iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054119

UUCD1 version

UUC-LoA-01018

Ensembl Protein ID

ENSLAFP00000005632.3

UniProt Accession

G3SYN8; G3SYN8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000006704.3	ENSLAFT00000006707.3	ENSLAFP00000005632.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.50e-189	628.7	408	881

Active Site

Position(s)	Description	Evidence
592	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+ +++llvGag++GcEllK ++l+G+     gsitv Dmd++e snl+rqFLfr++d+g +KA+vaaea+ +l
   Q: 408  YDGQIAVFGAGFQEKLSCQRYLLVGAGAIGCELLKGFALMGLgasdsGSITVADMDHIERSNLSRQFLFRPQDIGSPKAKVAAEAASRL 496
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           n+  +v++ + +++ ++e+i+   Ff+++d+V++ald+++ar +v+ +c ++ +pl+e+gt G++G + v+++++te y+++     ++
   Q: 497  NRGLQVTPLTHPLDHTTEHIFgdsFFSRVDGVAAALDSFQARSYVAARCAHYLKPLLEAGTQGTWGSAAVFMPHVTEPYRAPVsaaASE 585
           ***********************************************************************************9999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           + ++P+ct++ +p+++eht+ewa        +l ++ ++ ++++ + l+++d  + ++ +++v   l+  +++++++++++a+ +++ +
   Q: 586  DASNPVCTVRFFPSTVEHTLEWArnefeglfRLSAEAIKCHQQAPTSLADVDGPQVLTLLQPVLGVLRV-RPQTWQDCVAWARGHWQLC 673
           ***************************************************************888777.6****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++ si+qllk+f++d+v ++++pfw+                                                ++ ++ + +   +  
   Q: 674  FHDSITQLLKCFPPDKVLEDGTPFWSgskqcpqplefdanqdmhffyvlaaanlyaqmhglpgskdqtalrrllKLLPLPSPQHLAPIF 762
           ***********************************************************999999999999999999999999999999 PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           ++d e  +as +     l+ l +ale +++ + ++p  l fekddds  +vd+v aaa+lra+++gi+p +++ + k+i+g+iipaiat
   Q: 763  ASDLELAQASTTfgpeqLKELHKALEVWNEGPPLQP--LLFEKDDDSnfHVDFVVAAASLRAQNYGIPP-ANRAQSKRIVGQIIPAIAT 848
           99999999998899999******************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfd 402
            +a+v+Gl+ +E++Kvv g  +  ++++ +l++
   Q: 849  ATAAVAGLVGLELYKVVGGptPLGAFRHSYLHL 881
           *****************9955555566666665 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDVLETSKLL DEELYSRQLY VLGSEAMQRI QGAKVLLSGL RGLGAEVAKN LVLMGVGSLT 60
LHDPHPTCWS DLTAQFFLSE EDLGKSRAEA SQKPVSQLNG AVQVCVHTGA ITEDLLLDFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGTCC TAGAGACCTC CAAGTTACTG GATGAGGAAC TGTATTCACG GCAGCTGTAA 60
GGCCAGAGGT GGGGTGGGGA GTGGGGTGGC TTTCTGATCT CTGGTTTCCA ACCTGCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	76.71	0.00e+00	1433.00
IUUC-Bta-012665	Bos taurus	72.92	0.00e+00	1293.00
IUUC-Cja-019047	Callithrix jacchus	76.09	0.00e+00	1437.00
IUUC-Cfa-021225	Canis familiaris	77.48	0.00e+00	1482.00
IUUC-Cpo-022336	Cavia porcellus	70.41	0.00e+00	1311.00
IUUC-Csa-023462	Chlorocebus sabaeus	79.74	0.00e+00	1446.00
IUUC-Cho-024436	Choloepus hoffmanni	71.61	3.00e-89	323.00
IUUC-Dno-029347	Dasypus novemcinctus	80.43	0.00e+00	1504.00
IUUC-Dor-030997	Dipodomys ordii	71.50	0.00e+00	1334.00
IUUC-Ete-033124	Echinops telfairi	79.53	0.00e+00	1036.00
IUUC-Eca-033929	Equus caballus	79.15	0.00e+00	1535.00
IUUC-Eeu-034717	Erinaceus europaeus	66.67	0.00e+00	928.00
IUUC-Fca-036564	Felis catus	77.27	0.00e+00	1447.00
IUUC-Ggo-044480	Gorilla gorilla	79.14	0.00e+00	1447.00
IUUC-Hsa-046498	Homo sapiens	78.46	0.00e+00	1433.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	73.39	0.00e+00	1362.00
IUUC-Mcc-055597	Macaca mulatta	77.61	0.00e+00	1371.00
IUUC-Mdo-063058	Monodelphis domestica	56.51	0.00e+00	1035.00
IUUC-Mmu-063578	Mus musculus	68.73	0.00e+00	1320.00
IUUC-Mpu-066255	Mustela putorius furo	77.42	0.00e+00	1469.00
IUUC-Mlu-067814	Myotis lucifugus	71.73	0.00e+00	1268.00
IUUC-Nle-069193	Nomascus leucogenys	78.97	0.00e+00	1449.00
IUUC-Opr-070715	Ochotona princeps	68.77	0.00e+00	1282.00
IUUC-Oan-073306	Ornithorhynchus anatinus	55.38	0.00e+00	736.00
IUUC-Ocu-074162	Oryctolagus cuniculus	73.09	0.00e+00	1357.00
IUUC-Oga-088895	Otolemur garnettii	75.37	0.00e+00	1366.00
IUUC-Oar-089579	Ovis aries	72.92	0.00e+00	1292.00
IUUC-Ptr-090581	Pan troglodytes	78.75	0.00e+00	1409.00
IUUC-Pan-092458	Papio anubis	79.55	0.00e+00	1430.00
IUUC-Pab-098653	Pongo abelii	73.81	0.00e+00	1351.00
IUUC-Pca-100578	Procavia capensis	84.48	0.00e+00	1004.00
IUUC-Pva-102914	Pteropus vampyrus	75.84	0.00e+00	1129.00
IUUC-Rno-106066	Rattus norvegicus	69.93	0.00e+00	1362.00
IUUC-Sha-107368	Sarcophilus harrisii	60.53	0.00e+00	1151.00
IUUC-Ssc-115743	Sus scrofa	77.57	0.00e+00	1464.00
IUUC-Tbe-127587	Tupaia belangeri	70.56	0.00e+00	1165.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence