iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086889

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

BAAF04073864

Gene Name

herc1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000000695.1	ENSORLT00000000860.1	ENSORLP00000000859.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-89	301.2	4580	4914
E3 adaptor/Cullin RING/DCX/DWD	1.90e-13	50.3	3685	3714

Active Site

Position(s)	Description	Evidence
4883	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     +h+  F+flG+l+g+a+++++
   Q: 4580 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELESGVVDLLIPSPNATAEVGYNRDRFLFNPsacldDHMLQFKFLGILMGVAIRTKK 4666
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l+ledleevd  ++++lk+i++ ++s i+e +++ ++  ++ i ++++ ++  ++pgG++ip t +N++
   Q: 4667 PLDLHLAPLVWKQLCCIPLQLEDLEEVDLLYVQTLKSILHIEDSGITEDNFHEMIPLDSFIGQSADGKMvpIIPGGNSIPLTFSNRK 4753
           ********************************************************999998777777677**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ + yrl+e i++qv+a+reG+++++p  llsl+t+++le+++cG++ei  + lkk  +y++ + e++  ++wFw++leefs+
   Q: 4754 EYVERAIGYRLHE-IDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGMPEICCDVLKKVVRYRE-VDEQHTLVHWFWQTLEEFSN 4838
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k  ++ d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4839 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKVDRPfDSLPTSQTCFFQLRLPPYSSQAVMAERLRYAINNCRSIDM 4914
           *****************6.899999.779999955555***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H +s+t++++ ++  +l++++   t+k+W 
   Q: 3685 HRESITSMKWsPTgQILLTCAKEETVKLWA 3714
           99*********77799*************5 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MALMIPPVKL KWLEHLNSSW ITEDSESIAT REGVSVLYSK LLANKEAVLL PQQVLCLKGP 60
QLPDFERECL SSDEQEHYLD ALLSSQLALA KMVCSDSPFA AALRKRVLVL QRIFYAISNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCTAA TGATCCCGCC GGTGAAACTT AAATGGCTGG AGCACCTGAA CAGCTCTTGG 60
ATCACTGAGG ACAGTGAATC CATAGCCACA AGAGAGGGGG TGTCGGTGCT ATATTCCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	80.16	0.00e+00	7203.00
IUUC-Atr-003065	Amborella trichopoda	32.66	4.00e-47	183.00
IUUC-Apl-003461	Anas platyrhynchos	80.49	0.00e+00	7250.00
IUUC-Aca-004452	Anolis carolinensis	77.17	0.00e+00	6667.00
IUUC-Aly-006441	Arabidopsis lyrata	33.62	6.00e-41	162.00
IUUC-Bta-013213	Bos taurus	80.48	0.00e+00	7207.00
IUUC-Bol-015203	Brassica oleracea	34.31	3.00e-49	190.00
IUUC-Bra-017584	Brassica rapa	33.41	3.00e-48	187.00
IUUC-Cja-019298	Callithrix jacchus	80.18	0.00e+00	7198.00
IUUC-Cfa-021213	Canis familiaris	80.27	0.00e+00	7273.00
IUUC-Cpo-021674	Cavia porcellus	79.12	0.00e+00	4917.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	39.09	3.00e-51	195.00
IUUC-Csa-023341	Chlorocebus sabaeus	79.76	0.00e+00	7159.00
IUUC-Cho-024567	Choloepus hoffmanni	72.77	0.00e+00	1388.00
IUUC-Dre-028289	Danio rerio	79.56	0.00e+00	7170.00
IUUC-Dno-029988	Dasypus novemcinctus	79.78	0.00e+00	7167.00
IUUC-Dor-030636	Dipodomys ordii	82.00	0.00e+00	1876.00
IUUC-Ete-032598	Echinops telfairi	80.36	0.00e+00	1303.00
IUUC-Eca-033754	Equus caballus	80.25	0.00e+00	7216.00
IUUC-Eeu-034702	Erinaceus europaeus	72.15	0.00e+00	1195.00
IUUC-Fca-035900	Felis catus	80.39	0.00e+00	7231.00
IUUC-Fal-037034	Ficedula albicollis	78.21	0.00e+00	6188.00
IUUC-Gmo-039260	Gadus morhua	80.38	0.00e+00	1333.00
IUUC-Gga-040321	Gallus gallus	80.40	0.00e+00	7304.00
IUUC-Ggo-045134	Gorilla gorilla	73.87	0.00e+00	3693.00
IUUC-Hsa-046516	Homo sapiens	80.02	0.00e+00	7176.00
IUUC-Hvu-047529	Hordeum vulgare	32.88	1.00e-46	182.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	84.52	0.00e+00	2236.00
IUUC-Lch-049903	Latimeria chalumnae	81.18	0.00e+00	7296.00
IUUC-Lpe-051165	Leersia perrieri	34.83	1.00e-51	196.00
IUUC-Loc-052149	Lepisosteus oculatus	82.80	0.00e+00	5242.00
IUUC-Laf-053426	Loxodonta africana	80.42	0.00e+00	7265.00
IUUC-Mcc-055826	Macaca mulatta	80.00	0.00e+00	7210.00
IUUC-Meu-056521	Macropus eugenii	67.68	0.00e+00	1788.00
IUUC-Mga-059567	Meleagris gallopavo	87.81	0.00e+00	1911.00
IUUC-Mmr-061512	Microcebus murinus	79.72	0.00e+00	7122.00
IUUC-Mdo-062177	Monodelphis domestica	78.29	0.00e+00	7034.00
IUUC-Mmu-064373	Mus musculus	80.26	0.00e+00	7227.00
IUUC-Mpu-066148	Mustela putorius furo	80.13	0.00e+00	7210.00
IUUC-Mlu-067680	Myotis lucifugus	79.98	0.00e+00	7160.00
IUUC-Nle-069633	Nomascus leucogenys	79.76	0.00e+00	7120.00
IUUC-Opr-070609	Ochotona princeps	82.48	0.00e+00	1185.00
IUUC-Ont-071249	Oreochromis niloticus	88.95	0.00e+00	8203.00
IUUC-Oan-073157	Ornithorhynchus anatinus	80.02	0.00e+00	7181.00
IUUC-Ocu-074841	Oryctolagus cuniculus	80.10	0.00e+00	7231.00
IUUC-Oba-075262	Oryza barthii	34.16	2.00e-49	189.00
IUUC-Obr-076115	Oryza brachyantha	34.43	6.00e-49	187.00
IUUC-Ogl-077586	Oryza glaberrima	34.16	2.00e-49	189.00
IUUC-Ogu-078796	Oryza glumaepatula	33.92	7.00e-49	187.00
IUUC-Oin-079298	Oryza indica	33.92	1.00e-48	187.00
IUUC-Olo-080768	Oryza longistaminata	35.94	5.00e-54	204.00
IUUC-Ome-081908	Oryza meridionalis	33.42	7.00e-48	184.00
IUUC-Oni-082049	Oryza nivara	33.92	7.00e-49	187.00
IUUC-Opu-083608	Oryza punctata	34.00	1.00e-49	190.00
IUUC-Oru-084712	Oryza rufipogon	33.92	7.00e-49	187.00
IUUC-Osa-086078	Oryza sativa	33.92	7.00e-49	187.00
IUUC-Oga-088459	Otolemur garnettii	79.64	0.00e+00	7132.00
IUUC-Oar-089888	Ovis aries	80.42	0.00e+00	7193.00
IUUC-Ptr-091114	Pan troglodytes	80.00	0.00e+00	7190.00
IUUC-Pan-092442	Papio anubis	79.88	0.00e+00	7185.00
IUUC-Psi-093833	Pelodiscus sinensis	79.43	0.00e+00	4775.00
IUUC-Pma-094275	Petromyzon marinus	77.58	0.00e+00	1698.00
IUUC-Ppa-095790	Physcomitrella patens	36.47	1.00e-54	207.00
IUUC-Pfo-097262	Poecilia formosa	87.62	0.00e+00	7783.00
IUUC-Pab-097760	Pongo abelii	79.16	0.00e+00	4082.00
IUUC-Pca-100465	Procavia capensis	79.72	0.00e+00	3821.00
IUUC-Ppe-101345	Prunus persica	33.76	9.00e-51	195.00
IUUC-Pva-102950	Pteropus vampyrus	79.78	0.00e+00	3405.00
IUUC-Rno-104892	Rattus norvegicus	80.15	0.00e+00	7175.00
IUUC-Sha-106633	Sarcophilus harrisii	79.22	0.00e+00	7049.00
IUUC-Smo-108827	Selaginella moellendorffii	34.45	3.00e-51	197.00
IUUC-Sit-110415	Setaria italica	37.61	4.00e-54	205.00
IUUC-Sly-111155	Solanum lycopersicum	35.36	8.00e-52	198.00
IUUC-Stu-112166	Solanum tuberosum	31.46	6.00e-47	182.00
IUUC-Sar-113251	Sorex araneus	71.16	0.00e+00	1988.00
IUUC-Sbi-114352	Sorghum bicolor	32.38	7.00e-47	182.00
IUUC-Ssc-116391	Sus scrofa	80.40	0.00e+00	7239.00
IUUC-Tgu-116554	Taeniopygia guttata	80.01	0.00e+00	7240.00
IUUC-Tru-118695	Takifugu rubripes	87.22	0.00e+00	8066.00
IUUC-Tsy-119647	Tarsius syrichta	71.08	0.00e+00	4353.00
IUUC-Tni-120707	Tetraodon nigroviridis	87.14	0.00e+00	8005.00
IUUC-Tca-121094	Theobroma cacao	33.53	1.00e-49	191.00
IUUC-Tae-124157	Triticum aestivum	32.00	3.00e-45	177.00
IUUC-Tur-126300	Triticum urartu	34.01	5.00e-47	183.00
IUUC-Tbe-127346	Tupaia belangeri	75.90	0.00e+00	2204.00
IUUC-Ttr-128542	Tursiops truncatus	73.62	0.00e+00	4616.00
IUUC-Vpa-130611	Vicugna pacos	80.88	0.00e+00	3308.00
IUUC-Xtr-131933	Xenopus tropicalis	77.52	0.00e+00	6922.00
IUUC-Xma-134216	Xiphophorus maculatus	84.17	0.00e+00	7480.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence