iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012011.3	ENSOCUT00000033734.1	ENSOCUP00000026781.1
ENSOCUG00000012011.3	ENSOCUT00000012009.2	ENSOCUP00000010330.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	5.20e-07	29.7	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MSLLNCENSC GSGQSESDCC AAMASSCSAA AKDDSVSGTA STGNLSGSFV EDIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCACTTGGT AATTAAATTA CAATGAGTCT GCTAAACTGT GAAAACAGCT GTGGATCTGG 60
CCAGTCTGAA AGTGACTGCT GTGCGGCCAT GGCCAGCTCA TGCAGTGCTG CAGCCAAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

ocu:100343190

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	92.61	0.00e+00	973.00
IUUC-Apl-004062	Anas platyrhynchos	72.79	0.00e+00	815.00
IUUC-Aca-004636	Anolis carolinensis	72.08	0.00e+00	773.00
IUUC-Ame-011682	Astyanax mexicanus	55.43	3.00e-165	575.00
IUUC-Bta-012692	Bos taurus	89.30	0.00e+00	978.00
IUUC-Cja-019426	Callithrix jacchus	90.19	0.00e+00	966.00
IUUC-Cfa-020948	Canis familiaris	90.39	0.00e+00	858.00
IUUC-Cpo-021378	Cavia porcellus	90.98	0.00e+00	975.00
IUUC-Csa-024045	Chlorocebus sabaeus	90.76	0.00e+00	977.00
IUUC-Cho-024973	Choloepus hoffmanni	75.00	9.00e-101	360.00
IUUC-Csv-026300	Ciona savignyi	41.67	2.00e-46	178.00
IUUC-Dre-027557	Danio rerio	59.41	1.00e-175	609.00
IUUC-Dno-030032	Dasypus novemcinctus	87.73	4.00e-147	513.00
IUUC-Dor-030790	Dipodomys ordii	90.39	0.00e+00	967.00
IUUC-Dse-031478	Dothistroma septosporum	24.46	1.00e-11	65.10
IUUC-Dme-031921	Drosophila melanogaster	26.55	9.00e-40	157.00
IUUC-Ete-032952	Echinops telfairi	83.78	7.00e-165	573.00
IUUC-Eca-033924	Equus caballus	87.85	0.00e+00	889.00
IUUC-Eeu-034734	Erinaceus europaeus	83.36	0.00e+00	864.00
IUUC-Fca-036222	Felis catus	85.11	0.00e+00	858.00
IUUC-Fal-036834	Ficedula albicollis	73.89	0.00e+00	735.00
IUUC-Fox-037935	Fusarium oxysporum	30.70	1.00e-22	101.00
IUUC-Gmo-039061	Gadus morhua	64.81	2.00e-89	322.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.97	4.00e-12	66.20
IUUC-Gga-040599	Gallus gallus	73.77	0.00e+00	820.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.47	5.00e-169	587.00
IUUC-Ggo-044508	Gorilla gorilla	85.08	0.00e+00	894.00
IUUC-Hsa-046349	Homo sapiens	90.94	0.00e+00	985.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	91.87	0.00e+00	980.00
IUUC-Lch-049821	Latimeria chalumnae	67.08	0.00e+00	744.00
IUUC-Loc-051995	Lepisosteus oculatus	62.04	0.00e+00	642.00
IUUC-Laf-054115	Loxodonta africana	85.77	0.00e+00	946.00
IUUC-Mcc-055298	Macaca mulatta	90.76	0.00e+00	974.00
IUUC-Mor-057263	Magnaporthe oryzae	30.09	4.00e-17	82.80
IUUC-Mpo-057517	Magnaporthe poae	29.33	5.00e-15	75.90
IUUC-Mga-059340	Meleagris gallopavo	73.59	0.00e+00	818.00
IUUC-Mvi-060553	Microbotryum violaceum	28.10	6.00e-15	75.50
IUUC-Mmr-061063	Microcebus murinus	91.50	0.00e+00	965.00
IUUC-Mdo-062075	Monodelphis domestica	81.18	0.00e+00	899.00
IUUC-Mmu-063780	Mus musculus	88.70	0.00e+00	924.00
IUUC-Mpu-065748	Mustela putorius furo	92.05	0.00e+00	984.00
IUUC-Mlu-067888	Myotis lucifugus	90.02	0.00e+00	963.00
IUUC-Ncr-068632	Neurospora crassa	29.00	1.00e-18	87.80
IUUC-Nle-069234	Nomascus leucogenys	90.94	0.00e+00	980.00
IUUC-Opr-070393	Ochotona princeps	97.65	8.00e-124	437.00
IUUC-Ont-072459	Oreochromis niloticus	58.24	5.00e-176	610.00
IUUC-Oan-073578	Ornithorhynchus anatinus	83.27	0.00e+00	922.00
IUUC-Ola-087319	Oryzias latipes	63.83	3.00e-90	325.00
IUUC-Olu-087748	Ostreococcus lucimarinus	22.18	1.00e-08	53.90
IUUC-Oga-087936	Otolemur garnettii	91.30	0.00e+00	978.00
IUUC-Oar-089379	Ovis aries	88.93	0.00e+00	978.00
IUUC-Ptr-090758	Pan troglodytes	91.31	0.00e+00	980.00
IUUC-Pan-092590	Papio anubis	90.57	0.00e+00	971.00
IUUC-Psi-093948	Pelodiscus sinensis	72.76	0.00e+00	813.00
IUUC-Pma-094434	Petromyzon marinus	50.36	7.00e-75	275.00
IUUC-Pfo-096912	Poecilia formosa	56.39	2.00e-170	592.00
IUUC-Pab-097651	Pongo abelii	91.31	0.00e+00	981.00
IUUC-Pca-100958	Procavia capensis	84.95	0.00e+00	697.00
IUUC-Pva-103247	Pteropus vampyrus	92.86	3.00e-131	461.00
IUUC-Pte-104279	Pyrenophora teres	26.64	9.00e-13	68.90
IUUC-Rno-104994	Rattus norvegicus	86.67	0.00e+00	931.00
IUUC-Sha-106494	Sarcophilus harrisii	81.89	0.00e+00	901.00
IUUC-Sar-113375	Sorex araneus	86.35	0.00e+00	921.00
IUUC-Sre-115218	Sporisorium reilianum	27.63	4.00e-16	80.10
IUUC-Ssc-115417	Sus scrofa	90.39	0.00e+00	993.00
IUUC-Tgu-117232	Taeniopygia guttata	73.22	0.00e+00	790.00
IUUC-Tru-118321	Takifugu rubripes	55.07	5.00e-168	584.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.64	6.00e-165	573.00
IUUC-Tbe-127719	Tupaia belangeri	78.97	0.00e+00	821.00
IUUC-Ttr-129264	Tursiops truncatus	89.72	3.00e-126	445.00
IUUC-Uma-129620	Ustilago maydis	26.52	4.00e-18	86.70
IUUC-Vpa-130244	Vicugna pacos	90.51	4.00e-130	458.00
IUUC-Xtr-131948	Xenopus tropicalis	65.65	0.00e+00	730.00
IUUC-Xma-133132	Xiphophorus maculatus	57.37	3.00e-172	598.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence