l++e++++fe++i++a++ f++ ++n+i+qll +f++d  t+s++pfw+                                   
   Q: 212  GNQKETLETIRNYLTTERPRTFEDCIAWARQLFETEFSNKIQQLLYNFPKDSETSSGTPFWSgpkrapdalkfdpnnpshfgfivaaanlhafnyni 308
           7888899999999999************************************************************************999999999 PP
   S: 275  .....................sfcsnaealqvp..ekvekdeevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraes 346
                                  +s + ++q +  e ve +  +++++++++ l+++l + ++ +g +   ++fekddds  ++d++ta++nlrae+
   Q: 309  kspgtdrsiylreldnvivpdFTPSSNVKIQADdkEPVEPESSNFDDNDEIEKLTASLPSPSSLSGFQLVPVDFEKDDDSnhHIDFITACSNLRAEN 405
           99999999999999999999744444444443333667777778888888*********************************************** PP
   S: 347  lgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           ++iep +d++++k iag+iipaiatt+a v Gl+++E++K+++g  + e++kn f+++a+
   Q: 406  YKIEP-ADRHKTKFIAGKIIPAIATTTALVTGLVVLELYKIIDGkdDLEQYKNGFINLAL 464
           *****.**************************************888999******9875 PP

Organism

Fusarium oxysporum

Protein Sequence
(Fasta)

MNRQFLKPCV FARLKPMIGL GTGPEGKIWV TDMDSIERSN LNRQFLFRAD DVGQMKSDRA 60
ALAVQRMNPD LEGHMVTLKE RVSPETENVF NEDFWRNLDG VTNALDNVEA RTYVDRRCVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCGTC AATTCTTGAA GCCCTGCGTG TTCGCTCGTC TCAAGCCCAT GATTGGTCTC 60
GGAACAGGAC CCGAGGGCAA GATCTGGGTG ACTGACATGG ACTCGATCGA GAGGAGTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR023318--Ub_act_enz_dom_a
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	46.32	6.00e-133	466.00
IUUC-Aml-001311	Ailuropoda melanoleuca	53.68	4.00e-172	597.00
IUUC-Atr-002684	Amborella trichopoda	46.15	5.00e-142	497.00
IUUC-Apl-004158	Anas platyrhynchos	42.88	5.00e-104	370.00
IUUC-Aca-004620	Anolis carolinensis	54.10	1.00e-167	582.00
IUUC-Aly-005515	Arabidopsis lyrata	45.14	2.00e-141	494.00
IUUC-Ath-006891	Arabidopsis thaliana	44.80	9.00e-142	496.00
IUUC-Ago-007873	Ashbya gossypii	61.58	0.00e+00	693.00
IUUC-Acl-008181	Aspergillus clavatus	69.34	0.00e+00	813.00
IUUC-Afl-008455	Aspergillus flavus	69.57	0.00e+00	798.00
IUUC-Afu-009065	Aspergillus fumigatus	69.69	0.00e+00	812.00
IUUC-Ani-009371	Aspergillus nidulans	70.33	0.00e+00	820.00
IUUC-Ang-009737	Aspergillus niger	67.68	0.00e+00	803.00
IUUC-Aor-010007	Aspergillus oryzae	69.57	0.00e+00	798.00
IUUC-Ate-010466	Aspergillus terreus	70.21	0.00e+00	827.00
IUUC-Ame-010933	Astyanax mexicanus	52.98	9.00e-162	562.00
IUUC-Bgr-012281	Blumeria graminis	68.38	0.00e+00	823.00
IUUC-Bta-012767	Bos taurus	53.85	1.00e-172	598.00
IUUC-Bci-013721	Botrytis cinerea	71.40	0.00e+00	778.00
IUUC-Bdi-014335	Brachypodium distachyon	47.18	3.00e-143	501.00
IUUC-Bol-015665	Brassica oleracea	45.83	1.00e-137	482.00
IUUC-Bra-017522	Brassica rapa	45.49	1.00e-136	479.00
IUUC-Cel-018260	Caenorhabditis elegans	47.46	3.00e-134	471.00
IUUC-Cja-019152	Callithrix jacchus	54.02	2.00e-172	597.00
IUUC-Cfa-020622	Canis familiaris	51.79	2.00e-160	558.00
IUUC-Cpo-022526	Cavia porcellus	54.79	2.00e-167	581.00
IUUC-Cre-022702	Chlamydomonas reinhardtii	44.07	7.00e-125	439.00
IUUC-Csa-023780	Chlorocebus sabaeus	53.85	2.00e-171	594.00
IUUC-Cin-025790	Ciona intestinalis	50.75	3.00e-169	587.00
IUUC-Csv-026084	Ciona savignyi	51.84	1.00e-168	585.00
IUUC-Cgl-026512	Colletotrichum gloeosporioides	79.19	0.00e+00	955.00
IUUC-Cne-026960	Cryptococcus neoformans	58.52	2.00e-177	614.00
IUUC-Cme-027290	Cyanidioschyzon merolae	45.87	5.00e-135	473.00
IUUC-Dre-028149	Danio rerio	53.66	1.00e-162	565.00
IUUC-Dno-028884	Dasypus novemcinctus	54.19	2.00e-173	601.00
IUUC-Dor-030229	Dipodomys ordii	50.43	7.00e-159	553.00
IUUC-Dse-031524	Dothistroma septosporum	67.99	0.00e+00	814.00
IUUC-Dme-032045	Drosophila melanogaster	50.35	3.00e-161	561.00
IUUC-Ete-032544	Echinops telfairi	49.88	6.00e-105	373.00
IUUC-Eca-033330	Equus caballus	53.85	5.00e-172	596.00
IUUC-Eeu-034717	Erinaceus europaeus	35.23	3.00e-73	268.00
IUUC-Fca-036255	Felis catus	54.19	6.00e-173	599.00
IUUC-Fal-036848	Ficedula albicollis	41.30	3.00e-100	358.00
IUUC-Fso-038339	Fusarium solani	91.22	0.00e+00	1025.00
IUUC-Gmo-039338	Gadus morhua	51.19	9.00e-163	565.00
IUUC-Ggr-039823	Gaeumannomyces graminis	72.63	0.00e+00	886.00
IUUC-Gga-040747	Gallus gallus	43.04	4.00e-104	370.00
IUUC-Gac-041773	Gasterosteus aculeatus	53.40	4.00e-170	590.00
IUUC-Gma-043198	Glycine max	46.59	2.00e-142	498.00
IUUC-Ggo-045336	Gorilla gorilla	54.61	2.00e-168	584.00
IUUC-Hsa-045982	Homo sapiens	54.43	2.00e-167	581.00
IUUC-Hvu-047414	Hordeum vulgare	47.01	3.00e-142	497.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	53.85	3.00e-172	597.00
IUUC-Kpa-049112	Komagataella pastoris	63.29	0.00e+00	688.00
IUUC-Lch-050371	Latimeria chalumnae	54.36	1.00e-166	578.00
IUUC-Lpe-051520	Leersia perrieri	45.55	3.00e-140	491.00
IUUC-Loc-052936	Lepisosteus oculatus	54.51	1.00e-165	575.00
IUUC-Lma-053315	Leptosphaeria maculans	69.59	0.00e+00	837.00
IUUC-Laf-053948	Loxodonta africana	52.99	1.00e-163	568.00
IUUC-Mcc-055843	Macaca mulatta	53.85	8.00e-172	595.00
IUUC-Meu-056258	Macropus eugenii	54.36	6.00e-169	586.00
IUUC-Mor-057269	Magnaporthe oryzae	73.37	0.00e+00	845.00
IUUC-Mpo-057435	Magnaporthe poae	73.32	0.00e+00	855.00
IUUC-Mtr-058572	Medicago truncatula	47.35	4.00e-142	497.00
IUUC-Mla-059176	Melampsora laricipopulina	59.36	0.00e+00	629.00
IUUC-Mga-059721	Meleagris gallopavo	44.15	4.00e-102	364.00
IUUC-Mvi-060437	Microbotryum violaceum	56.32	7.00e-180	622.00
IUUC-Mmr-061405	Microcebus murinus	53.85	5.00e-172	596.00
IUUC-Mdo-062032	Monodelphis domestica	54.53	1.00e-172	598.00
IUUC-Mmu-063280	Mus musculus	53.33	5.00e-168	583.00
IUUC-Mac-065505	Musa acuminata	46.34	3.00e-138	484.00
IUUC-Mpu-066409	Mustela putorius furo	54.02	2.00e-172	597.00
IUUC-Mlu-067217	Myotis lucifugus	53.90	4.00e-167	580.00
IUUC-Nfi-068407	Neosartorya fischeri	70.03	0.00e+00	817.00
IUUC-Ncr-068698	Neurospora crassa	75.73	0.00e+00	875.00
IUUC-Nle-070072	Nomascus leucogenys	54.61	3.00e-168	584.00
IUUC-Opr-070715	Ochotona princeps	36.64	3.00e-89	321.00
IUUC-Ont-071671	Oreochromis niloticus	55.20	3.00e-164	570.00
IUUC-Oan-073268	Ornithorhynchus anatinus	41.62	1.00e-91	329.00
IUUC-Ocu-074544	Oryctolagus cuniculus	53.68	7.00e-172	596.00
IUUC-Oba-075120	Oryza barthii	48.13	3.00e-141	494.00
IUUC-Obr-076557	Oryza brachyantha	48.49	8.00e-144	503.00
IUUC-Ogl-077887	Oryza glaberrima	48.13	7.00e-142	496.00
IUUC-Ogu-078620	Oryza glumaepatula	48.31	2.00e-144	504.00
IUUC-Oin-079370	Oryza indica	48.31	5.00e-144	503.00
IUUC-Olo-081089	Oryza longistaminata	44.77	3.00e-137	481.00
IUUC-Ome-081942	Oryza meridionalis	47.96	8.00e-142	496.00
IUUC-Oni-082365	Oryza nivara	48.13	3.00e-142	497.00
IUUC-Opu-083301	Oryza punctata	48.13	4.00e-142	497.00
IUUC-Oru-084469	Oryza rufipogon	44.60	4.00e-136	477.00
IUUC-Osa-085949	Oryza sativa	48.31	7.00e-144	503.00
IUUC-Ola-087002	Oryzias latipes	54.25	1.00e-161	562.00
IUUC-Olu-087687	Ostreococcus lucimarinus	45.07	7.00e-124	436.00
IUUC-Oga-088594	Otolemur garnettii	54.08	5.00e-167	580.00
IUUC-Oar-090068	Ovis aries	53.50	3.00e-172	597.00
IUUC-Ptr-090609	Pan troglodytes	41.99	9.00e-99	353.00
IUUC-Pan-092114	Papio anubis	53.85	8.00e-172	595.00
IUUC-Psi-093489	Pelodiscus sinensis	41.85	2.00e-99	355.00
IUUC-Pno-095154	Phaeosphaeria nodorum	68.61	0.00e+00	823.00
IUUC-Ppa-095416	Physcomitrella patens	47.26	5.00e-139	487.00
IUUC-Pfo-097184	Poecilia formosa	53.92	5.00e-161	560.00
IUUC-Pab-097861	Pongo abelii	54.43	2.00e-164	571.00
IUUC-Pop-098934	Populus trichocarpa	45.73	1.00e-142	499.00
IUUC-Pca-100347	Procavia capensis	51.88	6.00e-157	546.00
IUUC-Ppe-102012	Prunus persica	47.01	4.00e-145	507.00
IUUC-Pva-102584	Pteropus vampyrus	53.68	2.00e-179	621.00
IUUC-Pgr-103336	Puccinia graminis	55.13	4.00e-166	577.00
IUUC-Ptt-103939	Puccinia triticina	55.83	1.00e-160	558.00
IUUC-Pte-104200	Pyrenophora teres	70.05	0.00e+00	840.00
IUUC-Pyt-104441	Pyrenophora triticirepentis	68.17	0.00e+00	831.00
IUUC-Rno-105462	Rattus norvegicus	53.50	5.00e-168	583.00
IUUC-Sce-106245	Saccharomyces cerevisiae	61.16	0.00e+00	697.00
IUUC-Sha-107142	Sarcophilus harrisii	54.02	7.00e-170	589.00
IUUC-Sja-107841	Schizosaccharomyces japonicus	59.14	0.00e+00	682.00
IUUC-Spo-108034	Schizosaccharomyces pombe	59.66	0.00e+00	655.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	71.58	0.00e+00	783.00
IUUC-Smo-108912	Selaginella moellendorffii	48.29	9.00e-135	473.00
IUUC-Sit-110281	Setaria italica	47.42	9.00e-141	493.00
IUUC-Sly-110914	Solanum lycopersicum	46.06	3.00e-144	504.00
IUUC-Stu-112109	Solanum tuberosum	45.72	6.00e-146	509.00
IUUC-Sar-113737	Sorex araneus	53.50	1.00e-170	591.00
IUUC-Sbi-114089	Sorghum bicolor	47.07	9.00e-141	492.00
IUUC-Sre-115148	Sporisorium reilianum	55.71	5.00e-173	599.00
IUUC-Ssc-115777	Sus scrofa	53.77	2.00e-172	598.00
IUUC-Tgu-116565	Taeniopygia guttata	40.91	1.00e-101	362.00
IUUC-Tru-118742	Takifugu rubripes	54.70	4.00e-164	570.00
IUUC-Tsy-119436	Tarsius syrichta	38.67	7.00e-94	337.00
IUUC-Tni-120401	Tetraodon nigroviridis	54.53	2.00e-164	571.00
IUUC-Tca-121672	Theobroma cacao	46.92	8.00e-147	513.00
IUUC-Tre-122009	Trichoderma reesei	85.15	0.00e+00	950.00
IUUC-Tvi-122259	Trichoderma virens	86.14	0.00e+00	960.00
IUUC-Tae-125113	Triticum aestivum	46.32	5.00e-133	467.00
IUUC-Tur-126189	Triticum urartu	46.50	1.00e-133	468.00
IUUC-Tme-127055	Tuber melanosporum	66.15	0.00e+00	727.00
IUUC-Tbe-127714	Tupaia belangeri	39.34	3.00e-99	354.00
IUUC-Ttr-128331	Tursiops truncatus	54.19	1.00e-172	598.00
IUUC-Uma-129387	Ustilago maydis	57.22	3.00e-179	620.00
IUUC-Vda-129977	Verticillium dahliae	82.10	0.00e+00	924.00
IUUC-Vpa-130716	Vicugna pacos	40.39	8.00e-99	353.00
IUUC-Vvi-130857	Vitis vinifera	45.73	1.00e-143	502.00
IUUC-Xma-133805	Xiphophorus maculatus	53.85	3.00e-161	561.00
IUUC-Yli-134547	Yarrowia lipolytica	61.35	0.00e+00	704.00
IUUC-Zma-135052	Zea mays	46.76	5.00e-142	496.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence