iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013495

UUCD1 version

UUC-BoT-00080

Ensembl Protein ID

ENSBTAP00000004657.5

UniProt Accession

A6QP14; F1MUT1; A6QP14_BOVIN

Genbank Protein ID

AAI49097.1

Protein Name

FBXW4 protein

Genbank Nucleotide ID

DAAA02058992

Gene Name

FBXW4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000003579.5	ENSBTAT00000004657.5	ENSBTAP00000004657.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.80e-06	26.8	7	68
E3 adaptor/Cullin RING/DCX/DWD	2.20e-17	62.6	198	231

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 78   seaaaapapapaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            eaaaa  pa  p+  p        l rlpee+l+ i+++ld + l+r+a+vcr +++++s + lw+++
   Q: 7    EEAAAAREPACRPAAGP-------ALLRLPEELLLLIFSYLDMQALGRLAQVCRWLRRFTSCDLLWRRI 68
           45666666655555444.......589*********************************999**9986 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H  +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 198  HVQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 231
           9999*****9449***************999875 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MATAAEEEAA AAREPACRPA AGPALLRLPE ELLLLIFSYL DMQALGRLAQ VCRWLRRFTS 60
CDLLWRRIAR ASLNSGFTRL GTDLMASVPV KERVKISQNW RLGRCREGIL LKWRCSQMPW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCAGGCCG GCAAGAGCAC AGGGACGAGG GGGTCAGGCT TGGGGCCGCC TCGCGGGGAC 60
ACGGGCGGCC ATGGCGACAG CGGCTGAGGA GGAGGCTGCG GCGGCCCGGG AGCCAGCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

bta:513977

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	97.33	0.00e+00	758.00
IUUC-Apl-003837	Anas platyrhynchos	71.30	6.00e-142	496.00
IUUC-Aca-004776	Anolis carolinensis	67.39	1.00e-139	489.00
IUUC-Ame-010651	Astyanax mexicanus	61.18	2.00e-112	398.00
IUUC-Cja-018901	Callithrix jacchus	97.02	0.00e+00	713.00
IUUC-Cfa-021251	Canis familiaris	96.26	0.00e+00	749.00
IUUC-Cpo-021750	Cavia porcellus	93.23	0.00e+00	641.00
IUUC-Csa-024026	Chlorocebus sabaeus	96.21	0.00e+00	743.00
IUUC-Cho-024496	Choloepus hoffmanni	75.07	2.00e-158	551.00
IUUC-Cin-025142	Ciona intestinalis	29.92	1.00e-21	96.70
IUUC-Csv-025883	Ciona savignyi	36.62	1.00e-62	233.00
IUUC-Dre-027447	Danio rerio	59.25	7.00e-129	453.00
IUUC-Dno-029572	Dasypus novemcinctus	81.62	6.00e-173	600.00
IUUC-Dor-030982	Dipodomys ordii	88.08	0.00e+00	664.00
IUUC-Dme-031804	Drosophila melanogaster	23.01	1.00e-12	67.40
IUUC-Ete-032917	Echinops telfairi	94.46	0.00e+00	650.00
IUUC-Eca-033969	Equus caballus	96.94	0.00e+00	724.00
IUUC-Eeu-034850	Erinaceus europaeus	85.64	0.00e+00	649.00
IUUC-Fca-036182	Felis catus	91.98	0.00e+00	687.00
IUUC-Fal-037391	Ficedula albicollis	68.27	3.00e-147	514.00
IUUC-Gmo-038632	Gadus morhua	57.10	1.00e-125	442.00
IUUC-Gga-040783	Gallus gallus	72.51	3.00e-159	554.00
IUUC-Gac-042314	Gasterosteus aculeatus	56.91	6.00e-110	390.00
IUUC-Ggo-044739	Gorilla gorilla	96.21	0.00e+00	742.00
IUUC-Hsa-046705	Homo sapiens	96.75	0.00e+00	713.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	97.23	2.00e-169	587.00
IUUC-Loc-052397	Lepisosteus oculatus	66.94	3.00e-140	491.00
IUUC-Laf-054544	Loxodonta africana	94.05	0.00e+00	657.00
IUUC-Meu-056363	Macropus eugenii	58.15	3.00e-101	361.00
IUUC-Mga-059275	Meleagris gallopavo	72.73	3.00e-143	500.00
IUUC-Mmr-060906	Microcebus murinus	96.21	0.00e+00	741.00
IUUC-Mdo-062400	Monodelphis domestica	77.01	3.00e-174	604.00
IUUC-Mmu-063556	Mus musculus	92.53	0.00e+00	714.00
IUUC-Mpu-066500	Mustela putorius furo	97.06	0.00e+00	756.00
IUUC-Mlu-068074	Myotis lucifugus	96.92	0.00e+00	660.00
IUUC-Nle-069601	Nomascus leucogenys	96.48	0.00e+00	743.00
IUUC-Opr-070904	Ochotona princeps	88.30	4.00e-147	513.00
IUUC-Ont-072679	Oreochromis niloticus	56.27	2.00e-119	422.00
IUUC-Oan-073434	Ornithorhynchus anatinus	72.43	2.00e-84	304.00
IUUC-Ocu-074649	Oryctolagus cuniculus	95.66	0.00e+00	728.00
IUUC-Ola-087336	Oryzias latipes	49.87	1.00e-101	362.00
IUUC-Oga-088590	Otolemur garnettii	93.56	0.00e+00	696.00
IUUC-Oar-090178	Ovis aries	96.80	0.00e+00	694.00
IUUC-Pan-092881	Papio anubis	96.48	0.00e+00	742.00
IUUC-Pfo-096176	Poecilia formosa	56.53	7.00e-111	394.00
IUUC-Pab-098285	Pongo abelii	96.48	0.00e+00	744.00
IUUC-Pca-100888	Procavia capensis	90.11	0.00e+00	686.00
IUUC-Pva-102184	Pteropus vampyrus	82.93	3.00e-178	617.00
IUUC-Rno-105668	Rattus norvegicus	93.30	0.00e+00	720.00
IUUC-Sha-106629	Sarcophilus harrisii	77.02	4.00e-154	536.00
IUUC-Ssc-116183	Sus scrofa	97.86	0.00e+00	761.00
IUUC-Tgu-116630	Taeniopygia guttata	71.43	1.00e-161	562.00
IUUC-Tru-118761	Takifugu rubripes	53.10	1.00e-115	409.00
IUUC-Tni-120651	Tetraodon nigroviridis	52.48	7.00e-60	223.00
IUUC-Ttr-128582	Tursiops truncatus	96.52	0.00e+00	712.00
IUUC-Vpa-130431	Vicugna pacos	75.76	2.00e-96	345.00
IUUC-Xtr-132655	Xenopus tropicalis	67.03	5.00e-149	520.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence