iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-007589

UUCD1 version

UUC-ArT-01602

Ensembl Protein ID

AT1G16890.3

UniProt Accession

Q9FZ48; Q3EDA7; UBC36_ARATH

Genbank Protein ID

AAY44875.1; AAF99844.1; AEE29515.1; AEE29516.1; AAK96500.1; AAL31253.1; AAM63831.1

Protein Name

Ubiquitin-conjugating enzyme E2 36; E2 ubiquitin-conjugating enzyme 36; Ubiquitin carrier protein 36

Genbank Nucleotide ID

DQ027049; AC051629; CP002684; CP002684; AY052307; AY061926; AY086780

Gene Name

UBC36; UBC13B; UBG13B; At1g16890; F17F16.19; F6I1.11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT1G16890	AT1G16890.2	AT1G16890.2
AT1G16890	AT1G16890.3	AT1G16890.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20435904; 16339806

Classification

Family	E-value	Score	Start	End
E2/UBC	6.20e-46	156.5	29	151

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 12   dppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsvesvllsiqsll 109
           dp++gisa+p++e ++  ++v+ilGp+++pYeggvFkle+ +pe+YP+ +Pkv+fltki+hPn+++ G++Cl+ilk  +kWspal++++vllsiq+ll
   Q: 29   DPSPGISASPSEE-NMRYFNVMILGPTQSPYEGGVFKLELFLPEEYPMAAPKVRFLTKIYHPNIDKLGRICLDILK--DKWSPALQIRTVLLSIQALL 123
           678**********.9************************************************************9..******************** PP
   S: 110  aepnpesplneeaaellkknreeykkkv 137
           + pnp++pl e++a+++k+n++e  +++
   Q: 124  SAPNPDDPLSENIAKHWKSNEAEAVETA 151
           ********************99877666 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Required for postreplication repair of UV-damaged DNA and for adapting root developmental programs to suboptimal availability of iron.

Protein Sequence
(Fasta)

MANSNLPRRI IKETQRLLSE PGNFITSFDP SPGISASPSE ENMRYFNVMI LGPTQSPYEG 60
GVFKLELFLP EEYPMAAPKV RFLTKIYHPN IDKLGRICLD ILKDKWSPAL QIRTVLLSIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCCGTAA AGGAAAAAAA GAAAGAATTA AAAGGATCAA AGGGGCACGA AACTAGAGAC 60
GACGAAGCGT ACTCGATTAT TATCAGCCTT TGGTAGCTTC GTTCTCTCTC AAAAACCCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination

KEGG

ath:AT1G16890

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cne-026809	Cryptococcus neoformans	75.00	5.00e-59	218.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence